Adult Neurogenesis of Teleost Fish Determines High Neuronal Plasticity and Regeneration DOI Open Access
Е. В. Пущина, Ilya A. Kapustyanov,

Gleb Gennadievich Kluka

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3658 - 3658

Published: March 25, 2024

Studying the properties of neural stem progenitor cells (NSPCs) in a fish model will provide new information about organization neurogenic niches containing embryonic and adult cells, reflecting their development, origin cell lines proliferative dynamics. Currently, molecular signatures these populations homeostasis repair vertebrate forebrain are being intensively studied. Outside telencephalon, regenerative plasticity NSPCs biological significance have not yet been practically The impressive capacity juvenile salmon to regenerate brain suggests that most likely multipotent, as they capable replacing virtually all lineages lost during injury, including neuroepithelial radial glia, oligodendrocytes, neurons. However, unique profile individual phenotypes diverse remains unclear. Various types neuronal precursors, previously shown, contained sufficient numbers different parts Pacific salmon. This review article aims an update on common models zebrafish other species, salmon, involvement homeostatic growth well reparative processes postraumatic period. Additionally, data presented participation astrocytic glia functioning circuits animal behavior. Thus, from aspect, seen be similar mammalian astrocytes, can therefore also referred astroglia. question exists if astroglia interact functionally with neurons, way counterparts. Future studies this complement those rodents important cellular physiological underlying astroglial function modulate activity behavior animals.

Language: Английский

Stem cell therapy for the treatment of psychiatric disorders: a real hope for the next decades DOI Creative Commons
Rosa Villanueva

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 7, 2025

In this review, it is evaluated the progress in application of stem cell therapy to ameliorate symptoms bipolar disorder, major depression, schizophrenia, and autism. These disorders are highly prevalent clinical medicine responsible for high levels psychosocial disability among patients. All them share common biomedical features, such as complex variable genetic substrates, significant susceptibility environmental changes, insufficient knowledge their pathogenesis. addition, responsiveness patients pharmacological treatment heterogeneous, some cases, no available. Therefore, development cell-based regenerative its possible combination with emerging therapeutic approaches that promote neural plasticity expected advance neuropsychiatry next few decades.

Language: Английский

Citations

0
Neuroprotective role of geniposide-loaded UMSC nanovesicles in depression via P2ry12 downregulation DOI

Guoxiang Duan,

Tianyu Zou, Xue Wu

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 140, P. 156581 - 156581

Published: March 13, 2025

Language: Английский

Citations

0
Adult Neurogenesis of Teleost Fish Determines High Neuronal Plasticity and Regeneration DOI Open Access
Е. В. Пущина, Ilya A. Kapustyanov,

Gleb Gennadievich Kluka

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3658 - 3658

Published: March 25, 2024

Studying the properties of neural stem progenitor cells (NSPCs) in a fish model will provide new information about organization neurogenic niches containing embryonic and adult cells, reflecting their development, origin cell lines proliferative dynamics. Currently, molecular signatures these populations homeostasis repair vertebrate forebrain are being intensively studied. Outside telencephalon, regenerative plasticity NSPCs biological significance have not yet been practically The impressive capacity juvenile salmon to regenerate brain suggests that most likely multipotent, as they capable replacing virtually all lineages lost during injury, including neuroepithelial radial glia, oligodendrocytes, neurons. However, unique profile individual phenotypes diverse remains unclear. Various types neuronal precursors, previously shown, contained sufficient numbers different parts Pacific salmon. This review article aims an update on common models zebrafish other species, salmon, involvement homeostatic growth well reparative processes postraumatic period. Additionally, data presented participation astrocytic glia functioning circuits animal behavior. Thus, from aspect, seen be similar mammalian astrocytes, can therefore also referred astroglia. question exists if astroglia interact functionally with neurons, way counterparts. Future studies this complement those rodents important cellular physiological underlying astroglial function modulate activity behavior animals.

Language: Английский

Citations

3