Neuropsychiatric Disease and Treatment,
Journal Year:
2023,
Volume and Issue:
Volume 19, P. 811 - 828
Published: April 1, 2023
Abstract:
A
healthy
stress
response
is
critical
for
good
mental
and
overall
health
promotes
neuronal
growth
adaptation,
but
the
intricately
balanced
biological
mechanisms
that
facilitate
a
can
also
result
in
predisposition
to
disease
when
equilibrium
disrupted.
The
hypothalamic-pituitary-adrenal
(HPA)
axis
neuroendocrine
system
plays
role
body's
adaptation
stress,
vasopressinergic
regulation
of
HPA
maintaining
responsiveness
during
chronic
stress.
However,
exposure
repeated
or
excessive
physical
emotional
trauma
shift
"new
normal"
underpinned
by
enduring
changes
function.
Exposure
early
life
due
adverse
childhood
experiences
lead
lasting
neurobiological
changes,
including
impairment
patients
with
depression
considered
among
most
reliable
findings
psychiatry,
has
been
shown
play
major
pathogenesis
onset
other
neuropsychiatric
disorders.
Modulating
activity,
example
via
targeted
antagonism
vasopressin
V
1b
receptor,
promising
approach
disorders
associated
impairment.
Despite
favorable
preclinical
indications
animal
models,
demonstration
clinical
efficacy
treatment
depressive
targeting
dysfunction
challenging,
possibly
heterogeneity
syndromal
nature
Measures
function,
such
as
elevated
cortisol
levels,
may
be
useful
biomarkers
identifying
who
benefit
from
treatments
modulate
activity.
Utilizing
identify
subsets
impaired
function
next
step
fine-tuning
activity
receptor.
Keywords:
allostatic
overload,
cortisol,
axis,
disorder,
PLoS ONE,
Journal Year:
2024,
Volume and Issue:
19(5), P. e0302597 - e0302597
Published: May 9, 2024
The
outbreak
of
SARS-CoV-2,
which
causes
COVID-19,
has
significantly
impacted
the
psychological
and
physical
health
a
wide
range
individuals,
including
healthcare
professionals
(HCPs).
This
umbrella
review
aims
provide
quantitative
summary
meta-analyses
that
have
investigated
prevalence
stress,
anxiety,
depression,
sleep
disturbance
among
HCPs
during
COVID-19
pandemic.
An
systematic
reviews
was
conducted.
search
performed
using
EMBASE,
PubMed,
CINAHL,
MEDLINE,
PsycINFO,
Google
Scholar
databases
from
01st
January
2020
to
15th
2024.
A
random-effects
model
then
used
estimate
with
95%
confidence
interval.
Subgroup
analysis
sensitivity
analyses
were
conducted
explore
heterogeneity
sample.
Seventy-two
involved
2,308
primary
studies
included
after
full-text
review.
revealed
pooled
pandemic
37%
(95%
CI
32.87-41.22),
31.8%
29.2-34.61)
29.4%
27.13-31.84)
36.9%
33.78-40.05)
respectively.
In
subgroup
anxiety
depression
higher
nurses
than
physicians.
Evidence
this
suggested
significant
proportion
experienced
information
will
support
authorities
when
implementing
specific
interventions
address
mental
problems
future
pandemics
or
any
other
crises.
Such
may
include
provision
services,
such
as
counseling
peer
programs,
well
implementation
organizational
strategies
reduce
workplace
stressors.
Journal of Affective Disorders,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
During
the
COVID-19
pandemic,
healthcare
workers
(HCWs)
experienced
several
changes
in
their
work
(e.g.,
longer
hours,
new
policies)
that
affected
mental
health.
In
this
study,
an
umbrella
review
and
meta-analysis
of
meta-analyses
was
conducted
to
examine
prevalence
various
health
problems
by
HCWs
during
pandemic.
We
a
systematic
searching
PubMed,
EMBASE,
PsycINFO,
Cochrane
Library,
Scopus
databases
(PROSPERO:
CRD42022304823).
performed
summarize
different
examined
whether
these
differed
as
function
job
category,
sex/gender,
sociodemographic
index
(SDI),
across
time.
Eighty-seven
were
included
meta-analysis,
including
1846
non-overlapping
articles
9,400,962
participants.
The
overall
ratio
for
outcomes
ranged
from
0.20
PTSD
(95
%
CI:
0.16-0.25)
0.44
burnout
0.32-0.56),
with
ratios
depressive
symptoms,
anxiety
psychological
distress,
perceived
stress,
sleep
problems,
insomnia
symptoms
falling
between
ranges.
Follow-up
analyses
revealed
little
variation
sex.
Prevalence
high
Administrators
policymakers
worldwide
need
address
growing
through
institutional
policies
wellness
programming.
International Journal of Environmental Research and Public Health,
Journal Year:
2022,
Volume and Issue:
19(16), P. 10106 - 10106
Published: Aug. 16, 2022
Nurses’
well-being
has
been
increasingly
recognised
due
to
the
ongoing
pandemic.
However,
no
validation
scales
measuring
nurses’
currently
exist.
Thus,
we
aimed
validate
WHO-5
Well-Being
Index
(WHO-5)
in
a
sample
of
nurses.
A
cross-sectional
multinational
study
was
conducted,
and
total
678
nurses
who
worked
during
COVID-19
pandemic
Spain
(36.9%),
Chile
(40.0%)
Norway
(23.1%)
participated
this
study.
The
completed
WHO-5,
Patient
Health
Questionnaire-2
(PHQ-2),
Generalized
Anxiety
Disorder-2
(GAD-2)
three
questions
about
quality
life
(QoL).
demonstrated
good
reliability
validity
countries.
Cronbach’s
alphas
ranged
from
0.81
0.90.
High
correlations
were
found
between
psychological
dimension
QoL,
negative
PHQ-2.
unidimensional
scale
structure
confirmed
all
countries,
explaining
more
than
68%
variance.
item
response
theory
likelihood
ratio
model
did
not
show
discernible
differences
across
To
conclude,
is
psychometrically
sound
for
showed
strong
construct
cross-cultural
comparisons;
however,
research
required
with
larger
sizes.
European Child & Adolescent Psychiatry,
Journal Year:
2023,
Volume and Issue:
32(12), P. 2593 - 2609
Published: Feb. 4, 2023
Increased
parental
stress,
poorer
mental
health,
and
an
increase
in
the
occurrence
of
child
maltreatment
(CM)
have
been
reported
earlier
phases
COVID-19
pandemic.
However,
data
from
later
pandemic
are
not
yet
available.
We
conducted
a
cross-sectional,
representative
survey
among
1087
parents
(48.8%
female;
mean
age
41.72
years,
SD
=
9.15)
Germany
December
2021.
Data
were
compared
to
previous
sample,
assessed
August
2020
(N
1024),
normative
scores
outcome
measures.
Predictors
for
CM
analyzed
by
logistic
regression.
Pandemic-related
stress
general
higher
physical
health
2021
sample
than
sample.
Occurrence
rates
varied
between
5
56%.
Verbal
emotional
abuse
(n
607,
56%),
witnessing
domestic
violence
446,
41%),
neglect
435,
40%)
most
frequently
reported.
For
these
subtypes,
risk
alcohol
(OR
2.1-2.7)
recent
experience
2.1-5.1)
strongest
predictors.
Across
all
subtypes
CM,
reporting
showed
on
outcomes,
with
medium-large-effect
sizes.
Results
confirm
high
burden
within
families,
almost
2
years
into
broad
spectrum
raise
further
concerns
well-being
children.
Family-oriented
intervention
efforts
needed
stabilize
families
provide
targeted
support.
Longitudinal
studies
description
at
outcomes.
Frontiers in Psychology,
Journal Year:
2022,
Volume and Issue:
13
Published: Oct. 20, 2022
Little
is
known
about
risk
factors
for
both
Long
COVID
and
somatic
symptoms
that
develop
in
individuals
without
a
history
of
COVID-19
response
to
the
pandemic.
There
reason
assume
an
interplay
between
pathophysiological
mechanisms
psychosocial
etiology
symptom
persistence.Therefore,
this
study
investigates
specific
deterioration
cohort
German
adults
with
prior
SARS-CoV-2
infection.German
healthcare
professionals
underwent
IgG
antibody
testing
completed
self-rating
questionnaires
at
baseline
21
months
later
April
2020
February
2022.
Differences
variables
time
points
were
analyzed
regression
analysis
was
performed
predict
follow-up.Seven
hundred
fifty-one
assessments.
Until
follow-up,
n
=
58
had
contracted
confirmed
by
serology.
Between
signs
mental
physical
strain
increased
significantly
sample.
Symptom
expectations
associated
self-reported
COVID-19,
but
not
serologically
infection,
predicted
follow-up.
A
further
predictor
psychological
burden.This
supports
disease-overarching
biopsychosocial
model
development
burdensome
during
pandemic
research
findings
burden
may
be
more
related
effects
than
infection
itself.
Future
studies
on
should
include
negative
control
groups
consider
order
avoid
overestimation
prevalence
rates.
Educational Psychology,
Journal Year:
2023,
Volume and Issue:
43(5), P. 430 - 451
Published: May 28, 2023
AbstractAbstractThe
aims
of
this
study
were
to
(1)
explore
the
state
students’
and
teachers’
well-being
(2)
examine
factors
that
predict
their
during
pandemic-related
school
closures
in
Philippines.
Our
sample
comprised
733
students
1168
teachers.
During
height
pandemic,
22.10%
13.44%
teachers
met
cut-off
for
depression;
13.91%
15.92%
anxiety.
Both
classical
statistics
machine
learning
approaches
used
identify
roles
demographic,
psychological,
socio-contextual
statistically
predicted
outcomes.
Results
highlighted
family
support
was
strongest
predictor
positive
well-being.
For
mental
health
outcomes,
predictors
depression
anxiety
stress,
while
depression,
fear
COVID.
Implications
amidst
COVID
are
discussed.Keywords:
student
well-beingteacher
well-beingwell-beingCOVID-19mental
healthmachine
Disclosure
statementNo
potential
conflict
interest
reported
by
authors.Author
contribution
statementThe
authors
confirm
paper
as
follows:
conception
design:
King,
R.B.,
&
Mendoza,
N.
B.;
data
collection:
analysis
interpretation
results:
Haw,
J.
Y.;
draft
manuscript
preparation:
editing
supervision:
R.
B.
All
reviewed
results
approved
final
version
manuscript.
Economic Notes,
Journal Year:
2025,
Volume and Issue:
54(1)
Published: Jan. 3, 2025
ABSTRACT
In
recent
literature,
various
social
implications
arising
from
the
COVID‐19
pandemic
have
been
extensively
deliberated
upon.
this
study,
we
introduce
an
ordinal
random
effects
model
designed
to
explore
changes
in
individual
perceived
happiness
during
periods
of
lockdown.
We
delve
into
impact
diverse
factors
such
as
and
family
relationships,
spirituality,
religiosity,
trust
institutions,
alongside
a
range
demographic
economic
variables.
Our
data
set
comprises
responses
1212
individuals
United
States
gathered
between
March
April
2020.
The
findings
reveal
anticipated
decline
overall
crisis,
particularly
noticeable
within
specific
behavioural
segments:
connections,
trust,
religiosity
exhibit
nuanced
variations,
contingent
upon
level
spirituality
institutions
under
consideration.
Journal of Medical Internet Research,
Journal Year:
2025,
Volume and Issue:
27, P. e64965 - e64965
Published: Feb. 5, 2025
Background
The
onset
of
the
COVID-19
pandemic
in
early
2020
introduced
unprecedented
disruptions
impacting
emotional
well-being
and
daily
routines
US
youths.
However,
patterns
persistence
these
impacts
over
pandemic’s
multiyear
course
remain
less
well
understood.
Objective
This
study
examined
longitudinal
changes
affect
mobility
observed
adolescence
young
adulthood
from
June
2016
to
April
2022.
aimed
quantify
youths’
mood
following
response
local
case
rates
as
effects
course.
Methods
Colorado-based
adolescent
adult
twins
(N=887;
n=479,
54%
female;
meanage
19.2,
SDage
1.5
years
on
January
01,
2020)
participating
CoTwins
between
2022
were
followed
via
a
smartphone
app,
which
recorded
persistent
GPS
location
data
and,
beginning
February
2019,
administered
an
abbreviated
Positive
Negative
Affect
Schedule
every
2
weeks.
Nonlinear
trajectories
time
counts
modeled
generalized
additive
mixed
models,
while
magnitude
pandemic-related
quantified
linear
regressions.
Results
Between
2020,
participants
experienced
28.6%
decline
locations
visited
(from
3.5
2.5;
SD
0.9)
60%
reduction
travel
distance
20.0
8.0
km;
9.4).
Mean
positive
similarly
declined
by
0.3
3.0
2.79;
0.6),
while,
correspondingly,
mean
negative
increased
1.85
2.10;
0.6).
Though
levels
partially
recovered
summer
remained
slightly
below
2019
through
study’s
conclusion
(standardized
β=–0.10;
P<.001).
Average
β=–0.20;
P<.001)
above
β=0.14;
P=.04)
Weekly
county-level
transmission
negatively
associated
with
positively
affect,
though
greatly
weakened
later
(eg,
2022)
or
when
high
>200
new
cases
per
100,000
people
week).
Conclusions
Findings
demonstrate
large
initial
declines
mobility,
moderate
increase
2020.
most
attenuated
time,
had
not
prepandemic
support
theories
hedonic
adaptation
resiliency
also
identifying
lingering
behavioral
consequences.
highlights
both
youth’s
adapting
major
stressors
underscoring
need
for
continued
youth
mental
health
psychosocial
functioning
aftermath.