Allicin: A natural weapon against Taxol resistance in non‐small cell lung cancer through Cathepsin B inhibition and lysosomal‐autophagy disruption DOI Creative Commons
Xudong Gao, Chang Xu, Ramesh Kumar Santhanam

et al.

Food Frontiers, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 23, 2024

Abstract Drug resistance in non‐small cell lung cancer (NSCLC) limits its therapeutic efficacy. Allicin may help to solve the problem of Taxol NSCLC. This study aimed explore potential mechanism by which allicin reverses The reversing vitro was evaluated using cytotoxicity assays, evaluation autophagy and lysosomal function. In addition, vivo model established evaluate effectiveness resistance. results showed that effectively inhibited proliferation, induced apoptosis, reversed It inhibits P‐gp expression, reduces drug efflux, disrupts autophagy. particular, Cathepsin B (CTSB), disrupted function, blocked flux, reduced mitochondrial membrane potential, enhanced sensitivity Taxol. combined with significantly growth tumor nodules their number, demonstrating reverse vivo. summary, inhibiting CTSB activity disrupting lysosomal‐autophagy pathway. These findings highlight for treatment development.

Language: Английский

Research progress on ferroptosis in the pathogenesis and treatment of neurodegenerative diseases DOI Creative Commons
Lijuan Wang,

Xiansong Fang,

Baodian Ling

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: March 7, 2024

Globally, millions of individuals are impacted by neurodegenerative disorders including Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), Parkinson's (PD), and Alzheimer's (AD). Although a great deal energy financial resources have been invested in disease-related research, breakthroughs therapeutic approaches remain elusive. The breakdown cells usually happens together with the onset diseases. However, mechanism that triggers neuronal loss is unknown. Lipid peroxidation, which iron-dependent, causes specific type cell death called ferroptosis, there evidence its involvement pathogenic cascade mechanisms still not well known. present article highlights basic processes underlie ferroptosis corresponding signaling networks. Furthermore, it provides an overview discussion current research on role across variety conditions.

Language: Английский

Citations

5
Ferroptosis: a novel mechanism of cell death in ophthalmic conditions DOI Creative Commons
Yaqi Yang,

Yumeng Lin,

Zhongyu Han

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: June 27, 2024

Ferroptosis, a new type of programmed cell death proposed in recent years, is characterized mainly by reactive oxygen species and iron-mediated lipid peroxidation differs from death, such as apoptosis, necrosis, autophagy. Ferroptosis associated with variety physiological pathophysiological processes. Recent studies have shown that ferroptosis can aggravate or reduce the occurrence development diseases targeting metabolic pathways signaling tumors, ischemic organ damage, other degenerative related to peroxidation. Increasing evidence suggests closely linked onset progression various ophthalmic conditions, including corneal injury, glaucoma, age-related macular degeneration, diabetic retinopathy, retinal detachment, retinoblastoma. Our review current research on reveals significant advancements our understanding pathogenesis, aetiology, treatment these conditions.

Language: Английский

Citations

5
Decoding ferroptosis: transforming orthopedic disease management DOI Creative Commons

Guochen Huo,

Yumeng Lin,

Lusheng Liu

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 6, 2024

As a mechanism of cell death, ferroptosis has gained popularity since 2012. The process is distinguished by iron toxicity and phospholipid accumulation, in contrast to autophagy, apoptosis, other death mechanisms. It implicated the advancement multiple diseases across body. Researchers currently know that osteosarcoma, osteoporosis, orthopedic disorders are caused NRF2, GPX4, star proteins. effective relief osteoarthritis symptoms from deterioration been confirmed clinical treatment with inhibitors. At same time, it should be reminded mechanisms involved regulate not understood. In this manuscript, we present discovery ferroptosis, role variety diseases. We expect manuscript can provide new perspective on diagnosis related

Language: Английский

Citations

1
Airway specific deregulation of asthma-related serpins impairs tracheal architecture and oxygenation in D. melanogaster DOI Creative Commons
Birte Ehrhardt, Hanna Angstmann,

Beate Höschler

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 17, 2024

Serine proteases are important regulators of airway epithelial homeostasis. Altered serum or cellular levels two serpins, Scca1 and Spink5, have been described for diseases but their function beyond antiproteolytic activity is insufficiently understood. To close this gap, we generated fly lines with overexpression knockdown each gene in the airways. Overexpression both homologues Spink5 induced growth additional branches, more variable results respective knockdowns. Dysregulation resulted a general delay fruit development, increases larval pupal mortality following gene. In addition, morphological changes airways were concomitant lower tolerance to hypoxia. conclusion, observed structural evidently had strong impact on our model as they manifested physical fitness animals. We assume that due insufficient tissue oxygenation. Future work will be directed at identification key molecular airway-specific dysregulation expression.

Language: Английский

Citations

1
Allicin: A natural weapon against Taxol resistance in non‐small cell lung cancer through Cathepsin B inhibition and lysosomal‐autophagy disruption DOI Creative Commons
Xudong Gao, Chang Xu, Ramesh Kumar Santhanam

et al.

Food Frontiers, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 23, 2024

Abstract Drug resistance in non‐small cell lung cancer (NSCLC) limits its therapeutic efficacy. Allicin may help to solve the problem of Taxol NSCLC. This study aimed explore potential mechanism by which allicin reverses The reversing vitro was evaluated using cytotoxicity assays, evaluation autophagy and lysosomal function. In addition, vivo model established evaluate effectiveness resistance. results showed that effectively inhibited proliferation, induced apoptosis, reversed It inhibits P‐gp expression, reduces drug efflux, disrupts autophagy. particular, Cathepsin B (CTSB), disrupted function, blocked flux, reduced mitochondrial membrane potential, enhanced sensitivity Taxol. combined with significantly growth tumor nodules their number, demonstrating reverse vivo. summary, inhibiting CTSB activity disrupting lysosomal‐autophagy pathway. These findings highlight for treatment development.

Language: Английский

Citations

0