Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Feb. 12, 2025
Global
evidence
on
the
association
between
vaccines
and
renal
adverse
events
(AEs)
is
inconclusive.
This
pharmacovigilance
study
analyzed
a
total
of
120,715,116
reports
from
VigiBase
collected
1967
2022.
We
evaluated
global
reporting
acute
kidney
injury
(AKI),
glomerulonephritis
(GN),
tubulointerstitial
nephritis
(TIN)
assessed
disproportionate
signals
AEs
using
odds
ratios
(ROR)
lower
limit
95%
confidence
interval
information
component
(IC025)
in
comparison
with
entire
database.
The
number
proportion
AKI,
GN,
TIN
gradually
increased,
substantial
increase
after
2020.
Disproportionate
AKI
was
significant
for
COVID-19
mRNA
(ROR,
2.38;
IC025,
1.09).
Fourteen
were
significantly
higher
GN
reporting,
highest
disproportionality
observed
13.41;
2.90)
hepatitis
B
11.35;
3.18).
2.43;
0.99)
human
papillomavirus
1.75;
0.19)
vaccines.
Significant
patients
exposed
to
multiple
vaccines,
including
alongside
increasing
vaccine-associated
AEs.
Viruses,
Journal Year:
2023,
Volume and Issue:
15(2), P. 389 - 389
Published: Jan. 29, 2023
An
increase
in
post-COVID
patients
with
late
sequelae
of
acute
COVID-19
infection
is
emerging
as
an
ongoing
challenge
for
physicians
and
healthcare
professionals.
Since
the
beginning
pandemic,
it
has
rapidly
become
evident
that
not
limited
to
respiratory
tract
but
several
organs,
including
cardiovascular
system,
can
be
affected.
Moreover,
a
significant
proportion
(ranging
from
about
10
up
50%)
former
COVID-19,
cardiopulmonary
symptoms
such
dyspnea,
palpitations,
restricted
physical
capacity,
cardiac
arrhythmias
persist
weeks
months
after
SARS-CoV-2
infection.
The
spectrum
COVID-19-associated
rather
wide,
most
likely
due
various
pathomechanisms.
In
this
article,
prevalence
underlying
pathologies
are
reviewed,
direct
myocardial
injury
abnormal
consequences
impact
on
electric
instability.
hyperinflammatory
reaction
host
immune
system
specifically
considered.
distinct
rhythm
disorders
occurring
discussed
regard
their
clinical
management.
Chemical Society Reviews,
Journal Year:
2023,
Volume and Issue:
53(1), P. 317 - 360
Published: Dec. 11, 2023
Gene
therapy
is
on
its
way
to
revolutionize
the
treatment
of
both
inherited
and
acquired
diseases,
by
transferring
nucleic
acids
correct
a
disease-causing
gene
in
target
cells
patients.
In
fight
against
infectious
mRNA-based
therapeutics
have
proven
be
viable
strategy
recent
Covid-19
pandemic.
Although
growing
number
therapies
been
approved,
success
rate
limited
when
compared
large
preclinical
clinical
trials
that
been/are
being
performed.
this
review,
we
highlight
some
hurdles
which
encounter
after
administration
into
human
body,
with
focus
acid
degradation
nucleases
are
extremely
abundant
mammalian
organs,
biological
fluids
as
well
subcellular
compartments.
We
overview
available
strategies
reduce
biodegradation
administration,
including
chemical
modifications
acids,
encapsulation
vectors
co-administration
nuclease
inhibitors
discuss
applied
for
clinically
approved
therapeutics.
final
part,
currently
methods
techniques
qualify
quantify
integrity
their
own
strengths
limitations.
Frontiers in Public Health,
Journal Year:
2024,
Volume and Issue:
12
Published: Aug. 8, 2024
The
messenger
RNA
(mRNA)
platform
emerged
at
the
forefront
of
vaccine
development
during
COVID-19
pandemic,
with
two
mRNA
vaccines
being
among
first
authorized
globally.
These
were
developed
rapidly.
Informed
by
decades
laboratory
research,
and
proved
to
be
safe
efficacious
tools
for
mitigating
global
impact
pandemic.
holds
promise
a
broader
medical
application
beyond
COVID-19.
Herein,
we
provide
an
overview
this
describe
lessons
learned
from
pandemic
help
formulate
strategies
toward
enhancing
uptake
future
mRNA-based
interventions.
We
identify
several
as
vital
acceptance
expanding
array
therapeutics,
including
education,
accurate
transparent
information
sharing,
targeted
engagement
campaigns,
continued
investment
in
safety
surveillance,
inclusion
diverse
participant
pools
clinical
trials,
addressing
deep-rooted
inequalities
access
healthcare.
present
findings
Global
Listening
Project
(GLP)
initiative,
which
draws
on
quantitative
qualitative
approaches
capture
perceptions
experiences
design
concrete
action
plans
improving
societal
preparedness
emergencies.
GLP
survey
(>70,000
respondents
70
countries)
revealed
tremendous
disparities
across
countries
sociodemographic
groups
regarding
willingness
accept
novel
medicines.
comfort
innovations
medicines
was
generally
low
(35%)
marginally
lower
women
(33%).
learnt
actionable
insights
into
designing
effective
enhance
Human Vaccines & Immunotherapeutics,
Journal Year:
2024,
Volume and Issue:
20(1)
Published: April 2, 2024
We
conducted
a
national
in-depth
analysis
including
pharmacovigilance
reports
and
clinical
study
to
assess
the
reporting
rate
(RR)
determine
profile
of
polymyalgia
rheumatica
(PMR)
giant
cell
arteritis
(GCA)
in
COVID-19-vaccinated
individuals.
First,
based
on
French
database,
we
estimated
RR
PMR
GCA
cases
individuals
aged
over
50
who
developed
their
initial
symptoms
within
one
month
receiving
BNT162b2
mRNA,
mRNA-1273,
ChAdOx1
nCoV-19,
Ad26.COV2.S
vaccines.
then
nationwide
survey
gather
profiles,
therapeutic
management,
follow-up
data
from
registered
study.
A
total
70
854
684
COVID-19
vaccine
doses
were
administered
25
260
485
adults,
among
which,
179
(RR
7.
1
cases/1
000
persons)
54
2.
have
been
reported.
The
allowed
characterization
60
35
cases.
Median
time
onset
first
was
10
(range
2–30)
7
2–25)
days
for
GCA,
respectively.
Phenotype,
GCA-related
ischemic
complications
-large
vessel
vasculitis
as
well
management
seemed
similar
according
number
shots
received
when
compared
literature
unvaccinated
population.
Although
rare,
short
between
immunization
suggests
temporal
association.
Physician
should
be
aware
this
potential
vaccine-related
phenomenon.
npj Vaccines,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Feb. 22, 2024
Abstract
Type
I
interferons
act
as
gatekeepers
against
viral
infection,
and
autoantibodies
that
neutralize
these
signaling
molecules
have
been
associated
with
COVID-19
severity
adverse
reactions
to
the
live-attenuated
yellow
fever
vaccine.
On
this
background,
we
sought
examine
whether
type
were
events
following
vaccination.
Our
nationwide
analysis
suggests
interferon
not
after
mRNA
or
viral-vector
vaccines.
Nanotheranostics,
Journal Year:
2024,
Volume and Issue:
8(2), P. 247 - 269
Published: Jan. 1, 2024
The
post-pandemic
era
following
the
global
spread
of
SARS-CoV-2
virus
has
brought
about
persistent
concerns
regarding
recurring
coinfections.While
significant
strides
in
genome
mapping,
diagnostics,
and
vaccine
development
have
controlled
pandemic
reduced
fatalities,
ongoing
mutations
necessitate
a
deeper
exploration
interplay
between
host's
immune
response.Various
vaccines,
including
RNA-based
ones
like
Pfizer
Moderna,
viral
vector
vaccines
Johnson
&
AstraZeneca,
protein
subunit
Novavax,
played
critical
roles
mitigating
impact
COVID-19.Understanding
their
strengths
limitations
is
crucial
for
tailoring
future
to
specific
variants
individual
needs.The
intricate
relationship
response
remains
focus
intense
research,
providing
insights
into
personalized
treatment
strategies
long-term
effects
long-COVID.This
article
offers
an
overview
landscape,
highlighting
emerging
variants,
summarizing
platforms,
delving
immunological
responses
phenomenon
long-COVID.By
presenting
clinical
findings,
it
aims
contribute
understanding
COVID-19's
progression
aftermath
pandemic.
Progress in Retinal and Eye Research,
Journal Year:
2024,
Volume and Issue:
102, P. 101285 - 101285
Published: June 24, 2024
There
is
an
increasing
body
of
knowledge
regarding
how
COVID-19
may
be
associated
with
ocular
disease
varying
severity
and
duration.
This
article
discusses
the
literature
on
manifestations
COVID-19,
including
appraisal
current
evidence,
suggested
mechanisms
action,
comorbidities
risk
factors,
timing
from
initial
infection
to
diagnosis
clinical
red
flags.
The
primarily
comprises
case
reports
series
which
inevitably
lack
control
groups
evidence
support
causality.
However,
these
early
data
have
prompted
development
larger
population-based
laboratory
studies
that
are
emerging.
As
new
become
available,
a
better
true
effects
eye
will
possible.
While
pandemic
was
officially
declared
no
longer
"global
health
emergency"
by
World
Health
Organization
(WHO)
in
May
2023,
numbers
continue
rise.
Reinfection
different
variants
predicted
lead
growing
cumulative
burden
disease,
particularly
as
more
chronic,
multi-organ
sequelae
apparent
potentially
significant
implications.
postulated
due
three
main
mechanisms:
firstly,
there
dysregulated
immune
response
linked
inflammatory
disease;
secondly,
patients
greater
tendency
towards
hypercoagulable
state,
leading
prothrombotic
events;
thirdly,
severe
requiring
hospitalisation
immunosuppressed
administered
corticosteroids
or
such
diabetes
mellitus
at
increased
secondary
infections,
endophthalmitis
rhino-orbital-mucormycosis.
Reported
ophthalmic
associations
therefore,
include
range
conditions
conjunctivitis,
scleritis,
uveitis,
endogenous
endophthalmitis,
corneal
graft
rejection,
retinal
artery
vein
occlusion,
non-arteritic
ischaemic
optic
neuropathy,
glaucoma,
neurological
orbital
sequelae.
With
need
consider
telemedicine
consultation
view
COVID-19's
infectivity,
understanding
present
during
following
essential
ensure
appropriately
triaged,
prompt
in-person
examination
for
management
sight-threatening
life-threatening
diseases.
Nursing and Health Sciences,
Journal Year:
2025,
Volume and Issue:
27(1)
Published: Jan. 20, 2025
Regret
over
COVID-19
vaccine
decisions
is
a
post-pandemic
phenomenon
that
needs
further
research.
This
mixed-method
research
was
conducted
to
examine
nursing-midwifery
students'
decision
regret
and
their
intention
get
vaccinated
in
the
next
pandemic.
The
includes
quantitative
qualitative
processes.
In
first
phase,
(cross-sectional)
study
conducted,
collecting
data
from
602
participants
who
met
inclusion
criteria.
second
semi-structured
interviews
were
with
16
participants.
Data
collected
using
Decision
Scale
interview
form.
analyzed
Student's
t-test,
one-way
anova
test,
inductive
content
analysis,
reported
Good
Reporting
of
Mixed
Methods
Study.
study,
it
determined
96.3%
had
received
50.0%
regretted
getting
vaccinated.
As
result
analysis
data,
following
themes
emerged
could
reveal
reasons
for
regret;
forced
compliance,
strange
pandemic,
unknown
effects,
hesitancy.
Students'
experiences
pandemic
have
potential
increase
negative
attitudes
towards
vaccines.
Deleted Journal,
Journal Year:
2025,
Volume and Issue:
70(1), P. 3 - 3
Published: Jan. 26, 2025
The
COVID-19
pandemic
has
highlighted
several
cardiovascular
complications,
including
myocarditis,
which
can
be
a
significant
cause
of
sudden
cardiac
death
in
young
people.
SARS-CoV-2
infection
muscle
inflammation
through
direct
mechanisms,
such
as
viral
invasion
myocardial
cells,
and
indirect
the
systemic
inflammatory
response.
Myocarditis
lead
to
life-threatening
electrical
dysfunctions
arrhythmias.
Although
post-infection
myocarditis
is
more
common,
rare
cases
post-vaccination
have
also
been
reported,
especially
with
mRNA
vaccines.
However,
these
tend
mild
self-limiting,
good
response
treatment.
Despite
associated
risks,
benefits
vaccination
far
outweigh
significantly
reducing
incidence
severity
infections
related
heart
complications.
It
crucial
continue
surveillance
research
better
understand
association
between
COVID-19,
improve
prevention
intervention
strategies.
In
this
literature
review,
we
analyzed
pathogenetic
mechanisms
histological
features
its
vaccination,
focused
on
correlation
death.
