Computers in Biology and Medicine, Journal Year: 2024, Volume and Issue: 185, P. 109497 - 109497
Published: Dec. 13, 2024
Language: Английский
The Oncologist, Journal Year: 2025, Volume and Issue: 30(3)
Published: March 1, 2025
Abstract Corticosteroids are widely used to prevent and treat chemotherapy-induced nausea vomiting (CINV) due their pleiotropic biological effects. However, concerns have been raised about immunosuppressive properties when combined with immunotherapy. Specifically, potential impact on the efficacy of immunotherapy, mainly immune checkpoint inhibitors (ICIs), remains a subject debate. This manuscript discusses mechanisms by which corticosteroids mitigate CINV, challenges associated concurrent use emerging therapeutic strategies evaluating dexamethasone-free regimens. A careful balance must be struck in corticosteroid effectively manage CINV while optimizing outcomes
Language: Английский
Citations
0
Antibodies, Journal Year: 2025, Volume and Issue: 14(2), P. 35 - 35
Published: April 11, 2025
Monoclonal antibodies (mAbs) targeting various pathways in cancer therapy play crucial roles enhancing the immune system's ability to recognise and eliminate tumour cells. These therapies are designed either block inhibitory checkpoint or target specific cell markers for direct destruction. Additionally, mAbs can modulate microenvironment, enhance antibody-dependent cellular cytotoxicity, inhibit angiogenesis, further amplifying their therapeutic impact. Below is a summary of monoclonal key pathways, along with indications mechanisms action, which reviewed based on mechanisms.
Language: Английский
Citations
0
Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 142575 - 142575
Published: May 1, 2025
Language: Английский
Citations
0
Nanoscale, Journal Year: 2024, Volume and Issue: 16(32), P. 14994 - 15008
Published: Jan. 1, 2024
Cancer has become a primary global health concern, which prompted increased attention towards targeted therapeutic approaches like photothermal therapy (PTT). The unique optical and magnetic properties of nanodiamonds (NDs) have made them versatile nanomaterials with promising applications in biomedicine. This comprehensive review focuses on the potential NDs as multifaceted platform for anticancer therapy, mainly focusing their dual functionality PTT temperature sensing. highlighted NDs' ability to enhance through hybridization or modification, underscoring adaptability delivering small molecule reagents effectively. Furthermore, NDs, particularly fluorescent (FNDs) negatively charged nitrogen-vacancy centers, enable precise monitoring, enhancing efficacy treatment. Integrating FNDs into holds promise advancing by providing valuable insights localized variations cell death mechanisms. highlights new cancer treatment strategies, showcasing revolutionize therapeutics improve patient outcomes.
Language: Английский
Citations
3
Current Pharmaceutical Design, Journal Year: 2024, Volume and Issue: 30(10), P. 727 - 741
Published: March 1, 2024
Abstract: This review investigates the revolutionary application of cell membrane-coated nanoparticles (CMNPs) as a promising avenue for cancer therapy within embryonic landscape nanotechnology. Nanoparticles, pivotal in treatment, are systematically examined their diverse physicochemical structures, categorized organic (lipid-based, protein-based, and polymer-assisted) inorganic (carbon-based metal) varieties. A significant focus is placed on CMNPs, which serve an innovative drug delivery vehicle, overcoming limitations associated with conventional nanoparticle therapies. manuscript accurately explores advantages challenges various membranes, including those derived from cells, red blood platelets, stem white cells. Importance roles enhancing precision, immune system circumvention, targeted recognition. Detailed insights into crafting CMNPs provided, elucidating membrane extraction fusion techniques, such sonication, extrusion, co-extrusion, microfluidic electroporation. Maintaining integrity during benefits coating techniques augmenting biocompatibility underscored. comprehensive resource consolidates latest advancements delivery, positioning itself at forefront nanotechnology biomedicine research. Encapsulating methodologies like electrospray, chemical conjugation, this showcases expanding toolbox available to researchers dynamic field. Focusing unique characteristics multifaceted applications biomedical research, particularly tumour therapy. It provides indepth analysis stability, evasion capabilities, increased payload capacity, retained biological functionality. The outlines current future prospects chemotherapy, photothermal photodynamic therapy, immunotherapy, gene therapeutic methods. concludes by highlighting transformative potential reshaping treatment.
Language: Английский
Citations
2
Asian Journal of Advances in Research, Journal Year: 2024, Volume and Issue: 7(1), P. 159 - 173
Published: April 24, 2024
A new era in cancer treatment has begun with the development of monoclonal antibodies (mAbs), which have improved therapeutic results and precision targeting to a great extent. Specialized (mAbs) are engineered attach specifically antigens, allowing them directly target tumor cells influence immune system for purposes. Significant advancements this field include approval clinical efficacy mAbs that B-cell lymphomas HER2-positive breast cancer. Notable cases like as trastuzumab rituximab highlight real benefits these treatments, better patient outcomes survival rates. Furthermore, by triggering body's immunological defenses against cells, checkpoint inhibitors pembrolizumab completely changed way is treated. For individuals previously difficult-to-treat illnesses, innovative technique shown extraordinary success across variety types. Innovative approaches including antibody-drug conjugates bispecific also been produced ongoing developments mAb engineering. These technical miracles improve overall safety profile (mAb) therapeutics compensating off-target effects optimizing efficacy. There still issues, such toxicity emergence drug resistance, spite significant progress. Even Nevertheless, continued research initiatives enormous potential customized plans. advances promise future patients everywhere highlighting quick evolution therapies encouraging increased innovation vital area medicine.
Language: Английский
Citations
1
Biomaterials Science, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Cancer immunotherapy involves a cutting-edge method that utilizes the immune system to detect and eliminate cancer cells.
Language: Английский
Citations
1
BMC Gastroenterology, Journal Year: 2024, Volume and Issue: 24(1)
Published: Dec. 18, 2024
PD-1 and PD-L1 inhibitors have emerged as promising therapies for advanced colorectal cancer (CRC), but their efficacy safety profiles require further evaluation. This meta-analysis aims to assess the of PD-1/PD-L1 in this patient population. A systematic review were conducted following PRISMA guidelines, with data sourced from PubMed, Embase, CENTRAL, Web Science, CNKI up August 3, 2024. Nine randomized controlled trials (RCTs) involving 1680 patients included. The primary outcomes overall survival (OS), progression-free (PFS) objective response rate (ORR), while was assessed through adverse events (AEs) grade ≥ 3 AEs. Effect sizes calculated using mean differences (MD) risk ratios (RR) 95% confidence intervals (CIs). Overall, showed that did not significantly extend OS (MD = 0.86, CI: -0.55, 2.27), they improved PFS 2.53, 0.92, 4.15). Additionally, increase ORR compared controls (RR 1.19, 0.99, 1.44). In terms safety, incidence Subgroup analysis indicated 1.24, 0.20, 2.29) 6.27, 0.56, 11.97), a significant impact on these outcomes. associated higher AEs 1.29, 1.07, 1.57), observed inhibitors. improve CRC, making them preferable option over inhibitors, which show limited severe These findings support prioritizing clinical practice group, caution is warranted due concerns. PROSPERO (CRD42024611696).
Language: Английский
Citations
1
Advances in Applied Mathematics, Journal Year: 2024, Volume and Issue: 13(04), P. 1248 - 1260
Published: Jan. 1, 2024
Language: Английский
Citations
0
Brazilian Journal of Implantology and Health Sciences, Journal Year: 2024, Volume and Issue: 6(4), P. 1705 - 1716
Published: April 18, 2024
Pregnancy presents unique challenges in diagnosing and treating non-melanoma skin cancer, the most common type of cancer. Hormonal immunological changes during pregnancy can influence development progression disease, while ethical issues concerns about fetal safety complicate therapeutic approach. Therefore, it is crucial to understand how this condition managed ensure best outcome for mother baby. Objective: The objective systematic literature review analyze approaches treatments used cancer pregnancy, with a focus on maternal safety. Methodology: followed PRISMA checklist guidelines. Articles published last 10 years were searched PubMed, Scielo Web Science databases. descriptors "non-melanoma cancer", "pregnancy", "treatment", "approach" "fetal safety". inclusion criteria studies that described cases addressing treatment options considerations. exclusion irrelevant topic, without access full text not available English, Portuguese or Spanish. Results: Analysis articles revealed several including surgery, photodynamic therapy cryotherapy. There was an emphasis individualized assessment each case, taking into account stage location tumor potential risks fetus. Prevention also highlighted, sun protection self-examination. However, some have been delayed until after birth due Conclusion: management requires multidisciplinary approach, considering benefits Prevention, early diagnosis adequate are essential guarantee result both. More research needed further guide clinical practices area.
Language: Английский
Citations
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