Tetramethylpyrazine nitrone exerts neuroprotection via activation of PGC-1α/Nrf2 pathway in Parkinson’s disease models

Journal of Advanced Research, Journal Year: 2023, Volume and Issue: 64, P. 195 - 211

Published: Nov. 19, 2023

Parkinson's disease (PD) is common neurodegenerative where oxidative stress and mitochondrial dysfunction play important roles in its progression. Tetramethylpyrazine nitrone (TBN), a potent free radical scavenger, has shown protective effects various neurological conditions. However, the neuroprotective mechanisms of TBN PD models remain unclear.

Language: Английский

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Autophagy and UPS pathway contribute to nicotine-induced protection effect in Parkinson’s disease

Experimental Brain Research, Journal Year: 2024, Volume and Issue: 242(4), P. 971 - 986

Published: March 2, 2024

Language: Английский

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Calcium Deregulation in Neurodegeneration and Neuroinflammation in Parkinson’s Disease: Role of Calcium-Storing Organelles and Sodium–Calcium Exchanger

Cells, Journal Year: 2024, Volume and Issue: 13(15), P. 1301 - 1301

Published: Aug. 4, 2024

Parkinson’s disease (PD) is a progressive neurodegenerative disorder that lacks effective treatment strategies to halt or delay its progression. The homeostasis of Ca2+ ions crucial for ensuring optimal cellular functions and survival, especially neuronal cells. In the context PD, systems regulating are compromised, leading Ca2+-dependent synaptic dysfunction, impaired plasticity, ultimately, loss. Recent research efforts directed toward understanding pathology PD have yielded significant insights, particularly highlighting close relationship between dysregulation, neuroinflammation, neurodegeneration. However, precise mechanisms driving selective loss dopaminergic neurons in remain elusive. disruption key factor, engaging various neuroinflammatory pathways affecting intracellular organelles store Ca2+. Specifically, functioning mitochondria, lysosomes, endoplasmic reticulum (ER) metabolism believed contribute disease’s pathophysiology. Na+-Ca2+ exchanger (NCX) considered an important regulator cell types, including neurons, astrocytes, microglia. Alterations NCX activity associated with processes different models PD. this review, we will explore role dysregulation neuroinflammation as primary drivers PD-related neurodegeneration, emphasis on pivotal Consequently, NCXs their interplay may emerge potentially players underlying providing promising avenue therapeutic intervention aimed at halting

Language: Английский

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Drug Development for Alzheimer’s and Parkinson’s Disease: Where Do We Go Now?

Published: April 5, 2024

Neurodegenerative diseases (NDs) are a set of progressive, chronic, and incurable characterized by the gradual loss neurons, culminating in decline cognitive and/or motor functions. Alzheimer’s disease (AD) Parkinson’s (PD) most common NDs represent an enormous burden both terms human suffering economic cost. The available therapies for AD PD only provide symptomatic palliative relief limited period unable to modify diseases’ progression. Over last decades, research efforts have been focused on developing new pharmacological treatments these NDs. However, date, no breakthrough treatment has discovered. Hence, development disease-modifying drugs able halt or reverse progression remains unmet clinical need. This review summarizes major hallmarks treatment. It also sheds light potential directions that can be pursued develop new, treat PD, thereby decreasing social burdens linked

Language: Английский

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Research progress on the protection and mechanism of active peptides in Alzheimer's disease and Parkinson's disease

Neuropeptides, Journal Year: 2024, Volume and Issue: 107, P. 102457 - 102457

Published: July 25, 2024

Language: Английский

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