Why the hypothesis of psychological mechanisms in long COVID is worth considering

Journal of Psychosomatic Research, Journal Year: 2023, Volume and Issue: 165, P. 111135 - 111135

Published: Jan. 4, 2023

Language: Английский

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Depression and anxiety before and at the beginning of the COVID-19 pandemic and incident persistent symptoms: a prospective population-based cohort study

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(10), P. 4261 - 4271

Published: July 19, 2023

Language: Английский

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Long-term effects of SARS-CoV-2 infection on human brain and memory

Cell Death Discovery, Journal Year: 2023, Volume and Issue: 9(1)

Published: June 29, 2023

Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have caused several waves of outbreaks. From the ancestral strain to Omicron variant, SARS-CoV-2 has evolved with high transmissibility and increased immune escape against vaccines. Because multiple basic amino acids in S1-S2 junction spike protein, widespread distribution angiotensin-converting enzyme (ACE2) receptor human body transmissibility, can infect organs led over 0.7 billion infectious cases. Studies showed that infection cause more than 10% patients Long-COVID syndrome, including pathological changes brains. This review mainly provides molecular foundations for understanding mechanism invading brain basis interfering memory, which are associated dysfunction, syncytia-induced cell death, persistence infection, microclots biopsychosocial aspects. We also discuss strategies reducing syndrome. Further studies analysis shared researches will allow further clarity regarding long-term health consequences.

Language: Английский

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Patients with persistent symptoms after COVID-19 attending a multidisciplinary evaluation: Characteristics, medical conclusions, and satisfaction

Journal of Psychosomatic Research, Journal Year: 2023, Volume and Issue: 174, P. 111475 - 111475

Published: Aug. 23, 2023

Language: Английский

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Psychological and Social Factors Associated With Reporting Post‐COVID Symptoms Among German Healthcare Workers: A Cross‐Sectional Study

Journal of Clinical Nursing, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

ABSTRACT Background Health care workers (HCW) with post‐COVID condition (PCC) are frequently reported to suffer from mental health impairment. Given HCW above‐average risk for health, research is necessary and factors need be assessed. Aim To compare of German without PCC identify associated psychological social factors. Design Cross‐sectional study. Method Overall, 2816 participated (332 PCC). Measures were symptom sum score (PCSS), symptoms depression (Patient Questionnaire‐2), anxiety (Generalised Anxiety Disorder‐2) post‐traumatic stress disorder (PTSD) (Impact Event Scale‐6), work–family conflict (Work–Family Conflict Scale), support (ENRICHD Social Support Inventory), sense coherence (Sense Of Coherence‐3 Scale) working conditions. Group differences investigated. Multiple linear regression analysis was performed PCC. PCSS the dependent variable. Independent variables a.m. measures age, gender, occupational group migration background. Results exhibited higher values, medium effect sizes, depression, PTSD. Small sizes observed conflict, support, Higher scores anxiety, PTSD levels, lower Being a physician PCSS. Conclusion Lower resources may play role in reporting severe symptoms. Further investigate these interactions using biopsychosocial theory. Implication Profession This study can help understand design adjusted treatments protect minimise their Reporting complies Journal article standards quantitative psychology: The APA Publications Communications Board task force report (Data S1). Public Contribution Caregivers sample group.

Language: Английский

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Development of an expectation management intervention for patients with Long COVID: A focus group study with affected patients

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(2), P. e0317905 - e0317905

Published: Feb. 3, 2025

Background A significant number of individuals who have contracted SARS-CoV-2 report persistent somatic symptoms after the infection has resolved. Evidence-based treatment options for Long COVID are lacking to date. To ensure that an expectation management intervention, designed research project SOMA.COV, addresses relevant patient needs as well promote acceptance and adherence, a participatory approach was chosen. Objective The aim present study explore wishes patients with regarding preliminary version intervention thereby inform further development manual. Methods Twenty-two affected by participated in one four focus groups June July 2023. Participants were presented draft content four-session intervention. Feedback audio-recorded, transcribed, analyzed using thematic analysis. Results Thirteen themes relating main components manual developed. Large parts received overall positive feedback, including psychoeducation on biopsychosocial etiology condition, elements cognitive restructuring, imagination exercise. Patients’ response vicious circle fear behavior change exercise mixed. Modifications made patients’ feedback. Conclusion Patients provided feedback while also highlighting important adaptations necessary this group. results informed finalization within SOMA.COV project, which investigates effectiveness three-armed randomized controlled trial.

Language: Английский

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Assessment of psychosocial aspects in adults in post-COVID-19 condition: the EURONET-SOMA recommendations on core outcome domains for clinical and research use

BMC Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 11, 2025

Abstract Background Harmonizing core outcome domains allows for pooling data, comparing interventions, and streamlining research evaluation. At the same time clinicians require concise feasible measures routine practice. Considering heterogeneity of post-COVID-19 condition, a biopsychosocial approach requires sufficient coverage psychosocial dimension with assessments. Previous recommendations sets have serious limitations regarding aspects condition. This paper specifically focuses on outcomes adults providing both comprehensive set streamlined clinical tailored use. Methods In structured Consensus Development Approach, European Network to improve diagnostic, treatment, healthcare patients persistent somatic symptoms (EURONET-SOMA) developed assessments The experts identified variables instruments which should be considered in studies suffering from are setting relevant research. Results We three higher-order dimensions each encompassing several domains: first dimension, “outcomes”, encompasses (1) classification/ diagnostics (2) (including fatigue), (3) psychopathological status mental comorbidities, (4) physical (5) neurocognitive symptoms, (6) illness consequences. second domain “mechanisms” (7) cognitive components, (8) affective (9) behavioral (10) social (11) psychobiological bridge markers (e.g., neuroimmunological psychoneuroendocrinological variables). third domain, “risk factors”, includes factors such as (12) socioeconomic sociocultural factors, (13) pre-existing health issues, (14) personality neuroticism), (15) adverse childhood experiences, (16) ongoing disability or pension claim, (17) media For specific suggested purposes Conclusions recommended help increase consistency condition across investigations, synergies, facilitate decision-making when different interventional approaches. It better identify subgroups heterogeneous populations offering practical tools practice through set.

Language: Английский

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Prevalence, spectrum, and the relations between short-term and long-term post-acute sequelae of COVID-19 in children

Journal of microbiology epidemiology immunobiology, Journal Year: 2025, Volume and Issue: 102(1), P. 43 - 61

Published: March 30, 2025

Background. Data on the prevalence of post-COVID-19 condition (PCC) in children differ due to lack specific diagnostic criteria, reliable biomarkers, and limitations many studies. It is important study association between PCC, previous functional disorders, any events post-acute period COVID-19 estimate true burden PCC children. The aim. To determine relation initial disorders during year after a mild form acute respiratory tract infections (ARTI) other etiologies. Materials methods. prospective using continuous sampling method included under 18 years age hospitalized with suspected COVID-19, whom was confirmed by RT-PCR (n = 121) or excluded molecular serological methods (ARTI group, n 105). Information patients collected from September 2020 December 2021 questionnaires at index points: hospital discharge 1, 3, 6 12 months. Severe chronic diseases were excluded. Functional anamnesis associated health observation, severity symptoms taken into account. analysis performed groups ≥ age. Symptoms grouped clusters. Results. Any identified frequency 32–39% (in ≥6 years, respectively). most common psycho-emotional, autonomic dysfunction (AD) cluster. cases duration 3–6 After adjustment for age, AD history recurrent ARTI episodes, no difference found symptom clusters except hyposmia, incidence which decreased 14.3% first point 2.4% one year. Among without an year, de novo rare phenomenon (2.7–8.0%) differences controls. risks significantly increased (adjusted OR 1 month 3.19 (95% CI 1.89–5.38), months 3.33 1.81–6.15)). Multiple (5–25) persistent (at all points) rated as significant occurred rarely (1.7% 0.4–4.9)), but more often — 25%) 95% 13.6–39.6%) (difference 23.3% (10.9–35.7%), 14.8 (4.4–50.6), p 0.001). Recurrent episodes risk factor increase cognitive cluster complaints vagotonic observation. Conclusion. results obtained indirectly support concept that somatoform disorder, probably sociogenic nature, who are anxious baseline. Some consequences really need medical psychosocial rehabilitation. provides new insights widespread viral infections.

Language: Английский

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Fatigue and perceived fatigability, not objective fatigability, are prevalent in people with post-COVID-19

Experimental Brain Research, Journal Year: 2022, Volume and Issue: 241(1), P. 211 - 219

Published: Dec. 3, 2022

Language: Английский

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Psychological burden associated with incident persistent symptoms and their evolution during the COVID-19 pandemic: a prospective population-based study

BMJ Mental Health, Journal Year: 2024, Volume and Issue: 27(1), P. e300907 - e300907

Published: Jan. 1, 2024

Background Identifying factors that predict the course of persistent symptoms occurred during COVID-19 pandemic is a public health issue. Modifiable could be targeted in therapeutic interventions. Objective This prospective study based on population-based CONSTANCES cohort examined whether psychological burden associated with incident (ie, first from March 2020) would having ≥1 symptom 6–10 months later. Methods A total 8424 participants (mean age=54.6 years (SD=12.6), 57.2% women) at baseline between December 2020 and February 2021) were included. The these was assessed Somatic Symptom Disorder-B Criteria Scale (SSD-12). outcome follow-up. Adjusted binary logistic regression models association SSD-12 score outcome. Findings At follow-up, 1124 (13.3%) still had symptom. follow-up both (OR (95% CI) for one IQR increase: 1.42 (1.09 to 1.84)) without SARS-CoV-2 infection prior (1.39 (1.25 1.55)). Female gender, older age, poorer self-rated also Conclusions predicted presence regardless baseline. Clinical implications Intervention studies should test reducing improve symptoms.

Language: Английский

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