Role of Flavonoids in Mitigating the Pathological Complexities and Treatment Hurdles in Alzheimer's Disease

Phytotherapy Research, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

With the passage of time, people step toward old age and become more prone to several diseases associated with age. One such is Alzheimer's disease (AD) which results into neuronal damage dementia progression The existing therapeutics has been hindered by various enkindles like less eminent between remote populations, affordability issues toxicity profiles. Moreover, lack suitable therapeutic option further worsens quality life in older population. Developing an efficient intervention cure AD still a challenge for medical fraternity. Recently, alternative approaches attain attention researchers focus on plant-based therapy mitigating AD. In this context, flavonoids gained centrality as feasible treatment modifying neurological deficits. This review mainly focuses pathological facets economic burden Furthermore, we have explored possible mechanism preclinical clinical aspects curing Flavonoids being potential therapeutic, target pathogenic factors oxidative stress, inflammation, metal toxicity, Aβ accumulation, modulate neurotransmission insulin signaling. review, emphasized neuroprotective effects pathology, both experimental findings. While studies suggest promising benefits, data remains limited inconclusive. Thus, high-quality trials are necessary validate efficacy study aim promote therapies encourage add regular diet avail beneficial preventive

Language: Английский

---

Panx1 deletion promotes synaptic reconfiguration and recruitment of cell death pathways in the Zebrafish MPTP model

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 28, 2024

Abstract Pannexin-1 channels have garnered attention for their implications in neurodevelopment, potentially having a dual role mediating delicate balance between cell death and survival. However, comprehensive understanding of the underlying molecular cellular mechanisms Panx1’s potential protective functions throughout neurodevelopment remains to be determined. Zebrafish larvae with loss Pannexin-1a function were subjected an acute exposure 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Early-life changes induced by uncoupling oxidative phosphorylation investigated computational Gene Set Expression Analysis RNA-seq data experimental testing light-stimulated locomotor behavior, death, bioelectrical properties local field potentials ascending visual pathway. A KEGG pathway analysis underscored Panx1a’s regulatory influence on neurodevelopment. Targeting Panx1a caused deregulation phosphorylation, glycolysis, reactive oxygen production, hypoxia, unfolded protein response pathways, reduced extracellular ATP. Further, ablation enhanced transcriptional activation 5’ AMP-activated kinase (AMPK) kinase, energy sensor activated falling status, largely activate glucose fatty acid uptake oxidation when is low. The AMPK knock-out correlated stimulation mammalian target rapamycin (mTORC1) that controls metabolism, catabolism, immune responses, autophagy, survival, proliferation, migration, maintain homeostasis. differential expression mTORC1 genes associated apoptosis signaling pathways. resultant was pronounced pallium tectum regions. cells interrelated trans-synaptic synaptic neurotransmitter receptor ion channel/transporter expression. Local recordings optic demonstrated involvement modulating neuronal networks altered. Collectively, results shed light impacts MPTP treatment transcriptomic shifts, metabolic disturbances, pivotal death. These insights enhance our comprehension intricate underpinning therapeutic strategies targeting Panx1 autism Alzheimer’s disease. Graphical Highlights genetic model combined neurotoxin explore roles zebrafish under stress conditions. beneficial impact superseded plasticity loss, dysfunctional mitochondrial activation. Loss amplifies AMPK/mTORC1 as regulator homeostasis identified.

Language: Английский

---

Potential involvement of connective tissue growth factor in chondrocytes apoptosis of Kashin-Beck disease

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 285, P. 117148 - 117148

Published: Oct. 1, 2024

Kashin-Beck disease (KBD) is an endemic osteoarthropathy characterized by excessive chondrocytes apoptosis. T-2 toxin exposure has been proved to be its etiology. Connective tissue growth factor (CTGF) exerts a profound influence on cartilage and metabolism. We investigated the potential role of CTGF in KBD development examined alterations under stimulation.

Language: Английский

---

Exploring phytochemical inhibitors of protein kinase C alpha for therapeutic targeting of Alzheimer's disease

Journal of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 10, 2024

Alzheimer's disease (AD) is characterized by neurodegeneration linked to amyloid-β (Aβ) plaques and tau protein tangles. Protein kinase C alpha (PKCα) plays a crucial role in modulating precursor (AβPP) processing, potentially mitigating AD progression. Consequently, PKCα stands out as promising target for therapy.

Language: Английский

---

Special Issue “Physiology and Pathophysiology of the Placenta”

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3594 - 3594

Published: March 22, 2024

The placenta is a transient but essential organ for normal in utero development, playing several functions pregnancy [...].

Language: Английский

---