Chinese Journal of Lasers, Journal Year: 2024, Volume and Issue: 51(21), P. 2107101 - 2107101
Published: Jan. 1, 2024
Materials Today Bio, Journal Year: 2024, Volume and Issue: 26, P. 101028 - 101028
Published: March 24, 2024
The expansion applications of semiconducting polymer dots (Pdots) among optical nanomaterial field have long posed a challenge for researchers, promoting their intelligent application in multifunctional nano-imaging systems and integrated nanomedicine carriers diagnosis treatment. Despite notable progress, several inadequacies still persist the Pdots, including development simplified near-infrared (NIR) nanoprobes, elucidation inherent biological behavior, integration information processing nanotechnology into biomedical applications. This review aims to comprehensively elucidate current status Pdots as classical nanophotonic material by discussing its advantages limitations terms biocompatibility, adaptability microenvironments vivo, etc. Multifunctional surface chemistry play crucial roles realizing Pdots. Information visualization based on physicochemical properties is pivotal achieving detection, sensing, labeling probes. Therefore, we refined underlying mechanisms constructed multiple comprehensive original mechanism summaries establish benchmark. Additionally, explored cross-linking interactions between nanomedicine, potential yet complete metabolic pathways, future research directions, innovative solutions integrating treatment strategies. presents possible expectations valuable insights advancing specifically from chemical, medical, photophysical practitioners' standpoints.
Language: Английский
Citations
8
Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1317, P. 139086 - 139086
Published: June 21, 2024
Language: Английский
Citations
5
Dyes and Pigments, Journal Year: 2025, Volume and Issue: 236, P. 112688 - 112688
Published: Feb. 4, 2025
Language: Английский
Citations
0
Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 210, P. 115330 - 115330
Published: May 10, 2024
Language: Английский
Citations
3
Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 266, P. 116684 - 116684
Published: Aug. 18, 2024
Language: Английский
Citations
3
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 2, 2025
ABSTRACT Rhodamine dyes are widely used fluorophores in super-resolution fluorescence imaging due to their exceptional optical properties and “aggregation-disaggregation” induced fluorogenic activation. However, excessive lipophilicity often reduces brightness aqueous environments causes off-target staining, limiting effectiveness high-resolution imaging. To address these challenges, we introduce an ether-decorated N-terminal modification strategy for rhodamine silicon-rhodamine (Si-rhodamine), replacing conventional N-alkyl groups. The ether chains enhance water solubility, decrease aggregate size, improve fluorogenicity across a wide concentration range. Their flexible, hydrophilic structure forms protective shield around the xanthene core, minimizing dye-water interactions reducing quenching. Additionally, inductive effect of decreases electron-donating strength amino groups, suppressing quenching caused by twisted intramolecular charge transfer (TICT). These modifications collectively increase quantum yields ER ESiR from 0.35 0.19 (for tetraethyl-substituted analogs) 0.70 0.41, respectively. Probes derived exhibit outstanding fluorogenicity, enhanced signal-to-noise ratios, improved resolution complex environments, demonstrating superior performance advanced techniques such as structured illumination microscopy (SIM), stimulated emission depletion (STED) microscopy, single-molecule localization (SMLM). This work introduces innovative fluorophore design, offering significant advancements applications.
Language: Английский
Citations
0
Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 150, P. 107554 - 107554
Published: June 10, 2024
Language: Английский
Citations
1
Royal Society of Chemistry eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 271 - 292
Published: Oct. 31, 2024
Proteins play a crucial role in shaping cellular processes, requiring accurate recognition, imaging, and dynamic tracking for understanding complex biological networks. The evolution of protein labeling, progressing from covalent coupling to advanced methodologies like click chemistry, genetically encoded tags, proximity has provided unprecedented attributes. Fluorescent which relies heavily on diverse technologies, predominantly employs organic dye-based fluorophores expanded beyond mere tagging proteins. This chapter explores the significance fluorogenic probes emphasizing their achieving efficient, high resolution, wash-free imaging. journey into mechanisms, specificities, advantages reveals as essential allies precision visualizing functions.
Language: Английский
Citations
0
Dyes and Pigments, Journal Year: 2024, Volume and Issue: 233, P. 112541 - 112541
Published: Nov. 13, 2024
Language: Английский
Citations
0
Chinese Journal of Lasers, Journal Year: 2024, Volume and Issue: 51(21), P. 2107101 - 2107101
Published: Jan. 1, 2024
Citations
0