Aging and Disease,
Journal Year:
2024,
Volume and Issue:
unknown, P. 0 - 0
Published: Jan. 1, 2024
Age-induced
alterations
in
human
immunity
are
often
considered
deleterious
and
referred
to
as
immunosenescence.
The
immune
system
monitors
the
number
of
senescent
cells
body,
while
immunosenescence
may
represent
initiation
systemic
aging.
Immune
cells,
particularly
T
most
impacted
involved
age-related
function
deterioration,
making
older
individuals
more
prone
different
diseases.
T-cell
senescence
can
impact
effectiveness
immunotherapies
that
rely
on
system's
function,
including
vaccines
adoptive
therapies.
research
practice
using
therapeutic
targets
intervene
diseases
their
nascent
stages.
Therefore,
this
review,
we
summarize
recent
related
literature
investigate
characteristics
well
formation
mechanisms,
relationship
with
various
aging-related
diseases,
means
intervention.
primary
objective
article
is
explore
prospects
possibilities
therapeutically
targeting
serving
a
valuable
resource
for
development
immunotherapy
treatment
Molecular Metabolism,
Journal Year:
2023,
Volume and Issue:
74, P. 101755 - 101755
Published: June 16, 2023
Recently,
the
hallmarks
of
aging
were
updated
to
include
dysbiosis,
disabled
macroautophagy,
and
chronic
inflammation.
In
particular,
low-grade
inflammation
during
aging,
without
overt
infection,
is
defined
as
"inflammaging,"
which
associated
with
increased
morbidity
mortality
in
population.
Emerging
evidence
suggests
a
bidirectional
cyclical
relationship
between
development
age-related
conditions,
such
cardiovascular
diseases,
neurodegeneration,
cancer,
frailty.
How
crosstalk
other
underlies
biological
mechanisms
disease
thus
particular
interest
current
geroscience
research.
GeroScience,
Journal Year:
2024,
Volume and Issue:
46(5), P. 5103 - 5132
Published: April 19, 2024
Cerebral
microhemorrhages
(CMHs,
also
known
as
cerebral
microbleeds)
are
a
critical
but
frequently
underestimated
aspect
of
small
vessel
disease
(CSVD),
bearing
substantial
clinical
consequences.
Detectable
through
sensitive
neuroimaging
techniques,
CMHs
reveal
an
extensive
pathological
landscape.
They
prevalent
in
the
aging
population,
with
multiple
often
being
observed
given
individual.
closely
associated
accelerated
cognitive
decline
and
increasingly
recognized
key
contributors
to
pathogenesis
vascular
impairment
dementia
(VCID)
Alzheimer's
(AD).
This
review
paper
delves
into
hypothesis
that
atherosclerosis,
age-related
large
disease,
extends
its
influence
microcirculation,
thereby
contributing
development
progression
CSVD,
specific
focus
on
CMHs.
We
explore
concept
continuum,
bridging
macrovascular
pathologies
like
atherosclerosis
microvascular
abnormalities
characteristic
CSVD.
posit
same
risk
factors
precipitating
vessels
(i.e.,
atherogenesis),
primarily
oxidative
stress
inflammatory
pathways,
similarly
instigate
aging.
Accelerated
leads
increased
fragility,
which
turn
predisposes
formation
The
presence
hypertension
amyloid
pathology
further
intensifies
this
process.
comprehensively
overview
current
body
evidence
supporting
interconnected
hypothesis.
Our
includes
examination
epidemiological
data,
provides
insights
prevalence
impact
context
Furthermore,
we
shared
mechanisms
between
aging,
atherogenesis,
particularly
focusing
how
these
intertwined
processes
contribute
genesis
By
highlighting
role
pathophysiology
CMHs,
seeks
enhance
understanding
CSVD
links
systemic
disorders.
aim
is
provide
could
inform
future
therapeutic
approaches
research
directions
realm
neurovascular
health.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Feb. 20, 2024
Abstract
In
mice,
periodic
cycles
of
a
fasting
mimicking
diet
(FMD)
protect
normal
cells
while
killing
damaged
including
cancer
and
autoimmune
cells,
reduce
inflammation,
promote
multi-system
regeneration,
extend
longevity.
Here,
we
performed
secondary
exploratory
analysis
blood
samples
from
randomized
clinical
trial
(NCT02158897)
show
that
3
FMD
in
adult
study
participants
are
associated
with
reduced
insulin
resistance
other
pre-diabetes
markers,
lower
hepatic
fat
(as
determined
by
magnetic
resonance
imaging)
increased
lymphoid
to
myeloid
ratio:
an
indicator
immune
system
age.
Based
on
validated
measure
biological
age
predictive
morbidity
mortality,
were
decrease
2.5
years
median
age,
independent
weight
loss.
Nearly
identical
findings
resulted
second
(NCT04150159).
Together
these
results
provide
initial
support
for
beneficial
effects
the
multiple
cardiometabolic
risk
factors
biomarkers
Immunity & Ageing,
Journal Year:
2022,
Volume and Issue:
19(1)
Published: Dec. 13, 2022
It
has
been
widely
accepted
that
monocytes
are
one
of
the
central
mediators
contributing
to
inflammaging.
However,
it
remains
unclear
whether
aged
monocytes,
similar
T
cells,
have
characteristics
hyperactivation
and
increased
expression
co-inhibitory
molecules.Peripheral
blood
mononuclear
cells
(PBMCs)
were
isolated
from
young
(21-40
years
old),
middle-aged
(41-60
older
human
subjects
(>
60
old).
Flow
cytometry
was
used
monitor
changes
in
surface
molecules
monocyte
subsets
cytokine-producing
capacity.We
observed
tumor
necrosis
factor-α:
TNF-α
decreased
interleukin-6
(IL-6)
production
adults
compared
with
adults.
Older
had
a
greater
percentage
intermediate
non-classical
subsets,
along
levels
immune
activation
markers
leukocyte
antigen-DR
(HLA-DR),
adhesion
cluster
differentiation
molecule
11b
(CD11b)
L-selectin
(CD62L).
Furthermore,
we
C-C
motif
chemokine
receptor
2
(CCR2)
on
classical
C-X3-C
1
(CX3CR1)
adult
subjects.
The
receptors
reduced
adults.Circulating
exhibit
activation,
adhesion,
migration
markers,
but
molecules.
International Journal of Environmental Research and Public Health,
Journal Year:
2023,
Volume and Issue:
20(10), P. 5845 - 5845
Published: May 17, 2023
The
gut
microbiota
(GM)
has
been
the
subject
of
intense
research
in
recent
years.
Therefore,
numerous
factors
affecting
its
composition
have
thoroughly
examined,
and
with
them,
their
function
role
individual's
systems.
microbiota's
taxonomical
dramatically
impacts
older
adults'
health
status.
In
this
regard,
it
could
either
extend
life
expectancy
via
modulation
metabolic
processes
immune
system
or,
case
dysbiosis,
predispose
them
to
age-related
diseases,
including
bowel
inflammatory
musculoskeletal
diseases
neurological
disorders.
general,
microbiome
elderly
tends
present
taxonomic
functional
changes,
which
can
as
a
target
modulate
improve
population.
GM
centenarians
is
unique,
faculty-promoting
pathways
capable
preventing
counteracting
different
associated
diseases.
molecular
mechanisms
by
exhibit
anti-ageing
properties
are
mainly
based
on
anti-inflammatory
antioxidant
actions.
This
review
focuses
analysing
current
knowledge
characteristics
modifiers,
relationship
ageing,
GM-modulating
approaches
increase
expectancy.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(7), P. 1774 - 1774
Published: April 5, 2023
Inflammaging
refers
to
a
chronic,
systemic,
low-grade
inflammation,
driven
by
immune
(mainly
macrophages)
and
non-immune
cells
stimulated
endogenous/self,
misplaced
or
altered
molecules,
belonging
physiological
aging.
This
age-related
inflammatory
status
is
characterized
increased
inflammation
decreased
macroautophagy/autophagy
(a
degradation
process
that
removes
unnecessary
dysfunctional
cell
components).
predisposes
diseases,
including
obesity,
type-2
diabetes,
cancer,
cardiovascular
neurodegenerative
disorders,
as
well
vulnerability
infectious
diseases
vaccine
failure,
representing
thus
major
target
for
anti-aging
strategies.
Phenolic
compounds—found
in
extra-virgin
olive
oil
(EVOO)—are
known
their
beneficial
effect
on
longevity.
Among
them,
hydroxytyrosol
(HTyr)
appears
greatly
contribute
healthy
aging
its
documented
potent
antioxidant
activity.
In
addition,
HTyr
can
modulate
autophagy,
possibly
counteracting
reducing
inflammaging.
this
review,
we
reference
the
literature
pure
modulatory
agent
of
order
highlight
possible
interference
with
HTyr-mediated
activity
might
delay
development
progression
related
