Stem cell biology and regenerative medicine, Journal Year: 2024, Volume and Issue: unknown, P. 29 - 114
Published: Jan. 1, 2024
Language: Английский
Molecular Pharmaceutics, Journal Year: 2023, Volume and Issue: 20(11), P. 5254 - 5277
Published: Aug. 19, 2023
Cancer remains the leading cause of death and rapidly evolving disease worldwide. The understanding pathophysiology has improved through advanced research investigation, several therapeutic strategies are being used for better cancer treatment. However, increase in relapse metastatic-related deaths indicate that available therapies clinically approved chemotherapy drugs not sufficient to combat cancer. Further, constant crosstalk between tumor cells microenvironment (TME) is crucial development, progression, metastasis, response tumors. In this regard, phytochemicals with multimodal targeting abilities can be as an alternative current therapy by inhibiting survival pathways or modulating TME. due their poor pharmacokinetics low bioavailability, success clinical trials limited. Therefore, developing phytochemical-based nanomedicine phytonanomedicine improve pharmacokinetic profile these phytochemicals. Herein, molecular characteristics pharmacological insights proposed tissue altering stem cells, chemoresistance, TME, immunity well discussed. we have highlighted perspective challenges filling gap potential therapeutics using various nanoplatforms. Overall, discussed how could make it more beneficial boost concept academic pharmaceutical fields counter metastases drug resistance.
Language: Английский
Citations
11
Translational Oncology, Journal Year: 2024, Volume and Issue: 46, P. 102023 - 102023
Published: June 8, 2024
Medulloblastoma is a type of brain cancer that primarily affects children. While chemotherapy has been shown to be effective in treating medulloblastoma, the development resistance remains challenge. One potential therapeutic approach selectively inhibit inducible transcription factor called STAT3, which known play crucial role survival and growth tumor cells. The activation STAT3 linked progression various cancers, including medulloblastoma. Inhibition sensitize medulloblastoma cells chemotherapy, leading improved treatment outcomes. Different approaches inhibition have developed, small-molecule inhibitors RNA interference. Preclinical studies efficacy clinical trials are currently ongoing evaluate their safety effectiveness patients with solid tumors, In addition, researchers also exploring ways optimize use combination identify biomarkers can predict will help develop personalized strategies. This review highlights selective as novel for suggests further research into could lead outcomes aggressive cancer.
Language: Английский
Citations
4
Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 99, P. 105980 - 105980
Published: July 16, 2024
The current standard therapy for GBM includes maximal surgical resection, followed by concurrent radiotherapy and oral chemotherapy; however, the median post-diagnosis survival period is only 15–18 months. Nanoparticles (NPs) their composite drug delivery systems (DDSs)—particularly those with liposomes polymeric nanoparticles (PNPs)—have become an increasingly popular route therapeutic in glioblastoma multiforme (GBM). These also have added benefit of enabling combinational therapies, which particularly necessary more resilient cancers like GBM. To ensure most effective means targeting tumor microenvironment (TME), stem cells (GSCs) can be used, both as targets vectors—both avenues showing promising results. However, DDSs directed towards brain must overcome many barriers associated cranial administration—including blood-brain-barrier (BBB) its derivatives, intracranial fluid pressure, induced regression from NP activating protocols involving heat or electromagnetic radiation, extended retention synthetic within tissue—before they finally circulate clinical domain. In this article, we review progress made incorporating GSCs design, well challenges that need to addressed facilitate a widespread regimen successfully treating
Language: Английский
Citations
4
Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 12
Published: Jan. 3, 2025
Recent experimental findings indicate that cancer stem cells originate from transformed very small embryonic-like cells. This finding represents an essential advancement in uncovering the processes drive onset and progression of cancer. In continuously growing cell lines, for first time, our team's follow-up research on leukemia, lung cancer, healthy embryonic kidney revealed stages resembles precursor review explores origin leukemic stem-like establish We explore theoretical model acute myeloid leukemia initiation progresses through various stages, as well basing HL60 line, present its hierarchical stage development vitro, highlighting role these primitive stages. also discuss potential implications further into unique cellular advancing treatment prevention.
Language: Английский
Citations
0
Biochemistry and Biophysics Reports, Journal Year: 2025, Volume and Issue: 41, P. 101909 - 101909
Published: Jan. 9, 2025
Language: Английский
Citations
0
Cancer Medicine, Journal Year: 2025, Volume and Issue: 14(9)
Published: May 1, 2025
ABSTRACT Background Triple‐negative breast cancer (TNBC) is one of the most heterogeneous and menacing forms cancer, with no sustainable cure available in current treatment landscape. Its lack targets makes it highly unresponsive to various modalities, which why chemotherapy continues be primary form treatment, despite high rates patients developing chemoresistance. In recent years, however, there has been significant progress identifying understanding role several aspects that might contribute genomic instability other hallmarks including cellular proteins, immune targets, epigenetic mechanisms, are desirable as they permit reversibility easier than often‐adamant genetic changes. Methods A literature review was conducted on TNBC associated biomarkers, their therapeutic applications, tumorigenesis tumor maintenance, a focus linking both driving biological mechanisms emerging options for TNBC. Conclusions Shifting identify crucial cell subpopulations such local populations stem cells, could potentially solve or simplify decades' worth problems TNBC, bolstering early detection evolution precision medicine treatment. The techniques can used here analysis RNA sequencing. Biomarkers, PD‐L1, survivin, ABC transporters, implicated processes maintain tumors, proliferation, metastasis, immunosuppression, stemness. Complex as, immunotherapy, pathway inhibition, PARP virotherapy, targeting have considered Phytochemicals also being modality supplement radiation therapy, sole
Language: Английский
Citations
0
Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)
Published: May 27, 2024
Abstract Cancer stem cells (CSCs) are a sub-population of possessing high tumorigenic potential, which contribute to therapeutic resistance, metastasis and recurrence. Eradication CSCs is widely recognized as crucial factor in improving patient prognosis, yet the effective targeting these remains major challenge. Here, we show that lysosomal cation channel TRPML1 represents promising target for CSCs. highly expressed breast cancer exhibits sensitivity salinomycin, drug known selectively eliminate Pharmacological inhibition genetic depletion promote ferroptosis CSCs, reduce their stemness, enhance chemotherapy doxorubicin. The knockout also demonstrate significant suppression tumor formation growth mouse xenograft model. These findings suggest may be an strategy treatment cancer.
Language: Английский
Citations
3
Discover Oncology, Journal Year: 2023, Volume and Issue: 14(1)
Published: Dec. 1, 2023
Cancer stem cells (CSCs), being the primary contributors in tumor initiation, metastasis, and relapse, ought to have seminal roles evasion of immune surveillance. Tumor-promoting CD4+CD25+FOXP3+ T-regulatory (Tregs) been described abolish host defense mechanisms by impeding activities other including effector T cells. However, whether CSCs can convert immune-suppressive Treg subset, if yes, mechanism underlying CSC-induced generation, are limitedly studied. In this regard, we observed a positive correlation between breast CSC signature markers both in-silico immunohistochemical analyses. Mirroring conditions during low number could successfully generate from infiltrating CD4+ lymphocytes contact-independent manner. Suppressing proliferation potential as well IFNγ production capacity cells, these might be inhibiting antitumor immunity, thereby hindering immune-elimination initiation. Furthermore, unlike non-stem cancer (NSCCs), escaped doxorubicin-induced apoptosis, thus constituting major surviving population after three rounds chemotherapy. These drug-survived were also able Our search for further unveiled role CSC-shed cytokine TGFβ, which was increased chemotherapy, generating conclusion, initiation when NSCCs not present microenvironment, CSCs, albeit numbers, immunosuppressive manner shedding high levels Treg-polarizing escaping initiating or causing relapse.
Language: Английский
Citations
7
Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: 223, P. 116178 - 116178
Published: March 30, 2024
Despite the significant improvements made in breast cancer therapy during last decades, this disease still has increasing incidence and mortality rates. Different targets involved general processes, like cell proliferation survival, have become alternative therapeutic options for disease, with some of them already used clinic, CDK4/6 inhibitors luminal A tumors treatment. Nevertheless, there is a demand novel strategies focused not only on tumor cells, but also their microenvironment. Tumor microenvironment (TME) very complex dynamic system that, more than surrounding supporting actively participates development progression. During it clear that cellular acellular components TME differ between various subtypes shape differences regarding severity prognosis. The pivotal role controlling growth influencing responses to represents potential source strategies. In review, we present description multiple different subtypes, as well influence may exert response distinct therapies, which cases explain failure by occurrence relapses resistance. Furthermore, ongoing studies use developing treatments are described.
Language: Английский
Citations
2
Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(9)
Published: April 29, 2024
Non-small-cell lung cancer (NSCLC) is a major cause of worldwide death, posing challenge for effective treatment. Our previous findings showed that Chinese herbal medicine (CHM) QiDongNing (QDN) could upregulate the expression p53 and trigger cell apoptosis in NSCLC. Here, our objective was to investigate mechanisms QDN-induced enhancement. We chose A549 NCI-H460 cells validation vitro, LLC were applied form subcutaneous transplantation tumour model more depth. indicated QDN inhibited multiple biological behaviours, including proliferation, cloning, migration, invasion induction apoptosis. further discovered increased pro-apoptotic BAX while inhibiting anti-apoptotic Bcl2. therapy led decline adenosine triphosphate (ATP) rise reactive oxygen species (ROS). Furthermore, elevated levels suppressor mitochondrial division factor DRP1 FIS1, decreased fusion molecules MFN1, MFN2, OPA1. The results verified by rescue experiments, inhibitor Pifithrin-α Mdivi1 partially dysfunction, whereas overexpression rather efficacy therapy. Additionally, growth with acceptable safety vivo. In conclusion, induced via triggering p53/DRP1-mediated fission NSCLC cells.
Language: Английский
Citations
2