Liver Research, Journal Year: 2024, Volume and Issue: 8(4), P. 207 - 217
Published: Nov. 22, 2024
Language: Английский
Nature Reviews Gastroenterology & Hepatology, Journal Year: 2024, Volume and Issue: 21(12), P. 834 - 851
Published: Aug. 15, 2024
Language: Английский
Citations
27
Hepatology International, Journal Year: 2025, Volume and Issue: 19(1), P. 1 - 69
Published: Feb. 1, 2025
Acute-on-chronic liver failure (ACLF) is a condition associated with high mortality in the absence of transplantation. There have been various definitions proposed worldwide. The first consensus report working party Asian Pacific Association for Study Liver (APASL) set 2004 on ACLF was published 2009, and "APASL Research Consortium (AARC)" formed 2012. AARC database has prospectively collected nearly 10,500 cases from countries Asia-Pacific region. This instrumental developing score grade ACLF, concept 'Golden Therapeutic Window', 'transplant window', plasmapheresis as treatment modality. Also, data key to identifying pediatric ACLF. European Liver-Chronic Failure (EASL CLIF) North American End Stage Disease (NACSELD) West added concepts organ infection precipitants development CLIF-Sequential Organ Assessment (SOFA) NACSELD scores prognostication. Chinese Group Severe Hepatitis B (COSSH) COSSH-ACLF criteria manage hepatitis b virus-ACLF without cirrhosis. literature supports these be equally effective their respective cohorts patients mortality. To overcome differences develop global consensus, APASL took initiative invited stakeholders, including opinion leaders Asia, EASL AASLD, other researchers field identify issues an evidence-based document. document presented hybrid format at annual meeting Kyoto March 2024. 'Kyoto Consensus' below carries final recommendations along relevant background information areas requiring future studies.
Language: Английский
Citations
2
Hepatology International, Journal Year: 2024, Volume and Issue: 18(6), P. 1661 - 1683
Published: Nov. 21, 2024
In Asia–Pacific region, hepatocellular carcinoma is a serious health threat attributing to over 600,000 deaths each year and account for 70% of global cases. Clinically, the major unmet needs are recurrence after curative-intent surgery, liver transplantation or local ablation disease progression in those with not eligible resection failed locoregional therapy. recent few years, new targeted therapy immune-checkpoint inhibitors have been registered as systemic address these issues. Notably, forms therapy, either first-line second-line unresectable now available. New data also emerging use prevent retard future, further implementation other immunotherapy expected bring paradigm management carcinoma. insight related immune-related adverse events has allso enabled optimization therapeutic approach patients The purpose this clinical practice guideline provide an up-to-date recommendation based on evidence experience from expert key opinion leaders field Three questions will be addressed, namely: (1) Which should considered therapy? (2) used? (3) How patient planned immune checkpoint-based managed monitored?
Language: Английский
Citations
7
Clinical and Molecular Hepatology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 24, 2025
Language: Английский
Citations
0
Updates in Surgery, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 31, 2025
Language: Английский
Citations
0
BMC Nursing, Journal Year: 2025, Volume and Issue: 24(1)
Published: Feb. 19, 2025
Language: Английский
Citations
0
Canadian Liver Journal, Journal Year: 2025, Volume and Issue: 8(1), P. 39 - 48
Published: Feb. 25, 2025
Background: Colon cancer surveillance post liver transplantation (LT) is generally recommended. This study aimed to determine the appropriate timing for first colonoscopy after LT and interval subsequent colonoscopies based on our single-centre real-world experience. Methods: The medical records of patients who underwent at Pusan National University Yangsan Hospital between December 2008 March 2024 were reviewed. Patients least once analyzed. After post-transplant colonoscopy, divided into an intensive a nonintensive group 3-year interval. Results: A total 404 recipients with 1,076 analysis included pre-transplant (n = 219), 404), 453). Cecal intubation failure poor bowel preparation higher in than (3.2% versus 0.8%, p 0.010; 13.2% 4.4%, < 0.001). Although high-risk polyps resected 17 (7.8%) through they also discovered (4.2%) colonoscopy. There no differences malignancy or polyp detection (median interval, 22 months) those did not 52 months; 0.6% 2.1%, 0.381 3.7% 0.598). Conclusions: Colonoscopy prior may be insufficient; therefore, should performed within 1 year. Subsequent follow general
Language: Английский
Citations
0
European Journal of Surgical Oncology, Journal Year: 2025, Volume and Issue: unknown, P. 110061 - 110061
Published: April 1, 2025
Language: Английский
Citations
0
Annals of Liver Transplantation, Journal Year: 2024, Volume and Issue: 4(1), P. 10 - 15
Published: May 24, 2024
Liver transplantation (LT) has significantly improved long-term survival rates, but recipients face increased risks of de novo malignancy (DNM) due to immunosuppression.DNM patterns differ worldwide, with post-transplant lymphoproliferative disorder common in Western countries, while South Korea sees more gastric and colorectal cancers.Risk factors include immunosuppressive drugs, underlying conditions, lifestyle factors.Screening strategies should be tailored regional DNM patterns, regular surveillance crucial for early detection management.Minimizing immunosuppressant usage prompt local treatment upon offer favorable outcomes LT recipients.
Language: Английский
Citations
1
Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(19), P. 5776 - 5776
Published: Sept. 27, 2024
Background: Intraoperative blood transfusion (IOBT) during liver transplantation (LT) has negative outcomes, and it been shown that an increasing number of these procedures may no longer require IOBT. Regarding living donor (LDLT), the literature on pre-transplant predictors IOBT is quite heterogeneous deficient. In this study, we reviewed our experience among a homogenous cohort adult right-lobe LDLTs. Methods: We conducted retrospective analysis prospectively collected data LDLT recipients between January 2018 October 2023. Two groups were constructed (No-IOBT vs. IOBT) for exploration pre- intraoperative using univariate multivariate analyses. An ROC curve was applied to identify possible cut-offs. The one-year post-LDLT overall survival compared Kaplan–Meier method. A p-value < 0.05 considered statistically significant. Results: total 219 enrolled. No-IOBT (n = 56) patients mostly males (p 0.016), with higher preoperative levels HGB 0.001), fibrinogen 0.005), albumin 0.007) lower incidence upper abdominal surgery 0.017), portal vein thrombosis 0.04), hepatorenal syndrome 0.015), ascites 0.02) than group 163). had shorter anhepatic phase 0.002) received fewer intravenous crystalloids 0.001). analysis, 0.04) independent IOBT, showing following cut-offs in analysis: ≤ 11.5 (AUC: 0.800, p 125 0.638, 0.0024), 3.6 0.663, 0.0002). These significantly associated group. 100% 83%, respectively 0.007). Conclusions: inferior outcomes. increased need LT can be predicted by evaluating serum hemoglobin, before transplantation.
Language: Английский
Citations
1