Connecting the Dots: LncRNAs in the KRAS Pathway and Cancer
Pathology - Research and Practice,
Journal Year:
2024,
Volume and Issue:
262, P. 155570 - 155570
Published: Aug. 29, 2024
Language: Английский
Therapeutic Potential and Mechanisms of Puerarin in Liver Disease: A Comprehensive Review of Pharmacological Effects and Drug Delivery Innovations
Pharmacological Research - Modern Chinese Medicine,
Journal Year:
2025,
Volume and Issue:
unknown, P. 100594 - 100594
Published: Feb. 1, 2025
Language: Английский
Innovative anti-aging strategies targeting WNT pathway epigenetics for gut function
Human Gene,
Journal Year:
2025,
Volume and Issue:
44, P. 201397 - 201397
Published: March 5, 2025
Language: Английский
Obovatol inhibits proliferation, invasion and immune escape of hepatocellular carcinoma cells through modulating the JAK/STST3/PD-L1 pathway
International Immunopharmacology,
Journal Year:
2024,
Volume and Issue:
141, P. 112775 - 112775
Published: Aug. 14, 2024
Language: Английский
Comment on “Chinese herbal medicine compound of flavonoids adjunctive treatment for oral cancer”
Journal of the Formosan Medical Association,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 1, 2024
Language: Английский
ML‐Based Screening of miRNA Inhibitors and Intervention of lncRNA/miRNA/mRNA Axis in Oncogenic KRAS‐Associated Colorectal Cancer
Advances in Public Health,
Journal Year:
2024,
Volume and Issue:
2024(1)
Published: Jan. 1, 2024
Mutant
KRAS
promotes
proliferation
and
tumorigenesis
in
several
cancers
such
as
colorectal
cancer
(CRC),
pancreatic
ductal
adenocarcinoma
(PDAC),
non–small
cell
lung
(NSCLC).
The
long
noncoding
RNAs
(lncRNAs)
regulate
the
microRNAs
(miRNAs)
that
further
result
dysregulation
of
messenger
(mRNAs)
various
mutant
KRAS‐associated
cancers.
Although
role
function
lncRNA
axis
are
not
clearly
understood,
studies
have
recently
focussed
on
evaluation
lncRNAs
CRNDE
SNHG7
highly
expressed
colon
(COAD),
a
major
subtype
CRC,
miRNA
expression
thus
indirectly
mRNA
levels.
In
present
study,
we
utilized
bioinformatics
approaches
differential
gene
(DEG)
analysis,
survival
immunohistochemistry
(IHC)
prediction
RNA–RNA
interaction,
stability
prediction,
binding
energy
evaluation.
Alongside,
machine
learning
(ML)–based
screening
was
also
performed
to
identify
potential
inhibitors
from
natural
source
using
RDKit.
From
our
observed
sponges
hsa‐miR‐181a‐5p
downregulates
their
expression,
regulates
CTNNB1
TCF4
COAD.
Also,
axis,
it
hsa‐miR‐216b‐5p
further,
GALNT1
downregulated
by
hsa‐miR‐216b‐5p.
Additionally,
ML‐based
revealed
some
particularly
based
anthraquinone,
quinazoline,
sulfonamide
scaffolds
against
Thus,
conclude
lncRNA/miRNA/mRNA
CRNDE/hsa‐miR‐181a‐5p/(CTNNB1/TCF4)
SNHG7/hsa‐miR‐216b‐5p/GALNT1
axes
significant
therapeutic
target
compounds
be
studied
more
detail
developed
inhibitors.
However,
predictions
were
supported
evidence
interaction
regulation
through
inhibitor
screening;
has
vitro
vivo
settings
near
future.
Language: Английский
Unlocking the potential: integrating phytoconstituents and nanotechnology in skin cancer therapy – A comprehensive review
Journal of Complementary and Integrative Medicine,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 13, 2024
Skin
carcinoma,
which
includes
basal
cell
carcinoma
(BCC),
squamous
(SCC),
and
melanoma,
is
influenced
by
various
factors
such
as
genetic
predisposition,
chemical
exposures,
immune
system
imbalances,
ultraviolet
(UV)
radiation.
This
review
delves
into
the
mechanisms
behind
development
of
these
cancers,
exploring
therapeutic
potential
microbial,
plant
derived
compounds
nanoparticles
in
advancing
skin
cancer
treatments.
Special
attention
given
to
cytotoxic
effects
anti-neoplastic
agents
from
microbial
sources
on
different
lines,
particularly
melanoma.
Additionally,
highlights
role
phytochemicals
-
quercetin,
resveratrol,
curcumin
alongside
vitamins,
terpenoids,
sulforaphane,
management
cancers
through
like
apoptosis
induction
cycle
regulation.
Recent
advancements
nanotechnology-based
drug
delivery
systems,
including
NP
microemulsion
formulations,
are
also
discussed
for
their
enhanced
ability
specifically
target
cells.
The
diverse
roles
NPs
therapy,
especially
terms
targeted
modulation,
reviewed.
These
innovative
formulations
have
showed
improved
penetration
tumor-specific
delivery,
reduced
systemic
toxicity
effectiveness.
Language: Английский