Springer eBooks, Journal Year: 2023, Volume and Issue: unknown, P. 383 - 403
Published: Jan. 1, 2023
Language: Английский
Cell Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 82(2), P. 1279 - 1289
Published: May 6, 2024
Language: Английский
Citations
2
Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 283, P. 116816 - 116816
Published: Aug. 2, 2024
Fluoride exposure is widespread worldwide and poses a significant threat to organisms, particularly their gastrointestinal tracts. However, due limited knowledge of the mechanism fluoride induced intestinal injury, it has been challenging develop an effective treatment. To address this issue, we used series molecular biology in vitro vivo experiments. NaF triggered m
Language: Английский
Citations
2
MedComm, Journal Year: 2024, Volume and Issue: 5(9)
Published: Sept. 1, 2024
Abstract N6‐methyladenosine (m6A) is the most abundant modification of RNA in eukaryotic cells. Previous studies have shown that m6A pivotal diverse diseases especially cancer. corelates with initiation, progression, resistance, invasion, and metastasis However, despite these insights, a comprehensive understanding its specific roles mechanisms within complex landscape cancer still elusive. This review begins by outlining key regulatory proteins their posttranslational modifications (PTMs), as well role chromatin accessibility transcriptional activity Additionally, it highlights impact progression modulating programmed cell death affecting tumor microenvironment through various cancer‐associated immune Furthermore, discusses how microorganisms can induce enduring epigenetic changes oncogenic effect microorganism‐associated cancers altering modifications. Last, delves into immunotherapy, encompassing therapy, checkpoint blockade, cytokine adoptive transfer direct targeting regulators. Overall, this clarifies multifaceted explores targeted therapies aimed at manipulating modification, aiming to advance research improve patient outcomes.
Language: Английский
Citations
2
Cancer Cell International, Journal Year: 2024, Volume and Issue: 24(1)
Published: Aug. 24, 2024
Gastrointestinal cancer is the most common malignancy in humans, often accompanied by poor prognosis. N6-methyladenosine (m6A) modification widely present eukaryotic cells as abundant RNA modification. It plays a crucial role splicing and processing, nuclear export, translation, stability. Human AlkB homolog 5 (ALKBH5) type of demethylase exhibiting abnormal expression various gastrointestinal cancers.It closely related to tumorigenesis, proliferation, migration, other biological functions cancer. However, recent studies indicated that mechanism ALKBH5 are complicated even controversial. Thus, this review summarizes advances elucidating tumor suppressor or promoter examines its potential therapeutic target, providing new perspectives insights for research.
Language: Английский
Citations
1
Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 220, P. 271 - 287
Published: May 9, 2024
Language: Английский
Citations
0
Life Sciences, Journal Year: 2024, Volume and Issue: 355, P. 123011 - 123011
Published: Aug. 23, 2024
Language: Английский
Citations
0
Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(17)
Published: Sept. 1, 2024
Abstract Whether N6‐Methyladenosine (m6A)‐ and ferroptosis‐related genes act on immune responses to regulate glioma progression remains unanswered. Data of corresponding normal brain tissues were fetched from the TCGA database GTEx. Differentially expressed (DEGs) identified for GO KEGG enrichment analyses. The FerrDb was based yield DEGs. Hub then screened out using cytoHubba validated in clinical samples. Immune cells infiltrating into analysed CIBERSORT R script. association gene signature underlying m6A‐related ferroptosis with tumour‐infiltrating checkpoints low‐grade gliomas analysed. Of 6298 DEGs enriched mRNA modifications, 144 ferroptosis‐related; NFE2L2 METTL16 showed strongest positive correlation. knockdown inhibited migrative invasive abilities induced vitro. anti‐m6A antibody. Moreover, reduced stability level (both p < 0.05). Proportions CD8+ T lymphocytes, activated mast M2 macrophages differed between tissues. expression negatively correlated while that positively gliomas. Gene signatures involved via bioinformatic interacted response gliomas, both molecules may be novel therapeutic targets
Language: Английский
Citations
0
Journal of Pharmacy and Pharmacology, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 25, 2024
Abstract Objectives This study investigates the dual role of ALKBH5, an eraser enzyme, in colorectal cancer (CRC), focusing on how N6-methyladenosine (m6A) mutations influence CRC development and progression. Methods We reviewed various studies that highlighted ALKBH5 (CRC). includes impact tumor cell behavior including immune system interactions, invasion, proliferation CRC. also looked into acts as a suppressor under different conditions analyzed clinical data to assess expression outcomes patients. Key findings In CRC, plays role. certain situations, it inhibits progression tumor, but other circumstances, promotes growth immunosuppression. The interaction with RABA5 Having elevated levels has been associated unfavorable patient outcomes, such reduced survival rates more advanced stages. Various factors, differentiation, TNM stages, carcinoembryonic antigen (CEA) levels, be linked expression. Conclusions complicated situation-specific Targeting could result novel therapy options balance its tumor-promoting tumor-fighting properties Further research m6A alterations enhance treatment approaches outcomes.
Language: Английский
Citations
0
Cell Biology and Toxicology, Journal Year: 2024, Volume and Issue: 40(1)
Published: Nov. 18, 2024
In the clinical setting, cisplatin-induced nephrotoxicity primarily manifests as acute kidney injury (AKI). Recent studies have indicated that ferroptosis, a type of iron-dependent cell death, is closely involved in cisplatin nephrotoxicity. AlkB homologue 5 (ALKBH5), an N6-methyladenosine (m6A) eraser protein expressed various tissues, including kidneys, has been implicated this process. However, specific role ALKBH5 remains unknown. Our findings was upregulated AKI, and vivo study results were consistent with vitro study. Additionally, knockout transgenic animals found to mitigate renal dysfunction, whereas its knock-in exacerbated effects. revealed controls traditional ferroptosis metabolic pathway, leading worsening AKI experiments conducted both vitro. The efficacy pharmacological intervention targeting animal models demonstrated, ALKBH5-based gene therapy confirmed these displayed renoprotective effects against AKI. conclusion, highlighted crucial key regulator Overall, our research demonstrates significant impact controlling suggesting focusing on could be promising approach for treating cisplatin-related damage.
Language: Английский
Citations
0
Gastroenterology, Journal Year: 2023, Volume and Issue: 165(6), P. 1581 - 1581
Published: Sept. 1, 2023
Language: Английский
Citations
1