COVID-19 mortality risk correlates inversely with vitamin D3 status, and a mortality rate close to zero could theoretically be achieved at 50 ng/ml 25(OH)D3: Results of a systematic review and meta-analysis DOI Creative Commons
Lorenz Borsche, Bernd Glauner, Julian von Mendel

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2021, Volume and Issue: unknown

Published: Sept. 25, 2021

Abstract Background Much research shows that blood calcidiol (25(OH)D3) levels correlate strongly with SARS-CoV-2 infection severity. There is open discussion regarding whether low D3 caused by the or if deficiency negatively affects immune defense. The aim of this study was to collect further evidence on topic. Methods Systematic literature search performed identify retrospective cohort as well clinical studies COVID-19 mortality rates versus levels. Mortality from were corrected for age, sex and diabetes. Data analyzed using correlation linear regression. Results One population seven identified, which reported pre-infection day hospital admission. They independently showed a negative Pearson risk (r(17)=-.4154, p=.0770/r(13)=-.4886, p=.0646). For combined data, median (IQR) 23.2 ng/ml (17.4 – 26.8), significant observed (r(32)=-.3989, p=.0194). Regression suggested theoretical point zero at approximately 50 D3. Conclusions two datasets provide strong predictor rather than side effect infection. Despite ongoing vaccinations, we recommend raising serum 25(OH)D above prevent mitigate new outbreaks due escape mutations decreasing antibody activity. Trial registration Not applicable.

Language: Английский

High prevalence of vitamin D deficiency among the South Asian adults: a systematic review and meta-analysis DOI Creative Commons
Mahbubul H. Siddiqee, Badhan Bhattacharjee,

Umme Ruman Siddiqi

et al.

BMC Public Health, Journal Year: 2021, Volume and Issue: 21(1)

Published: Oct. 9, 2021

Abstract Background Vitamin-D deficiency is linked to a wide range of chronic and infectious diseases. Body literature suggested that the prevalence this can have geographical variation. Although vitamin D frequently reported in South Asian population, scarcity systematic reviews meta-analysis means true extent disease underlying factors causing it are poorly characterized. Methods A search was performed using two databases (PubMed Scopus) one engine (Google Scholar) for original studies on population (published from January 1, 2001, December 31, 2019). Following search, random effect calculate population-level weighted average, pooled deficiency, heterogeneity among different countries genders; addition Asia as whole. Results Our study, based our selection criteria narrowed down total 44,717 participants; which spanned over 65 five countries. Overall, 68% [95% CI: 64 72%] with significant (I 2 = 98%; p 0.00). The average level ranged 4.7 32 ng/mL, mean 19.15 ng/mL (weighted standard deviation 11.59 ng/mL). highest found Pakistan (73%;95% 63 83%) followed by Bangladesh (67%; 95% 50 83%), India 61 73%), Nepal (57%; 53 60%) Sri Lanka (48%; 41 55%), respectively. This finding indicated high degree population. 98.76%), Furthermore, gender-wise analysis Asia, higher females than males. Conclusion findings reveal highly prevalent variable adults Findings review would be helpful generate hypotheses explore affecting inter-country variability, alongside strengthening evidence governments prioritize mitigation strategies region.

Language: Английский

Citations

119
Association of vitamin D status with COVID-19 and its severity DOI Open Access
Jae Hyun Bae, Hun Jee Choe, Michael F. Holick

et al.

Reviews in Endocrine and Metabolic Disorders, Journal Year: 2022, Volume and Issue: 23(3), P. 579 - 599

Published: Jan. 4, 2022

Language: Английский

Citations

79
COVID-19 and endocrine and metabolic diseases. An updated statement from the European Society of Endocrinology DOI Creative Commons
Manel Puig‐Domingo, Mónica Marazuela, Bülent Okan Yıldız

et al.

Endocrine, Journal Year: 2021, Volume and Issue: 72(2), P. 301 - 316

Published: May 1, 2021

COVID-19 has completely changed our daily clinical practice as well social relations. Many organs and biological systems are involved in SARS-Cov-2 infection, either due to direct virus-induced damage or indirect effects that can have systemic consequences. Endocrine system is not only an exception but its involvement so relevant "endocrine phenotype" of progressively acquired relevance.

Language: Английский

Citations

100
Molecular Simulations suggest Vitamins, Retinoids and Steroids as Ligands of the Free Fatty Acid Pocket of the SARS‐CoV‐2 Spike Protein** DOI Open Access

Deborah K. Shoemark,

Charlotte K. Colenso, Christine Toelzer

et al.

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 60(13), P. 7098 - 7110

Published: Jan. 20, 2021

Abstract We investigate binding of linoleate and other potential ligands to the recently discovered fatty acid site in SARS‐CoV‐2 spike protein, using docking molecular dynamics simulations. Simulations suggest that dexamethasone stabilize locked conformation, thus reducing opportunity for ACE2 interaction. In contrast, cholesterol may expose receptor‐binding domain by destabilizing closed structure, preferentially a different hinge region open structure. docked library FDA‐approved drugs an approach reproduces structure complex. Docking identifies steroids (including vitamin D); retinoids (some known be active vitro, A); K as conformation. The bind diverse array ligands, including dietary components, therefore provides promising target therapeutics or prophylaxis.

Language: Английский

Citations

94
Increased risk for COVID-19 in patients with vitamin D deficiency DOI Open Access
Joseph Katz,

Sijia Yue,

Wei Xue

et al.

Nutrition, Journal Year: 2020, Volume and Issue: 84, P. 111106 - 111106

Published: Dec. 4, 2020

Language: Английский

Citations

93
Aging & COVID-19 susceptibility, disease severity, and clinical outcomes: The role of entangled risk factors DOI Open Access
Melina Farshbafnadi,

Sara Kamali Zonouzi,

Mohammadmahdi Sabahi

et al.

Experimental Gerontology, Journal Year: 2021, Volume and Issue: 154, P. 111507 - 111507

Published: Aug. 3, 2021

Language: Английский

Citations

86
COVID-19 Mortality Risk Correlates Inversely with Vitamin D3 Status, and a Mortality Rate Close to Zero Could Theoretically Be Achieved at 50 ng/mL 25(OH)D3: Results of a Systematic Review and Meta-Analysis DOI Open Access
Lorenz Borsche, Bernd Glauner, Julian von Mendel

et al.

Nutrients, Journal Year: 2021, Volume and Issue: 13(10), P. 3596 - 3596

Published: Oct. 14, 2021

Much research shows that blood calcidiol (25(OH)D3) levels correlate strongly with SARS-CoV-2 infection severity. There is open discussion regarding whether low D3 caused by the or if deficiency negatively affects immune defense. The aim of this study was to collect further evidence on topic.

Language: Английский

Citations

76
Diverse Immunological Factors Influencing Pathogenesis in Patients with COVID-19: A Review on Viral Dissemination, Immunotherapeutic Options to Counter Cytokine Storm and Inflammatory Responses DOI Creative Commons
Ali A. Rabaan,

Shamsah H. Al-Ahmed,

Mohammed Garout

et al.

Pathogens, Journal Year: 2021, Volume and Issue: 10(5), P. 565 - 565

Published: May 7, 2021

The pathogenesis of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome 2 (SARS-CoV-2), is still not fully unraveled. Though preventive vaccines and treatment methods are out on the market, a specific cure for has been discovered. Recent investigations research studies primarily focus immunopathology disease. A healthy immune system responds immediately after viral entry, causing immediate annihilation recovery. However, an impaired causes extensive systemic damage due to unregulated response characterized hypersecretion chemokines cytokines. elevated levels cytokine or hypercytokinemia leads distress (ARDS) along with multiple organ damage. Moreover, against SARS-CoV-2 linked race, gender, age; hence, this infection's outcome differs among patients. Many therapeutic strategies focusing immunomodulation have tested assuage storm in patients COVID-19. thorough understanding diverse signaling pathways triggered virus essential before contemplating relief measures. This present review explains interrelationships hyperinflammatory severity. Furthermore, we thrown light mechanisms risk factors that influence molecular lead infection Recognition altered dysregulated can be loophole identify potential target markers. Identifying biomarkers pathway aid better clinical management COVID-19 special also given potent inhibitors proinflammatory cytokines, immunomodulatory immunotherapeutic options ameliorate inflammatory responses affected

Language: Английский

Citations

74
Vitamin D: Bolus Is Bogus—A Narrative Review DOI Creative Commons
Richard B. Mazess, Heike A. Bischoff‐Ferrari, Bess Dawson‐Hughes

et al.

JBMR Plus, Journal Year: 2021, Volume and Issue: 5(12)

Published: Oct. 14, 2021

In this review we summarize the impact of bolus versus daily dosing vitamin D on 25(OH)D and 1,25(OH)

Language: Английский

Citations

73
Association of Vitamin D Levels, Race/Ethnicity, and Clinical Characteristics With COVID-19 Test Results DOI Creative Commons
David O. Meltzer, Thomas J. Best, Zhang Hui

et al.

JAMA Network Open, Journal Year: 2021, Volume and Issue: 4(3), P. e214117 - e214117

Published: March 19, 2021

Deficient (ie, <20 ng/mL) or insufficient 20 to <30 25-hydroxyvitamin D (also known as calcifediol) levels are more common in Black individuals than White and associated with increased coronavirus disease 2019 (COVID-19) risk. Whether COVID-19 risk is differences vitamin of 30 ng/mL greater not known.

Language: Английский

Citations

72