Modulating Autophagy in Osteoarthritis: Exploring Emerging Therapeutic Drug Targets DOI Open Access
Corina Andrei, Dragoș Paul Mihai, George Mihai Niţulescu

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13695 - 13695

Published: Dec. 21, 2024

Osteoarthritis (OA) is a degenerative joint disease characterized by the breakdown of cartilage and subsequent inflammation tissues, leading to pain reduced mobility. Despite advancements in symptomatic treatments, disease-modifying therapies for OA remain limited. This narrative review examines dual role autophagy OA, emphasizing its protective functions during early stages potential contribute degeneration later stages. By delving into molecular pathways that regulate autophagy, this highlights intricate interplay with oxidative stress inflammation, key drivers progression. Emerging therapeutic strategies aimed at modulating are explored, including pharmacological agents such as AMP kinase activators, microRNA-based therapies. Preclinical studies reveal encouraging results, demonstrating enhancing can reduce decelerate degradation. However, benefits modulation depend on precise, stage-specific approaches. Excessive or dysregulated advanced may lead chondrocyte apoptosis, exacerbating damage. underscores promise autophagy-based interventions bridging gap between experimental research clinical application. advancing our understanding autophagy’s these findings pave way innovative effective Nonetheless, further essential optimize strategies, address off-target effects, develop safe, targeted treatments improve outcomes patients.

Language: Английский

Recent Advances in Aptamers-Based Nanosystems for Diagnosis and Therapy of Cardiovascular Diseases: An Updated Review DOI Creative Commons

Hongqin Yu,

Jie Yu, Gang Yao

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 2427 - 2443

Published: Feb. 1, 2025

The increasing global prevalence of cardiovascular diseases highlights the urgent need for innovative diagnostic and therapeutic strategies. Aptamers, small single-stranded nucleic acid molecules with exceptional specificity affinity target biomolecules, have emerged as promising tools precise diagnostics targeted therapies. Their selective binding capabilities provide valuable insights into molecular mechanisms underlying conditions. When integrated nanosystems, aptamers enhance delivery, bioavailability, stability agents, addressing challenges solubility degradation. This integration enables more drug advanced imaging techniques, improved interventions, ultimately improving management diseases. Recent advancements in aptamer selection methodologies, coupled their unique three-dimensional structures, significantly expanded application potential health. By combining novel approaches to disease diagnosis treatment are emerging, enhanced efficacy, safety, precision. review explores recent progress development aptamer-based nanosystems

Language: Английский

Citations

2
The intersection of aging and estrogen in osteoarthritis DOI Creative Commons
Aysegul Atasoy‐Zeybek,

Kelly K. Showel,

Christopher V. Nagelli

et al.

npj Women s Health, Journal Year: 2025, Volume and Issue: 3(1)

Published: Feb. 25, 2025

Osteoarthritis (OA) is a chronic joint disease characterized by cartilage degradation, inflammation, and pain. While multiple factors contribute to OA development, age sex are primary risk factors, particularly affecting postmenopausal women. The dramatic increase in after menopause suggests estrogen deficiency accelerates progression. This review explores the molecular mechanisms connecting aging focusing on key genes pathways identified through RNA sequencing.

Language: Английский

Citations

2
10-hydroxy-2-decenoic acid prevents osteoarthritis by targeting aspartyl β hydroxylase and inhibiting chondrocyte senescence in male mice preclinically DOI Creative Commons

Nana Geng,

Mengtian Fan,

Biao Kuang

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Sept. 4, 2024

Language: Английский

Citations

5
Liquiritin reduces chondrocyte apoptosis through P53/PUMA signaling pathway to alleviate osteoarthritis DOI
Min Qiu,

Liangyan Cheng,

Jianbo Xu

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 343, P. 122536 - 122536

Published: Feb. 28, 2024

Language: Английский

Citations

3
Elucidation of the key therapeutic targets and potential mechanisms of Andrographolide multi-targets against osteoarthritis via network pharmacological analysis and experimental validation DOI

Tengyun Yang,

Tingting Cao, Xianguang Yang

et al.

Gene, Journal Year: 2024, Volume and Issue: 911, P. 148351 - 148351

Published: March 8, 2024

Language: Английский

Citations

2
Transcriptomic changes during the replicative senescence of human articular chondrocytes DOI Creative Commons
Aysegul Atasoy‐Zeybek,

Gresin P. Hawse,

Christopher V. Nagelli

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 7, 2023

Osteoarthritis (OA) is a degenerative joint disease and leading cause of disability worldwide. Aging major risk factor for OA, but the specific mechanisms underlying this connection remain unclear. Although chondrocytes rarely divide in adult articular cartilage, they undergo replicative senescence vitro which provides an opportunity to study changes related aging under controlled laboratory conditions. In pilot study, we performed bulk RNA sequencing on early- late-passage human identify transcriptomic associated with cellular aging. Chondrocytes were isolated from cartilage three donors, two OA (age 70-80 years) one healthy 26 years). serially passaged until extracted cells. Principal component analysis all genes showed clear separation between chondrocytes, indicating substantial age-related differences gene expression. Differentially expressed (DEGs) confirmed distinct profiles chondrocytes. Hierarchical clustering revealed contrasting expression patterns isolates osteoarthritic samples sample. Focused DEGs transcripts turnover extra-cellular matrix senescence-associated secretory phenotype (SASP) consistent downregulation Col2A1 ACAN, upregulation MMP19, ADAMTS4, ADAMTS8 late passage across samples. SASP components including IL-1α, IL-1β, IL-6, IL-7, p16INK4A (CDKN2A) CCL2 demonstrated significant originally Pathway sexes shared pathways such as extracellular (ECM) organization, collagen formation, skeletal muscle development, nervous system development. Sex-specific observed, males showing distinctions ECM regulation cell cycle process well neuron differentiation. contrast, females exhibited unique variations process, DNA metabolic PID-PLK1 pathway.

Language: Английский

Citations

1
The Expression of a Subset of Aging and Antiaging Markers Following the Chondrogenic and Osteogenic Differentiation of Mesenchymal Stem Cells of Placental Origin DOI Creative Commons
Mahmoud Zhra, Ahmad M. Magableh, Lara Samhan

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(12), P. 1022 - 1022

Published: June 12, 2024

Mesenchymal stem cells (MSCs) of placental origin hold great promise in tissue engineering and regenerative medicine for diseases affecting cartilage bone. However, their utility has been limited by tendency to undergo premature senescence phenotypic drift into adipocytes. This study aimed explore the potential involvement a specific subset aging antiaging genes measuring expression prior following vitro-induced differentiation MSCs chondrocytes osteoblasts as opposed The targeted interest included various

Language: Английский

Citations

0
Microbial amidases: Characterization, advances and biotechnological applications DOI Open Access
Rajendra Singh,

Refana Shahul,

Vijay L. Kumar

et al.

Biotechnology Notes, Journal Year: 2024, Volume and Issue: 6, P. 44 - 58

Published: Dec. 20, 2024

Language: Английский

Citations

0
Modulating Autophagy in Osteoarthritis: Exploring Emerging Therapeutic Drug Targets DOI Open Access
Corina Andrei, Dragoș Paul Mihai, George Mihai Niţulescu

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13695 - 13695

Published: Dec. 21, 2024

Osteoarthritis (OA) is a degenerative joint disease characterized by the breakdown of cartilage and subsequent inflammation tissues, leading to pain reduced mobility. Despite advancements in symptomatic treatments, disease-modifying therapies for OA remain limited. This narrative review examines dual role autophagy OA, emphasizing its protective functions during early stages potential contribute degeneration later stages. By delving into molecular pathways that regulate autophagy, this highlights intricate interplay with oxidative stress inflammation, key drivers progression. Emerging therapeutic strategies aimed at modulating are explored, including pharmacological agents such as AMP kinase activators, microRNA-based therapies. Preclinical studies reveal encouraging results, demonstrating enhancing can reduce decelerate degradation. However, benefits modulation depend on precise, stage-specific approaches. Excessive or dysregulated advanced may lead chondrocyte apoptosis, exacerbating damage. underscores promise autophagy-based interventions bridging gap between experimental research clinical application. advancing our understanding autophagy’s these findings pave way innovative effective Nonetheless, further essential optimize strategies, address off-target effects, develop safe, targeted treatments improve outcomes patients.

Language: Английский

Citations

0