Clinical & Translational Oncology, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 29, 2024
Language: Английский
Heliyon, Journal Year: 2024, Volume and Issue: 10(7), P. e28639 - e28639
Published: March 24, 2024
Language: Английский
Citations
2
Antioxidants, Journal Year: 2024, Volume and Issue: 13(10), P. 1197 - 1197
Published: Oct. 2, 2024
Melatonin (5-methoxy-N-acetyltryptamine) is an indoleamine compound that plays a critical role in the regulation of circadian rhythms. While melatonin primarily synthesized from amino acid tryptophan pineal gland brain, it can also be produced locally various tissues, such as skin and intestines. Melatonin's effects target tissues mediated through receptor-dependent mechanisms. Additionally, exerts actions via receptor-independent pathways. In biological systems, its endogenous metabolites often produce similar effects. injuries are common daily life, promoting optimal wound healing essential for patient well-being healthcare outcomes. Beyond regulating rhythms neuroendocrine hormone, may enhance (1) potent antioxidant properties, (2) anti-inflammatory actions, (3) infection control, (4) vascular reactivity angiogenesis, (5) analgesic (pain-relieving) effects, (6) anti-pruritic (anti-itch) This review aims to provide comprehensive overview scientific studies demonstrate melatonin's potential roles supporting effective healing.
Language: Английский
Citations
2
Trends in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Language: Английский
Citations
2
Brain Research Bulletin, Journal Year: 2024, Volume and Issue: unknown, P. 111141 - 111141
Published: Dec. 1, 2024
Using a chronic unpredictable mild stress (CUMS) combined with multi-platform water environment sleep deprivation (SD) as an animal model, the occurrence and development of human depression insomnia were simulated. The abnormal mitochondrial autophagy signaling caused by putative kinase 1/Parkin E3 ubiquitin protein ligase (Pink1/Parkin) pathway directly affects normal secretion melatonin pineal gland, which may explain pathogenesis insomnia. This study aims to explore depression-like behavior, changes, central oxidative response, damage, secretion, histopathological changes expression Pink1/Parkin signaling-related factors in CUMS+SD rats. results showed that levels reactive oxygen species (ROS) cerebrospinal fluid rats significantly increased along inflammatory Interleukin-1β (IL-1β) nuclear factor kappa-B (NF-κB) fluid. In addition, number gland cells decreased, cell boundaries became blurred, volume shrank, apoptotic bodies appeared tissue under HE staining, indicating inflammation. Sleep further disrupted damage factors, including histamine (MDA), glutathione (GSH), catalase (CAT), CUMS + SD Transmission electron microscopy revealed autophagy. 5-hydroxytryptamine (5-HT) aromatic amine-N-acetyltransferase (AANAT) fluid, well decreased. Additionally, IL-1β, NF-κB, Pink1, Parkin increased. microtubule-associated 1 light chain 3-β (LC3), selective adaptor (P62), cytochrome c oxidase IV (COXIV), outer membrane translocation enzyme 20 (TOM20) proteins downstream was enhanced, while brain-derived neurotrophic (BDNF), Beclin 1, BCL2 interacting 3 (BNIP3) negatively regulated. specifically respond affecting synthesis gland. summary, rats, is closely related specific impairment pathway, mediate
Language: Английский
Citations
1
Heliyon, Journal Year: 2024, Volume and Issue: 10(18), P. e38098 - e38098
Published: Sept. 1, 2024
Language: Английский
Citations
0
Published: Jan. 1, 2024
Language: Английский
Citations
0
Matter, Journal Year: 2024, Volume and Issue: unknown, P. 101878 - 101878
Published: Oct. 1, 2024
Language: Английский
Citations
0
Poultry Science, Journal Year: 2024, Volume and Issue: 104(1), P. 104496 - 104496
Published: Nov. 12, 2024
The objective of this study is to examine the impact monochromatic light on circadian rhythms blood melatonin and insulin-like growth factor 1 (IGF-1) levels, liver clock genes, receptors. A total 144 male Yangzhou geese were randomly assigned four groups based color, with each group consisting 36 geese. provided ad libitum access food water, raised for 70 days under a photoperiod 16 hours 8 darkness. They weighed every 10 days, blood, liver, pituitary gland samples collected at six time points when reached age. findings indicated that exposure green (GL) had stimulating weight gain in geese, while not significantly affecting feed-to-weight ratio. After undergoing photochromic treatments, both plasma levels positive feedback gene expression displayed diurnal low-night high pattern, reaching their peak evening. Conversely, IGF-1 negative genes exhibited an opposite trend. However, down-regulated expression, amplitude retinoic acid receptor-related orphan receptor α (RORα), as well advancing or delaying phase rhythm. Among them, GL up-regulated receptors 1C (MEL1C); blue (BL) increased concentration decreased period 3 (PER3), resulting almost no difference PER3 times; red (RL) MEL1C peaks amplitudes seven especially locomotor output cycles kaput (CLOCK). Moreover, BL are identical, except PER3. offer theoretical framework facilitating development meat implementing logical approach managing lighting conditions.
Language: Английский
Citations
0
Clinical & Translational Oncology, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 29, 2024
Language: Английский
Citations
0