Role of Intermittent Fasting In Starving Cancer Cells DOI Creative Commons
Sakina Sakina, Akshaya K. Meher,

Narendra Nath Ravi

et al.

Lviv clinical bulletin, Journal Year: 2024, Volume and Issue: 3 (47), P. 96 - 109

Published: Sept. 30, 2024

Introduction. An absolute burden of over 35 million new cancer cases is predicted by 2050. Although significant progress has been made in the field oncology via use surgical removal, radiation treatment, chemotherapy, and introduction immunotherapy, overall rates survival prognoses for patients are still unsatisfactory. In last decade, intermittent fasting (IF) become increasingly popular weight control potential health benefits. Additionally, research primarily focused on investigating impact IF metabolism, mitochondrial function, stress responses, repair mechanisms, autophagy. The aim study. To make a literature review about role starving cells. Materials methods. This narrative involved comprehensive search through databases such as PubMed Google Scholar. Distinct keywords - ″intermittent fasting″, regimens″, ″calorie restriction″, ″oncology″, ″chemotherapy″ ″tumor microenvironment″ were used. Results. exhibits impacts immune system's ability to fight against tumors strengthening hematopoietic stem cells replenish themselves enhance immunosuppression. Under an program, certain tissues organs exhibit enhanced resilience various stressors. Emerging shows that effectiveness tolerance anticancer medicines, regulate carcinogenic influences, reprogram clock genes' rhythmic expression tumor environments, inhibit growth modifying natural processes like insulin signalling, heme oxygenase-1, prevent proliferation myeloid-derived suppressor priming microenvironment support drug delivery targets tumors. Cancer treatment notably shields normal while raising efficacy chemotherapy (CT) reducing CT-induced inflammation several immunological, biochemical, molecular mechanisms. Conclusions. Regularly practising more than one day may confer notable benefits protecting healthy deleterious effects radiation. synergistic therapeutic alongside suggests it enhances also chemotherapy-induced inflammation. While promise cancers, breast cancer, its other types remains uncertain, necessitating further personalized plans.

Language: Английский

Type 2 Diabetes Mellitus: A Comprehensive Review of Pathophysiology, Comorbidities, and Emerging Therapies DOI
Aditi Singh,

Sucharita Shadangi,

Pulkit Kr. Gupta

et al.

Comprehensive physiology, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 1, 2025

ABSTRACT Humans are perhaps evolutionarily engineered to get deeply addicted sugar, as it not only provides energy but also helps in storing fats, which survival during starvation. Additionally, sugars (glucose and fructose) stimulate the feel‐good factor, they trigger secretion of serotonin dopamine brain, associated with reward sensation, uplifting mood general. However, when consumed excess, contributes imbalance, weight gain, obesity, leading onset a complex metabolic disorder, generally referred diabetes. Type 2 diabetes mellitus (T2DM) is one most prevalent forms diabetes, nearly affecting all age groups. T2DM clinically diagnosed cardinal sign chronic hyperglycemia (excessive sugar blood). Chronic hyperglycemia, coupled dysfunctions pancreatic β‐cells, insulin resistance, immune inflammation, further exacerbate pathology T2DM. Uncontrolled T2DM, major public health concern, significantly toward progression several micro‐ macrovascular diseases, such diabetic retinopathy, nephropathy, neuropathy, atherosclerosis, cardiovascular including cancer. The current review discusses epidemiology, causative factors, pathophysiology, comorbidities, existing emerging therapies related It future roadmap for alternative drug discovery management

Language: Английский

Citations

1
Asociación entre variables sociodemográficas, hábitos saludables y estrés con diabesidad DOI
Ángel Arturo López‐González, Emilio Martínez-Almoyna Rifá, Hernán Paublini

et al.

Clínica e Investigación en Arteriosclerosis, Journal Year: 2025, Volume and Issue: unknown, P. 500754 - 500754

Published: Jan. 1, 2025

Language: Английский

Citations

0
Diabesidad y mortalidad de causa cardiovascular en una cohorte prospectiva de origen poblacional seguida más de 20 años DOI
Julio A. Carbayo Herencia,

Marta Simarro Rueda,

L. Ródenas

et al.

Clínica e Investigación en Arteriosclerosis, Journal Year: 2025, Volume and Issue: unknown, P. 500768 - 500768

Published: Feb. 1, 2025

Language: Английский

Citations

0
Different action of glucocorticoid receptor in adipose tissue remodelling to modulate energy homeostasis by chronic restraint stress DOI Creative Commons

Yinghua Luo,

Qinyu Liu, Yaqian Mao

et al.

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 27, 2025

Abstract Background Chronic stress in daily life is a well-known trigger for various health issues. Despite advancements obesity research, the mechanisms governing lipid metabolism adipose tissue during cachexia remain poorly understood. Methods A chronic restraint (CRS) model was used to induce significant physiological and psychological mice. Mice were subjected 6 h of 50 mL plastic tubes seven consecutive days. fasting control group included comparison. Post-stress assessments behavioural tests, glucose insulin tolerance tests indirect calorimetry. Blood samples collected mRNA protein analyses. Results CRS induced changes mice, including depression-like behaviours, weight loss reduced sensitivity. Notably, caused extensive remodelling. White (WAT) underwent ‘browning’ accompanied by an increase expression thermogenic proteins. This counteracted stress-induced ‘whitening’ brown (BAT), which exhibited impaired thermogenesis functionality, thereby maintaining energy balance systematically. The glucocorticoid receptor (GR) plays crucial role regulation these changes. GR levels inversely correlated BAT WAT, but aligned with patterns proteins across tissues. These findings suggest that under metabolic stress, mediates tissue-specific responses tissues, driving functional phenotypic transitions WAT maintain homeostasis. Conclusions study provides novel insights into contrasting phenotypes emaciation highlights critical GRs remodelling its potential as therapeutic target. Addressing GR-mediated tissues may help alleviate dysfunction promote browning, enhancing resistance.

Language: Английский

Citations

0
Normal Weight, Overweight and Obesity Conditions Associated to Prostate Neoplasm Stages—A Systematic Review and Meta-Analysis DOI Creative Commons
Elsa Vitale, Alessandro Rizzo, Kurvatteppa Halemani

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(5), P. 1182 - 1182

Published: May 13, 2025

Background/Objective: Prostate cancer (PCa) represents the second-most common among men worldwide. Obesity is generally considered as a risk factor for and it has been associated with 20–30% increased of PCa death. The present systematic review meta-analyses aimed to highlight any existing trends between prostate neoplasm stages according normal weight, overweight obesity conditions. Methods: All interventional records such randomized clinical trials, quasi-experimental studies observational were included in meta-analysis which reported Gleason (GS) or TNM scores BMI-related incidence, groups. Results: Twenty-nine study. As regards GS scoring system, 1.09% high grade was weights. Among overweights, 0.98% low registered GS. same trend recorded obese patients, since 0.79% also registered. scores, both patients significant incidence non-advanced score, without differences considering higher assessments. Conclusions: Although literature seemed be more favor associations BMI GS, no specific mechanisms highlighted progression. In this regard, androgen microenvironment could play an important role, but further will necessary direction.

Language: Английский

Citations

0
Childhood Obesity and Overweight Are Associated with Higher Risk of Perceived Stress and Poor Sleep Quality: A Cross-Sectional Study in Children Aged 6–9 Years DOI Creative Commons

Maria Mentzelou,

Aikaterini Louka,

Theofanis Vorvolakos

et al.

Metabolites, Journal Year: 2025, Volume and Issue: 15(6), P. 345 - 345

Published: May 22, 2025

Background/Objectives: The number of children with overweight and obesity is gradually increasing worldwide. This an emergent public health problem as persist through the next stages human life, being associated high risk morbidity mortality. In this respect, purpose current cross-sectional survey to explore whether overweight/obesity aged 6–9 years may be related developing perceived stress poor sleep quality symptoms. Methods: study recruited 4350 primary school from diverse Greek rural urban regions. mothers enrolled completed relevant questionnaires on maternal sociodemographics, anthropometric parameters, perinatal outcomes, breastfeeding practices, lifestyle factors. also Perceived Stress Scale (PSS) Pittsburgh Sleep Quality Index (PSQI) evaluate their matched children, respectively. Results: Our analysis reveals independently significant associations between factors children’s such child’s gender, family economic status, gestational weight gain, childbirth weight, kind delivery, exclusive breastfeeding, physical activity. Childhood were a more than three-fold higher two-fold likelihood after adjustment for multiple confounding Conclusions: Obesity are enhanced in years. Public policies dietary counseling interventions should applied inform new about harmful effects childhood direct them adopt healthy practices children.

Language: Английский

Citations

0
Effect of Stress on Hormone Levels in the Blood Serum of Rats with Alimentary Obesity DOI

Vladimir Vladimirovich Shotaev,

Karina Ruslanovna Doshkhokloeva,

Petimat Hozh-Ahmedovna Vakhidova

et al.

Pharmacophore, Journal Year: 2024, Volume and Issue: 15(3), P. 47 - 52

Published: Jan. 1, 2024

Language: Английский

Citations

2
Integrating the metabolic and molecular circuits in diabetes, obesity and cancer: a comprehensive review DOI Creative Commons
Shweta Anand, Trupti Patel

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 18, 2024

The progressive globalization of sedentary lifestyles and diets rich in lipids processed foods has caused two major public health hazards-diabetes obesity. strong interlink between obesity type 2 diabetes mellitus their combined burden encompass them into a single term 'Diabesity'. They have also been tagged as the drivers for onset cancer. clinical association diabetes, obesity, several types human cancer demands an assessment vital junctions correlating three. This review focuses on revisiting molecular axis linking to through pathways that get imbalanced owing metabolic upheaval. We attempt describe functional disruptions DNA repair mechanisms due overwhelming oxidative damage by diabesity. Genomic instability, known hallmark results when does not work optimally, will be inferred from this obtruded homeostasis creates favorable microenvironment supporting reprogramming enabling malignancies. Altered hormonal landscapes these morbidities provide novel connection metabolomics oncogenesis. Understanding various aspects tumorigenic process diabesity-induced cancers might help discovery new biomarkers prompt targeted therapeutic interventions.

Language: Английский

Citations

2
Recent Progress in Biosensors for Depression Monitoring—Advancing Personalized Treatment DOI Creative Commons

Jiaju Yin,

Xinyuan Jia,

Haorong Li

et al.

Biosensors, Journal Year: 2024, Volume and Issue: 14(9), P. 422 - 422

Published: Aug. 30, 2024

Depression is currently a major contributor to unnatural deaths and the healthcare burden globally, patient's battle with depression often long one. Because causes, symptoms, effects of medications are complex highly individualized, early identification personalized treatment key improving outcomes. The development wearable electronics, machine learning, other technologies in recent years has provided more possibilities for realization this goal. Conducting regular monitoring through biosensing technology allows comprehensive objective analysis than previous self-evaluations. This includes identifying depressive episodes, distinguishing somatization analyzing etiology, evaluating effectiveness programs. review summarizes research on depression. Special attention given that can be portable or wearable, potential enable patient use outside hospital, periods.

Language: Английский

Citations

1
Diabetes and Cancer: The Perfect Storm and a PRICE to Pay DOI Open Access
Marco Gallo

Cancers, Journal Year: 2024, Volume and Issue: 16(12), P. 2247 - 2247

Published: June 18, 2024

Diabetes, obesity, cardiovascular diseases, and cancer are noncommunicable diseases representing the main global health challenges of current century [...]

Language: Английский

Citations

0