Social Experience Shapes Fighting Strategies for Reproductive Success DOI Open Access

Can Gao,

Mingze Ma, Jie Chen

et al.

Published: Dec. 13, 2024

Social isolation generally increases aggression but decreases mating competition, resulting in an intricate and ambiguous relationship between social experience, aggression, reproductive success. In male Drosophila , is often characterized by lunging, a frequent comparatively gentle combat behavior. Here, we establish behavioral paradigm for studying less more vigorous fighting form known as tussling. We discover that while enrichment aligning with past observations, it heightens the forceful tussling These two forms of rely on different olfactory receptor neurons, specifically Or67d lunging Or47b further identify three pairs central pC1 neurons promote Moreover, shifting from to socially enriched males facilitates better territory control success, mitigating disadvantages associated aging. findings reveal how experience shapes strategies optimize

Language: Английский

Sexually dimorphic dopaminergic circuits determine sex preference DOI
Anqi Wei,

Anran Zhao,

Chaowen Zheng

et al.

Science, Journal Year: 2025, Volume and Issue: 387(6730)

Published: Jan. 9, 2025

Sociosexual preference is critical for reproduction and survival. However, neural mechanisms encoding social decisions on sex remain unclear. In this study, we show that both male female mice exhibit but shift to when facing survival threats; their mediated by the dimorphic changes in excitability of ventral tegmental area dopaminergic (VTA DA ) neurons. males, VTA projections nucleus accumbens (NAc) mediate preference, those medial preoptic preference. females, firing-pattern (phasic-like versus tonic-like) alteration -NAc projection determines sociosexual preferences. These findings define neurons as a key node decision-making reveal sexually circuit underlying

Language: Английский

Citations

7
GABAB Receptor: Structure, Biological Functions, and Therapy for Diseases DOI Creative Commons
Weijie Xie, Yuan Li, Xinyue Wang

et al.

MedComm, Journal Year: 2025, Volume and Issue: 6(5)

Published: April 16, 2025

ABSTRACT Gamma‐aminobutyric acid (GABA) B receptors (GABA Rs) that acts slowly and maintains the inhibitory tone are versatile regulators in complex nervous behaviors their involvement various neuropsychiatric disorders, such as anxiety, epilepsy, pain, drug addiction, Alzheimer's disease. Additional study advances have implied crucial roles of GABA Rs regulating feeding‐related behaviors, yet therapeutic potential addressing binge eating, disorders remains underutilized. This general review summarized physiological structure functions R, explored regulation psychiatric feeding metabolism fully discussed targeting its regulator‐binding sites for treatment different eating even obesity. While agonists directly bind to R1 some negative side effects, positive allosteric modulators (PAMs) R2 demonstrate excellent efficacy tolerability better safety indexes. Moreover, phosphorylation downstream may be novel targets Further studies, clinical trials particular, will essential confirming value PAMs other agents R pathways a setting.

Language: Английский

Citations

1
A hypothalamic-amygdala circuit underlying sexually dimorphic aggression DOI
Zhenggang Zhu,

Lu Miao,

Kaiyuan Li

et al.

Neuron, Journal Year: 2024, Volume and Issue: 112(18), P. 3176 - 3191.e7

Published: July 16, 2024

Language: Английский

Citations

8
A neural pathway for social modulation of spontaneous locomotor activity (SoMo-SLA) in Drosophila DOI
H. W. Zhao, Xinyu Jiang, Mingze Ma

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(9)

Published: Feb. 23, 2024

Social enrichment or social isolation affects a range of innate behaviors, such as sex, aggression, and sleep, but whether there is shared mechanism not clear. Here, we report neural underlying modulation spontaneous locomotor activity (SoMo-SLA), an internal-driven behavior indicative internal states. We find that specifically reduces in male flies. identify neuropeptides Diuretic hormone 44 (DH44) Tachykinin (TK) to be up- down-regulated by necessary for SoMo-SLA. further demonstrate sexually dimorphic circuit, which the male-specific P1 neurons encoding states form positive feedback with interneurons coexpressing doublesex ( dsx ) Tk promote locomotion, while also negative DH44 inhibit locomotion. These two opposing neuromodulatory recurrent circuits represent potentially common underlies regulation multiple behaviors.

Language: Английский

Citations

7
Microplastic exposure disturbs sleep structure, reduces lifespan, and decreases ovary size in <i>Drosophila</i> <i>melanogaster</i> DOI
Wei Yan, Zijie Li, Ziyi Lin

et al.

动物学研究, Journal Year: 2024, Volume and Issue: 45(4), P. 805 - 820

Published: Jan. 1, 2024

The organ-specific toxicity resulting from microplastic (MP) exposure has been extensively explored, particularly concerning the gut, liver, testis, and lung. However, under natural conditions, these effects are not restricted to specific organs or tissues. Investigating whether MP presents a systemic threat an entire organism, impacting factors such as lifespan, sleep, fecundity, is essential. In this study, we investigated of dietary two different doses MPs (1-5 μm) using terrestrial model organism

Language: Английский

Citations

5
Bio-Inspired Design of Superconducting Spiking Neuron and Synapse DOI Creative Commons
Andrey E. Schegolev, N. V. Klenov, Georgy I. Gubochkin

et al.

Nanomaterials, Journal Year: 2023, Volume and Issue: 13(14), P. 2101 - 2101

Published: July 19, 2023

The imitative modelling of processes in the brain living beings is an ambitious task. However, advances complexity existing hardware models are limited by their low speed and high energy consumption. A superconducting circuit with Josephson junctions closely mimics neuronal membrane channels involved operation sodium-potassium pump. dynamic such a system characterised duration picoseconds level attojoules. In this work, two biological neuron studied. New modes identified, including so-called bursting mode, which plays important role neural networks. possibility switching between different situ shown, providing control system. synaptic connection that short-term potentiation synapse developed demonstrated. Finally, simplest two-neuron chain comprising proposed bio-inspired components simulated, prospects biosimilars briefly discussed.

Language: Английский

Citations

12
A neural pathway underlying hunger modulation of sexual receptivity in Drosophila females DOI Creative Commons
Mengshi Sun, Mingze Ma, Bowen Deng

et al.

Cell Reports, Journal Year: 2023, Volume and Issue: 42(10), P. 113243 - 113243

Published: Oct. 1, 2023

Accepting or rejecting a mate is one of the most crucial decisions female will make, especially when faced with food shortage. Previous studies have identified core neural circuity from sensing male courtship mating status to decision-making for sexual receptivity in Drosophila females, but how hunger and satiety states modulate poorly understood. Here, we identify circuit its neuromodulation underlying modulation receptivity. We find that adipokinetic hormone receptor (AkhR)-expressing neurons inhibit starvation-dependent manner. AkhR are octopaminergic act on subset Octβ1R-expressing LH421 neurons. Knocking down Octβ1R expression eliminates starvation-induced suppression further sex-promoting pC1 via GABA-resistant dieldrin (Rdl) signaling. also integrate stimulation thus serve as common integrator multiple internal external cues decision-making.

Language: Английский

Citations

12
Molecular and cellular origins of behavioral sex differences: a tiny little fly tells a lot DOI Creative Commons
Kosei Sato,

Daisuke Yamamoto

Frontiers in Molecular Neuroscience, Journal Year: 2023, Volume and Issue: 16

Published: Oct. 16, 2023

Behavioral sex differences primarily derive from the sexually dimorphic organization of neural circuits that direct behavior. In Drosophila melanogaster , sex-determination genes fruitless ( fru ) and doublesex dsx play pivotal roles in producing sexual dimorphism for Here we examine three groups expressing and/or i.e., P1 cluster, aSP-f aSP-g cluster pairs aDN which causal relationships between behavior characteristics are best illustrated. aSP-f, clusters represent examples where or switches cell-autonomously their neurite structures female-type male-type. Processed sensory inputs impinging on these neurons may result outputs encode different valences, culminate execution distinct according to sex. contrast, is male-specific as its female counterpart undergoes -driven cell death, lowers threshold induction behaviors. We propose products genes, terminal selectors neuronal wiring, induce maintain sex-typical chromatin state at postembryonic stages, orchestrating transcription effector shape single neuron govern survival death.

Language: Английский

Citations

11
Why it hurts: with freedom comes the biological need for pain DOI
Keith D. Farnsworth, Robert W. Elwood

Animal Cognition, Journal Year: 2023, Volume and Issue: 26(4), P. 1259 - 1275

Published: April 8, 2023

Language: Английский

Citations

10
A hormone-to-neuropeptide pathway inhibits sexual receptivity in immature Drosophila females DOI Creative Commons
Jie Chen, Pei‐Wen Zhu,

Sihui Jin

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(8)

Published: Feb. 21, 2025

Newborns, typically asexual, undergo a process of sexual transition to reach maturity, but the regulatory mechanism underlying this is not clear. Here, we studied how female behavior modulated during by hormones and neuromodulators in Drosophila . We found that neuropeptide Leucokinin (LK) inhibits receptivity specifically period immature females, younger or mature females. Moreover, steroid hormone ecdysone, which mainly synthesized ovary maturation, acts on LK neurons via ecdysone receptor suppress receptivity. further suppresses through its LKR central pC1 neurons, decision center for behavior. These findings reveal hormone-to-neuropeptide pathway maturation , shedding light coordinate development behaviors.

Language: Английский

Citations

0