Life,
Journal Year:
2024,
Volume and Issue:
15(1), P. 3 - 3
Published: Dec. 24, 2024
The
human
microbiota
constitute
a
very
complex
ecosystem
of
microorganisms
inhabiting
both
the
inside
and
outside
our
bodies,
in
which
health
maintenance
disease
modification
are
main
regulatory
features.
recent
explosion
microbiome
research
has
begun
to
detail
its
important
role
neurological
health,
particularly
concerning
cerebral
small
vessel
(CSVD),
disorder
associated
with
cognitive
decline
vascular
dementia.
This
narrative
review
represents
state-of-the-art
knowledge
intimate,
interplay
between
brain
through
gut-brain
axis
(GBA)
emerging
glymphatic
system
dysfunction
(glymphopathy)
circulating
cell-derived
microparticles
(MPs)
as
mediators
these
interactions.
We
discuss
how
microbial
dysbiosis
promotes
neuroinflammation,
dysfunction,
impaired
waste
clearance
brain,
critical
factors
pathogenesis
CSVD.
Further,
we
lifestyle
that
shape
composition
functionality
microbiota,
focusing
on
sleep
modifiable
risk
factor
disorders.
presents
from
neuroscientific
perspective
establish
future
therapeutic
avenues
targeting
improve
reduce
burden
Ageing Research Reviews,
Journal Year:
2024,
Volume and Issue:
101, P. 102480 - 102480
Published: Sept. 3, 2024
Mitochondria
functionally
degrade
as
neurons
age.
Degenerative
changes
cause
inefficient
oxidative
phosphorylation
(OXPHOS)
and
elevated
electron
leakage
from
the
transport
chain
(ETC)
promoting
increased
intramitochondrial
generation
of
damaging
reactive
oxygen
nitrogen
species
(ROS
RNS).
The
associated
progressive
accumulation
molecular
damage
causes
an
increasingly
rapid
decline
in
mitochondrial
physiology
contributing
to
aging.
Melatonin,
a
multifunctional
free
radical
scavenger
indirect
antioxidant,
is
synthesized
matrix
neurons.
Melatonin
reduces
ETC
elevates
ATP
production;
it
also
detoxifies
ROS/RNS
via
SIRT3/FOXO
pathway
upregulates
activities
superoxide
dismutase
2
glutathione
peroxidase.
influences
glucose
processing
by
In
neurogenerative
diseases,
often
adopt
Warburg-type
metabolism
which
excludes
pyruvate
mitochondria
causing
reduced
acetyl
coenzyme
A
production.
Acetyl
supports
citric
acid
cycle
OXPHOS.
Additionally,
required
co-substrate
for
arylalkylamine-N-acetyl
transferase,
rate
limits
melatonin
synthesis;
therefore,
production
diminished
cells
that
experience
making
more
vulnerable
stress.
Moreover,
endogenously
produced
diminishes
during
aging,
further
increasing
components.
More
normal
preserved
aging
with
supplementation.
Aging-related
disorders
pose
significant
challenges
due
to
their
complex
interplay
of
physiological
and
metabolic
factors,
including
inflammation,
oxidative
stress,
mitochondrial
dysfunction.
Curcumin,
a
natural
compound
with
potent
antioxidant
anti-inflammatory
properties,
has
emerged
as
promising
candidate
for
mitigating
these
age-related
processes.
However,
gaps
in
understanding
the
precise
mechanisms
curcumin's
effects
optimal
dosages
different
conditions
necessitate
further
investigation.
This
systematic
review
synthesizes
current
evidence
on
potential
addressing
disorders,
emphasizing
its
impact
cognitive
function,
neurodegeneration,
muscle
health
older
adults.
By
evaluating
safety,
efficacy,
action
curcumin
supplementation,
this
aims
provide
insights
into
therapeutic
promoting
healthy
aging.
A
search
across
three
databases
using
specific
keywords
yielded
2,256
documents,
leading
selection
15
clinical
trials
synthesis.
Here
we
highlight
multifaceted
agent
combating
disorders.
The
findings
suggest
that
could
offer
effective
approach
enhancing
quality
life
aging
individuals.
Further
research
well-designed
are
essential
validate
optimize
use
personalized
medicine
approaches
conditions.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(16), P. 2721 - 2721
Published: Aug. 15, 2024
Aging-related
disorders
pose
significant
challenges
due
to
their
complex
interplay
of
physiological
and
metabolic
factors,
including
inflammation,
oxidative
stress,
mitochondrial
dysfunction.
Curcumin,
a
natural
compound
with
potent
antioxidant
anti-inflammatory
properties,
has
emerged
as
promising
candidate
for
mitigating
these
age-related
processes.
However,
gaps
in
understanding
the
precise
mechanisms
curcumin’s
effects
optimal
dosages
different
conditions
necessitate
further
investigation.
This
systematic
review
synthesizes
current
evidence
on
potential
addressing
disorders,
emphasizing
its
impact
cognitive
function,
neurodegeneration,
muscle
health
older
adults.
By
evaluating
safety,
efficacy,
action
curcumin
supplementation,
this
aims
provide
insights
into
therapeutic
promoting
healthy
aging.
A
search
across
three
databases
using
specific
keywords
yielded
2256
documents,
leading
selection
15
clinical
trials
synthesis.
Here,
we
highlight
multifaceted
agent
combating
disorders.
The
findings
suggest
that
could
offer
effective
approach
enhancing
quality
life
aging
individuals.
Further
research
well-designed
are
essential
validate
optimize
use
personalized
medicine
approaches
conditions.
GeroScience,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 21, 2025
Abstract
Vascular
cognitive
impairment
(VCI)
is
a
leading
cause
of
age-related
decline,
driven
by
cerebrovascular
dysfunction
and
cerebral
small
vessel
disease
(CSVD).
Emerging
evidence
suggests
that
cerebromicrovascular
endothelial
senescence
plays
an
important
role
in
the
pathogenesis
VCI
promoting
blood
flow
dysregulation,
neurovascular
uncoupling,
blood–brain
barrier
(BBB)
disruption,
development
microhemorrhages
(CMHs).
This
review
explores
concept
as
continuum
vascular
aging,
linking
macrovascular
atherosclerosis
with
microvascular
dysfunction.
It
examines
mechanisms
which
drives
pathology
highlights
impact
cardiovascular
risk
factors
accelerating
these
processes.
We
examine
preclinical
clinical
studies
provide
compelling
atherosclerosis-induced
exacerbates
impairment.
In
particular,
findings
suggest
targeting
senescent
cells
through
senolytic
therapy
can
restore
function
improve
outcomes
experimental
models
atherosclerosis.
Given
growing
recognition
therapeutic
target,
further
research
warranted
to
explore
novel
interventions
such
senolytics,
anti-inflammatory
agents,
metabolic
modulators.
The
circulating
biomarkers
(e.g.,
senescence-associated
secretory
phenotype
[SASP]
components
endothelial-derived
extracellular
vesicles)
could
enable
early
detection
stratification
individuals
at
high
for
VCI.
Additionally,
lifestyle
modifications,
including
Mediterranean
diet,
hold
promise
delaying
mitigating
decline.
conclusion,
key
mechanistic
link
between
Addressing
aging
modifiable
factor
targeted
offers
promising
strategy
reducing
burden
preserving
populations.
GeroScience,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 15, 2024
Abstract
Aging
is
a
multifaceted
process
characterized
by
gradual
decline
in
physiological
function
and
increased
susceptibility
to
range
of
chronic
diseases.
Among
the
molecular
cellular
mechanisms
driving
aging,
genomic
instability
fundamental
hallmark,
contributing
mutation
load
genetic
heterogeneity
within
populations.
This
review
explores
role
aging
hematopoietic
system,
with
particular
focus
on
clonal
hematopoiesis
indeterminate
potential
(CHIP),
monoclonal
gammopathy
undetermined
significance
(MGUS),
B-cell
lymphocytosis
(MBL)
as
biomarkers.
CHIP
involves
expansion
stem
cells
somatic
mutations.
In
contrast,
MGUS
presence
plasma
producing
immunoglobulins,
while
MBL
proliferation
B
cells.
These
conditions
are
prevalent
population
serve
measurable
indicators
underlying
instability.
Studying
these
entities
offers
valuable
insights
into
which
mutations
accumulate
drive
evolution
providing
deeper
understanding
how
impacts
tissue
homeostasis.
summary,
system
serves
powerful
model
for
investigating
interplay
between
aging.
Incorporating
age-related
hematological
research,
alongside
other
biomarkers
such
epigenetic
clocks,
can
enhance
precision
predictive
power
biological
age
assessments.
provide
comprehensive
view
process,
facilitating
early
detection
diseases
hopefully
enabling
personalized
healthcare
strategies.
