Metabolomic in severe traumatic brain injury: exploring primary, secondary injuries, diagnosis, and severity

Critical Care, Journal Year: 2025, Volume and Issue: 29(1)

Published: Jan. 15, 2025

Traumatic brain injury (TBI) is a major public health concern worldwide, contributing to high rates of injury-related death and disability. Severe traumatic (sTBI), although it accounts for only 10% all TBI cases, results in mortality rate 30–40% significant burden disability those that survive. This study explored the potential metabolomics diagnosis sTBI examine probable primary secondary sTBI. Serum samples from 59 adult patients with 35 age- sex-matched orthopedic controls were subjected quantitative metabolomics, including proton nuclear magnetic resonance (1H-NMR) direct infusion/liquid chromatography-tandem mass spectrometry (DI/LC–MS/MS), identify quantify metabolites on days 1 4 post-injury. In addition, we used advanced analytical methods discover metabo-patterns associated related injury. Our showed different serum metabolic profiles between (OI) controls, changes measured day post-brain The number altered extent their change more pronounced as compared post-injury, suggesting an evolution mechanisms Data sensitivity specificity separating OI diagnosis. Energy-related such glucose, pyruvate, lactate, mannose, polyamine metabolism (spermine putrescine), well increased acylcarnitines sphingomyelins, occurred mainly Metabolites neurotransmission, catecholamine, excitotoxicity glutamate, phenylalanine, tyrosine, branched-chain amino acids (BCAAs) greater degree 4. Further, there was association multiple metabolites, (ACs), lysophosphatidylcholines (LysoPCs), severity at 4, while pyruvate correlated 1. demonstrate has diagnostic may reflect molecular injuries when comparing metabolite These early provide insight into pathways or ongoing injuries, revealing therapeutic targets work also highlights need further research validation biomarkers larger cohort.

Language: Английский

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Evaluating Brain Activity in Patients With Chronic Disorders of Consciousness After Traumatic Brain Injury Using EEG Microstate Analysis During Hyperbaric Oxygen Therapy

CNS Neuroscience & Therapeutics, Journal Year: 2025, Volume and Issue: 31(1)

Published: Jan. 1, 2025

ABSTRACT Background Hyperbaric oxygen (HBO) therapy is an efficacious intervention for patients with prolonged disorders of consciousness (pDOC). Electroencephalographic (EEG) microstate analysis can provide assessment the global state brain. Currently, misdiagnosis rate consciousness‐level assessments in pDOC high. Therefore, we aimed to assess levels and outcomes by analyzing changes EEG signals during HBO therapy. Methods data were collected from 32 traumatic brain injury before after 20 min obtained sessions. Modified k‐means clustering was used segment into microstates. A paired sample t test compare characteristics Results The duration, occurrence, coverage D significantly increased minimally conscious (MCS) group Significant increases same parameters observed among unresponsive wakefulness group. Furthermore, greater improvements Coma Recovery Scale‐Revised scores (i.e., more than three points) showed significant D. Both MCS improvement presented Conclusions Microstate may be associated recovery patients. This study verified safety feasibility real‐time pDOC. serve as a complement electroencephalographic indices useful predicting levels.

Language: Английский

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Genetic and peripheral biomarkers of comorbid posttraumatic stress disorder and traumatic brain injury: a systematic review

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 27, 2025

Background Posttraumatic stress disorder (PTSD) commonly cooccurs with traumatic brain injury (TBI) in military populations and is a significant predictor of poor long-term outcomes; however, it unclear to what extent specific biological variables are associated comorbidity. This PROSPERO-registered systematic review evaluates the current body literature on genetic peripheral biomarkers comorbid TBI PTSD. Methods Searches were conducted four databases (PubMed, PsycInfo, PTSDPubs, Scopus). We included published studies examining differences among civilian, military, veteran participants both PTSD compared those alone as well as, some cases, healthy controls. Data extracted from evidence quality was assessed. Results Our final analysis 16 studies, majority which based data active duty participants. The results suggest that multiple gene variants likely contribute cumulative risk TBI. An elevated circulating level pro-inflammatory cytokine IL-6 most consistently replicated blood-based indicator illness, mTBI alone. Conclusion Several protein markers cellular inflammation appear be promising indicators chronic pathology Additional research needed determine how such factors indicate, predict, comorbidity they represent viable targets for development novel diagnostic tools therapeutic interventions.

Language: Английский

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Trajectories of systemic immune inflammation index and mortality risk in patients with moderate-to-severe traumatic brain injury: a retrospective cohort study

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 12, 2025

Background Some studies have shown a strong link between the central nervous system and peripheral immune system, but prognostic implications of dynamic immune-inflammatory responses in patients with traumatic brain injury (TBI) remain unclear. This study aimed to determine trajectory patterns Systemic Immune Inflammation Index (SII) TBI assess its association all-cause hospital mortality. Methods retrospective cohort utilized large public database sourced from eICU Collaborative Research Database (eICU-CRD). Group-Based Trajectory Modeling (GBTM) was used analyze daily SII trajectories during initial 0–7 days hospitalization. Logistic regression employed relationship different groups Receiver Operating Characteristic (ROC) curves were generated based on logistic model. Results A total 312 included this study, 52 whom died Using GBTM, three distinct identified: Group 1 (low-level, rapid decline; 18.90%), 2 (moderate-level, slow 60.20%), 3 (sustained high-level; 20.80%). Compared 1, those Groups had higher risk mortality (odds ratio [OR] 4.09; 95% confidence interval [CI] 1.21, 19.75) (OR 5.84; CI 1.52, 30.67), respectively. ROC analysis revealed an area under curve (AUC) 0.838, sensitivity: 75.0%, specificity: 83.8% for cohort. Conclusion identified trajectories, suggesting that post-TBI are heterogeneous associated The sustained high-level may serve as marker disease deterioration, highlighting need targeted interventions. Describing evolution through GBTM correlation clinical outcomes can enhance our understanding neuroinflammation system.

Language: Английский

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Nicotinamide adenine dinucleotide alleviates neuroinflammation in rats with traumatic brain injury

Neuroscience Letters, Journal Year: 2025, Volume and Issue: 852, P. 138178 - 138178

Published: Feb. 22, 2025

Language: Английский

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