Nrf2: The Guardian of Cellular Harmony – Unveiling Its Role in Cell Biology and Senescence DOI
Mai A. Samak

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: July 12, 2024

Nrf2, a key cellular regulator, plays complex and multifaceted role in both protecting healthy cells potentially promoting disease progression. This chapter delves into the intricate mechanisms by which Nrf2 exerts its protective effects, including combating carcinogens, maintaining integrity, inducing controlled cell death under severe stress. However, also explores “dark side” of where activity cancer can contribute to chemoresistance, adaptation, growth, hindering effective treatment. The further investigates current research avenues for harnessing Nrf2’s potential therapeutic benefit. Strategies activation inhibition are explored, highlighting importance context-dependent balancing protection harm, minimizing off-target effects. Promising new directions, such as developing tissue-specific modulators, identifying predictive biomarkers, combining modulators with other approaches, discussed. By understanding roles, we pave way development safer more strategies that leverage beneficial effects while mitigating drawbacks various diseases.

Language: Английский

SIRT5 Regulates Ferroptosis through the Nrf2/HO-1 Signaling Axis to Participate in Ischemia-Reperfusion Injury in Ischemic Stroke DOI
Jian Li, Wei Gao,

Zhaoming Song

et al.

Neurochemical Research, Journal Year: 2024, Volume and Issue: 49(4), P. 998 - 1007

Published: Jan. 3, 2024

Language: Английский

Citations

15
Calcium (Ca2+) hemostasis, mitochondria, autophagy, and mitophagy contribute to Alzheimer's disease as early moderators DOI
Fatemeh Hadi,

Mahsa Mortaja,

Zahra Hadi

et al.

Cell Biochemistry and Function, Journal Year: 2024, Volume and Issue: 42(5)

Published: July 1, 2024

Abstract This review rigorously investigates the early cerebral changes associated with Alzheimer's disease, which manifest long before clinical symptoms arise. It presents evidence that dysregulation of calcium (Ca 2+ ) homeostasis, along mitochondrial dysfunction and aberrant autophagic processes, may drive disease's progression during its asymptomatic, preclinical stage. Understanding intricate molecular interplay unfolds this critical period offers a window into identifying novel therapeutic targets, thereby advancing treatment neurodegenerative disorders. The delves both established emerging insights alterations precipitated by disruption Ca balance, setting stage for cognitive decline neurodegeneration.

Language: Английский

Citations

9
Crosstalk between ROS-inflammatory gene expression axis in the progression of lung disorders DOI
Sumel Ashique, Neeraj Mishra, Shubhrajit Mantry

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 28, 2024

Language: Английский

Citations

7
Deferasirox Causes Leukaemia Cell Death through Nrf2-Induced Ferroptosis DOI Creative Commons

Wan‐Yi Hsu,

Li‐Ting Wang, Pei‐Chin Lin

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(4), P. 424 - 424

Published: March 29, 2024

Acute lymphoblastic leukaemia (ALL) is the most prevalent cancer in children, and excessive iron buildup resulting from blood transfusions chemotherapy potentially has a negative impact on treatment outcomes prognosis patients with ALL. Therefore, initiating early chelation therapy during ALL logical approach. Ideally, selected chelator should also possess anti-leukaemia properties. The aim of present study was to explore potential underlying mechanism deferasirox (DFX) therapy. This proved that DFX, an chelator, capable inducing cell death through ferroptosis, which achievable by increasing expression acetylated nuclear factor erythroid 2-related 2 (NRF2). More specifically, NRF2 acetylation Lys599 facilitated acetyltransferase-p300/CBP. These findings indicate DFX could serve as potent adjunctive medication for Moreover, may offer dual benefits treatment, functioning both NRF2-modulating agent. Further research clinical trials are necessary fully elucidate therapeutic incorporate it into protocols.

Language: Английский

Citations

4
Exploring the structure–activity relationships and molecular mechanisms of food-derived antioxidative peptides in mitigating oxidative stress: A comprehensive review DOI Creative Commons
Atif Ali,

Kiran Kareem Bukhsh,

Muhammad Mohsin Raza

et al.

Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 127, P. 106751 - 106751

Published: March 22, 2025

Language: Английский

Citations

0
NRF2 Modulators of Plant Origin and Their Ability to Overcome Multidrug Resistance in Cancers DOI Open Access
Piotr Wadowski, Michał Juszczak, Katarzyna Woźniak

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11500 - 11500

Published: Oct. 26, 2024

Cancer is one of the most common causes death in world. Despite fact that there are many types therapies available, cancer treatment remains a major challenge. The main reason for ineffectiveness chemotherapy acquisition multidrug resistance (MDR) by cells. One factors responsible MDR NRF2 transcription factor, which regulates expression proteins such as HO-1, NQO1, MRP1, MRP2, and GST. In normal cells, first line defense against oxidative stress, thereby preventing carcinogenesis. Still, its hyperactivation cells them to acquire MDR, significantly reduces or eliminates effectiveness chemotherapy. Considering important role plays modulators and, above all, inhibitors being sought after, including among compounds plant origin. inhibition may prove be key element anticancer therapy. This review summarizes current state knowledge about presents effects their use overcoming cancer.

Language: Английский

Citations

2
Cordycepin Enhanced Therapeutic Potential of Gemcitabine against Cholangiocarcinoma via Downregulating Cancer Stem-Like Properties DOI Creative Commons
Hong Kyu Lee,

Yun-Jung Na,

Su‐Min Seong

et al.

Biomolecules & Therapeutics, Journal Year: 2024, Volume and Issue: 32(3), P. 368 - 378

Published: April 9, 2024

Cordycepin, a valuable bioactive component isolated from

Language: Английский

Citations

0
Rosolic acid as a novel activator of the Nrf2/ARE pathway in arsenic-induced male reproductive toxicity: An in silico study DOI Creative Commons
Anirban Goutam Mukherjee, Abilash Valsala Gopalakrishnan

Biochemistry and Biophysics Reports, Journal Year: 2024, Volume and Issue: 39, P. 101801 - 101801

Published: July 29, 2024

Male reproductive toxicity as a result of arsenic exposure is linked with oxidative stress and excessive generation reactive oxygen species (ROS). It leads to an imbalance between ROS production antioxidant defense mechanisms ultimately resulting in male infertility. The nuclear factor erythroid 2 (NFE2)-related (Nrf2) transcription that responds cellular stressors controlling the state, mitochondrial dysfunction, inflammation, proteostasis. This study aims investigate potential Rosolic acid (ROA) act novel Nrf2 activator by mitigating combat arsenic-induced toxicity. protein ligands were prepared BIOVIA Discovery Studio, followed protein-ligand docking using auto dock vina integrated PyRx-Virtual Screening Tool. Then ADME properties analyzed SwissADME tool get clear idea about physicochemical properties, lipophilicity, water solubility, pharmacokinetics, drug likeliness ROA. was molecular dynamics simulation (MDS) studies GROMACS. 3D 2D interaction maps revealed interactions Keap 1 Keap1-ROA complex found have binding energy -7.8 kcal/mol. ROA showed 0 violations for Lipinski alerts each PAINS Brenk bioavailability score 0.55. BOILED-Egg representation showcases predicted passively crossing blood-brain barrier (BBB). MDS described 2FLU-ROA stable system. work portrays can be potent exhibiting inhibitory activity against Keap1 thus

Language: Английский

Citations

0
Effect of Agkistrodon acutus venom (AAVC-I) on apoptosis through modulation of the Keap1/Nrf2 pathway in HSC-3 oral squamous cell carcinoma cells DOI Open Access
Tao Tao, Wenzhong Zhang, Linjiang Chai

et al.

Translational Cancer Research, Journal Year: 2024, Volume and Issue: 13(8), P. 4341 - 4353

Published: Aug. 1, 2024

Oral squamous cell carcinoma (OSCC) is the most common malignant tumor in oral and maxillofacial regions. Patients with OSCC exhibit a poor response to conventional chemoradiotherapies, which are associated severe side effects. Therefore, it essential identify an effective therapeutic method treat patients OSCC. An anti-tumor compound,

Language: Английский

Citations

0
Nrf2: The Guardian of Cellular Harmony – Unveiling Its Role in Cell Biology and Senescence DOI
Mai A. Samak

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: July 12, 2024

Nrf2, a key cellular regulator, plays complex and multifaceted role in both protecting healthy cells potentially promoting disease progression. This chapter delves into the intricate mechanisms by which Nrf2 exerts its protective effects, including combating carcinogens, maintaining integrity, inducing controlled cell death under severe stress. However, also explores “dark side” of where activity cancer can contribute to chemoresistance, adaptation, growth, hindering effective treatment. The further investigates current research avenues for harnessing Nrf2’s potential therapeutic benefit. Strategies activation inhibition are explored, highlighting importance context-dependent balancing protection harm, minimizing off-target effects. Promising new directions, such as developing tissue-specific modulators, identifying predictive biomarkers, combining modulators with other approaches, discussed. By understanding roles, we pave way development safer more strategies that leverage beneficial effects while mitigating drawbacks various diseases.

Language: Английский

Citations

0