A Parabrachial to Hypothalamic Pathway Mediates Defensive Behavior DOI Creative Commons
Fan Wang, Yuge Chen, Yuxin Lin

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: June 1, 2022

Abstract Defensive behaviors are critical for animal’s survival. Both the paraventricular nucleus of hypothalamus (PVN) and parabrachial (PBN) have been shown to be involved in defensive behaviors. However, whether there direct connections between them mediate remains unclear. Here, by retrograde anterograde tracing, we uncover that cholecystokinin (CCK)-expressing neurons lateral PBN (LPB CCK ) directly project PVN. By vivo fiber photometry recording, found LPB actively respond various threat stimuli. Selective photoactivation promotes aversion Conversely, photoinhibition attenuates rat or looming stimuli-induced flight responses. Optogenetic activation axon terminals within PVN glutamatergic promote Whereas chemogenetic pharmacological inhibition local prevent -PVN pathway activation-driven These data suggest recruit downstream engage Our study identifies a previously unrecognized role controlling

Language: Английский

Sexually dimorphic dopaminergic circuits determine sex preference DOI
Anqi Wei,

Anran Zhao,

Chaowen Zheng

et al.

Science, Journal Year: 2025, Volume and Issue: 387(6730)

Published: Jan. 9, 2025

Sociosexual preference is critical for reproduction and survival. However, neural mechanisms encoding social decisions on sex remain unclear. In this study, we show that both male female mice exhibit but shift to when facing survival threats; their mediated by the dimorphic changes in excitability of ventral tegmental area dopaminergic (VTA DA ) neurons. males, VTA projections nucleus accumbens (NAc) mediate preference, those medial preoptic preference. females, firing-pattern (phasic-like versus tonic-like) alteration -NAc projection determines sociosexual preferences. These findings define neurons as a key node decision-making reveal sexually circuit underlying

Language: Английский

Citations

10
Glutamatergic Projection from the Ventral Tegmental Area to the Zona Incerta Regulates Fear Response DOI
Xinyi Wang, Hongquan Zhang,

Kun Tong

et al.

Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

Citations

7
Neurons for infant social behaviors in the mouse zona incerta DOI
Yuexuan Li, Zhong Wu Liu, Gustavo M. Santana

et al.

Science, Journal Year: 2024, Volume and Issue: 385(6707), P. 409 - 416

Published: July 25, 2024

Understanding the neural basis of infant social behaviors is crucial for elucidating mechanisms early and emotional development. In this work, we report a specific population somatostatin-expressing neurons in zona incerta (ZI

Language: Английский

Citations

7
Targeting the insular cortex for neuropathic pain modulation: Insights into synaptic and neuronal mechanisms DOI Creative Commons
Kyeongmin Kim, Guanghai Nan, Hee Young Kim

et al.

The FASEB Journal, Journal Year: 2025, Volume and Issue: 39(2)

Published: Jan. 20, 2025

Abstract Neuropathic pain, caused by nerve damage, greatly affects quality of life. Recent research proposes modulating brain activity, particularly through electrical stimulation the insular cortex (IC), as a treatment option. This study aimed to understand how IC (ICS) pain modulation. In rat neuropathy model, researchers used optogenetic and ICS techniques evaluate changes in mechanical allodynia synaptic changes, focusing on glutamate receptors (AMPAR, NR2A, NR2B). Optogenetic inhibition neurons relieved without altering plasticity. However, repetitive combined with activation diminished pain‐relieving effects increased AMPAR NR2B receptor levels. Additionally, activating inhibitory also reduced while excitatory lessened effectiveness was associated heightened expression. These findings suggest that inhibiting or could help modulate neuropathic conditions, shedding light can influence management

Language: Английский

Citations

1
A parabrachial to hypothalamic pathway mediates defensive behavior DOI Creative Commons
Fan Wang, Yuge Chen, Yuxin Lin

et al.

eLife, Journal Year: 2023, Volume and Issue: 12

Published: March 17, 2023

Defensive behaviors are critical for animal’s survival. Both the paraventricular nucleus of hypothalamus (PVN) and parabrachial (PBN) have been shown to be involved in defensive behaviors. However, whether there direct connections between them mediate remains unclear. Here, by retrograde anterograde tracing, we uncover that cholecystokinin (CCK)-expressing neurons lateral PBN (LPB CCK ) directly project PVN. By vivo fiber photometry recording, find LPB actively respond various threat stimuli. Selective photoactivation promotes aversion Conversely, photoinhibition attenuates rat or looming stimuli-induced flight responses. Optogenetic activation axon terminals within PVN glutamatergic Whereas chemogenetic pharmacological inhibition local prevent -PVN pathway activation-driven These data suggest recruit downstream engage Our study identifies a previously unrecognized role controlling

Language: Английский

Citations

14
Disentangling the identity of the zona incerta: a review of the known connections and latest implications DOI Creative Commons

Giulia Arena,

Fabrizio Londei, Francesco Ceccarelli

et al.

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 93, P. 102140 - 102140

Published: Nov. 24, 2023

The zona incerta (ZI) is a subthalamic region composed by loosely packed neurochemically mixed neurons, juxtaposed to the main ascending and descending bundles. extreme neurochemical diversity that characterizes this area, together with diffuseness of its connections entire neuraxis hard-to-reach positioning in brain caused ZI keep halo mystery for over century. However, last decades, rich albeit fragmentary body knowledge regarding both incertal anatomical functional implications has been built mostly based on rodent studies lack cohesion makes difficult depict an integrated, exhaustive picture roles. This review aims provide unified resource summarizes current profile interactions rodents non-human primates significance connections, highlighting aspects still unbeknown research.

Language: Английский

Citations

14
Mapping the topographic organization of the human zona incerta using diffusion MRI DOI Open Access
Roy A.M. Haast, Jason Kai, Alaa Taha

et al.

Published: Feb. 3, 2025

The zona incerta (ZI) is a deep brain region originally described by Auguste Forel as an “immensely confusing area about which nothing can be said.” Despite the elusive nature of this structure, mounting evidence supports role ZI and surrounding regions across diverse range functions candidate target for neuromodulatory therapies. Using in vivo diffusion MRI data-driven connectivity, we identify topographic organization between neocortex. Specifically, our methods rostral-caudal gradient predominantly connecting frontopolar ventral prefrontal cortices with rostral ZI, primary sensorimotor caudal ZI. Moreover, demonstrate how clustering approaches build complementary including facilitating mapping central connected dorsal cortex. These results were shown to replicable multiple datasets at individual subject level, building important mediating frontal lobe-associated tasks, ranging from motor cognitive emotional control. Finally, consider impact on refinement targets. pave way increasingly detailed understanding substructures, considerations targeting neuromodulation.

Language: Английский

Citations

0
Mapping the topographic organization of the human zona incerta using diffusion MRI DOI Open Access
Roy A.M. Haast, Jason Kai, Alaa Taha

et al.

Published: Feb. 3, 2025

The zona incerta (ZI) is a deep brain region originally described by Auguste Forel as an “immensely confusing area about which nothing can be said.” Despite the elusive nature of this structure, mounting evidence supports role ZI and surrounding regions across diverse range functions candidate target for neuromodulatory therapies. Using in vivo diffusion MRI data-driven connectivity, we identify topographic organization between neocortex. Specifically, our methods rostral-caudal gradient predominantly connecting frontopolar ventral prefrontal cortices with rostral ZI, primary sensorimotor caudal ZI. Moreover, demonstrate how clustering approaches build complementary including facilitating mapping central connected dorsal cortex. These results were shown to replicable multiple datasets at individual subject level, building important mediating frontal lobe-associated tasks, ranging from motor cognitive emotional control. Finally, consider impact on refinement targets. pave way increasingly detailed understanding substructures, considerations targeting neuromodulation.

Language: Английский

Citations

0
Zona Incerta: A Bridge for Infant-Mother Interaction DOI
Ya-Wen Huang, Jun Wang, Na Liu

et al.

Neuroscience Bulletin, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Language: Английский

Citations

0
Defense or death? A review of the neural mechanisms underlying sensory modality-triggered innate defensive behaviors DOI

Huating Gu,

Fan Zhao, Zhihui Liu

et al.

Current Opinion in Neurobiology, Journal Year: 2025, Volume and Issue: 92, P. 102977 - 102977

Published: Feb. 27, 2025

Language: Английский

Citations

0