Therapiemöglichkeiten der Depression nach Non-Response DOI
Henrik Walter, Raoul Haaf, Stephan Köhler

et al.

Nervenheilkunde, Journal Year: 2023, Volume and Issue: 42(07/08), P. 419 - 429

Published: June 1, 2023

ZUSAMMENFASSUNG Die unipolare Depression stellt eine der häufigsten psychiatrischen Erkrankungen dar. Ein beträchtlicher Prozentsatz Menschen, die an einer leiden, erfahren trotz leitliniengerechter Ersttherapie mittels moderner psychopharmakologischer und/oder psychotherapeutischer Verfahren keine ausreichende Linderung ihrer Symptome. Therapie von Patienten mit „therapieresistenten“ oder „schwer zu behandelnden“ daher häufige Herausforderung in alltäglichen Praxis Anders als Terminus „therapieresistent“ suggeriert, existieren jedoch Vielzahl evidenzbasierten Therapieoptionen, bei unzureichendem Ansprechen auf Standardtherapie Antidepressivum und Psychotherapie eingesetzt werden können. Mittels selektiver Literaturrecherche unter Bezugnahme kürzlich veröffentlichte 3. Version Deutschen S3-Leitlinie zur gibt vorliegender Artikel einen Überblick über weitere Therapieoptionen sowie Basismaßnahmen jenseits Standardtherapien unipolaren Depression.

Ethics of Psychiatric Neurosurgery DOI
Sabine Müller

˜The œInternational Library of Bioethics, Journal Year: 2025, Volume and Issue: unknown, P. 469 - 491

Published: Jan. 1, 2025

Language: Английский

Citations

0
Optogenetic behavioral studies in depression research: A systematic review DOI Creative Commons

Anika Spreen,

Dana Alkhoury,

Henrik Walter

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(5), P. 109776 - 109776

Published: April 18, 2024

Optogenetics has made substantial contributions to our understanding of the mechanistic underpinnings depression. This systematic review employs quantitative analysis investigate impact optogenetic stimulation in mice and rats on behavioral alterations social interaction, sucrose consumption, mobility. The analyses studies using standardized tests detect changes induced via stressed or stress-naive rats. Behavioral were evaluated as either positive, negative, not effective. comprises outcomes 248 168 described 37 articles, including negative null results. Test compared for each behavior, depending animal cohort, applied type stimulated neuronal circuit cell type. presented synthesis contributes toward a comprehensive picture research context

Language: Английский

Citations

2
Clinical outcomes of deep brain stimulation for obsessive‐compulsive disorder: Insight as a predictor of symptom changes DOI Creative Commons
Nicola Acevedo, Susan L. Rossell, David Castle

et al.

Psychiatry and Clinical Neurosciences, Journal Year: 2023, Volume and Issue: 78(2), P. 131 - 141

Published: Nov. 21, 2023

Deep brain stimulation (DBS) is a safe and effective treatment option for people with refractory obsessive-compulsive disorder (OCD). Yet our understanding of predictors response prognostic factors remains rudimentary, long-term comprehensive follow-ups are lacking. We aim to investigate the efficacy DBS therapy OCD patients, clinical response.

Language: Английский

Citations

4
Neuroablative Intervention for Refractory Obsessive-Compulsive Disorder DOI Open Access
Jhin Goo Chang, Se Joo Kim, Chan‐Hyung Kim

et al.

Psychiatry Investigation, Journal Year: 2023, Volume and Issue: 20(11), P. 997 - 1006

Published: Nov. 22, 2023

Objective This review aims to investigate the progression of neuroablation, along with documented clinical efficacy and safety, in management treatment-resistant obsessive-compulsive disorder (OCD).Methods We searched compiled research results neuroablation therapy reported date. extracted outcomes related efficacy, side effects, surgical complications. Additionally, we summarized key claims findings.Results Neuroablative intervention is a potential treatment approach for refractory OCD. Recent advancements, such as real-time magnetic resonance monitoring minimally invasive techniques employing ultrasound laser, offer distinct advantages terms safety comparative when compared conventional methods. However, absence randomized controlled trials long-term outcome data underscores need cautious consideration selecting neuroablation.Conclusion shows promise OCD, but vigilant essential both patient selection method choices due rare yet serious

Language: Английский

Citations

2
The promise and challenges of transcranial magnetic stimulation and deep brain stimulation as therapeutic options for obsessive-compulsive disorder DOI
Nicola Acevedo, David Castle, Susan L. Rossell

et al.

Expert Review of Neurotherapeutics, Journal Year: 2024, Volume and Issue: 24(2), P. 145 - 158

Published: Jan. 22, 2024

Introduction Obsessive compulsive disorder (OCD) represents a complex and often difficult to treat disorder. Pharmacological psychotherapeutic interventions are associated with sub-optimal outcomes, 40–60% of patients resistant first line therapies thus left few treatment options. OCD is underpinned by aberrant neurocircuitry within cortical, striatal, thalamic brain networks. Considering the impairments that underlie symptomology, neurostimulation provide an opportunity modulate psychopathology in personalized manner. Also, probing pathological neural networks, enhanced understanding disease states can be obtained.

Language: Английский

Citations

0
The persistent value of lesions in psychiatric neurosurgery DOI

Hael Abdulrazeq,

Alexander P. Philips, Rahul A. Sastry

et al.

The Lancet Psychiatry, Journal Year: 2024, Volume and Issue: 11(12), P. 1022 - 1029

Published: June 18, 2024

Language: Английский

Citations

0
Psychosurgery DOI

Rena Far,

Zelma H. T. Kiss

Published: Jan. 1, 2024

Citations

0
Gamma knife radiosurgery in psychiatry: a review DOI Creative Commons
Robert Kwinta, Katarzyna Kopcik, Agnieszka Koberling

et al.

European Journal of Translational and Clinical Medicine, Journal Year: 2024, Volume and Issue: 7(1), P. 87 - 96

Published: May 6, 2024

Gamma knife radiosurgery (GKRS) is a minimally invasive technique frequently employed in neurosurgery or oncology, and it has applications psychiatric patients as well. While commonly used conditions like obsessive-compulsive disorder, GKRS also efficacy treating major depression generalized anxiety autism spectrum disorder anorexia nervosa. Promising outcomes have been observed, particularly cases resistant to conventional treatment, leading significant improvements the patients' quality of life. Severe adverse effects from procedures are rare. To enhance our understanding utilization psychiatry, further extensive research, especially through double-blinded studies involving larger cohorts, imperative. Determining ideal volume radiation dose for radiosurgical capsulotomy remains key topic research. When comes neurosurgical procedures, decision-making process should be personalized each patient, taking all relevant factors into consideration.

Language: Английский

Citations

0
Call to revise the Royal Australian and New Zealand College of Psychiatrists’ clinical memorandum on deep brain stimulation for obsessive-compulsive disorder DOI Creative Commons
Nicola Acevedo, David Castle, Peter Bosanac

et al.

Australian & New Zealand Journal of Psychiatry, Journal Year: 2023, Volume and Issue: 57(10), P. 1304 - 1307

Published: July 3, 2023

Language: Английский

Citations

1
Therapiemöglichkeiten der Depression nach Non-Response DOI
Henrik Walter, Raoul Haaf, Stephan Köhler

et al.

Nervenheilkunde, Journal Year: 2023, Volume and Issue: 42(07/08), P. 419 - 429

Published: June 1, 2023

ZUSAMMENFASSUNG Die unipolare Depression stellt eine der häufigsten psychiatrischen Erkrankungen dar. Ein beträchtlicher Prozentsatz Menschen, die an einer leiden, erfahren trotz leitliniengerechter Ersttherapie mittels moderner psychopharmakologischer und/oder psychotherapeutischer Verfahren keine ausreichende Linderung ihrer Symptome. Therapie von Patienten mit „therapieresistenten“ oder „schwer zu behandelnden“ daher häufige Herausforderung in alltäglichen Praxis Anders als Terminus „therapieresistent“ suggeriert, existieren jedoch Vielzahl evidenzbasierten Therapieoptionen, bei unzureichendem Ansprechen auf Standardtherapie Antidepressivum und Psychotherapie eingesetzt werden können. Mittels selektiver Literaturrecherche unter Bezugnahme kürzlich veröffentlichte 3. Version Deutschen S3-Leitlinie zur gibt vorliegender Artikel einen Überblick über weitere Therapieoptionen sowie Basismaßnahmen jenseits Standardtherapien unipolaren Depression.

Citations

1