Stem cell biology and regenerative medicine, Journal Year: 2024, Volume and Issue: unknown, P. 29 - 114
Published: Jan. 1, 2024
Language: Английский
Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)
Published: Jan. 19, 2024
Abstract The production and release of tumor-derived small extracellular vesicles (TDSEVs) from cancerous cells play a pivotal role in the propagation cancer, through genetic biological communication with healthy cells. TDSEVs are known to orchestrate invasion-metastasis cascade via diverse pathways. Regulation early metastasis processes, pre-metastatic niche formation, immune system regulation, angiogenesis initiation, matrix (ECM) remodeling, modulation, epithelial-mesenchymal transition (EMT) among pathways regulated by TDSEVs. MicroRNAs (miRs) carried within as double-edged sword can either promote or inhibit cancer progression. serve excellent markers for detection tumors, tumor metastases. From therapeutic point view, risk may be reduced limiting On other hand, represent promising approach vivo delivery cargo present review article discusses recent developments current views field research clinical applications.
Language: Английский
Citations
35
Nanoscale, Journal Year: 2024, Volume and Issue: 16(13), P. 6330 - 6364
Published: Jan. 1, 2024
Graphical representation of recent advancements in combinatorial anticancer treatment modalities.
Language: Английский
Citations
16
International Immunopharmacology, Journal Year: 2024, Volume and Issue: 131, P. 111876 - 111876
Published: March 16, 2024
Language: Английский
Citations
9
Cancer Science, Journal Year: 2024, Volume and Issue: 115(7), P. 2333 - 2345
Published: April 27, 2024
Doublecortin (DCX)-positive neural progenitor-like cells are purported components of the cancer microenvironment. The number DCX-positive in tissues reportedly correlates with progression; however, little is known about mechanism by which these affect progression. Here we demonstrated that cells, found all major histological subtypes lung cancer, cancer-associated Schwann (CAS) and contribute to chemoresistance establishing an adrenergic Mechanistically, activation Hippo transducer YAP/TAZ was involved acquisition new traits CAS DCX positivity. We further revealed express catecholamine-synthesizing enzymes synthesize adrenaline, potentiates through YAP/TAZ. Our findings shed light on CAS, drive formation microenvironment reciprocal regulation tissues.
Language: Английский
Citations
9
Drug Development and Industrial Pharmacy, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 20
Published: Jan. 19, 2025
Objective
Language: Английский
Citations
1
Military Medical Research, Journal Year: 2025, Volume and Issue: 12(1)
Published: Feb. 11, 2025
Abstract Cancer recurrence, driven by the phenomenon of tumor dormancy, presents a formidable challenge in oncology. Dormant cancer cells have ability to evade detection and treatment, leading relapse. This review emphasizes urgent need comprehend dormancy its implications for recurrence. Despite notable advancements, significant gaps remain our understanding mechanisms underlying lack reliable biomarkers predicting provides comprehensive analysis cellular, angiogenic, immunological aspects dormancy. It highlights current therapeutic strategies targeting dormant cells, particularly combination therapies immunotherapies, which hold promise preventing By elucidating these proposing innovative research methodologies, this aims deepen ultimately facilitating development more effective recurrence improving patient outcomes.
Language: Английский
Citations
1
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 277 - 277
Published: Feb. 20, 2025
Increasing evidence shows that a very small population of cancer stem cells (CSCs) is responsible for recurrence, drug resistance, and metastasis. CSCs usually reside in hypoxic tumor regions are characterized by high tumorigenicity. Their inaccessible nature allows them to avoid the effects conventional treatments such as chemotherapy, radiotherapy, surgery. In addition, chemo- radiotherapy potentially toxic could help spread survive. New therapeutic targets against sought, including different signaling pathways distinct cell surface markers. Recent advances nanotechnology have provided hope development new avenues eradicate CSCs. this review, we present newly discovered nanoparticles can be co-loaded with an apoptosis-inducing agent or differentiation-inducing agent, stability, cellular penetration, release. We also summarize molecular characteristics their survival maintenance. Controlled release targeting aims reduce stemness-related suppress growth, prevent relapse metastases.
Language: Английский
Citations
1
European Journal of Cell Biology, Journal Year: 2023, Volume and Issue: 102(2), P. 151321 - 151321
Published: April 30, 2023
The ability of cancer cells to finally overcome various lines treatment in due course has always baffled the scientific community. Even with most promising therapies, relapse is ultimately seen, and this resilience proved be a major hurdle management cancer. Accumulating evidence now attributes plasticity. Plasticity change their properties substantial as it helps normal tissue regeneration or post-injury repair processes. It also overall maintenance homeostasis. Unfortunately, critical cells, when activated incorrectly, can lead numerous diseases, including Therefore, review, we focus on plasticity aspect an emphasis stem (CSCs). We discuss forms that provide survival advantages CSCs. Moreover, explore factors affect Furthermore, therapeutic implications Finally, insight into future targeted therapies involving for better clinical outcomes.
Language: Английский
Citations
21
Genes & Diseases, Journal Year: 2023, Volume and Issue: 11(3), P. 101043 - 101043
Published: July 19, 2023
There are few tumor cell subpopulations with stem characteristics in tissue, defined as cancer cells (CSCs) or stem-like (CSLCs), which can reconstruct neoplasms malignant biological behaviors such invasiveness via self-renewal and unlimited generation. The microenvironment that CSCs depend on consists of various cellular components corresponding medium components. Among these factors existing at a variety levels forms, cytokine networks numerous signal pathways play an important role signaling transduction. These promote maintain stemness, participate recurrence, metastasis, resistance. This review aims to summarize the recent molecular data concerning multilayered relationship between CSC-favorable microenvironments. We also discuss therapeutic implications targeting this synergistic interplay, hoping give insight into stemness for therapy prognosis.
Language: Английский
Citations
18
OpenNano, Journal Year: 2022, Volume and Issue: 8, P. 100091 - 100091
Published: Oct. 29, 2022
Cancer is a complex syndrome with high mortality rate worldwide due to the lack of effective treatments. The coordination between tumor cells and immune system components may be an important reason for failure successfully eliminated after treatment. Tumor microenvironment (TME) barriers hinder entry dispersion nanotherapeutic medicines in tumors. Extracellular vesicles (EVs) are membrane-bound structures responsible cell-to-cell carry different biomolecules physiological pathological communication cells. Their role has been mystery decades, over past two their structure content have revealed some amazing facts.Recent studies shown that exosomes play key intercellular during pathogenesis diseases such as cancer proliferation metastasis. Inspired by endogenous lipid membranes, researchers tried mimic fine laboratory load certain biological chemical drugs. Therefore, received particular attention nanotechnology, these polymeric micelles emerged potential candidates nanocarriers nanotechnology overcome various obstacles targeted drug delivery. In view importance exosomes, this review highlights use nanodrug-based medication majority investigation fields not yet moved out laboratory. It will take lot time work implement experimental findings clinical settings.
Language: Английский
Citations
21