Cited by Epigenetic and Posttranslational Regulation of Ferroptosis

Amino acid transporters within the solute carrier superfamily: Underappreciated proteins and novel opportunities for cancer therapy DOI

Kiavash Hushmandi, Behzad Einollahi, Seyed Hassan Saadat

et al.

Molecular Metabolism, Journal Year: 2024, Volume and Issue: 84, P. 101952 - 101952

Published: May 3, 2024

Solute carrier (SLC), a diverse family of membrane proteins, are instrumental in orchestrating the intake and efflux nutrients including amino acids, vitamins, ions, nutrients, etc, across cell membranes. This dynamic process is critical for sustaining metabolic demands cancer cells, promoting their survival, proliferation, adaptation to tumor microenvironment. Amino acids fundamental building blocks playing essential roles not only protein synthesis but also nutrient sensing, signaling pathways that can promote tumorigenesis. As key transporters SLCs have emerged as crucial players maintaining cellular acid homeostasis, dysregulation implicated various types. Thus, understanding intricate connections between SLCs, pivotal unraveling novel therapeutic targets strategies. uptake by positively affects progression. However, some studies revealed suppressor function SLCs. Although body evaluated SLC7A11 SLC1A5, SLC proteins studied sufficiently cancer. In this review, we delve into significant impact carriers on growth progression explore current state knowledge field, shedding light molecular mechanisms underlie these relationships highlighting potential avenues future research clinical interventions. comprehensive review provides insights rapidly evolving area biology focusing one most important materials cells need, within superfamily.

Language: Английский

Citations

Insights into the Roles of Epigenetic Modifications in Ferroptosis DOI

Jinghua Kong,

Hao Lyu,

Qian Ouyang

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(2), P. 122 - 122

Published: Feb. 15, 2024

Ferroptosis is a non-apoptotic mode of cell death driven by membrane lipid peroxidation and characterized elevated intracellular levels Fe

Language: Английский

Citations

Targeting ferroptosis regulators by natural products in colorectal cancer DOI

Yiping Zhang, Jun Xie

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 27, 2024

Colorectal cancer (CRC) poses a significant global health challenge, ranking as the third most diagnosed and second leading cause of cancer-related deaths. Despite advancements in treatment, challenges such delayed diagnosis, multidrug resistance, limited therapeutic effectiveness persist, emphasizing need for innovative approaches. This review explores potential natural products, nutraceuticals, phytochemicals targeting ferroptosis-related regulators novel strategy CRC. Ferroptosis, form regulated cell death characterized by iron-dependent lethal lipid peroxide accumulation, holds substantial importance CRC progression therapy resistance. Natural known their diverse bioactive effects favorable safety profiles, emerge promising candidates to induce ferroptosis cells. Exploring amino acid, iron, metabolism regulators, oxidative stress reveals avenues inducing comprehensive provides insights into multifaceted products on proteins integral regulation, including GPX4, SLC7A11, ACSL4, NCOA4, HO-1. By elucidating intricate mechanisms through which modulate these proteins, this lays foundation

Language: Английский

Citations

Demethylases in tumors and the tumor microenvironment: Key modifiers of N6-methyladenosine methylation DOI

Junchen Guo,

Liang Zhao,

Meiqi Duan

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 174, P. 116479 - 116479

Published: March 26, 2024

RNA methylation modifications are widespread in eukaryotes and prokaryotes, with N

Language: Английский

Citations

Targeting RNA modifications with pharmacological agents: New frontiers in cancer therapy DOI

Angel Guan, Justin Wong

Cancer Medicine, Journal Year: 2024, Volume and Issue: 13(7)

Published: March 28, 2024

Abstract The N6‐methyladenosine (m6A) RNA modification has gained significant prominence as a new layer of regulatory mechanism that governs gene expression. Over the past decade, various m6A regulators responsible for introducing, eliminating, and recognising methylation have been identified. Notably, these often exhibit altered expression patterns in cancer, occasionally offering prognostic value. Nonetheless, complex roles human cancer pathology remain enigmatic, with conflicting outcomes reported different studies.In recent years, multitude inhibitors activators targeting reported. Several compounds demonstrated promising efficacy both vitro vivo models. These findings collectively underscore dynamic landscape regulation biology, revealing its potential therapeutic target indicator.

Language: Английский

Citations

Ferroptosis: a critical mechanism of N6-methyladenosine modification involved in carcinogenesis and tumor progression DOI

Qingqing Wei,

Changning Xue,

Mengna Li

et al.

Science China Life Sciences, Journal Year: 2024, Volume and Issue: 67(6), P. 1119 - 1132

Published: Feb. 28, 2024

Language: Английский

Citations

m6A demethylase ALKBH5 reduces ferroptosis in diabetic retinopathy through the m6A‐YTHDF1‐ACSL4 axis DOI

Qinghui Liao,

Yan Li,

Meijing Cui

et al.

Diabetic Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Abstract Aim Diabetic retinopathy (DR) represents the main ocular complication of diabetes. Targeting ferroptosis is a promising treatment choice for various diabetic complications. N6‐methyladenosine (m6A) demethylase alkylation repair homolog protein 5 (ALKBH5) functions as pivotal regulator ferroptosis, and we investigated its role molecular mechanisms in DR. Methods A DR mouse model was developed by streptozotocin (STZ) intraperitoneal injection. High glucose (HG)‐induced human retinal pigment epithelial cells (ARPE‐19) were used vitro . ALKBH5, YTH RNA binding 1 (YTHDF1) acyl‐CoA synthetase long‐chain family member 4 (ACSL4) expression levels examined RT‐qPCR Western blot. The biological ALKBH5 vivo gain‐of‐function loss‐of‐function analyses. ALKBH5's downstream regulatory detected bioinformatics analysis, pull‐down, MeRIP‐qPCR actinomycin D assay. Results under‐expressed while YTHDF1 ACSL4 up‐regulated tissues STZ‐induced mice HG‐stimulated ARPE‐19 cells. Ectopically expressed or knockdown partially reversed increased , evidenced decreased Fe 2+ malondialdehyde reactive oxygen species yet glutathione level. mediated m6A modification mRNA disrupted stability YTHDF1‐dependent manner. Importantly, data demonstrated that overexpression repressed alleviated down‐regulating ACSL4. Conclusion These findings suggest may delay progression reducing through m6A‐YTHDF1‐ACSL4 axis, offering therapeutic paradigms

Language: Английский

Citations

Correlation between RNA N6-methyladenosine and ferroptosis in cancer: current status and prospects DOI

Qianzi Liu,

Linxi Lv,

Xueding Cai

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: March 13, 2024

N 6 -methyladenosine (m A) is the most abundant chemical modification in eukaryotic cells. It a post-transcriptional of mRNA, dynamic reversible process catalyzed by methyltransferase, demethylase, and binding proteins. Ferroptosis, unique iron-dependent cell death, regulated various metabolic events, including many disease-related signaling pathways. And different ferroptosis inducers or inhibitors have been identified that can induce inhibit onset through targets mechanisms. They potential clinical value treatment diverse diseases. Until now, it has shown several cancer diseases m A be involved regulation ferroptosis, which impact subsequent treatment. This paper focuses on concept, function, biological role methylation interaction between to provide new therapeutic strategies for treating malignant protecting organism targeting regulate ferroptosis.

Language: Английский

Citations

Impact of curcumin on ferroptosis‐related genes in colorectal cancer: Insights from in‐silico and in‐vitro studies DOI

Ali Ahmadizad Firouzjaei, Seyed Hamid Aghaee‐Bakhtiari,

Ali Tafti

et al.

Cell Biochemistry and Function, Journal Year: 2023, Volume and Issue: 41(8), P. 1488 - 1502

Published: Nov. 28, 2023

Colorectal cancer (CRC) is responsible for a significant number of cancer-related fatalities worldwide. Researchers are investigating the therapeutic potential ferroptosis, type iron-dependent controlled cell death, in context CRC. Curcumin, natural compound found turmeric, exhibits anticancer properties. This study explores effects curcumin on genes related to ferroptosis (FRGs) To gather CRC data, we used Gene Expression Profiling Interactive Analysis (GEPIA) and Omnibus (GEO) databases, while FRGs were obtained from FerrDb database PubMed. We identified 739 differentially expressed (DEGs) discovered 39 that common between DEGs. The DEGs enriched with various biological processes molecular functions, including regulation signal transduction glucose metabolism. Using Drug Interaction Database (DGIdb), predicted drugs targeting CRC-DEGs 17 drug targets. Additionally, eight essential proteins CRC, MYC, IL1B, SLC1A5. Survival analysis revealed alterations gene expression CDC25A, DDR2, FABP4, SNCA, TFAM associated prognosis patients. In SW480 human cells, treatment decreased EZH2 mRNA, simultaneously increasing SLCA5 CAV1. findings this suggest could regulate have be utilized as agent treating

Language: Английский

Citations

Autophagy/ferroptosis in colorectal cancer: Carcinogenic view and nanoparticle-mediated cell death regulation DOI

Zhibin Zhang,

Yintao Zhao,

Yuman Wang

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 238, P. 117006 - 117006

Published: Sept. 3, 2023

Language: Английский

Citations