A Detailed Review on the Synthesis and Mechanistic Study of Pyrrole Fused Quinone/Naphthoquinone DOI
Susanta Kumar Manna,

Sampa Mondal,

Tapas Ghosh

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(46)

Published: Dec. 1, 2024

Abstract This review article intends to explore the versatility in formation of pyrrole‐fused quinone/naphthoquinone derivatives described literature from 2008 2024. It deals with multitude paths its synthesis a variety precursors using both metal‐ and metal‐free catalytic systems their potential applications. also documented several bioactive cores accommodating indoloquinone analog. Noteworthy, mitomycin A acts as excellent medicine for cancer treatment analog EO‐9 is under clinical trial. Here we present natural products zyzzyanone A, murrayaquinones B indolequinone‐based naloxone prodrugs exiguamine (NQO1)‐targeted hypoxia specific activation, antibiotic uthamycin analog, indolequinone fused ursolic acid (a triterpenoid rich many Chinese medicines), which vital scaffold preparation novel anticancer agent. Indoloquinone‐fused medicines) Recent two cyanobacterial metabolites Calothrixins has been documented. discusses intermediate, where lymphostin alkaloid can be developed. Lamellarin D product easily prepared by developed strategy.

Language: Английский

PEG-mediated synthesis of naphthoquinone/coumarin fused dihydropyridine derivatives DOI

Aatka Mehar,

Tasneem Parvin

Tetrahedron, Journal Year: 2024, Volume and Issue: 160, P. 134025 - 134025

Published: May 7, 2024

Language: Английский

Citations

2
Multicomponent synthesis of 3-(1H-indol-3-yl)-2-phenyl-1H-benzo[f]indole-4,9-dione derivatives DOI

Darakshan,

Ujjain Chaurasia,

Aatka Mehar

et al.

Molecular Diversity, Journal Year: 2024, Volume and Issue: unknown

Published: June 5, 2024

Language: Английский

Citations

1
Efficient, Concise, and Chemoselective Synthesis of 1H‐Benzo[f]indole‐4,9‐dione with 4‐Hydroxycoumarin Substituent via a One‐Pot Three‐Component Reaction DOI
Abdolali Alizadeh, Hamidreza Hasanpour, Reza Rezaiyehraad

et al.

ChemistrySelect, Journal Year: 2023, Volume and Issue: 8(48)

Published: Dec. 19, 2023

Abstract Extensive studies on the biological activities of several quinone‐fused heterocycles have confirmed their outstanding antitumor activity. Therefore, a new family 1 H ‐benzo[ f ]indole‐4,9‐dione derivatives with 4‐hydroxycoumarin substitution was prepared by high‐yield, one‐pot, concise three‐component reaction between arylglyoxals, 4‐hydroxycoumarin, and 2‐aminonaphthalene‐1,4‐dione under reflux in EtOH. This efficient protocol showed chemoselectivity addition to facile operation procedure easy purification.

Language: Английский

Citations

2
A Detailed Review on the Synthesis and Mechanistic Study of Pyrrole Fused Quinone/Naphthoquinone DOI
Susanta Kumar Manna,

Sampa Mondal,

Tapas Ghosh

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(46)

Published: Dec. 1, 2024

Abstract This review article intends to explore the versatility in formation of pyrrole‐fused quinone/naphthoquinone derivatives described literature from 2008 2024. It deals with multitude paths its synthesis a variety precursors using both metal‐ and metal‐free catalytic systems their potential applications. also documented several bioactive cores accommodating indoloquinone analog. Noteworthy, mitomycin A acts as excellent medicine for cancer treatment analog EO‐9 is under clinical trial. Here we present natural products zyzzyanone A, murrayaquinones B indolequinone‐based naloxone prodrugs exiguamine (NQO1)‐targeted hypoxia specific activation, antibiotic uthamycin analog, indolequinone fused ursolic acid (a triterpenoid rich many Chinese medicines), which vital scaffold preparation novel anticancer agent. Indoloquinone‐fused medicines) Recent two cyanobacterial metabolites Calothrixins has been documented. discusses intermediate, where lymphostin alkaloid can be developed. Lamellarin D product easily prepared by developed strategy.

Language: Английский

Citations

0