Cancer Cell International,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: July 4, 2024
Abstract
MicroRNAs
(miRNAs)
are
small
RNA
molecules
that
regulate
genes
and
involved
in
various
biological
processes,
including
cancer
development.
Researchers
have
been
exploring
the
potential
of
miRNAs
as
therapeutic
agents
treatment.
Specifically,
targeting
mammalian
target
rapamycin
(mTOR)
pathway
with
has
shown
promise
improving
effectiveness
radiotherapy
(RT),
a
common
This
review
provides
an
overview
current
understanding
mTOR
to
enhance
RT
outcomes
patients.
It
emphasizes
importance
specific
their
impact
on
radiosensitivity
for
personalized
treatment
approaches.
The
also
discusses
role
cell
homeostasis,
proliferation,
immune
response,
well
its
association
oncogenesis.
highlights
different
ways
which
can
potentially
affect
implications
immune-related
diseases.
Preclinical
findings
suggest
combining
modulators
inhibit
tumor
growth
through
anti-angiogenic
anti-vascular
effects,
but
further
research
clinical
trials
needed
validate
efficacy
safety
using
combination
RT.
Overall,
this
comprehensive
need
translate
these
into
improved
outcomes.
Pharmaceuticals,
Journal Year:
2023,
Volume and Issue:
16(10), P. 1410 - 1410
Published: Oct. 4, 2023
Metal
nanoparticles
(NPs)
have
garnered
considerable
attention,
due
to
their
unique
physicochemical
properties,
that
render
them
promising
candidates
for
various
applications
in
medicine
and
industry.
This
article
offers
a
comprehensive
overview
of
the
most
recent
advancements
manufacturing,
characterization,
biomedical
utilization
metal
NPs,
with
primary
focus
on
silver
gold
NPs.
Their
potential
as
effective
anticancer,
anti-inflammatory,
antimicrobial
agents,
drug
delivery
systems,
imaging
agents
diagnosis
treatment
variety
disorders
is
reviewed.
Moreover,
translation
therapeutic
settings,
issue
inclusion
clinical
trials,
are
assessed
light
over
30
investigations
concentrate
administering
either
or
NPs
conditions
ranging
from
nosocomial
infections
different
types
cancers.
paper
aims
not
only
examine
biocompatibility
nanomaterials
but
also
emphasize
challenges
may
limit
safe
integration
into
healthcare
practices.
More
than
100
nanomedicines
currently
market,
which
justifies
ongoing
study
use
medicine.
Overall,
present
review
highlight
innovative
therapeutics
field
biomedicine,
citing
some
relevant
current
applications.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(11), P. 5842 - 5842
Published: May 27, 2024
This
study
provides
a
brief
discussion
of
the
major
nanopharmaceuticals
formulations
as
well
impact
nanotechnology
on
future
pharmaceuticals.
Effective
and
eco-friendly
strategies
biofabrication
are
also
highlighted.
Modern
approaches
to
designing
pharmaceutical
nanoformulations
(e.g.,
3D
printing,
Phyto-Nanotechnology,
Biomimetics/Bioinspiration,
etc.)
outlined.
paper
discusses
need
use
natural
resources
for
“green”
design
new
with
therapeutic
efficiency.
Nanopharmaceuticals
research
is
still
in
its
early
stages,
preparation
nanomaterials
must
be
carefully
considered.
Therefore,
safety
long-term
effects
not
overlooked.
The
testing
represents
an
essential
point
their
further
applications.
Vegetal
scaffolds
obtained
by
decellularizing
plant
leaves
represent
valuable,
bioinspired
model
nanopharmaceutical
that
avoids
using
animals.
Nanoformulations
critical
various
fields,
especially
pharmacy,
medicine,
agriculture,
material
science,
due
unique
properties
advantages
over
conventional
allows
improved
solubility,
bioavailability,
targeted
drug
delivery,
controlled
release,
reduced
toxicity.
have
transitioned
from
experimental
stages
being
vital
component
clinical
practice,
significantly
improving
outcomes
medical
fields
cancer
treatment,
infectious
diseases,
neurological
disorders,
personalized
advanced
diagnostics.
Here
key
points
highlighting
importance.
significant
challenges,
opportunities,
directions
mentioned
final
section.
Scientific Reports,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: Oct. 19, 2023
Lactoferrin
(LF)
is
a
non-heme
iron-binding
glycoprotein
involved
in
the
transport
of
iron
blood
plasma.
In
addition,
it
has
many
biological
functions,
including
antibacterial,
antiviral,
antimicrobial,
antiparasitic,
and,
importantly,
antitumor
properties.
this
study,
we
have
investigated
potential
employing
lactoferrin-iron
oxide
nanoparticles
(LF-IONPs)
as
treatment
modality
for
gastric
cancer.
The
study
confirms
formation
LF-IONPs
with
spherical
shape
and
an
average
size
5
±
2
nm,
embedded
within
protein
matrix.
FTIR
Raman
analysis
revealed
that
Fe-O
bond
stabilized
particle
interactions.
Further,
conducted
hyperthermia
studies
to
ascertain
whether
proposed
composite
can
generate
sufficient
rise
temperature
at
low
frequency.
results
confirmed
achieve
about
7
°C
242.4
kHz,
which
be
further
harnessed
cancer
treatment.
particles
were
tested
their
anti-cancer
activity
on
AGS
cells,
without
hyperthermia.
Results
indicate
(10
µg/ml)
significantly
enhance
cytotoxicity,
resulting
demise
67.75
5.2%
cells
post
hyperthermia,
while
also
exhibiting
inhibitory
effect
cell
migration
compared
control
most
inhibition
observed
after
36
h
These
findings
suggest
targeted
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(6), P. e28281 - e28281
Published: March 1, 2024
Due
to
the
low
toxicity,
biocompatibility
and
eco-friendliness,
microorganisms
have
received
a
lot
of
attention
for
gold
nanoparticles
(AuNPs)
synthesis.
This
work
isolated
fungal
strain
capable
efficiently
generating
AuNPs
from
aerobic
granular
sludge,
named
XY3.
Comparison
18S
rDNA
sequence
results
showed
that
fungus
XY3
belongs
Candida
rugopelliculosa.
were
synthesized
by
initiating
an
Au3+-induced
stress
response
prompted
reduction
Au3+
Au0
It
is
worth
noting
addition
nutritional
substrates
weakens
induced
Au3+,
resulting
in
decrease
yield
AuNPs.
As
evidenced
nystatin
inhibition
studies,
synthesis
based
on
biochemical
reactions
rather
than
purely
physical
changes.
The
XRD
suggested
XY3-secreted
biomolecules
involved
three
variation
patterns
reducing
power,
biomolecules,
absorbance
revealed
was
mostly
dependent
polysaccharides.
In
addition,
extracellular
proteins
shown
be
AuNPs,
which
responsible
uniform
distribution
provided
wide
cost-effective
seed
source
synthesis,
also
offered
resourceful
solution
residual
sludge
treatment
type
sludge.
