Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Oct. 18, 2023
Abstract
Cancer
stem
cells
play
crucial
roles
in
the
development
of
cancer
chemoresistance.
L-Theanine,
a
nonproteinogenic
amino
acid
derived
from
green
tea,
is
gaining
more
and
attentions
reversing
drug
resistance.
However,
its
lung
chemoresistance
still
unknown.
To
investigate
effects
L-Theanine
on
explore
underlying
mechanism
cancer,
we
performed
panel
experiments
vitro
combined
with
RNA-seq
analysis
demonstrated
improved
to
cisplatin
(cis-diamminedichloroplatinum;
DDP)
inhibited
stemness
DDP-resistant
but
not
non-resistant
STAT3/NOTCH1
signaling
was
potential
dominant
process
involved
improving
cancer.
Mechanistically,
impedes
migration
activation
via
regulating
expression
STAT3/NOTCH1/BMAL1
signaling-induced
markers,
reducing
proliferation
as
well
inhibiting
resistance-related
genes
cells.
In
addition,
combination
Stat3
blockade
synergistically
summary,
chemoresistant
through
signaling,
finally
The
finding
might
provide
research
evidence
for
therapeutic
options
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(7), P. 3127 - 3127
Published: March 28, 2025
Oral
squamous
cell
carcinoma
(OSCC)
is
one
of
the
most
common
types
cancer
in
head
and
neck
region.
In
advanced
stages
OSCC,
chemotherapy
commonly
used
for
treatment,
despite
some
cells
having
low
sensitivity
to
anticancer
drugs.
We
focused
on
RBM17/SPF45
as
an
essential
drug-sensitizing
factor
context
malignant
acquiring
chemoresistance.
Here,
we
demonstrate
how
RBM17
affects
drug
resistance
OSCC
suggest
possible
mechanism
underlying
its
effects.
After
exposing
oral
lines
fluorouracil
(5-FU)
cisplatin,
but
not
paclitaxel,
gene
protein
expression
increased.
found
that
siRNA-mediated
RBM17-knockdown
gained
a
significantly
higher
5-FU,
which
was
remarkably
followed
by
decrease
checkpoint
kinase
1
(CHEK1)
protein,
whereas
treatment
with
CHEK1
inhibitor
did
affect
lines.
These
results
indicate
involved
development
cytotoxic
chemotherapy.
propose
promotes
ATM/ATR
pathway,
triggering
chemoresistance
cells.
Cancer Drug Resistance,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 16, 2025
A
common
barrier
to
the
development
of
effective
anticancer
agents
is
drug
resistance.
This
obstacle
remains
a
challenge
successful
clinical
translation,
particularly
for
targeted
agents.
Nicotinamide
phosphoribosyltransferase
(NAMPT)
inhibitors
represent
clinically
applicable
class
that
exploits
increased
dependence
cancer
cells
on
nicotinamide
adenine
dinucleotide
(NAD+),
coenzyme
essential
metabolism
and
other
cellular
functions.
NAMPT
catalyzes
rate-limiting
step
in
NAD+
salvage
pathway
mammalian
overexpressed
numerous
types
cancers.
Preclinical
research
has
demonstrated
pharmacological
targeting
may
be
an
strategy
against
certain
cancers,
while
several
early-phase
trials
testing
refractory
cancers
have
been
completed,
resistance
concern.
work
variety
models
emergence
multiple
through
recurrent
mechanisms.
review
represents
first
article
summarizing
current
state
knowledge
regarding
mechanisms
acquired
with
particular
focus
upregulation
compensatory
production
enzymes
nicotinate
(NAPRT)
quinolinate
(QPRT),
mutations
NAMPT,
metabolic
reprogramming,
altered
expression
ATP-binding
cassette
(ABC)
efflux
transporter
ABCB1.
An
understanding
how
these
interact
biology
each
given
cell
type
predispose
acquisition
inhibitor
will
necessary
develop
strategies
optimize
use
moving
forward.
Phytotherapy Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Feb. 14, 2024
Abstract
Chemoresistance
is
the
adaptation
of
cancer
cells
against
therapeutic
agents.
When
exhibited
by
cells,
chemoresistance
helps
them
to
avoid
apoptosis,
cause
relapse,
and
metastasize,
making
it
challenging
for
chemotherapeutic
agents
treat
cancer.
Various
strategies
like
dosage
modification
drugs,
nanoparticle‐based
delivery
chemotherapeutics,
antibody‐drug
conjugates,
so
on
are
being
used
target
reverse
chemoresistance,
one
among
such
combination
therapy.
It
uses
two
or
more
multidrug
resistance
improve
effects
chemotherapy.
Phytochemicals
known
exhibit
chemosensitizing
properties
found
be
effective
various
cancers.
Tocotrienols
(T3)
tocopherols
(T)
natural
bioactive
analogs
vitamin
E,
which
important
medicinal
value
potential
curative
apart
from
serving
as
an
antioxidant
nutrient
supplement.
Notably,
T3
exhibits
a
variety
pharmacological
activities
anticancer,
anti‐inflammatory,
antiproliferative,
on.
The
property
tocotrienol
modulating
several
signaling
pathways
molecular
targets
involved
in
cell
survival,
proliferation,
invasion,
migration,
metastasis
NF‐κB,
STATs,
Akt/mTOR,
Bax/Bcl‐2,
Wnt/β‐catenin,
many
more.
sensitizes
drugs
including
cisplatin,
doxorubicin,
paclitaxel
increasing
drug
concentration
cytotoxicity.
Discussed
herewith
tocotrienols
types
when
combined
with
biological
molecules.
European Journal of Medicinal Chemistry,
Journal Year:
2024,
Volume and Issue:
270, P. 116334 - 116334
Published: March 26, 2024
Mesothelioma
is
a
malignant
neoplasm
of
mesothelial
cells
caused
by
exposure
to
asbestos.
The
average
survival
time
after
diagnosis
usually
nine/twelve
months.
A
multi-therapeutic
approach
therefore
required
treat
and
prevent
recurrence.
Boronated
derivatives
containing
carborane
cage,
sulfamido
group
an
ureido
functionality
(CA-USF)
have
been
designed,
synthesised
tested,
in
order
couple
Boron
Neutron
Capture
Therapy
(BNCT)
the
inhibition
Carbonic
Anhydrases
(CAs),
which
are
overexpressed
many
tumours.
In
vitro
studies
showed
greater
than
reference
drug
acetazolamide
(AZ).
To
increase
solubility
aqueous
media,
CA-USFs
were
used
as
inclusion
complexes
hydroxypropyl
β-cyclodextrin
(HP-β-CD)
all
cell
experiments.
BNCT
experiments
carried
out
on
AB22
(murine
mesothelioma)
lines
marked
proliferation
CA-USFs,
one
case
complete
twenty
days
neutron
irradiation.
Finally,
vivo
irradiation
mouse
model
mesothelioma
demonstrated
efficiency
combining
CA
IX
treatment.
Indeed,
reduction
tumour
mass
was
observed
treated
mice
compared
untreated
mice,
with
significant
higher
effect
when
combined
BNCT.
For
administered
molecular
weight
β-CD
polymers
thus
increasing
selective
extravasation
into
tissue
reducing
clearance.
this
way,
boron
uptake
maximised
be
well
tolerated
at
therapeutic
dose.
strategy
herein
described
could
expanded
other
cancers
increased
activity,
such
melanoma,
glioma,
breast
cancer.
AJP Cell Physiology,
Journal Year:
2024,
Volume and Issue:
327(1), P. C11 - C33
Published: May 6, 2024
In
contrast
to
other
types
of
cancers,
there
is
no
available
efficient
pharmacological
treatment
improve
the
outcomes
patients
suffering
from
major
primary
liver
i.e.,
hepatocellular
carcinoma
and
cholangiocarcinoma.
This
dismal
situation
partly
due
existence
in
these
tumors
many
different
synergistic
mechanisms
resistance,
accounting
for
lack
response
patients,
not
only
classical
chemotherapy
but
also
more
modern
agents
based
on
inhibition
tyrosine
kinase
receptors
(TKIs)
stimulation
immune
against
tumor
using
checkpoint
inhibitors
(ICIs).
review
summarizes
efforts
develop
strategies
overcome
this
severe
limitation,
including
searching
novel
drugs
derived
synthetic,
semisynthetic,
or
natural
products
with
vectorial
properties
therapeutic
targets
increase
drug
uptake
reduce
export
cancer
cells.
Besides,
immunotherapy
a
promising
line
research
that
already
starting
be
implemented
clinical
practice.
Although
less
successful
than
foreseen
future
strategy
treating
cancers
considerable.
Similarly,
epigenetic
highly
promising.
Many
“epidrugs,”
able
act
“writer,”
“reader,”
“eraser”
players,
are
currently
being
evaluated
preclinical
studies.
Finally,
gene
therapy
broad
field
fight
chemoresistance,
impressive
advances
recently
achieved
manipulation.
sum,
although
present
still
dismal,
reason
hope
non-too-distant
future.
Frontiers in Bioscience-Landmark,
Journal Year:
2024,
Volume and Issue:
29(6), P. 226 - 226
Published: June 21, 2024
Background:
L-Theanine,
a
nonproteinogenic
amino
acid
derived
from
green
tea,
is
being
recognized
as
an
anti-cancer
candidate.
However,
it's
roles
in
the
development
of
cancer
chemoresistance
still
unknown
and
molecular
mechanism
urgently
to
be
explored.
Methods:
The
effects
L-Theanine
on
lung
were
validated
by
Cell
Counting
Kit-8
(CCK-8)
assay,
transwell
vitro
tumor
spheroid
formation
assay;
expression
proteins
was
detected
using
polymerase
chain
reaction
(PCR)
western
blotting.
RNA-sequencing
(RNA-seq)
bioinformatics
analysis
used
identify
differentially
expressed
genes
induced
L-Theanine.
BMAL1
knockdown
overexpression
constructed
lentivirus-mediated
transfection
system.
Results:
improved
cis-diamminedichloroplatinum
(DDP)
inhibited
stemness
DDP-resistant
cells
but
not
non-resistant
cells.
results
RNA-seq
showed
that
STAT3/NOTCH1
pathway
potential
dominant
signaling
involved
improving
cancer.
Mechanistically,
impeded
migration
activation
via
regulating
STAT3/NOTCH1/BMAL1
signaling-induced
markers
well
inhibiting
levels
drug
resistance-related
genes.
In
addition,
combination
Stat3
blockade
synergistically
Conclusion:
improves
signaling,
reducing
stemness,
finding
might
provide
some
evidence
for
therapeutic
options
overcoming
cancers,
including
Biomedicines,
Journal Year:
2023,
Volume and Issue:
11(12), P. 3155 - 3155
Published: Nov. 27, 2023
Ovarian
cancer
is
the
leading
cause
of
death
among
gynecologic
cancers.
Paclitaxel
used
as
a
standard
first-line
therapeutic
agent
for
ovarian
cancer.
However,
chemotherapeutic
resistance
and
high
recurrence
rates
are
major
obstacles
to
treating
We
have
found
that
tephrosin,
natural
rotenoid
isoflavonoid,
can
resensitize
paclitaxel-resistant
cells
paclitaxel.
Cell
viability,
immunoblotting,
flow
cytometric
analysis
showed
combination
treatment
made
up
paclitaxel
tephrosin
induced
apoptotic
death.
Tephrosin
inhibited
phosphorylation
AKT,
STAT3,
ERK,
p38
MAPK,
all
which
simultaneously
play
important
roles
in
survival
signaling
pathways.
Notably,
downregulated
FGFR1
its
specific
adapter
protein
FRS2,
but
it
had
no
effect
on
EGFR.
Immunoblotting
fluo-3
acetoxymethyl
assay
did
not
affect
expression
or
function
P-glycoprotein.
Additionally,
with
N-acetylcysteine
restore
cell
cytotoxicity
caused
by
showing
reactive
oxygen
species
scavenging
pathway.
Interestingly,
reduced
anti-apoptotic
factor
XIAP.
This
study
demonstrates
potent
antitumor
be
via
inhibition
