Hypoxic Encephalopathy Post-Cardiac Arrest

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Edaravone attenuates cerebral inflammation by inhibiting mast cells degranulation via ROS/STIM1 signaling pathway in HIE model

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 159, P. 114880 - 114880

Published: May 19, 2025

Language: Английский

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Gastrodin: a potential natural product for the prevention and treatment of cerebral ischemia-reperfusion injury

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: May 19, 2025

Ethnopharmacological relevance Gastrodin is the main bioactive metabolite of Gastrodia elata Blume traditional Chinese medicine, which has pharmacological effects such as anti-inflammatory, antioxidant, neuroprotective, vasoprotective, hypoglycemic, lipotropic, analgesic, anticancer, antiviral and so on, it been widely used in treatment a wide range diseases, especially neurological disorders. Aim review Cerebral ischemia-reperfusion injury (CIRI) defined transient or permanent ischemia brain tissue that further exacerbated by restoration blood supply. Due to complexity pathological processes CIRI, current treatments have not shown expected effects. More more researchers are beginning turn their focus on combating CIRI natural metabolites derived from botanical drugs. This provides an overview progress research chemical composition, pharmacokinetics, safety, CIRI. It aims emphasize important mechanisms prevention provide reference for drug development, well future application Materials methods A systematic literature search was conducted using keywords “Gastrodin,” “traditional medicine,” “chemical components,” “metabolites,” “cerebral injury,” “CIRI,” “pharmacological effects” identify relevant published establishment database January 2025. Databases including PubMed, Web Science, Google Scholar, CNKI were utilized. Raw data included clinical trials animal experiments. Other studies, reviews evaluations, excluded. Results GAS can prevent treat cerebral ischemia/reperfusion-induced regulating variety molecular signals, exerting anti-oxidative stress, inhibition inflammatory response, cell death, modulation neurotransmitters, alleviation neurotoxicity, promotion neural repair, protection blood-brain barrier, edema, making potential effective Conclusion significant value there extensive evidence support its use Further exploration necessary fully utilize therapeutic potential.

Language: Английский

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LncRNA TCONS_00067339 as a key regulatory factor inducing decreased cell viability and ferroptosis in neonatal hypoxic-ischemic brain damage

Brain Research, Journal Year: 2025, Volume and Issue: 1854, P. 149562 - 149562

Published: March 8, 2025

Language: Английский

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Hypotonia in the Newborn Infant

Pediatric Clinics of North America, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

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Protopine Exerts Neuroprotective Effects on Neonatal Hypoxic-Ischemic Brain Damage in Rats via Activation of the AMPK/PGC1α Pathway

Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 4975 - 4992

Published: Nov. 1, 2024

Neonatal hypoxic-ischemic encephalopathy (HIE), caused by perinatal asphyxia, is characterized high morbidity and mortality, but there are still no effective therapeutic drugs. Mitochondrial biogenesis apoptosis play key roles in the pathogenesis of HIE. Protopine (Pro), an isoquinoline alkaloid, has anti-apoptotic neuro-protective effects. However, protective Pro on neonatal brain injury remain unclear. In this study, we established a CoCl2-induced PC12 cell model vitro rat (HI) damage vivo to explore effects try elucidate potential mechanisms. Our results showed that significantly reduced cerebral infarct volume, alleviated edema, inhibited glia activation, improved mitochondrial biogenesis, relieved neuron loss, decreased reactive oxygen species (ROS) after HI damage. addition, intervention upregulated levels p-AMPK/AMPK PGC1α as well downstream related factors, such nuclear respiratory factor 1 (NRF1) transcription A (TFAM), AMPK inhibitor compound c (CC) could reverse these Pro. may exert neuroprotective via activation AMPK/PGC1α pathway, suggesting be promising candidate for HIE, our study firstly demonstrate HIE models.

Language: Английский

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AEBP1 Silencing Protects Against Cerebral Ischemia/Reperfusion Injury by Regulating Neuron Ferroptosis and Microglia M2 Polarization Through PRKCA‐PI3K‐Akt Axis

Drug Development Research, Journal Year: 2024, Volume and Issue: 85(8)

Published: Dec. 1, 2024

ABSTRACT Cerebral ischemia/reperfusion injury is one of the main causes neuronal damage. Neuron ferroptosis and microglia polarization are considered as critical processes during cerebral ischemia/reperfusion. Adipocyte enhancer‐binding protein 1 (AEBP1) usually acts a transcriptional repressor which involved in various diseases. However, it still remains unknown whether AEBP1 could have important roles regulating neuron injury. The oxygen‐glucose deprivation reperfusion (OGD/R)‐treated cells middle artery occlusion (MCAO)‐treated mice were used vitro vivo models. differentially expressed factors analyzed according to GEO datasets. Relative mRNA expression levels detected by qRT‐PCR western blot analysis. Cell viability was measured CCK‐8 assay. ROS, GSH iron contents using specifical assay kits. CD26 CD206 immunofluorescence Inflammatory cytokines ELISA. association between PRKCA assessed luciferase reporter ChIP analyses. damage TTC staining neurological deficit score. Transcription factor increased OGD/R‐treated HT22 BV2 cells. silencing attenuated OGD/R‐induced cell through increasing viability, GPX4 levels, decreasing ACSL4 levels. knockdown promoted M2 CD206‐positive Arg‐1 level, reducing iNOS, TNF‐α, IL‐1β IL‐6 transcriptionally repressed expression, further regulated PI3K/Akt signaling activation. Inhibition or reversed effects on polarization. downregulation infarct size scores MCAO‐treated mice. mitigated activating signaling, indicating potentially protective action

Language: Английский

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Single-cell Transcriptomic Profiling of Brains in Newborn Rats Following Hypoxic Ischemic Encephalopathy

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Background Neonatal hypoxic-ischemic encephalopathy (HIE) is a severe neurological condition associated with high rates of mortality or long-term disability. Despite its clinical significance, the detailed cellular mechanisms underlying HIE remain unclear. Single-cell RNA sequencing (scRNA-seq) has emerged as powerful tool for investigating heterogeneity across development, aging, and disease processes. However, no scRNA-seq studies have yet addressed neonatal HIE. Methods We employed to examine during hyperacute (3 hours), acute (2 days), subacute (7 days) phases Uniform Manifold Approximation Projection (UMAP) was used visualize cell clustering. Differentially expressed genes (DEGs) were calculated identified using Seurat’s FindAllMarkers function, which enriched pathway analysis (GO, KEGG pathway, WikiPathways, Reactome Gene Sets). CytoTRACE v2 identify maturity state each type pseudotime performed Monocle v3. Results analyzed total 87,580 high-quality brain cells transcriptional changes In phase, we observed activation astrocytes in response reactive oxygen species, involvement microglia phagocytosis, Stat3-mediated ischemic responses oligodendrocyte precursor cells, an increase senescent lymphatic endothelial cells. found exacerbate inflammation impede while proliferated. Neuroblasts affected by metal ions, oligodendrocytes decreased. facilitated tissue repair, inflammatory highly expressing MHC II induced IL27 I interferon pathways expanded. Additionally, peripheral immune played vital roles Specifically, neutrophils infiltrated expanded throughout all post-HIE. Spp1^high macrophages, T plasmacytoid dendritic increased phases, B phase. Conclusion This study offers deep insights into molecular alterations key types following HIE, elucidating pathological processes involved. These findings significant implications developing effective strategies managing

Language: Английский

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Targeting mitochondrial dynamics: A promising approach for intracerebral hemorrhage therapy

Life Sciences, Journal Year: 2024, Volume and Issue: unknown, P. 123317 - 123317

Published: Dec. 1, 2024

Language: Английский

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Early Impact of Maternal Voice Stimulation on Cortical Recovery and Neurodevelopment in Neonates with Severe Asphyxia

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 18, 2024

Objective This study aimed to evaluate the effects of maternal voice stimulation on cortical activity, physiological stabilization, and neurodevelopmental outcomes in neonates with severe asphyxia. Methods A total 72 were enrolled divided into three groups: asphyxia intervention (SM, n = 23), standard care (SC, 19), normal controls (NC, 30). The SM group received 15-minute sessions structured playback times daily for 10 days. EEG power spectral density (PSD) was analyzed across 0–8 Hz frequency ranges before after intervention. Neurodevelopmental assessed at one year using Gesell Developmental Scale. Physiological parameters, including heart rate, respiratory oxygen saturation, monitored during sessions. Results showed significant increases overall PSD within range following (P < 0.05), achieving levels comparable NC group, while no improvement observed SC group. Maternal also stabilized reductions rate improvements saturation 0.05). At year, demonstrated developmental quotients motor, adaptive, language domains, whereas exhibited delays Conclusion enhances stabilizes vital signs, supports recovery offers a promising, non-invasive approach improving high-risk neonatal intensive units.

Language: Английский

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