Radiological Thoracic Vertebral Fractures are Highly Prevalent in COVID-19 and Predict Disease Outcomes DOI Creative Commons
Luigi di Filippo, Anna Maria Formenti,

Mauro Doga

et al.

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2020, Volume and Issue: 106(2), P. e602 - e614

Published: Oct. 21, 2020

Abstract Context and Objective COVID-19 has become the most relevant medical issue globally. Despite several studies that have investigated clinical characteristics of patients, no data been reported on prevalence vertebral fractures (VFs). Since VFs may influence cardiorespiratory function disease outcomes, aim this study was to assess impact in COVID-19. Design Patients This a retrospective cohort performed at San Raffaele Hospital, tertiary health care hospital Italy. We included patients for whom lateral chest x-rays emergency department were available. detected using semiquantitative evaluation shape x-rays. Results A total 114 thoracic 41 (36%). with older more frequently affected by hypertension coronary artery (P < 0.001, P = 0.007, 0.034; respectively). Thirty-six (88%) VFs+ group compared 54 (74%) VFs− hospitalized 0.08). required noninvasive mechanical ventilation those without 0.02). Mortality 22% 10% 0.07). In particular, mortality higher severe moderate mild 0.04). Conclusions integrate risk being useful easy measure marker fragility poor prognosis. suggest morphometric should be all suspected undergoing

Language: Английский

Management of Graves Thyroidal and Extrathyroidal Disease: An Update DOI Creative Commons
George J. Kahaly

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2020, Volume and Issue: 105(12), P. 3704 - 3720

Published: Sept. 14, 2020

Abstract Context Invited update on the management of systemic autoimmune Graves disease (GD) and associated orbitopathy (GO). Evidence acquisition Guidelines, pertinent original articles, reviews, meta-analyses. synthesis Thyrotropin receptor antibodies (TSH-R-Abs), foremost stimulatory TSH-R-Abs, are a specific biomarker for GD. Their measurement assists in differential diagnosis hyperthyroidism offers accurate rapid Thyroid ultrasound is sensitive imaging tool Worldwide, thionamides favored treatment (12-18 months) newly diagnosed GD, with methimazole (MMI) as preferred drug. Patients persistently high TSH-R-Abs and/or persistent at 18 months, or relapse after completing course MMI, can opt definitive therapy radioactive iodine (RAI) total thyroidectomy (TX). Continued long-term, low-dose MMI administration valuable safe alternative. Patient choice, both initial presentation GD recurrence, should be emphasized. Propylthiouracil to during first trimester pregnancy. TX best performed by high-volume thyroid surgeon. RAI avoided patients active GO, especially smokers. Recently, promising an anti-insulin-like growth factor-1 monoclonal antibody active/severe GO was approved Food Drug Administration. COVID-19 infection risk factor poorly controlled hyperthyroidism, which contributes infection–related mortality risk. If not severe, steroid postponed while local preventive measures offered. Conclusions A clear trend towards serological medical has emerged.

Language: Английский

Citations

167
A Basic Review of the Preliminary Evidence That COVID-19 Risk and Severity Is Increased in Vitamin D Deficiency DOI Creative Commons
Linda Benskin

Frontiers in Public Health, Journal Year: 2020, Volume and Issue: 8

Published: Sept. 10, 2020

As the attention of world has been riveted upon growing Covid-19 pandemic, many researchers have written brief reports supporting hypothesis that vitamin D deficiency is related to incidence and severity Covid-19. A literature search was performed on PubMed Google Scholar, with searches providing additional sources. The research evidence a link between risks already quite strong. Vitamin can help explain why each high risk group more likely develop severe Covid-19, certain areas fatalities, produces cytokine storm in high-risk individuals. strongly supports supplements during pandemic for people who are less able synthesize it from sun. review found prophylactically correcting possible 2000IU daily extremely safe.

Language: Английский

Citations

152
Disruption in food supply chain and undernourishment challenges: An empirical study in the context of Asian countries DOI
Syed Abdul Rehman Khan,

Asif Razzaq,

Zhang Yu

et al.

Socio-Economic Planning Sciences, Journal Year: 2021, Volume and Issue: 82, P. 101033 - 101033

Published: Feb. 15, 2021

Language: Английский

Citations

141
Vitamin D: Dosing, levels, form, and route of administration: Does one approach fit all? DOI Creative Commons
John P. Bilezikian, Anna Maria Formenti, Robert A. Adler

et al.

Reviews in Endocrine and Metabolic Disorders, Journal Year: 2021, Volume and Issue: 22(4), P. 1201 - 1218

Published: Dec. 1, 2021

The 4

Language: Английский

Citations

123
Predicting mortality due to SARS-CoV-2: A mechanistic score relating obesity and diabetes to COVID-19 outcomes in Mexico DOI Creative Commons
Omar Yaxmehen Bello‐Chavolla, Jessica Paola Bahena-López, Neftalí Eduardo Antonio-Villa

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2020, Volume and Issue: unknown

Published: April 24, 2020

ABSTRACT BACKGROUND The SARS-CoV-2 outbreak poses challenge to healthcare systems due high complication rates in patients with cardiometabolic diseases. Here, we identify risk factors and propose a clinical score predict COVID-19 lethality, including specific for diabetes obesity its role improving prediction. METHODS We obtained data of confirmed negative cases their demographic health characteristics from the General Directorate Epidemiology Mexican Ministry Health. investigated associated positivity mortality explored impact on modifying related lethality. Finally, built RESULTS Among 177,133 subjects at May 18 th , 2020, observed 51,633 5,332 deaths. Risk lethality include early-onset diabetes, obesity, COPD, advanced age, hypertension, immunosuppression, CKD; that mediates 49.5% effect Early-onset conferred an increased hospitalization ICU admission intubation. Our predictive included age ≥65 years, <40 CKD, immunosuppression significantly discriminates lethal non-lethal (c-statistic=0.823). mechanistic approach evaluate complications attributable considering Mexico. offers tool quick determination high-risk susceptibility first contact scenario.

Language: Английский

Citations

128
Impact of obesity on COVID-19 patients DOI Open Access

Wanqi Yu,

Kristen E. Rohli, Shujuan Yang

et al.

Journal of Diabetes and its Complications, Journal Year: 2020, Volume and Issue: 35(3), P. 107817 - 107817

Published: Nov. 26, 2020

Language: Английский

Citations

127
COVID-19 in people living with diabetes: An international consensus DOI Open Access
A. Enrique Caballero, Antonio Ceriello, Anoop Misra

et al.

Journal of Diabetes and its Complications, Journal Year: 2020, Volume and Issue: 34(9), P. 107671 - 107671

Published: July 6, 2020

Language: Английский

Citations

126
Impact of obesity on hospitalizations and mortality, due to COVID-19: A systematic review DOI Open Access

João Vitor Vieira de Siqueira,

Lucas Garrido Almeida,

Bruno Otávio Zica

et al.

Obesity Research & Clinical Practice, Journal Year: 2020, Volume and Issue: 14(5), P. 398 - 403

Published: July 23, 2020

Language: Английский

Citations

110
COVID-19 and endocrine and metabolic diseases. An updated statement from the European Society of Endocrinology DOI Creative Commons
Manel Puig‐Domingo, Mónica Marazuela, Bülent Okan Yıldız

et al.

Endocrine, Journal Year: 2021, Volume and Issue: 72(2), P. 301 - 316

Published: May 1, 2021

COVID-19 has completely changed our daily clinical practice as well social relations. Many organs and biological systems are involved in SARS-Cov-2 infection, either due to direct virus-induced damage or indirect effects that can have systemic consequences. Endocrine system is not only an exception but its involvement so relevant "endocrine phenotype" of progressively acquired relevance.

Language: Английский

Citations

100
Should patients with obesity be more afraid of COVID‐19? DOI Creative Commons
Anna Maria Rychter, Agnieszka Zawada, Alicja Ewa Ratajczak

et al.

Obesity Reviews, Journal Year: 2020, Volume and Issue: 21(9)

Published: June 24, 2020

COVID-19 crisis has lasted since the late 2019 to present day. The severity of disease is positively correlated with several factors, such as age and coexisting diseases. Furthermore, obesity increasingly considered a yet another risk factor, particularly, because it been observed that people suffering from excessive body weight may experience more severe course infection. On basis current research, in our nonsystematic review, we have investigated extent which can affect SARS-CoV-2 identify potential mechanisms disease. We also described role proper nutrition, physical activity other aspects relevant management obesity.

Language: Английский

Citations

98