Bioengineered,
Journal Year:
2022,
Volume and Issue:
13(4), P. 10373 - 10385
Published: April 1, 2022
As
an
endocrine
and
metabolic
disorder,
polycystic
ovarian
syndrome
(PCOS)
is
common
in
females
at
childbearing
age.
Our
work
was
intended
to
uncover
the
underlying
role
of
LINC00173
its
potential
regulatory
mechanism
PCOS
based
on
two
cell
lines
(PCOS
granulosa
cells
KGN
cells)
vivo
model
established
from
Sprague
Dawley
rats.
It
revealed
that
JAG1
expressions
were
upregulated,
while
miR-124-3p
poorly
expressed
patients
Functional
assays
showed
overexpression
repressed
proliferation
stimulated
apoptosis
cells,
downregulation
exhibited
opposite
effects.
Besides,
it
verified
upregulated
expression
via
competitively
binding
miR-124-3p.
Similarly,
abundance
inversely
related
level
PCOS.
Subsequently,
rescue
elucidated
upregulation
or
eliminated
effects
mediated
by
knockdown.
In
addition,
found
adversely
modulated
positively
LINC00173.
Moreover,
further
demonstrated
reduced
vitality
increased
induced
overexpressing
could
be
relieved
deletion.
These
findings
suggested
a
latent
regulating
factor
for
progression
modulating
miR-124-3p/JAG1
cascade.
Molecules,
Journal Year:
2022,
Volume and Issue:
27(17), P. 5481 - 5481
Published: Aug. 26, 2022
Despite
advances
in
antimicrobial
and
anti-inflammatory
therapies,
inflammation
its
consequences
still
remain
a
significant
problem
medicine.
Acute
inflammatory
responses
are
responsible
for
directly
life-threating
conditions
such
as
septic
shock;
on
the
other
hand,
chronic
can
cause
degeneration
of
body
tissues
leading
to
severe
impairment
their
function.
Neuroinflammation
is
defined
an
response
central
nervous
system
involving
microglia,
astrocytes,
cytokines
including
chemokines.
It
considered
important
neurodegerative
diseases,
Alzheimer's
disease,
Parkinson's
disease
amyotrophic
lateral
sclerosis.
Lipopolysaccharide
(LPS)
strong
immunogenic
particle
present
outer
membrane
Gram-negative
bacteria.
major
triggering
factor
cascade
bacteria
infection.
The
use
LPS
pro-inflammatory
agent
well-known
model
applied
both
vivo
vitro
studies.
This
review
offers
summary
pathogenesis
associated
with
exposure,
especially
field
neuroinflammation.
Moreover,
we
analyzed
different
models
utilized
area
neuroscience.
paper
presents
recent
knowledge
focused
new
insights
experimental
model.
Journal of Neurochemistry,
Journal Year:
2021,
Volume and Issue:
159(5), P. 804 - 825
Published: Sept. 23, 2021
Alzheimer's
disease
(AD)
is
the
most
prevalent
form
of
dementia,
with
complex
pathophysiology
that
not
fully
understood.
While
β-amyloid
plaque
and
neurofibrillary
tangles
define
pathology
disease,
mechanism
neurodegeneration
uncertain.
Ferroptosis
an
iron-mediated
programmed
cell
death
characterised
by
phospholipid
peroxidation
has
been
observed
in
clinical
AD
samples.
This
review
will
outline
growing
molecular
evidence
implicating
ferroptosis
pathogenesis
AD,
implications
for
disease-modifying
therapies.
Frontiers in Behavioral Neuroscience,
Journal Year:
2024,
Volume and Issue:
18
Published: Jan. 30, 2024
Postoperative
cognitive
dysfunction
(POCD)
commonly
occurs
after
surgery,
particularly
in
elderly
individuals.
It
is
characterized
by
a
notable
decline
performance,
encompassing
memory,
attention,
coordination,
orientation,
verbal
fluency,
and
executive
function.
This
reduction
abilities
contributes
to
extended
hospital
stays
heightened
mortality.
The
prevalence
of
POCD
can
reach
40%
within
1
week
following
cardiovascular
surgery
remains
as
high
17%
3
months
post-surgery.
Furthermore,
exacerbates
the
long-term
risk
Alzheimer’s
disease
(AD).
As
result,
numerous
studies
have
been
conducted
investigate
molecular
mechanisms
underlying
potential
preventive
strategies.
article
provides
review
research
progress
on
POCD.
Frontiers in Aging Neuroscience,
Journal Year:
2021,
Volume and Issue:
13
Published: March 15, 2021
Alzheimer's
disease
(AD)
is
an
irrevocable
neurodegenerative
condition
characterized
by
the
presence
of
senile
plaques
comprising
amassed
β-amyloid
peptides
(Aβ)
and
neurofibrillary
tangles
mainly
extremely
phosphorylated
Tau
proteins.
Recent
studies
have
emphasized
role
microRNAs
(miRNAs)
in
development
AD.
A
number
miRNAs,
namely,
miR-200a-3p,
miR-195,
miR-338-5p,
miR-34a-5p,
miR-125b-5p,
miR-132,
miR-384,
miR-339-5p,
miR-135b,
miR-425-5p,
been
shown
to
participate
AD
through
interacting
with
BACE1.
Other
miRNAs
might
affect
inflammatory
responses
course
Aberrant
expression
several
plasma
samples
subjects
has
aptitude
for
differentiation
from
healthy
subjects.
Finally,
a
AD-modifying
agents
miRNA
profile
cell
cultures
or
animal
models.
We
performed
comprehensive
search
summarized
obtained
data
about
function
current
review
article.
European Journal of Neuroscience,
Journal Year:
2021,
Volume and Issue:
54(9), P. 7006 - 7047
Published: Sept. 25, 2021
Neurological
disorders
following
brain
injuries
and
neurodegeneration
are
on
the
rise
worldwide
cause
disability
suffering
in
patients.
It
is
crucial
to
explore
novel
neuroprotectants.
Dexmedetomidine,
a
selective
α2-adrenoceptor
agonist,
commonly
used
for
anxiolysis,
sedation
analgesia
clinical
anaesthesia
critical
care.
Recent
studies
have
shown
that
dexmedetomidine
exerts
protective
effects
multiple
organs.
This
review
summarized
discussed
current
neuroprotective
of
dexmedetomidine,
as
well
underlying
mechanisms.
In
preclinical
studies,
reduced
neuronal
injury
improved
functional
outcomes
several
models,
including
hypoxia-induced
injury,
ischaemic-reperfusion
intracerebral
haemorrhage,
post-traumatic
anaesthetic-induced
substance-induced
neuroinflammation,
epilepsy
neurodegeneration.
Several
mechanisms
associated
with
function
neurotransmitter
regulation,
inflammatory
response,
oxidative
stress,
apoptotic
pathway,
autophagy,
mitochondrial
other
cell
signalling
pathways.
summary,
has
potential
be
agent
wide
range
neurological
disorders.
Molecular Neurodegeneration,
Journal Year:
2023,
Volume and Issue:
18(1)
Published: April 21, 2023
Abstract
Failed
proteostasis
is
a
well-documented
feature
of
Alzheimer’s
disease,
particularly,
reduced
protein
degradation
and
clearance.
However,
the
contribution
failed
to
neuronal
circuit
dysfunction
an
emerging
concept
in
neurodegenerative
research
will
prove
critical
understanding
cognitive
decline.
Our
objective
convey
disease
progression
with
growing
evidence
for
bidirectional
relationship
sleep
disruption
failure.
Proteostasis
tauopathy
disrupts
neurons
that
regulate
sleep–wake
cycle,
which
presents
behavior
as
impaired
slow
wave
rapid
eye
movement
patterns.
Subsequent
loss
further
impairs
Sleep
defined
seen
early
many
disorders
contributes
memory
impairments
disease.
Canonical
pathological
hallmarks,
β-amyloid,
tau,
directly
disrupt
sleep,
neurodegeneration
locus
coeruleus,
hippocampal
hypothalamic
from
tau
proteinopathy
causes
circuitry
sleep.
Acting
positive-feedback-loop,
circadian
rhythm
then
increase
spread
β-amyloid
through
proteasome,
autophagy,
unfolded
response
glymphatic
This
phenomenon
extends
beyond
interactions
impairment
homeostasis
TDP-43,
α-synuclein,
FUS,
huntingtin
proteins,
implicating
important
consideration
array
diseases
cases
mixed
neuropathology.
Critically,
dynamics
this
interaction
environment
are
not
fully
elucidated
deserving
discussion
research.
Finally,
we
propose
sleep-enhancing
therapeutics
potential
interventions
promoting
healthy
proteostasis,
including
clearance,
mechanistically
linking
these
processes.
With
clinical
preclinical
research,
dynamic
diagnostic
therapeutic
framework,
informing
precise
single-
combinatorial-treatments
other
brain
disorders.
Graphical
Frontiers in Molecular Neuroscience,
Journal Year:
2023,
Volume and Issue:
16
Published: Sept. 4, 2023
MicroRNAs
(miRNAs)
are
short
non-coding
and
well-conserved
RNAs
that
linked
to
many
aspects
of
development
disorders.
control
the
expression
genes
related
different
biological
processes
play
a
prominent
role
in
harmonious
genes.
During
neural
central
nervous
system,
miRNAs
regulated
time
space.
In
mature
brain,
dynamic
continues,
highlighting
their
functional
importance
neurons.
The
hippocampus,
as
one
crucial
brain
structures,
is
key
component
major
connections
brain.
Gene
abnormalities
hippocampus
lead
disturbance
neurogenesis,
maturation
synaptic
formation.
These
disturbances
at
root
several
neurological
disorders
behavioral
deficits,
including
Alzheimer's
disease,
epilepsy
schizophrenia.
There
strong
evidence
contributed
neurodegenerative
mechanisms
through
imbalanced
activity
ion
channels,
neuronal
excitability,
plasticity
apoptosis.
Some
affect
oxidative
stress,
inflammation,
differentiation,
migration
neurogenesis
hippocampus.
Furthermore,
signaling
cascades
neurodegeneration,
such
NF-Kβ
signaling,
PI3/Akt
Notch
pathway,
closely
modulated
by
miRNAs.
observations,
suggest
microRNAs
significant
regulators
complicated
network
gene
regulation
current
review,
we
focus
on
miRNA
progression
normal
We
also
consider
how
for
pathophysiological
pathways.
Alzheimer s Research & Therapy,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: Jan. 9, 2024
Abstract
Background
Alzheimer’s
dementia
(AD)
pathogenesis
involves
complex
mechanisms,
including
microRNA
(miRNA)
dysregulation.
Integrative
network
and
machine
learning
analysis
of
miRNA
can
provide
insights
into
AD
pathology
prognostic/diagnostic
biomarkers.
Methods
We
performed
co-expression
to
identify
modules
associated
with
AD,
its
neuropathology
markers,
cognition
using
brain
tissue
profiles
from
the
Religious
Orders
Study
Rush
Memory
Aging
Project
(ROS/MAP)
(
N
=
702)
as
a
discovery
dataset.
association
hub
miRNAs
cognition.
After
selecting
target
genes
miRNAs,
we
their
then
pathway-based
enrichment
analysis.
For
replication,
consensus
ROS/MAP
dataset
an
independent
16)
Gene
Expression
Omnibus
(GEO).
Furthermore,
approach
assess
performance
for
classification.
Results
Network
identified
glucose
metabolism
pathway-enriched
module
(M3)
significantly
Five
(miR-129-5p,
miR-433,
miR-1260,
miR-200a,
miR-221)
M3
had
significant
associations
clinical
and/or
pathologic
traits,
miR129-5p
by
far
strongest
across
all
phenotypes.
Gene-set
corresponding
enriched
biological
pathways
ErbB,
AMPK,
MAPK,
mTOR
signaling
pathways.
Consensus
two
AD-associated
(miR-129-5p
miR-221).
Machine
showed
that
classification
(area
under
curve
(AUC)
0.807)
age,
sex,
APOE
ε4
carrier
status
was
improved
6.3%
inclusion
five
miRNAs.
Conclusions
signatures,
especially
miR-129-5p,
cognition,
enhancing
our
understanding
leading
better
potential
diagnostic/prognostic
