Targeting the Arginine Vasopressin V1b Receptor System and Stress Response in Depression and Other Neuropsychiatric Disorders DOI Creative Commons

Stephen Kanes,

Lara Dennie,

Philip Perera

et al.

Neuropsychiatric Disease and Treatment, Journal Year: 2023, Volume and Issue: Volume 19, P. 811 - 828

Published: April 1, 2023

Abstract: A healthy stress response is critical for good mental and overall health promotes neuronal growth adaptation, but the intricately balanced biological mechanisms that facilitate a can also result in predisposition to disease when equilibrium disrupted. The hypothalamic-pituitary-adrenal (HPA) axis neuroendocrine system plays role body's adaptation stress, vasopressinergic regulation of HPA maintaining responsiveness during chronic stress. However, exposure repeated or excessive physical emotional trauma shift "new normal" underpinned by enduring changes function. Exposure early life due adverse childhood experiences lead lasting neurobiological changes, including impairment patients with depression considered among most reliable findings psychiatry, has been shown play major pathogenesis onset other neuropsychiatric disorders. Modulating activity, example via targeted antagonism vasopressin V 1b receptor, promising approach disorders associated impairment. Despite favorable preclinical indications animal models, demonstration clinical efficacy treatment depressive targeting dysfunction challenging, possibly heterogeneity syndromal nature Measures function, such as elevated cortisol levels, may be useful biomarkers identifying who benefit from treatments modulate activity. Utilizing identify subsets impaired function next step fine-tuning activity receptor. Keywords: allostatic overload, cortisol, axis, disorder,

Language: Английский

Stress, anxiety, depression and sleep disturbance among healthcare professional during the COVID-19 pandemic: An umbrella review of 72 meta-analyses DOI Creative Commons
Mohammed Al Maqbali, Ahmad R. Alsayed,

Ciara Hughes

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(5), P. e0302597 - e0302597

Published: May 9, 2024

The outbreak of SARS-CoV-2, which causes COVID-19, has significantly impacted the psychological and physical health a wide range individuals, including healthcare professionals (HCPs). This umbrella review aims provide quantitative summary meta-analyses that have investigated prevalence stress, anxiety, depression, sleep disturbance among HCPs during COVID-19 pandemic. An systematic reviews was conducted. search performed using EMBASE, PubMed, CINAHL, MEDLINE, PsycINFO, Google Scholar databases from 01st January 2020 to 15th 2024. A random-effects model then used estimate with 95% confidence interval. Subgroup analysis sensitivity analyses were conducted explore heterogeneity sample. Seventy-two involved 2,308 primary studies included after full-text review. revealed pooled pandemic 37% (95% CI 32.87-41.22), 31.8% 29.2-34.61) 29.4% 27.13-31.84) 36.9% 33.78-40.05) respectively. In subgroup anxiety depression higher nurses than physicians. Evidence this suggested significant proportion experienced information will support authorities when implementing specific interventions address mental problems future pandemics or any other crises. Such may include provision services, such as counseling peer programs, well implementation organizational strategies reduce workplace stressors.

Language: Английский

Citations

13

Students’ subjective well-being, school bullying, and belonging during the COVID-19 pandemic: Comparison between PISA 2018 and PISA 2022 DOI Creative Commons
Li J, Eryong Xue, Wenhao Zhou

et al.

Humanities and Social Sciences Communications, Journal Year: 2025, Volume and Issue: 12(1)

Published: Jan. 3, 2025

Language: Английский

Citations

1

An umbrella review and meta-analysis of 87 meta-analyses examining healthcare workers' mental health during the COVID-19 pandemic DOI Creative Commons
Vincent Boucher,

Maria Dahl,

Jayden Lee

et al.

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

During the COVID-19 pandemic, healthcare workers (HCWs) experienced several changes in their work (e.g., longer hours, new policies) that affected mental health. In this study, an umbrella review and meta-analysis of meta-analyses was conducted to examine prevalence various health problems by HCWs during pandemic. We a systematic searching PubMed, EMBASE, PsycINFO, Cochrane Library, Scopus databases (PROSPERO: CRD42022304823). performed summarize different examined whether these differed as function job category, sex/gender, sociodemographic index (SDI), across time. Eighty-seven were included meta-analysis, including 1846 non-overlapping articles 9,400,962 participants. The overall ratio for outcomes ranged from 0.20 PTSD (95 % CI: 0.16-0.25) 0.44 burnout 0.32-0.56), with ratios depressive symptoms, anxiety psychological distress, perceived stress, sleep problems, insomnia symptoms falling between ranges. Follow-up analyses revealed little variation sex. Prevalence high Administrators policymakers worldwide need address growing through institutional policies wellness programming.

Language: Английский

Citations

1

Psychometric Properties of the WHO-5 Well-Being Index among Nurses during the COVID-19 Pandemic: A Cross-Sectional Study in Three Countries DOI Open Access
Mariela Loreto Lara‐Cabrera, Moisés Betancort, C. Amparo Muñoz-Rubilar

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(16), P. 10106 - 10106

Published: Aug. 16, 2022

Nurses’ well-being has been increasingly recognised due to the ongoing pandemic. However, no validation scales measuring nurses’ currently exist. Thus, we aimed validate WHO-5 Well-Being Index (WHO-5) in a sample of nurses. A cross-sectional multinational study was conducted, and total 678 nurses who worked during COVID-19 pandemic Spain (36.9%), Chile (40.0%) Norway (23.1%) participated this study. The completed WHO-5, Patient Health Questionnaire-2 (PHQ-2), Generalized Anxiety Disorder-2 (GAD-2) three questions about quality life (QoL). demonstrated good reliability validity countries. Cronbach’s alphas ranged from 0.81 0.90. High correlations were found between psychological dimension QoL, negative PHQ-2. unidimensional scale structure confirmed all countries, explaining more than 68% variance. item response theory likelihood ratio model did not show discernible differences across To conclude, is psychometrically sound for showed strong construct cross-cultural comparisons; however, research required with larger sizes.

Language: Английский

Citations

33

Could mindfulness diminish mental health disorders? The serial mediating role of self-compassion and psychological well-being DOI Open Access
Minh Anh Quang Tran, Tan Vo‐Thanh, Mohammad Soliman

et al.

Current Psychology, Journal Year: 2022, Volume and Issue: 43(15), P. 13909 - 13922

Published: Aug. 3, 2022

Language: Английский

Citations

30

Almost 2 years into the COVID-19 pandemic: an update on parental stress, parent mental health, and the occurrence of child maltreatment DOI Creative Commons
Claudia Calvano, Lara Engelke, Anna Katharina Holl

et al.

European Child & Adolescent Psychiatry, Journal Year: 2023, Volume and Issue: 32(12), P. 2593 - 2609

Published: Feb. 4, 2023

Increased parental stress, poorer mental health, and an increase in the occurrence of child maltreatment (CM) have been reported earlier phases COVID-19 pandemic. However, data from later pandemic are not yet available. We conducted a cross-sectional, representative survey among 1087 parents (48.8% female; mean age 41.72 years, SD = 9.15) Germany December 2021. Data were compared to previous sample, assessed August 2020 (N 1024), normative scores outcome measures. Predictors for CM analyzed by logistic regression. Pandemic-related stress general higher physical health 2021 sample than sample. Occurrence rates varied between 5 56%. Verbal emotional abuse (n 607, 56%), witnessing domestic violence 446, 41%), neglect 435, 40%) most frequently reported. For these subtypes, risk alcohol (OR 2.1-2.7) recent experience 2.1-5.1) strongest predictors. Across all subtypes CM, reporting showed on outcomes, with medium-large-effect sizes. Results confirm high burden within families, almost 2 years into broad spectrum raise further concerns well-being children. Family-oriented intervention efforts needed stabilize families provide targeted support. Longitudinal studies description at outcomes.

Language: Английский

Citations

17

Risk factors for worsening of somatic symptom burden in a prospective cohort during the COVID-19 pandemic DOI Creative Commons

Petra Engelmann,

Bernd Löwe, Thomas Theo Brehm

et al.

Frontiers in Psychology, Journal Year: 2022, Volume and Issue: 13

Published: Oct. 20, 2022

Little is known about risk factors for both Long COVID and somatic symptoms that develop in individuals without a history of COVID-19 response to the pandemic. There reason assume an interplay between pathophysiological mechanisms psychosocial etiology symptom persistence.Therefore, this study investigates specific deterioration cohort German adults with prior SARS-CoV-2 infection.German healthcare professionals underwent IgG antibody testing completed self-rating questionnaires at baseline 21 months later April 2020 February 2022. Differences variables time points were analyzed regression analysis was performed predict follow-up.Seven hundred fifty-one assessments. Until follow-up, n = 58 had contracted confirmed by serology. Between signs mental physical strain increased significantly sample. Symptom expectations associated self-reported COVID-19, but not serologically infection, predicted follow-up. A further predictor psychological burden.This supports disease-overarching biopsychosocial model development burdensome during pandemic research findings burden may be more related effects than infection itself. Future studies on should include negative control groups consider order avoid overestimation prevalence rates.

Language: Английский

Citations

24

The mental health and well-being of students and teachers during the COVID-19 pandemic: combining classical statistics and machine learning approaches DOI
Norman B. Mendoza, Ronnel B. King, Joseph Y. Haw

et al.

Educational Psychology, Journal Year: 2023, Volume and Issue: 43(5), P. 430 - 451

Published: May 28, 2023

AbstractAbstractThe aims of this study were to (1) explore the state students’ and teachers’ well-being (2) examine factors that predict their during pandemic-related school closures in Philippines. Our sample comprised 733 students 1168 teachers. During height pandemic, 22.10% 13.44% teachers met cut-off for depression; 13.91% 15.92% anxiety. Both classical statistics machine learning approaches used identify roles demographic, psychological, socio-contextual statistically predicted outcomes. Results highlighted family support was strongest predictor positive well-being. For mental health outcomes, predictors depression anxiety stress, while depression, fear COVID. Implications amidst COVID are discussed.Keywords: student well-beingteacher well-beingwell-beingCOVID-19mental healthmachine Disclosure statementNo potential conflict interest reported by authors.Author contribution statementThe authors confirm paper as follows: conception design: King, R.B., & Mendoza, N. B.; data collection: analysis interpretation results: Haw, J. Y.; draft manuscript preparation: editing supervision: R. B. All reviewed results approved final version manuscript.

Language: Английский

Citations

15

Understanding Happiness Amidst COVID‐19: Exploring Relations, Religion and Trust DOI Creative Commons

Matteo A. Ruberto,

Giulia Gioeli,

Matteo Rizzolli

et al.

Economic Notes, Journal Year: 2025, Volume and Issue: 54(1)

Published: Jan. 3, 2025

ABSTRACT In recent literature, various social implications arising from the COVID‐19 pandemic have been extensively deliberated upon. this study, we introduce an ordinal random effects model designed to explore changes in individual perceived happiness during periods of lockdown. We delve into impact diverse factors such as and family relationships, spirituality, religiosity, trust institutions, alongside a range demographic economic variables. Our data set comprises responses 1212 individuals United States gathered between March April 2020. The findings reveal anticipated decline overall crisis, particularly noticeable within specific behavioural segments: connections, trust, religiosity exhibit nuanced variations, contingent upon level spirituality institutions under consideration.

Language: Английский

Citations

0

Investigating the Magnitude and Persistence of COVID-19 Related Impacts on Affect and GPS-Derived Daily Mobility Patterns in Adolescence and Emerging Adulthood: Insights From a Smartphone-Based Intensive Longitudinal Study of Colorado-Based Youth from June 2016—April 2022 (Preprint) DOI Creative Commons
Jordan D. Alexander, Kelly A. Duffy, Samantha M. Freis

et al.

Journal of Medical Internet Research, Journal Year: 2025, Volume and Issue: 27, P. e64965 - e64965

Published: Feb. 5, 2025

Background The onset of the COVID-19 pandemic in early 2020 introduced unprecedented disruptions impacting emotional well-being and daily routines US youths. However, patterns persistence these impacts over pandemic’s multiyear course remain less well understood. Objective This study examined longitudinal changes affect mobility observed adolescence young adulthood from June 2016 to April 2022. aimed quantify youths’ mood following response local case rates as effects course. Methods Colorado-based adolescent adult twins (N=887; n=479, 54% female; meanage 19.2, SDage 1.5 years on January 01, 2020) participating CoTwins between 2022 were followed via a smartphone app, which recorded persistent GPS location data and, beginning February 2019, administered an abbreviated Positive Negative Affect Schedule every 2 weeks. Nonlinear trajectories time counts modeled generalized additive mixed models, while magnitude pandemic-related quantified linear regressions. Results Between 2020, participants experienced 28.6% decline locations visited (from 3.5 2.5; SD 0.9) 60% reduction travel distance 20.0 8.0 km; 9.4). Mean positive similarly declined by 0.3 3.0 2.79; 0.6), while, correspondingly, mean negative increased 1.85 2.10; 0.6). Though levels partially recovered summer remained slightly below 2019 through study’s conclusion (standardized β=–0.10; P<.001). Average β=–0.20; P<.001) above β=0.14; P=.04) Weekly county-level transmission negatively associated with positively affect, though greatly weakened later (eg, 2022) or when high >200 new cases per 100,000 people week). Conclusions Findings demonstrate large initial declines mobility, moderate increase 2020. most attenuated time, had not prepandemic support theories hedonic adaptation resiliency also identifying lingering behavioral consequences. highlights both youth’s adapting major stressors underscoring need for continued youth mental health psychosocial functioning aftermath.

Language: Английский

Citations

0