Alterations in Glutathione Redox Homeostasis in Metabolic Dysfunction-Associated Fatty Liver Disease: A Systematic Review DOI Creative Commons
Lucia Cesarini, Flavia Grignaffini, Anna Alisi

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1461 - 1461

Published: Nov. 28, 2024

Low molecular weight (LMW) thiols, particularly glutathione, play pathogenic roles in various multiorgan diseases. The liver is central for the production and systemic distribution of LMW thiols; thus, it susceptible to imbalance redox status that may determine increased oxidative stress trigger damage observed metabolic dysfunction-associated steatotic disease (MASLD) models humans. Indeed, thiols at cellular extracellular levels be associated with severity MASLD. Here, we present a systematic literature review recent studies assessing MASLD vivo vitro human subjects. Based on PRISMA 2020 criteria, search was conducted using PubMed Scopus by applying inclusion/exclusion filters. initial returned 1012 documents, from which 165 eligible were selected, further described, qualitatively analysed. Of these studies, most focused animal models, while minority used fluids. analysis revealed heterogeneity methods sample processing measurement thiol levels, hinder cut-off values diagnostic use. Standardisation measure necessary facilitate future studies.

Language: Английский

Metabolic-Associated Fatty Liver Disease: The Influence of Oxidative Stress, Inflammation, Mitochondrial Dysfunctions, and the Role of Polyphenols DOI Creative Commons

Raissa Bulaty Tauil,

Paula Takano Golono,

Enzo Pereira de Lima

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(10), P. 1354 - 1354

Published: Oct. 10, 2024

Metabolic-Associated Fatty Liver Disease (MAFLD) is a clinical-pathological scenario that occurs due to the accumulation of triglycerides in hepatocytes which considered significant cause liver conditions and contributes an increased risk death worldwide. Even though possible causes MAFLD can involve interaction genetics, hormones, nutrition, lifestyle (diet sedentary lifestyle) most influential factor developing this condition. Polyphenols comprise many natural chemical compounds be helpful managing metabolic diseases. Therefore, aim review was investigate impact oxidative stress, inflammation, mitochondrial dysfunction, role polyphenols MAFLD. Some reverse part damage related or among them are anthocyanin, baicalin, catechin, curcumin, chlorogenic acid, didymin, epigallocatechin-3-gallate, luteolin, mangiferin, puerarin, punicalagin, resveratrol, silymarin. These have actions reducing plasma enzymes, body mass index, waist circumference, adipose visceral indices, lipids, glycated hemoglobin, insulin resistance, HOMA index. They also reduce nuclear factor-KB (NF-KB), interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), blood pressure, fat content, steatosis fibrosis. On other hand, they improve HDL-c, adiponectin levels, fibrogenesis markers. results show promising prevention treatment

Language: Английский

Citations

13
Association of prebiotic/probiotic intake with MASLD: evidence from NHANES and randomized controlled trials in the context of prediction, prevention, and a personalized medicine framework DOI
Senlin Wang, Ruimin Zhang, Peisen Guo

et al.

The EPMA Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Language: Английский

Citations

1
The role of gut–islet axis in pancreatic islet function and glucose homeostasis DOI Creative Commons
Qi Chen,

Yuanyuan Gao,

Fangyu Li

et al.

Diabetes Obesity and Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Abstract The gastrointestinal tract plays a vital role in the occurrence and treatment of metabolic diseases. Recent studies have convincingly demonstrated bidirectional axis communication between gut islets, enabling to influence glucose metabolism energy homeostasis animals strongly. ‘gut–islet axis’ is an essential endocrine signal that regulates islet function through dialogue intestinal microecology metabolism. discovery glucagon‐like peptide‐1 (GLP‐1), gastric inhibitory peptide (GIP) other hormones has initially set up bridge cells. However, factors remains largely unknown, such as microbiota integrity barrier. Although primarily resides affect function, they also extra‐intestinal organs by absorbing transferring metabolites derived from microorganisms. As result this transfer, islets may be continuously exposed gut‐derived components. Changes composition can damage barrier varying degrees, resulting increased permeability bacteria their derivatives. All these changes contribute severe disturbance critical pathways peripheral tissues organs. In review, we outlined different gut–islet signalling mechanisms associated with summarized latest progress complex molecules microbiota. addition, will discuss impact renin–angiotensin system (RAS) on various components regulate homeostasis. This work indicates therapeutic approaches aiming restore microbial homeostasis, probiotics faecal transplantation (FMT), shown great potential improving outcomes, enhancing patient prognosis slowing down disease progression. Future research should further uncover molecular links explore individualized strategies, which provide innovative perspective approach for diagnosis

Language: Английский

Citations

0
1-benzyl-6-nitro-4-phenyl-4-(methoxycarbonyl)-2(1H)-pyridinone, a novel pirfenidone derivative, alleviate hepatic fibrosis through T cells DOI Open Access

Meng-Xue Hu,

Jiaqi Li, Hongwei Zhang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 184, P. 117907 - 117907

Published: Feb. 19, 2025

Language: Английский

Citations

0
Research Progress of the Relationship between Metabolic-Associated Fatty Liver Disease and Colorectal Neoplasia DOI

杨 包

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(02), P. 1996 - 2004

Published: Jan. 1, 2025

Language: Английский

Citations

0
Immune cells in metabolic associated fatty liver disease: Global trends and hotspots (2004-2024) DOI
Wenying Qi,

Shihao Zheng,

Size Li

et al.

World Journal of Hepatology, Journal Year: 2025, Volume and Issue: 17(3)

Published: March 25, 2025

The interplay between immune cells and metabolic associated fatty liver disease (MAFLD) is a critical research frontier, bridging immunology hepatology. bibliometric findings can guide future funding priorities in the field by highlighting key areas of focus potential therapeutic targets. To analyze literature on MAFLD, identifying trends hotspots. A systematic search Web Science Core Collection from January 1, 2004 to May 20, 2024, yielded 1936 articles MAFLD. Excluding non-research documents, data were analyzed using R packages Cluster profiler, enrichplot, ggplot2, VOSviewer CiteSpace. Visualizations created for countries, institutions, authors, journals, fields, co-cited references, keywords, genes, diseases, with gene Citexs. gained momentum 2006, United States America China as leading contributors. Key themes included oxidative stress, syndrome, fibrosis, role Kupffer cells. Bioinformatics identified interleukin-6, tumor necrosis factor signal transducer activator transcription 3 central proteins responses inflammation, suggesting targets Clinically, these hub genes play pivotal roles pathogenesis For instance, targeting signaling pathway could reduce while modulating interleukin-6 expression may improve function, offering new strategies MAFLD therapy. This analysis reports hotspots emerging through bioinformatics.

Language: Английский

Citations

0
Clinical Study of Intelligent Tongue Diagnosis and Oral Microbiome for Classifying TCM Syndromes in MASLD DOI
Juncai Deng,

Shixuan Dai,

Shi Liu

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Abstract Background This study aimed to analyze the tongue image features and oral microbial markers in different TCM syndromes related metabolic dysfunction-associated steatotic liver disease (MASLD). Methods involved 34 healthy volunteers 66 MASLD patients [36 with Dampness-Heat (DH) 30 Qi-Deficiency (QD) syndrome]. Oral microbiome analysis was conducted through 16S rRNA sequencing. Tongue feature extraction used Uncertainty Augmented Context Attention Network (UACANet), while syndrome classification performed using five machine learning methods based on microbiota. Results Significant differences color, coating, microbiota were noted between DH band QD patients. exhibited a red-crimson color greasy coating enriched Streptococcus Rothia tongue. In contrast, displayed pale higher abundances of Neisseria, Fusobacterium, Porphyromonas Haemophilus. Combining characteristics differentiated an AUC 0.939 accuracy 85%. Conclusion suggests that are metabolism, possess distinct biomarkers, supporting classification.

Language: Английский

Citations

0
The synergistic role of gut microbiota and RNA in metabolic diseases: mechanisms and therapeutic insights DOI Creative Commons
Zhuo Huang, Qinyan Yao,

Shuang Ma

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 29, 2025

The gut microbiota plays a pivotal role in human metabolic health by influencing immune responses, digestion, and homeostasis. Recent research highlights the intricate interactions between RNA, especially non-coding RNAs, regulating processes. Dysbiosis of has been linked to disorders such as type 2 diabetes, obesity, metabolic-associated fatty liver disease (MAFLD) heart disease. Microbial metabolites, including short-chain acids (SCFAs), modulate RNA expression, lipid metabolism, glucose regulation, inflammatory responses. Additionally, microRNAs (miRNAs) long RNAs (lncRNAs) serve critical regulators these processes, with emerging evidence showing that gut-derived metabolites affect post-transcriptional gene regulation. This review synthesizes current understanding microbiota-RNA axis its diseases. By exploring molecular mechanisms, particularly how microbiota-derived signals pathways, underscores potential targeting this for therapeutic interventions. Furthermore, it examines dysbiosis leads epigenetic changes m6A methylation, contributing pathogenesis. These insights offer new perspective on prevention treatment diseases, applications personalized medicine.

Language: Английский

Citations

0
Unraveling the Metabolic Pathways Between Metabolic-Associated Fatty Liver Disease (MAFLD) and Sarcopenia DOI Open Access

Marina Ribas Losasso,

Maria Luiza Cesto Parussolo,

Antony Oliveira Silva

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(10), P. 4673 - 4673

Published: May 14, 2025

Metabolic-Associated Fatty Liver Disease (MAFLD) is a public health concern that constantly expanding, with fast-growing prevalence, and it affects about quarter of the world's population. This condition significant risk factor for cardiovascular, hepatic, oncologic diseases, such as hypertension, hepatoma, atherosclerosis. Sarcopenia was long considered to be an aging-related syndrome, but today, acknowledged secondarily related chronic diseases metabolic cardiovascular conditions, liver among other comorbidities associated insulin resistance inflammation, besides inactivity poor nutrition. The physiopathology involving MAFLD sarcopenia has still not been solved. Inflammation, oxidative stress, mitochondrial dysfunction, seem some keys this relationship since hormone target mainly skeletal muscle. review aimed comprehensively discuss main physiological pathways involved in these conditions. are interconnected by complex network pathophysiological mechanisms, resistance, muscle tissue production capacity, inflammatory state, which contributors relationship. In addition, clinical analysis, patients manifest more severe hepatitis fibrosis when compared only MAFLD. These patients, both disorders, also present improvement their treated sarcopenia, reinforcing association between them. Lifestyle changes accompanied non-pharmacological interventions, dietary therapy increased physical activity, undoubtedly improve scenario.

Language: Английский

Citations

0
Alterations in Glutathione Redox Homeostasis in Metabolic Dysfunction-Associated Fatty Liver Disease: A Systematic Review DOI Creative Commons
Lucia Cesarini, Flavia Grignaffini, Anna Alisi

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1461 - 1461

Published: Nov. 28, 2024

Low molecular weight (LMW) thiols, particularly glutathione, play pathogenic roles in various multiorgan diseases. The liver is central for the production and systemic distribution of LMW thiols; thus, it susceptible to imbalance redox status that may determine increased oxidative stress trigger damage observed metabolic dysfunction-associated steatotic disease (MASLD) models humans. Indeed, thiols at cellular extracellular levels be associated with severity MASLD. Here, we present a systematic literature review recent studies assessing MASLD vivo vitro human subjects. Based on PRISMA 2020 criteria, search was conducted using PubMed Scopus by applying inclusion/exclusion filters. initial returned 1012 documents, from which 165 eligible were selected, further described, qualitatively analysed. Of these studies, most focused animal models, while minority used fluids. analysis revealed heterogeneity methods sample processing measurement thiol levels, hinder cut-off values diagnostic use. Standardisation measure necessary facilitate future studies.

Language: Английский

Citations

0