Neuroimaging characteristics of pruritus induced by eczema: An fMRI study DOI Creative Commons
Xiangyu Wei,

Larissa Tao,

Tae‐Eun Kim

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 14, 2023

Abstract Objective : To explore the neuroimaging characteristics of eczema-induced pruritus with resting-state functional Magnetic Resonance Imaging (rs-fMRI). Methods 42 patients eczema were recruited in PE group, and healthy participants included HC group. The Visual Analogue Score (VAS), 12-Item Pruritus Severity Scale (12-PSS), Pittsburgh Sleep Quality Index (PSQI) Self-rating Anxiety (SAS) recorded different values fraction Amplitude Low Frequency Fluctuation (fALFF) connectivity(FC) compared after rs-fMRI scanning. Results: Compared fALFF left precentral gyrus, postcentral supplementary motor area (SMA) midcingulate cortex group increased. FC between gyrus bilateral superior temporal hippocampus, inferior occipital decreased. SMA 12-PSS score was positively correlated value gyrus. Conclusion: caused increased spontaneous activity given cerebral regions, involving perception itch, control scratching movements, expression itch-related emotions. Simultaneously, aberrant result corresponding alterations networks, primarily characterized by a decrease symmetry such as hippocampus. Meanwhile, there is correlation regions clinical scales, which provided potential neurobiological markers for future study pruritus.

Language: Английский

The projection from the rostral anterior cingulate cortex to the ventral tegmental area regulates 5-HT-induced itch aversion and scratching in rats DOI Creative Commons

Jun-Fei Teng,

Xingyu Lu,

Jun-hui Long

et al.

Neurobiology of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 106844 - 106844

Published: Feb. 1, 2025

Language: Английский

Citations

1

Orexin neurons play contrasting roles in itch and pain neural processing via projecting to the periaqueductal gray DOI Creative Commons
Tatsuroh Kaneko,

Asuka Oura,

Yoshiki Imai

et al.

Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: March 8, 2024

Abstract Pain and itch are recognized as antagonistically regulated sensations; pain suppresses itch, whilst inhibition enhances itch. The neural mechanisms at the central nervous system (CNS) underlying these pain-itch interactions still need to be explored. Here, we revealed contrasting role of orexin-producing neurons (ORX neurons) in lateral hypothalamus (LH), which while enhancing processing, by applying optogenetics acute pruritus model. We also that circuit ORX from LH periaqueductal gray regions served modulation processing using optogenetic terminal techniques. Additionally, an atopic dermatitis model, confirmed involvement regulating chronic could lead a novel therapeutic target for persistent clinical settings. Our findings provide new insight into mechanism antagonistic regulation between CNS.

Language: Английский

Citations

4

Prelimbic cortex-nucleus accumbens core projection positively regulates itch and itch-related aversion DOI

Jun-hui Long,

Pujun Wang, Xuan Li

et al.

Behavioural Brain Research, Journal Year: 2024, Volume and Issue: 468, P. 114999 - 114999

Published: April 13, 2024

Language: Английский

Citations

3

Upregulation of KDM6B in the anterior cingulate cortex contributes to neonatal maternal deprivation-induced chronic visceral pain in mice DOI Creative Commons

Zi-Long Yi,

Jin-Nan Lu, Jinjin Zhu

et al.

Molecular Pain, Journal Year: 2024, Volume and Issue: 20

Published: Jan. 1, 2024

Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disease characterized by chronic visceral pain with complex etiology and challenging treatment. Although accumulating evidence supports the involvement of central nervous system sensitization in development pain, precise molecular mechanisms remain incompletely understood. In this study, we highlight critical regulatory role lysine-specific demethylase 6B (KDM6B) anterior cingulate cortex (ACC) pain. To simulate clinical IBS conditions, utilized neonatal maternal deprivation (NMD) mouse model. Our results demonstrated that NMD induced anxiety-like behaviors mice. Notably, protein expression level KDM6B significantly increased ACC mice, leading to reduction H32K7me3. Immunofluorescence staining revealed primarily co-localizes neurons ACC, minimal presence microglia astrocytes. Injecting GSK-J4 (a KDM6B-specific inhibitor) into resulted significant alleviation behaviors, as well remarkable NR2B level. ChIP assay further indicated regulates influencing demethylation H3K27me3. summary, our findings underscore regulating These insights provide basis for understanding pathways involved may pave way targeted therapeutic interventions.

Language: Английский

Citations

3

The projection from the prelimbic cortex to the ventral tegmental area negatively regulates 5-HT-induced itch-scratching and positively regulates itch-related aversion in rats DOI Creative Commons
Xingyu Lu,

Jun-Fei Teng,

Juan Yao

et al.

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: 223, P. 111283 - 111283

Published: Feb. 28, 2025

Language: Английский

Citations

0

Neuroimaging Characteristics of Pruritus Induced by Eczema: An fMRI Study DOI Creative Commons

Tae‐eun Kim,

Jin Li,

Larissa Tao

et al.

Brain and Behavior, Journal Year: 2025, Volume and Issue: 15(3)

Published: March 1, 2025

To explore the neuroimaging characteristics of eczema-induced pruritus with resting-state functional magnetic resonance imaging (rs-fMRI). A total 42 patients eczema were recruited in PE group, and healthy participants included HC group. The Visual Analogue Score (VAS), 12-Item Pruritus Severity Scale (12-PSS), Pittsburgh Sleep Quality Index (PSQI), Self-Rating Anxiety (SAS) recorded different values fraction amplitude low-frequency fluctuation (fALFF) connectivity (FC) compared after rs-fMRI scanning. Compared fALFF left precentral gyrus, postcentral supplementary motor area (SMA), midcingulate cortex group increased. FC between bilateral superior temporal hippocampus, inferior occipital gyrus decreased. SMA 12-PSS score was positively correlated value gyrus. caused increased spontaneous activity given cerebral regions, involving perception itch, control scratching movements, expression itch-related emotions. Meanwhile, there is a correlation regions clinical scales, which provided potential neurobiological markers for future study pruritus.

Language: Английский

Citations

0

Different subregions of the anterior cingulate cortex differentially regulate acute itch-scratching behavior in rats DOI

Jun-Fei Teng,

Xueqiang Hu, Yamin Li

et al.

Behavioural Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 115616 - 115616

Published: May 1, 2025

Language: Английский

Citations

0

Excitatory Projections from the Prefrontal Cortex to Nucleus Accumbens Core D1-MSNs and κ Opioid Receptor Modulate Itch-Related Scratching Behaviors DOI Creative Commons
Xiaobo Wu,

Qian Zhu,

Ming-Hui Gao

et al.

Journal of Neuroscience, Journal Year: 2023, Volume and Issue: 43(8), P. 1334 - 1347

Published: Jan. 18, 2023

Itch is an uncomfortable and complex sensation that elicits the desire to scratch. The nucleus accumbens (NAc) activity important in driving sensation, motivation, emotion. Excitatory afferents from medial prefrontal cortex (mPFC), amygdala, hippocampus are crucial tuning of dopamine receptor D1-expressing D2-expressing medium spiny neurons (Drd1-MSN Drd2-MSN) NAc. However, a cell-type neural circuity-based mechanism NAc underlying acute itch remains unclear. We found induced by compound 48/80 (C48/80) decreased intrinsic membrane excitability Drd1-MSNs, but not Drd2-MSNs, core male mice. Chemogenetic activation Drd1-MSNs alleviated C48/80-induced scratching behaviors itch-related anxiety-like behaviors. In addition, C48/80 enhanced frequency spontaneous EPSCs (sEPSCs) reduced paired-pulse ratio (PPR) electrical stimulation-evoked Drd1-MSNs. Furthermore, increased excitatory synaptic mPFC, basolateral amygdala (BLA) or ventral (vHipp). Consistently, mPFC-NAc projecting pyramidal was after treatment. inhibition relieved Moreover, pharmacological κ opioid (KOR) suppressed behaviors, modulation KOR resulted changes presynaptic inputs C48/80-treated Together, these results reveal plasticity synapses mPFC indicate modulatory role behaviors.SIGNIFICANCE STATEMENT stimuli cause strongly anxiety patients. related mechanisms remain largely present study, we demonstrated pruritogen shapes (Drd1-MSNs) glutamatergic (mPFC) neurons. relieves alleviates itch. Thus, targeting may provide effective treatments for

Language: Английский

Citations

8

A thalamic nucleus reuniens–lateral septum–lateral hypothalamus circuit for comorbid anxiety–like behaviors in chronic itch DOI Creative Commons

Su-Shan Guo,

Yu Gong, Tingting Zhang

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(33)

Published: Aug. 16, 2024

Chronic itch often clinically coexists with anxiety symptoms, creating a vicious cycle of itch-anxiety comorbidities that are difficult to treat. However, the neuronal circuit mechanisms underlying comorbidity in chronic remain elusive. Here, we report anxiety-like behaviors mouse models and identify γ-aminobutyric acid–releasing (GABAergic) neurons lateral septum (LS) as key player itch–induced anxiety. In addition, is accompanied enhanced activity synaptic plasticity excitatory projections from thalamic nucleus reuniens (Re) onto LS GABAergic neurons. Selective chemogenetic inhibition Re → notably alleviated anxiety, no impact on induced by restraint stress. Last, hypothalamus (LH) receive monosynaptic mediate These findings underscore potential significance LH pathway regulating comorbid symptoms associated itch.

Language: Английский

Citations

2

CCL2 Potentiates Inflammation Pain and Related Anxiety-Like Behavior Through NMDA Signaling in Anterior Cingulate Cortex DOI

Huan Guo,

Wenchao Hu, Hang Xian

et al.

Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 61(8), P. 4976 - 4991

Published: Dec. 29, 2023

Language: Английский

Citations

5