Apmis,
Journal Year:
2024,
Volume and Issue:
132(10), P. 688 - 705
Published: Sept. 9, 2024
Bacterial
biofilm
plays
a
vital
role
in
influencing
several
diseases,
infections,
metabolic
pathways
and
communication
channels.
Biofilm
influence
over
colorectal
cancer
(CRC)
has
been
booming
area
of
research
interest.
The
virulence
factors
bacterial
pathogen
have
high
tendency
to
induce
pathway
accelerate
CRC.
species
may
through
regulating
the
major
signalling
responsible
for
cell
proliferation,
differentiation,
survival
growth.
Activation
signals
get
initiated
from
chronic
infections
species.
Integrin
mediates
activation
promoting
cancer.
Integrin‐mediated
are
expected
be
greatly
influenced
by
biofilm.
Integrins
identified
as
an
important
dimer,
whose
dysfunction
alter
cascade
specially
focusing
on
TGF‐β,
PI3K/Akt/mToR,
MAPK
Wnt
pathway.
Along
with
shield,
tumour
gains
greater
resistance
radiation,
chemotherapy
also
other
antibiotics.
barrier
is
known
cause
challenges
CRC
patients
undergoing
treatment.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(9), P. 1232 - 1232
Published: Sept. 21, 2024
Silver
nanoparticles
(AgNPs)
are
leading
the
way
in
nanotechnological
innovation,
combining
captivating
properties
of
silver
with
accuracy
nanoscale
engineering,
thus
revolutionizing
material
science.
Three
main
techniques
arise
within
alchemical
domains
AgNP
genesis:
chemical,
physical,
and
biological
synthesis.
Each
possesses
its
distinct
form
magic
for
controlling
size,
shape,
scalability—key
factors
necessary
achieving
expertise
practical
application
nanoparticles.
The
story
unravels,
describing
careful
coordination
chemical
reduction,
environmentally
sensitive
charm
green
synthesis
utilizing
plant
extracts,
precise
physical
techniques.
AgNPs
highly
praised
field
healthcare
their
powerful
antibacterial
characteristics.
These
little
warriors
display
a
wide-ranging
attack
against
bacteria,
fungi,
parasites,
viruses.
Their
critical
significance
combating
hospital-acquired
surgical
site
infections
is
praised,
serving
as
beacon
hope
fight
challenging
problem
antibiotic
resistance.
In
addition
to
ability
kill
also
known
promote
tissue
regeneration
facilitate
wound
healing.
cancer
has
observed
adaptability
AgNPs.
review
documents
role
innovative
carriers
drugs,
specifically
designed
target
cells
accuracy,
minimizing
harm
healthy
tissues.
Additionally,
it
explores
potential
therapy
or
anticancer
agents
capable
disrupting
growth
tumors.
food
business,
utilized
enhance
durability
packing
materials
coatings
by
infusing
them
bactericidal
properties.
This
results
improved
safety
measures
significant
increase
duration
that
products
can
be
stored,
thereby
tackling
crucial
issue
preservation.
academic
analysis
recognizes
many
difficulties
come
creation
incorporation
statement
pertains
evaluation
environmental
effort
synthetic
processes.
predicts
future
pursuits,
envisioning
progress
will
usefulness
importance
from
being
new
becoming
essential
realms
science
industry.
Besides,
not
only
subject
scholarly
interest
but
component
continuous
tackle
some
most
urgent
health
conservation
concerns
contemporary
society.
aims
explore
complex
process
highlight
numerous
uses,
special
focus
on
growing
business
sectors.
invites
scientific
community
extensive
possibilities
order
fully
understand
utilize
potential.
BMC Urology,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Feb. 18, 2025
Prostate
cancer
(PCa)
is
one
of
the
most
common
malignancies
in
men
worldwide.
Despite
advances
treatment,
many
patients
develop
resistance
to
conventional
therapies.
Solute
carrier
(SLC)
proteins,
as
transmembrane
transporters,
have
recently
emerged
potential
therapeutic
targets
due
their
role
tumor
metabolism
and
progression.
This
review
summarizes
key
roles
six
SLC
proteins
PCa,
including
involvement
metabolic
reprogramming,
regulation
signaling
pathways,
effects
on
microenvironment.
Although
targeting
family
members
prostate
remains
an
underexplored
area,
growing
body
evidence
suggests
that
it
holds
for
future
development.
Kinases and Phosphatases,
Journal Year:
2025,
Volume and Issue:
3(2), P. 9 - 9
Published: April 21, 2025
Kinase
inhibitors
are
small
molecules
that
block
kinase
activity
and
have
significant
applications
in
both
therapy
diagnostics.
Recent
studies
suggest
these
hold
great
potential
as
targets
for
treating
a
range
of
diseases,
including
autoimmune
disorders,
cardiovascular
conditions,
cancer,
inflammatory
diseases
like
ulcerative
colitis.
Ongoing
research
focuses
on
developing
effective
carriers
tyrosine
(TKIs)
to
enhance
treatment
outcomes
while
reducing
side
effects.
The
nano-scale
drug
demonstrated
the
ability
encapsulate
wide
imaging
therapeutic
agents,
enhancing
tumor
diagnosis
treatment.
Notably,
incorporation
drugs
with
poor
pharmacokinetics
into
nanocarriers
enhances
their
solubility
stability,
offering
renewed
opportunity
assess
full
potential.
entrapped
agents
can
be
released
controlled
manner
maintain
specific
concentration
within
framework
or
triggered
by
stimuli
such
time
pH
target
particular
tissues
cells.
multifunctionality
nanosystems
offers
promising
avenue
innovative
inhibitor
(TKI)
delivery
strategies
serve
alternative
options
cancer
other
diseases.
This
review
aims
provide
comprehensive
overview
systems
TKIs,
standalone
treatments
combination
approaches.
We
discuss
comparative
advantages
limitations
future
small-molecule
TKIs
research.
