Association Between Platelet-to-High-Density Lipoprotein Cholesterol Ratio and Cognitive Function in Older Americans: Insights from a Cross-Sectional Study DOI Creative Commons
Ruwen Zheng, Siqi Zhang, Hongyu Qin

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 16, 2024

Abstract Aims The main aim of this study was to explore the correlation between platelet/high-density lipoprotein cholesterol ratio (PHR) and cognitive function in elderly individuals from United States. Methods This investigation leveraged data encompassing 2299 participants, all aged 60 years above, National Health Nutrition Examination Survey conducted 2011 2014. Inclusion criteria were based on availability complete datasets for PHR assessments. analytical approach incorporated multivariate logistic regression discern association impairment. Additionally, employed restricted cubic splines (RCS) potential non-linear relationships subgroup analyses identify variations observed associations across different demographic clinical subgroups. Results In fully adjusted model, an increment 10 units associated with a decline 0.014 scores (β=-0.014, 95% CI: -0.025, -0.002; P<0.05). Compared lowest quartile, participants highest quartile exhibited 38.4% increased prevalence impairment per one-unit increase (OR=1.384, 1.012, 1.893; P<0.05). Subgroup analysis revealed consistent results regarding relationship A using RCS, indicating that above 111.49 significantly elevated incidence (P<0.05). Conclusions Our proves higher is linked greater risk U.S. population, warranting consideration assessments interventions.

Language: Английский

The Impact of Stress and Social Determinants on Diet in Cardiovascular Prevention in Young Women DOI Open Access
Francesca Coppi, Valentina Bucciarelli,

Kateryna Solodka

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(7), P. 1044 - 1044

Published: April 3, 2024

The prevention of cardiovascular diseases is a fundamental pillar for reducing morbidity and mortality caused by non-communicable diseases. Social determinants, such as socioeconomic status, education, neighborhood, physical environment, employment, social support networks, access to health care, play crucial role in influencing outcomes inequities within populations. determinants stress women are interconnected factors that can significantly impact women’s well-being. Pregnancy good time engage young introduce them beneficial behaviors, adopting essential life skills, especially diet, learning management techniques. Stress influences more likely unhealthy eating behaviors emotional or coping with food. Strong action needed improve lifestyle starting at age considering this lays the foundation lower risk adults elderly. objective review examine primary healthy women, focusing particularly on unresolved issues influence well correlation stressors their diet.

Language: Английский

Citations

9
Unraveling the Role of Endothelial Dysfunction in Osteonecrosis of the Femoral Head: A Pathway to New Therapies DOI Creative Commons
Wenkai Shao, Ping Wang, Xiao Lv

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(3), P. 664 - 664

Published: March 15, 2024

Osteonecrosis of the femoral head (ONFH) is a disabling disease characterized by disruption blood supply to head, leading apoptosis and necrosis bone cells subsequent joint collapse. Total hip arthroplasty not optimal since most patients are young. Multiple risk factors contribute osteonecrosis, including glucocorticoid (GC) usage, excessive alcohol intake, hypercholesterolemia, smoking. Continuous stimulation many variables causes chronic inflammatory milieu, with clinical repercussions endothelial dysfunction, thrombosis, coagulopathy, poor angiogenesis. Immune primary regulators inflammation. Innate adaptive immune interact hinder regeneration repair lesions. An in-depth examination pathological drivers ONFH reveals that dysfunction may be major cause osteonecrosis. Understanding involvement in inflammation osteonecrosis could aid development possible therapies. This review summarizes role further explains pathophysiological mechanism this from perspective provide new ideas for treatment

Language: Английский

Citations

7
The Vaso-Occlusive Pain Crisis in Sickle Cell Patients: A Focus on Pathogenesis DOI
Fatemeh Javaherforooshzadeh,

Azadeh Fateh,

Hedieh Saffari

et al.

Current Research in Translational Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 103512 - 103512

Published: March 1, 2025

Language: Английский

Citations

0
Investigating the Effectiveness of Intraovarian Injection of Platelet-Rich Plasma (PRP) on Improving Ovarian Reserve in Infertile Women Due to Decreased Ovarian Reserve DOI Open Access
Leila Nazari,

Ladan Ajori,

Seyed Sadegh Salehi sadati

et al.

Jundishapur Journal of Chronic Disease Care, Journal Year: 2025, Volume and Issue: 14(2)

Published: April 5, 2025

Background: Injection of platelet-rich plasma (PRP) into the ovary is a therapeutic strategy to increase fertility infertile women. PRP also regulates expression sex hormones, including follicle-stimulating hormone (FSH) and anti-Müllerian (AMH), through growth factors cytokines. Objectives: In this study, we evaluated effect injection on increasing ovarian reserve in patients. Methods: This semi-experimental study was conducted 17 women referred Nikan Hospital between 2021 2022 who were candidates for due reduced reserve. After puncture, 3 cc injected. third menstrual cycle, after checking FSH AMH serum levels presence at least one antral follicle count (AFC) ultrasound, patients underwent ovulation stimulation cycle again. The improvement response determined by evaluating parameters number quality retrieved oocytes, obtained embryos, FSH, AFC ultrasound. relevant data then entered SPSS26 software analysis. Results: average age participants 36.94 ± 3.76 years, Body Mass Index (BMI) 22.36 2.89 kg/m2. results showed that AFC, oocytes IVF, embryos IVF increased significantly intraovarian (P = 0.009). Additionally, mean level 0.014). However, did not change 0.661). Conclusions: Based it appears can improve embryos.

Language: Английский

Citations

0
Potential Player of Platelet in the Pathogenesis of Cardiotoxicity: Molecular Insight and Future Perspective DOI

Arash Amin,

Ahmad Mohajerian,

Sara Rashki Ghalehnoo

et al.

Cardiovascular Toxicology, Journal Year: 2024, Volume and Issue: 24(12), P. 1381 - 1394

Published: Oct. 14, 2024

Language: Английский

Citations

3
Pathogenetic association of inflammation and hemostasis markers in the blood of patients with injuries of large joints DOI Open Access
Stanislav Bondarenko, Volodymyr Filipenko, Friedа Leontyeva

et al.

TRAUMA, Journal Year: 2025, Volume and Issue: 26(1), P. 1 - 10

Published: March 7, 2025

Background. In patients with injuries of large joints, the activation inflammation causes risk thrombophilia. The prediction thrombotic complications and their prevention can improve quality treatment. purpose: to investigate data scientific medical literature on pathogenetic association between markers hemostasis in degenerative diseases post-traumatic joints. Materials methods. search for has been made PubMed database 10 years. Sixty works were selected. Results. A total 60 papers selected analysis. They recorded information about relationship mechanisms hypercoagulability trauma. specified are given this work. Conclusions. orthopedics traumatology, considerable attention is paid surgical treatment trauma, particular, Individuals trauma or surgery joints have a correlation biochemical common clinical inflammation, metabolism glycoproteins, proteoglycans collagen laboratory indicators hemostasis. case, significant damage formation vicious circle observed: decrease plasminogen content, which under action activators converted plasmin, trigger factor fibrinolytic system, that at same time activity acceleration dystrophic processes accumulation blood serum an excessive amount acute phase glycoproteins. addition, there increase plasma following coagulation markers: fibrinogen, soluble fibrin monomer complexes, D-dimers, inflammatory such as C-reactive protein, haptoglobin. From this, it follows postoperative requires timely monitoring markers, well measures prevent thrombophilia, including prehospital stage.

Language: Английский

Citations

0
Association between platelet-to-high-density lipoprotein cholesterol ratio and cognitive function in older americans: insights from a cross-sectional study DOI Creative Commons
Tianyi Wang, Ruwen Zheng, Siqi Zhang

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 28, 2024

The main aim of this study was to explore the correlation between platelet/high-density lipoprotein cholesterol ratio (PHR) and cognitive function in elderly individuals from United States. This investigation leveraged data encompassing 2299 participants, all aged 60 years above, National Health Nutrition Examination Survey conducted 2011 2014. Inclusion criteria were based on availability complete datasets for PHR assessments. analytical approach incorporated multivariate logistic regression discern association function. Additionally, employed restricted cubic splines (RCS) potential non-linear relationships subgroup analyses identify variations observed associations across different demographic clinical subgroups. In fully adjusted model, an increment 10 units associated with a decline 0.014 scores (β=-0.014, 95% CI: -0.025, -0.002; P < 0.05). Compared lowest quartile, participants highest quartile exhibited 38.4% increased prevalence impairment per one-unit increase (OR = 1.384, 1.012, 1.893; Subgroup analysis revealed consistent results regarding relationship A using RCS, indicating that above 111.49 significantly elevated incidence (P Our demonstrates higher is greater risk older U.S. population, although further validation needed, warrants consideration assessments interventions.

Language: Английский

Citations

2
Evaluation of common genes and molecular pathways between atherosclerosis and inflammatory bowel disease: A systems biology approach DOI
Sara Shafieipour,

Mohammadjavad Mohammadtaghizadeh

Human Gene, Journal Year: 2024, Volume and Issue: 40, P. 201277 - 201277

Published: March 15, 2024

Language: Английский

Citations

1
Normal Value of Thrombocytes Indices in Indonesian Adults: Focus on Gender and Ages DOI Creative Commons
Usi Sukorini, Adika Zhulhi Arjana, Tri Ratnaningsih

et al.

The Indonesian Biomedical Journal, Journal Year: 2024, Volume and Issue: 16(4), P. 363 - 71

Published: Aug. 28, 2024

BACKGROUND: Monitoring platelet count and related indices is crucial for managing hematological disorders. No studies are reporting normal in the adult Indonesian population. Therefore, this study was conducted to establish reference values a healthy population Indonesia investigate their association with each parameter.METHODS: This cross-sectional included adults from both sexes who underwent testing our laboratory. Two mL of venous blood drawn analyzed using an automated machine ADVIA 2120 identify count, mean volume (MPV), distribution width (PDW), plateletcrit (PCT), component (MPC), (PCDW), mass (MPM), (PMDW), large count.RESULTS: 1037 subjects median 27 (18–58) years old. Normal range Indonesians established, which significantly different between males females (p<0.05) following parameters: (191.77–400.37 vs. 203.00–433.00 ×109/L), MPV (7.30–9.91 7.20–10.00 fL), PDW (38.09–59.83 37.10–58.50%), PCT (0.17–0.33 0.17–0.35%), PMDW (0.68–1.06 0.67–1.04 pg) females, respectively. However, other parameters such as MPC, PCDW, MPM, platelet, did not show any significant differences.CONCLUSION: The intervals were previously established values, indicating importance dedicated interval determination gender consideration.KEYWORDS: thrombocyte indices, hematology analysis

Language: Английский

Citations

0
Association Between Platelet-to-High-Density Lipoprotein Cholesterol Ratio and Cognitive Function in Older Americans: Insights from a Cross-Sectional Study DOI Creative Commons
Ruwen Zheng, Siqi Zhang, Hongyu Qin

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 16, 2024

Abstract Aims The main aim of this study was to explore the correlation between platelet/high-density lipoprotein cholesterol ratio (PHR) and cognitive function in elderly individuals from United States. Methods This investigation leveraged data encompassing 2299 participants, all aged 60 years above, National Health Nutrition Examination Survey conducted 2011 2014. Inclusion criteria were based on availability complete datasets for PHR assessments. analytical approach incorporated multivariate logistic regression discern association impairment. Additionally, employed restricted cubic splines (RCS) potential non-linear relationships subgroup analyses identify variations observed associations across different demographic clinical subgroups. Results In fully adjusted model, an increment 10 units associated with a decline 0.014 scores (β=-0.014, 95% CI: -0.025, -0.002; P<0.05). Compared lowest quartile, participants highest quartile exhibited 38.4% increased prevalence impairment per one-unit increase (OR=1.384, 1.012, 1.893; P<0.05). Subgroup analysis revealed consistent results regarding relationship A using RCS, indicating that above 111.49 significantly elevated incidence (P<0.05). Conclusions Our proves higher is linked greater risk U.S. population, warranting consideration assessments interventions.

Language: Английский

Citations

0