The association between vitamin D deficiency and the clinical outcomes of hospitalized COVID-19 patients DOI Creative Commons
Andhika Rachman,

Rizky Rahmaniyah,

Andi Khomeini

et al.

F1000Research, Journal Year: 2024, Volume and Issue: 12, P. 394 - 394

Published: Feb. 5, 2024

Background Vitamin D deficiency is an emerging public health problem that affects more than one billion people worldwide. has been shown to be effective in preventing and reducing the severity of viral respiratory diseases, including influenza. However, role vitamin COVID-19 infection remains controversial. This study aimed analyze association on clinical outcome hospitalized patients. Methods A prospective cohort was conducted among patients at two referral hospitals Indonesia from October 2021 until February 2022. Results The median serum 25(OH)D level 191 13.6 [IQR=10.98] ng/mL. levels were significantly lower with who had cardiovascular disease (p-value=0.04), use a ventilator (p-value=0.004), severe cases (p-value=0.047), mortality (p-value=0.002). Furthermore, different between mild (p-value=0.019). Serum moderate (p-value=0.031). Lower associated increased number comorbidities (p-value=0.03), (p-value=0.002), mechanical ventilation (p-value=0.032). Mortality found 7.3% deficient levels. either sufficient or insufficient did not develop mortality. Conclusions having disease, mortality, cases, used ventilation. comorbidities, severity, mechanical-ventilation. Thus, we suggest reach status improve disease.

Language: Английский

Tissue location of SARS-CoV-2 RNA: A focus on bone and implications for skeletal health DOI
Edoardo Guazzoni, Luigi di Filippo, Alberto Castelli

et al.

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 485 - 492

Published: Jan. 1, 2024

Language: Английский

Citations

1
Serum 25-hydroxyvitamin D levels and health outcomes of hospitalization owing to COVID-19: a retrospective cross-sectional study DOI Creative Commons
Irina Metonidze,

Nestan Bostoganashvili,

Tamar Goderidze

et al.

Journal of International Medical Research, Journal Year: 2024, Volume and Issue: 52(8)

Published: Aug. 1, 2024

Objective We investigated the role of serum 25(OH)D (25-hydroxyvitamin D) in COVID-related health outcomes. Methods conducted a retrospective cross-sectional study using data National Center Disease Control and Public Health, Georgia. extracted patient including length hospital stay, transfer to intensive care unit, requirement for oxygen therapy, treatment with glucocorticoids, symptoms. After obtaining written informed consent, 384 individuals were enrolled. divided participants into three groups according levels: group 1 = <12 ng/mL (n 83), 2 12–20 141), 3 >20 160). Results The odds ratio (OR) hospitalization versus was 8.7 (95% confidence interval [CI] 3.6–21.3) 5.6 CI 2.7–11.9). Regarding OR 28.41 3.7–220.5) 5.2 1.9–14.1). 3.7 1.1–12.5) 8.4 1.8–40.7). Conclusion COVID-19-related morbidity associated decreased levels. Future studies should investigate potential vitamin D sufficiency preventing SARS-CoV-2 infection mortality.

Language: Английский

Citations

1
Correlation between rs7041 and rs4588 polymorphisms in vitamin D binding protein gene and COVID-19-related severity and mortality DOI Creative Commons
Ehab Hamed,

Shaymaa Abdelraheem Abdelhady,

Shimaa A. Al-Touny

et al.

BMC Medical Genomics, Journal Year: 2024, Volume and Issue: 17(1)

Published: Dec. 2, 2024

The vitamin D binding protein (DBP) plays a critical role in both innate and adaptive immune systems, participating several clinical conditions, including coronavirus disease 2019 infection severity, mortality rate. study aimed to investigate the correlation between rs7041 rs4588 polymorphisms DBP gene Coronavirus Disease-2019 (COVID-19) severity mortality, patients of Suez Canal University Hospitals Ismailia, Egypt. A case-control enrolled 220 individuals; 140 COVID-19 80 healthy controls. Serum 25(OH) levels were determined by enzyme-linked immunosorbent assay (ELISA), genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). found that groups had deficiency, which was considerably lower group compared Among patients, there significant difference according indicating can be used as predictors severity. Negative correlations genetic variants CA genotype TT prevalence (p = 0.006 0.009 respectively) proved. No all > 0.05). Positive TG 0.029 0.031 respectively). deficiency increased COVID-19. correlated with mortality.

Language: Английский

Citations

1
Short-Term Outcomes in Patients With Coexistence of COVID-19 Infection and Vitamin D Deficiency: A Large Cohort Study DOI Open Access
Yap‐Hang Chan,

Chia‐Chen Chen,

Jheng‐Yan Wu

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 20, 2024

Vitamin D deficiency (VDD) is prevalent worldwide and may influence the severity of infectious diseases, including COVID-19. This study aimed to evaluate association between VDD 30-day clinical outcomes in patients with

Language: Английский

Citations

1
The association between vitamin D deficiency and the clinical outcomes of hospitalized COVID-19 patients DOI Creative Commons
Andhika Rachman,

Rizky Rahmaniyah,

Andi Khomeini

et al.

F1000Research, Journal Year: 2024, Volume and Issue: 12, P. 394 - 394

Published: Feb. 5, 2024

Background Vitamin D deficiency is an emerging public health problem that affects more than one billion people worldwide. has been shown to be effective in preventing and reducing the severity of viral respiratory diseases, including influenza. However, role vitamin COVID-19 infection remains controversial. This study aimed analyze association on clinical outcome hospitalized patients. Methods A prospective cohort was conducted among patients at two referral hospitals Indonesia from October 2021 until February 2022. Results The median serum 25(OH)D level 191 13.6 [IQR=10.98] ng/mL. levels were significantly lower with who had cardiovascular disease (p-value=0.04), use a ventilator (p-value=0.004), severe cases (p-value=0.047), mortality (p-value=0.002). Furthermore, different between mild (p-value=0.019). Serum moderate (p-value=0.031). Lower associated increased number comorbidities (p-value=0.03), (p-value=0.002), mechanical ventilation (p-value=0.032). Mortality found 7.3% deficient levels. either sufficient or insufficient did not develop mortality. Conclusions having disease, mortality, cases, used ventilation. comorbidities, severity, mechanical-ventilation. Thus, we suggest reach status improve disease.

Language: Английский

Citations

0