International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 124971 - 124971
Published: Nov. 1, 2024
Language: Английский
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 70 - 70
Published: Jan. 7, 2025
Malignant growth is expected to surpass other significant causes of death as one the top reasons for dismalness and mortality worldwide. According a World Health Organization (WHO) study, this illness approximately between 9 10 million instances deaths annually. Chemotherapy, radiation, surgery are three main methods treating cancer. These seek completely eradicate all cancer cells while having fewest possible unintended impacts on healthy cell types. Owing lack target selectivity, majority medications have substantial side effects. On hand, nanomaterials transformed identification, diagnosis, management Nanostructures with biomimetic properties been grown late, fully intent observing sickness. nanostructures be consumed by in areas profound disease. Furthermore, because their extraordinary physicochemical properties, which incorporate nanoscale aspects, more prominent surface region, explicit geometrical features, ability embody different substances within or outside surfaces, remarkable nano-vehicles conveying restorative specialists designated regions. This review discusses recent developments nanostructured materials such graphene, dendrimers, cell-penetrating peptide nanoparticles, nanoliposomes, lipid magnetic nano-omics diagnosis
Language: Английский
Citations
2
Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
This review discusses the recent developments in copper-based nanomaterials that utilize copper-induced cell death, categorized by materials systems, while highlighting limitations of current cuproptosis related nanomaterials.
Language: Английский
Citations
2
Cancers, Journal Year: 2024, Volume and Issue: 16(17), P. 2975 - 2975
Published: Aug. 27, 2024
Malignant gliomas present great difficulties in treatment, with little change over the past 30 years median survival time of 15 months. Current treatment options include surgery, radiotherapy (RT), and chemotherapy. New therapies aimed at suppressing formation new vasculature (antiangiogenic treatments) or destroying formed tumor (vascular disrupting agents) show promise. This study summarizes existing knowledge regarding processes by which glioblastoma (GBM) tumors acquire resistance to antiangiogenic treatments. The discussion encompasses activation redundant proangiogenic pathways, heightened cell invasion metastasis, induced hypoxia, creation vascular mimicry channels, regulation immune microenvironment. Subsequently, we explore potential strategies overcome this resistance, such as combining other methods, personalizing treatments for each patient, focusing on therapeutic targets, incorporating immunotherapy, utilizing drug delivery systems based nanoparticles. Additionally, would like discuss limitations methods future directions enhance beneficial effects patients GBM. Therefore, review aims research outcome GBM provide a more promising opportunity thoroughly exploring mechanisms investigating novel strategies.
Language: Английский
Citations
9
Nano TransMed, Journal Year: 2024, Volume and Issue: 3, P. 100041 - 100041
Published: July 9, 2024
Artificial Intelligence (AI) and Nanotechnology are two cutting-edge fields that hold immense promise for revolutionizing various aspects of science, technology, everyday life. This review delves into the intersection these disciplines, highlighting synergistic relationship between AI Nanotechnology. It explores how techniques such as machine learning, deep neural networks being employed to enhance efficiency, precision, scalability nanotechnology applications. Furthermore, it discusses challenges, opportunities, future prospects integrating with nanotechnology, paving way transformative advancements in diverse domains ranging from healthcare materials science environmental sustainability beyond.
Language: Английский
Citations
7
Asian Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 101021 - 101021
Published: Jan. 1, 2025
Although with aggressive standards of care like surgical resection, chemotherapy, and radiation, high-grade gliomas (HGGs) brain metastases (BM) treatment has remained challenging for more than two decades. However, technological advances in this field immunotherapeutic strategies have revolutionized the HGGs BM. Immunotherapies immune checkpoint inhibitors, CAR-T targeting, oncolytic virus-based therapy, bispecific antibody treatment, vaccination approaches, etc., are emerging as promising avenues offering new hope refining patient's survival benefits. selective trafficking across blood-brain barrier (BBB), immunosuppressive tumor microenvironment (TME), metabolic alteration, heterogeneity limit therapeutic efficacy immunotherapy Furthermore, to address concern, NanoBioTechnology-based bioinspired delivery system been gaining tremendous attention recent years. With such Trojan horse targeting infusing/camouflaging nanoparticles surface biological molecules/cells immunocytes, erythrocytes, platelets, glioma cell lysate and/or integrating these get hybrid membrane homotypic recognition. These biomimetic nanotherapy offers advantages over conventional nanoparticles, focusing on greater target specificity, increased circulation stability, higher active loading capacity, BBB permeability (inherent inflammatory chemotaxis neutrophils), decreased immunogenicity, efficient metabolism-based combinatorial effects, prevention recurrence by induction immunological memory, etc. provide age improved immunotherapies outcomes against In review, we emphasize neuro-immunotherapy versatility nano-delivery precise hard-to-treat most lethal Moreover, challenges impeding clinical translatability approaches were addressed unmet medical needs cancers.
Language: Английский
Citations
0
Clinical Breast Cancer, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: March 21, 2025
In this study, a novel cascade nano delivery system, Cur/Gox@LCOF, was developed for enhanced breast cancer therapy. The system loads curcumin (Cur) and glucose oxidase (Gox) into lipid copper-based organic framework (LCOF) carrier tumor nanoparticles were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), dynamic light scattering (DLS), which showed that they had uniform spherical morphology with an average particle size of about 80 nm, displaying stable colloidal properties. excellent stability under simulated physiological conditions exhibited pH-responsive drug release properties, contributing to the controlled Cur Gox. results in vitro cellular experiments Cur/Gox@LCOF significantly production reactive oxygen species (ROS), leading significant cytotoxicity cells. addition, also demonstrated therapeutic efficacy good biocompatibility mouse model. Thus, study nanocarrier platform triple synergistic chemokinetic/chemotherapy/starvation therapy, has promising applications efficient treatment tumors.
Language: Английский
Citations
0
BioNanoScience, Journal Year: 2025, Volume and Issue: 15(2)
Published: March 24, 2025
Language: Английский
Citations
0
Published: Jan. 1, 2025
Language: Английский
Citations
0
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 26, 2025
Abstract Multimodal therapy often demonstrates superior therapeutic effects compared to monotherapy. Phototherapy is a promising approach for cancer treatment, as it can induce tumor pyroptosis and activate antitumor immune responses. However, mitochondrial oxidative stress during frequently stimulates protective autophagy in cells, thereby seriously impeding the progress of pyroptosis. Therefore, developing that enhances through inhibiting critical improving treatment efficacy. In this study, photoactivated mitochondrial‐targeting self‐assembled nanomicelle ( 3M@C ) integrates an aggregation‐induced emission photosensitizer inhibitor chloroquine designed. generate both type I II reactive oxygen species heat under light exposure, inducing dysfunction triggering pyroptosis, achieving photodynamic synergistic photothermal therapy. Meanwhile, inhibit mitophagy, further enhance effects, vivo experiments demonstrate strategy exhibits excellent biosafety significant efficacy, effectively suppressing growth. addition, method nanomicelles mitophagy inhibition providing novel photoimmunotherapy.
Language: Английский
Citations
0