The
retina
is
the
sensory
tissue
responsible
for
first
stages
of
visual
processing,
with
a
conserved
anatomy
and
functional
architecture
among
vertebrates.
To
date,
retinal
eye
diseases,
such
as
diabetic
retinopathy,
age-related
macular
degeneration,
retinitis
pigmentosa,
glaucoma
others,
affect
nearly
170
million
people
worldwide,
resulting
in
vision
loss
blindness.
tackle
disorders,
embryonic
has
been
explored
versatile
model
to
study
development,
broad
neurochemical
repertoire,
approached
last
decades
terms
signaling
diseases.
Retina,
dissociated
arranged
typical
cultures
are
valuable
understand
both
neuronal
glial
compartments,
mixed
or
neuron-
glia-enriched,
and/or
organized
neurospheres
organoids
which
have
contributed
reveal
mechanisms
between
transmitter
systems
well
antioxidants,
trophic
factors,
extracellular
matrix
proteins.
Overall,
contributions
understanding
neurogenesis,
differentiation,
connectivity,
plasticity,
cell
death
widely
described.
A
complete
access
genome
several
vertebrates,
recent
transcriptome
at
single
level
different
development
also
anticipates
future
advances
providing
cues
target
blinding
diseases
dysfunctions.
Brain Sciences,
Journal Year:
2023,
Volume and Issue:
14(1), P. 19 - 19
Published: Dec. 23, 2023
The
term
“neuroinflammation”
defines
the
typical
inflammatory
response
of
brain
closely
related
to
onset
many
neurodegenerative
diseases
(NDs).
Neuroinflammation
is
well
known,
but
its
mechanisms
and
pathways
are
not
entirely
comprehended.
Some
progresses
have
been
achieved
through
efforts
research.
Consequently,
new
cellular
molecular
mechanisms,
diverse
conventional,
emerging.
In
listing
some
those
that
will
be
subject
our
description
discussion,
essential
important
roles
peripheral
infiltrated
monocytes
clonotypic
cells,
alterations
in
gut–brain
axis,
dysregulation
apelinergic
system,
endothelial
glycocalyx
component
neuronal
vascular
units,
variations
expression
genes
levels
encoding
molecules
by
action
microRNAs
(miRNAs),
or
other
epigenetic
factors
distinctive
transcriptional
factors,
as
role
autophagy,
ferroptosis,
sex
differences,
modifications
circadian
cycle.
Such
can
add
significantly
understanding
complex
etiological
puzzle
neuroinflammation
ND.
addition,
they
could
represent
biomarkers
targets
ND,
which
increasing
elderly.
The
retina
is
the
sensory
tissue
responsible
for
first
stages
of
visual
processing,
with
a
conserved
anatomy
and
functional
architecture
among
vertebrates.
To
date,
retinal
eye
diseases,
such
as
diabetic
retinopathy,
age-related
macular
degeneration,
retinitis
pigmentosa,
glaucoma
others,
affect
nearly
170
million
people
worldwide,
resulting
in
vision
loss
blindness.
tackle
disorders,
developing
has
been
explored
versatile
model
to
study
intercellular
signaling,
it
presents
broad
neurochemical
repertoire.
Retina,
dissociated
arranged
typical
cultures,
mixed
or
neuron-
glia-enriched,
and/or
organized
neurospheres
organoids
are
valuable
understand
both
neuronal
glial
compartments
which
have
contributed
reveal
roles
mechanisms
transmitter
systems
well
antioxidants,
trophic
factors,
extracellular
matrix
proteins.
Overall,
contributions
understanding
neurogenesis,
development,
differentiation,
connectivity,
plasticity,
cell
death
widely
described.
A
complete
access
genome
several
vertebrates,
recent
transcriptome
at
single
level
different
development
also
anticipates
future
advances
providing
cues
target
blinding
diseases
dysfunctions.
Planta Medica,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 14, 2025
Abstract
Alzheimerʼs
disease
is
a
progressive
neurodegenerative
disorder
characterized
by
tau
protein
hyperphosphorylation
and
neurofibrillary
tangle
formation,
which
are
central
to
its
pathogenesis.
This
review
focuses
on
the
therapeutic
potential
of
natural
products
in
targeting
phosphorylation,
key
factor
progression.
It
comprehensively
summarizes
current
research
various
compounds,
including
flavonoids,
alkaloids,
saponins,
polysaccharides,
phenols,
phenylpropanoids,
terpenoids,
highlighting
their
multitarget
mechanisms,
such
as
modulating
kinases
phosphatases.
The
ability
these
compounds
mitigate
oxidative
stress,
inflammation,
pathology
while
enhancing
cognitive
function
underscores
value
anti-Alzheimerʼs
therapeutics.
By
integrating
recent
advances
extraction
methods,
pharmacological
studies,
artificial
intelligence-driven
screening
technologies,
this
provides
valuable
reference
for
future
development
product-based
interventions
disease.
Metabolites,
Journal Year:
2024,
Volume and Issue:
14(2), P. 81 - 81
Published: Jan. 23, 2024
Geijera
Schott
is
a
plant
genus
of
the
Rutaceae
Juss.
(rue
and
citrus)
family,
comprising
six
species
which
are
all
native
to
Oceania.
Of
plants
belonging
this
genus,
most
significant
that
has
customary
use
parviflora,
was
used
by
Indigenous
Australians,
primarily
as
pain
reliever.
Herein,
comprehensive
review
literature
published
on
from
1930
2023
conducted.
This
first
for
it
highlights
chemical
constituents
reported
date,
together
with
range
pharmacological
properties
described
various
different
parts
plant.
These
include
anti-inflammatory,
anti-microbial,
anti-parasitic,
insect
repellent,
analgesic,
neuroactive,
anti-cancer
activities.
Finally,
reflection
some
important
areas
future
focused
studies
provided.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(2), P. 1120 - 1120
Published: Jan. 17, 2024
The
retina
is
the
sensory
tissue
responsible
for
first
stages
of
visual
processing,
with
a
conserved
anatomy
and
functional
architecture
among
vertebrates.
To
date,
retinal
eye
diseases,
such
as
diabetic
retinopathy,
age-related
macular
degeneration,
retinitis
pigmentosa,
glaucoma,
others,
affect
nearly
170
million
people
worldwide,
resulting
in
vision
loss
blindness.
tackle
disorders,
developing
has
been
explored
versatile
model
to
study
intercellular
signaling,
it
presents
broad
neurochemical
repertoire
that
approached
last
decades
terms
signaling
diseases.
Retina,
dissociated
arranged
typical
cultures,
mixed
or
neuron-
glia-enriched,
and/or
organized
neurospheres
organoids,
are
valuable
understand
both
neuronal
glial
compartments,
which
have
contributed
revealing
roles
mechanisms
between
transmitter
systems
well
antioxidants,
trophic
factors,
extracellular
matrix
proteins.
Overall,
contributions
understanding
neurogenesis,
development,
differentiation,
connectivity,
plasticity,
cell
death
widely
described.
A
complete
access
genome
several
vertebrates,
recent
transcriptome
at
single
level
different
also
anticipates
future
advances
providing
cues
target
blinding
diseases
dysfunctions.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(6), P. e28222 - e28222
Published: March 1, 2024
Recent
studies
have
revealed
that
endophytes
in
plants
can
produce
metabolites
with
activity
is
comparable
to
or
identical
the
host.
Dendrobine
has
attracted
much
attention
field
of
neurodegenerative
diseases
by
exhibiting
anti-oxidative
stress
and
neuroprotective
effects.
This
study
aimed
investigate
protective
effects
mechanisms
dendrobium
Pseudomonas
protegens
CM-YJ44
Priestia
megaterium
D-HT207
against
H2O2-induced
oxidative
injury
SH-SY5Y
cells.
Results
showed
there
were
50
compounds
72
D-HT207.
Those
both
increased
significantly
cell
viability,
decreased
contents
ROS
It
was
confirmed
inhibited
cells,
which
mechanism
related
inhibition
production,
alteration
MMP,
apoptosis
inflammatory
factors
expression
via
Nrf2/Keap1
pathway.
