An Optimized Graphene-Based Surface Plasmon Resonance Biosensor for Detecting SARS-CoV-2 DOI Creative Commons
Talía Tene, Fabian Arias Arias, Karina I. Paredes-Páliz

et al.

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(22), P. 10724 - 10724

Published: Nov. 19, 2024

Graphene-enhanced surface plasmon resonance (SPR) biosensors offer promising advancements in viral detection, particularly for SARS-CoV-2. This study presents the design and optimization of a multilayer SPR biosensor incorporating silver, silicon nitride, single-layer graphene, thiol-tethered ssDNA to achieve high sensitivity specificity. Key metrics, including angle shift (Δθ), (S), detection accuracy (DA), figure merit (FoM), were assessed across SARS-CoV-2 concentrations from 150 525 mM. The optimized achieved 315.91°/RIU at 275 mM maximum Δθ 4.2° 400 mM, demonstrating strong responsiveness virus binding. sensor maintained optimal lower concentrations, with linear response up after which saturation limited further responsiveness. These results highlight suitability real-time, point-of-care low loads, supporting its potential early diagnostics epidemiological monitoring.

Language: Английский

Comprehensive Genomic, Mutation, Phylogenetic, and Statistical Analysis of the Monkeypox Virus Across Multiple Countries DOI
Imran Zafar,

Faheem kanwal,

Muhammad Azmat

et al.

Indian Journal of Microbiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Language: Английский

Citations

0
An Optimized Graphene-Based Surface Plasmon Resonance Biosensor for Detecting SARS-CoV-2 DOI Creative Commons
Talía Tene, Fabian Arias Arias, Karina I. Paredes-Páliz

et al.

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(22), P. 10724 - 10724

Published: Nov. 19, 2024

Graphene-enhanced surface plasmon resonance (SPR) biosensors offer promising advancements in viral detection, particularly for SARS-CoV-2. This study presents the design and optimization of a multilayer SPR biosensor incorporating silver, silicon nitride, single-layer graphene, thiol-tethered ssDNA to achieve high sensitivity specificity. Key metrics, including angle shift (Δθ), (S), detection accuracy (DA), figure merit (FoM), were assessed across SARS-CoV-2 concentrations from 150 525 mM. The optimized achieved 315.91°/RIU at 275 mM maximum Δθ 4.2° 400 mM, demonstrating strong responsiveness virus binding. sensor maintained optimal lower concentrations, with linear response up after which saturation limited further responsiveness. These results highlight suitability real-time, point-of-care low loads, supporting its potential early diagnostics epidemiological monitoring.

Language: Английский

Citations

3