Current Psychiatry Research and Reviews,
Journal Year:
2023,
Volume and Issue:
20(4), P. 297 - 322
Published: Aug. 23, 2023
Abstract:
General
practitioners
observe
a
high
prevalence
of
anxiety
and
depression
symptoms.
Depressed
or
anxious
patients
frequently
develop
both
conditions.
The
symptoms
diseases
may
be
present
at
the
same
time.
There
has
been
numerous
studies
on
higher
levels
depression,
bipolar
disorder
II,
mixed
depression.
So,
we
ended
up
reviewing
different
drug
delivery
targets.
Even
low
dosages,
antidepressants
were
better
absorbed
more
effective
when
given
by
nose.
In
this
review,
focused
cutting-edge
methods
for
intranasal
antidepressant
vehicles.
Consequently,
it
seems
that
drugs
are
sufficiently
effective,
have
fewer
side
effects,
less
expensive.
researchers
in
metaanalysis
set
out
to
determine
whether
not
they
used
successfully
traditional
medicine
treat
human
animal
studies.
Frontiers in Aging Neuroscience,
Journal Year:
2024,
Volume and Issue:
15
Published: Jan. 17, 2024
The
unique
anatomical
and
physiological
connections
between
the
nasal
cavity
brain
provide
a
pathway
for
bypassing
blood–brain
barrier
to
allow
direct
brain-targeted
drug
delivery
through
administration.
There
are
several
advantages
of
administration
compared
with
other
routes;
example,
first-pass
effect
that
leads
metabolism
orally
administered
drugs
can
be
bypassed,
poor
compliance
associated
injections
minimized.
Nasal
also
help
maximize
delivery,
allowing
high
pharmacological
activity
at
lower
dosages,
thereby
minimizing
likelihood
adverse
effects
providing
highly
promising
treatment
central
nervous
system
diseases.
aim
this
review
article
was
briefly
describe
structures
brain,
pathways
which
enter
nose,
factors
affecting
methods
improve
systems
application
related
biomaterials,
common
experimental
used
in
intranasal
research,
current
limitations
such
approaches,
solid
foundation
further
in-depth
research
on
(see
Graphical
Abstract
).
Brain Sciences,
Journal Year:
2024,
Volume and Issue:
14(3), P. 238 - 238
Published: Feb. 29, 2024
Increasing
evidence
suggests
that
the
gut
microbiota
may
represent
potential
strategies
for
Parkinson’s
disease
(PD)
treatment.
Our
previous
research
revealed
a
decreased
abundance
of
Akkermansia
muciniphila
(Akk)
in
PD
mice;
however,
whether
Akk
is
beneficial
to
unknown.
To
answer
this
question,
mice
received
MPTP
intraperitoneally
construct
subacute
model
and
were
then
supplemented
with
orally
21
consecutive
days.
Motor
function,
dopaminergic
neurons,
neuroinflammation,
neurogenesis
examined.
In
addition,
intestinal
inflammation,
serum
fecal
short-chain
fatty
acids
(SCFAs)
analyses,
assessed.
We
found
treatment
effectively
inhibited
reduction
neurons
substantia
nigra
pars
compacta
(SNpc)
partially
improved
motor
function
mice.
Additionally,
markedly
alleviated
neuroinflammation
striatum
hippocampus
promoted
hippocampal
neurogenesis.
It
also
level
colon
inflammation.
Furthermore,
these
aforementioned
changes
are
mainly
accompanied
by
alterations
isovaleric
acid
levels,
lower
permeability.
strongly
neuroprotective
agent
therapy.
Journal of Lipids,
Journal Year:
2024,
Volume and Issue:
2024, P. 1 - 10
Published: April 8, 2024
Gangliosides,
sialic
acid-containing
glycosphingolipids,
are
abundant
in
cell
membranes
and
primarily
involved
controlling
signaling
communication.
The
altered
ganglioside
pattern
has
been
demonstrated
several
neurodegenerative
diseases,
characterized
during
early-onset
or
infancy,
emphasizing
the
significance
of
gangliosides
brain.
Enzymes
required
for
biosynthesis
linked
to
devastating
neurological
disorders,
including
Alzheimer’s
disease
(AD),
Parkinson’s
(PD),
Huntington’s
(HD),
amyotrophic
lateral
sclerosis
(ALS),
hereditary
spastic
paraplegia
(HSP).
In
this
review,
we
summarized
not
only
critical
roles
biosynthetic
enzymes
their
inhibitors
metabolism
but
also
efficacy
treatment
strategies
address
those
diseases.
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: Nov. 10, 2023
Parkinson’s
disease
(PD)
is
a
common
neurodegenerative
disorder
with
motor
symptoms,
which
caused
by
the
progressive
death
of
dopaminergic
(DA)
neurons
in
substantia
nigra
pars
compacta
(SNpc).
Accumulating
evidence
shows
that
endoplasmic
reticulum
(ER)
stress
occurring
SNpc
DA
an
early
event
development
PD.
ER
triggers
activation
unfolded
protein
response
(UPR)
to
reduce
and
restore
function.
However,
excessive
continuous
UPR
exacerbate
risk
neuron
through
crosstalk
other
PD
events.
Thus,
considered
promising
therapeutic
target
for
treatment
Various
strategies
targeting
modulation
signaling,
increase
ER’s
folding
ability,
enhancement
degradation
are
developed
alleviate
neuronal
models.
In
this
review,
we
summarize
pathological
role
update
improve
homeostasis
PD-related
Ageing and Neurodegenerative Diseases,
Journal Year:
2025,
Volume and Issue:
5(1)
Published: Jan. 26, 2025
With
aging,
neural
stem
cells
(NSCs)
undergo
age-related
changes,
including
metabolic
abnormalities,
disrupted
protein
homeostasis,
mitochondrial
dysfunction,
reduced
genetic
stability,
and
more
notably,
a
diminished
capacity
for
proliferation
differentiation.
These
changes
may
contribute
to
the
development
of
neurodegenerative
diseases
such
as
Alzheimer’s
disease
(AD)
Parkinson’s
(PD).
In
these
conditions,
disease-specific
pathological
interact
with
alterations
NSCs,
resulting
in
impairment
neurogenesis,
which
further
leads
cognitive,
mood,
motor
decline.
Based
on
potential
therapeutics
targeting
neurogenesis
cell-based
therapies
restore
functions
NSCs
replace
degenerated
neurons,
aiming
ameliorate
functional
decline
diseases.
While
therapies,
cell
transplantation
secretome
therapy,
show
great
treatment
diseases,
challenges
tumorigenesis,
immune
rejection,
extraction
or
storage
need
be
addressed.
A
better
understanding
age-
disease-related
underlying
mechanism
driving
benefits
drawbacks
therapeutic
approaches
provide
insights
novel
disease-modifying
interventions
future
Glia,
Journal Year:
2023,
Volume and Issue:
72(1), P. 167 - 183
Published: Sept. 5, 2023
Abstract
The
postnatal
neural
stem
cell
(NSC)
pool
hosts
quiescent
and
activated
radial
glia‐like
NSCs
contributing
to
neurogenesis
throughout
adulthood.
However,
the
underlying
regulatory
mechanism
during
transition
from
in
NSC
niche
is
not
fully
understood.
Lipid
metabolism
lipid
composition
play
important
roles
regulating
fate
determination.
Biological
membranes
define
individual
cellular
shape
help
maintain
organization
are
highly
heterogeneous
structure
there
exist
diverse
microdomains
(also
known
as
rafts),
which
enriched
with
sugar
molecules,
such
glycosphingolipids.
An
often
overlooked
but
key
aspect
that
functional
activities
of
proteins
genes
dependent
on
their
molecular
environments.
We
previously
reported
ganglioside
GD3
predominant
species
reduced
pools
observed
global
GD3‐synthase
knockout
(GD3S‐KO)
mouse
brains.
specific
determining
stage
cell‐lineage
determination
remain
unclear,
since
GD3S‐KO
mice
cannot
distinguish
if
regulates
or
developmental
impacts.
Here,
we
show
inducible
deletion
promotes
activation,
resulting
loss
long‐term
maintenance
adult
pools.
subventricular
zone
(SVZ)
dentate
gyrus
(DG)
GD3S‐conditional‐knockout
led
impaired
olfactory
memory
functions.
Thus,
our
results
provide
convincing
evidence
maintains
state
niche.
Heliyon,
Journal Year:
2023,
Volume and Issue:
10(1), P. e21789 - e21789
Published: Nov. 1, 2023
Parkinson's
and
Alzheimer's
disease
is
the
main
cause
of
dementia,
which
associated
with
progressive
deterioration
intelligence
senses.
Free
radicals
are
created
during
oxidative
stress
in
cells,
considered
one
destructive
factors
neurodegenerative
diseases.
In
this
study,
antifibrillar
antioxidant
properties
cerium
oxide
nanoparticles
(CeO
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(10), P. e30730 - e30730
Published: May 1, 2024
Neurogenesis,
play
a
vital
role
in
neuronal
plasticity
of
adult
mammalian
brains,
and
its
dysregulation
is
present
the
pathophysiology
Parkinson's
disease
(PD).
While
subthalamic
nucleus
deep
brain
stimulation
(STN-DBS)
at
various
frequencies
has
been
proven
effective
alleviating
PD
symptoms,
influence
on
neurogenesis
remains
unclear.
This
study
aimed
to
investigate
effects
1-week
electrical
60Hz,
130Hz,
180Hz
subventricular
zone
(SVZ)
rats.
A
hemiparkinsonian
rat
model
was
established
using
6-hydroxydopamine
categorized
into
six
groups:
control,
PD,
sham
stimulation,
60Hz
130Hz
stimulation.
Motor
function
assessed
open
field
test
rotarod
after
one
week
STN-DBS
different
frequencies.
Tyrosine
hydroxylase
(TH)
expression
tissue
analyzed
via
Western
blot
immunohistochemistry.
Immunofluorescence
analysis
conducted
evaluate
BrdU/Sox2,
BrdU/GFAP,
Ki67/GFAP,
BrdU/DCX
bilateral
SVZ
rostral
migratory
stream
(RMS).
Our
findings
revealed
that
high-frequency
improved
motor
function.
Specifically,
increased
dopaminergic
neuron
survival
model,
while
significantly
enhancing
proliferation
neural
stem
cells
(NSCs)
neuroblasts
SVZ.
Moreover,
this
effectively
facilitated
generation
new
NSCs
ipsilateral
RMS
triggered
emergence
fresh
RMS,
with
notable
presence
within
lesioned
striatum.
Conversely,
did
not
exhibit
comparable
effects.
The
observed
promotion
rats
following
provides
valuable
insights
mechanistic
basis
therapeutic
approach
for
PD.
Theranostics,
Journal Year:
2024,
Volume and Issue:
14(11), P. 4499 - 4518
Published: Jan. 1, 2024
Adult
neurogenesis
in
the
subventricular
zone
(SVZ)
is
essential
for
maintaining
neural
homeostasis,
and
its
dysregulation
contributes
to
anosmia
delayed
tissue
healing
neurological
disorders,
such
as
Parkinson's
disease
(PD).
Despite
intricate
regulatory
networks
identified
SVZ
neurogenesis,
molecular
mechanisms
dynamically
stem/progenitor
cells
(NSPCs)
response
physiological
pathological
stimuli
remain
incompletely
elucidated.
