The Neuroprotective Effect of Short-chain Fatty Acids Against Hypoxia-reperfusion Injury DOI Creative Commons

Anjit K. Harijan,

Retnamony Kalaiarasan,

Amit Ghosh

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 23, 2023

Abstract Gut microbe-derived short-chain fatty acids (SCFAs) are known to have a profound impact on various brain functions, including cognition, mood, and overall neurological health. However, their role, if any, in protecting against hypoxic injury ischemic stroke has not been extensively studied. In this study, we investigated the effects of two major SCFAs abundant gut, propionate (P) butyrate (B), hypoxia-reperfusion using neuronal cell line zebrafish model. Neuro 2a (N2a) cells treated with P B exhibited reduced levels mitochondrial cytosolic reactive oxygen species (ROS), diminished loss membrane potential, suppressed caspase activation, lower rates death when exposed CoCl 2 -induced hypoxia, compared control group. Furthermore, adult fed SCFAs-supplemented feeds showed less susceptibility conditions group, as indicated by multiple behavioral measures. Histological analysis TTC-stained sections revealed lesser damage SCFAs-fed We also found that FABP7 (also BLBP), neuroprotective acid binding protein, was upregulated brains Additionally, overexpressed N2a cells, it protected from injury. Overall, our data clearly demonstrates role suggests potential dietary supplementation mitigate stroke-induced damage. Highlights Short-chain (SCFA) Propionate Butyrate (B) protect hypoxia-reperfusion. Zebrafish, an SCFA-supplemented diet, more resilient diet boost expression (fatty protein). overexpression provides protection reduce (ROS) increase FABP7, contributing neuroprotection.

Language: Английский

From the Gut to the Brain: Is Microbiota a New Paradigm in Parkinson’s Disease Treatment? DOI Creative Commons
Cristiana Vilela, Bruna Araújo, Carla Guedes

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(9), P. 770 - 770

Published: April 30, 2024

Parkinson’s disease (PD) is recognized as the second most prevalent primary chronic neurodegenerative disorder of central nervous system. Clinically, PD characterized a movement disorder, exhibiting an incidence and mortality rate that increasing faster than any other neurological condition. In recent years, there has been growing interest concerning role gut microbiota in etiology pathophysiology PD. The establishment brain–gut axis now real, with evidence denoting bidirectional communication between brain through metabolic, immune, neuronal, endocrine mechanisms pathways. Among these, vagus nerve represents direct form gut. Given potential interactions bacteria drugs, it observed therapies for can have impact on composition microbiota. Therefore, scope present review, we will discuss current understanding whether this may be new paradigm treating devastating disease.

Language: Английский

Citations

3
Gut Microbiota Metabolite Messengers in Brain Function and Pathology at a View of Cell Type-Based Receptor and Enzyme Reaction DOI Creative Commons

Bada Lee,

Soo Min Lee,

Jae Won Song

et al.

Biomolecules & Therapeutics, Journal Year: 2024, Volume and Issue: 32(4), P. 403 - 423

Published: June 20, 2024

The human gastrointestinal (GI) tract houses a diverse microbial community, known as the gut microbiome comprising bacteria, viruses, fungi, and protozoa.The plays crucial role in maintaining body's equilibrium has recently been discovered to influence functioning of central nervous system (CNS).The communication between GI occurs through two-way network called gut-brain axis.The can modulate each other activated neuronal cells, immune system, metabolites produced by microbiome.Extensive research both preclinical clinical realms, highlighted complex relationship diseases associated with CNS, such Alzheimer's disease, Parkinson's amyotrophic lateral sclerosis.This review aims delineate receptor target enzymes linked microbiota explore their specific roles within brain, particularly impact on CNS-related diseases.

Language: Английский

Citations

2
A comparative analysis of Parkinson’s disease and inflammatory bowel disease gut microbiomes highlights shared depletions in key butyrate-producing bacteria DOI

Maeve E. Krueger,

Jake Boles, Zachary D. Simon

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 29, 2024

Abstract Epidemiological studies reveal that a diagnosis of inflammatory bowel disease (IBD) is associated with an increased risk developing Parkinson’s (PD). The presence gut dysbiosis has been documented in both PD and IBD patients, however it currently unknown how alterations the microbiome may contribute to epidemiological link between diseases. To identify shared distinct features microbiome, we performed first joint analysis 54 PD, 26 IBD, 16 healthy control metagenomes recruited from clinics at University Florida, directly compared microbiomes persons. Larger, publicly available metagenomic datasets were also analyzed validate extend our findings. Depletions short-chain fatty acid (SCFA) producing bacteria, including Roseburia intestinalis, Faecalibacterium prausnitzii, Anaerostipes hadrus, Eubacterium rectale , as well depletions SCFA synthesis pathways, demonstrated across datasets. We posit direct comparison will be important identifying within which PD. data revealed consistent depletion SCFA-producing bacteria suggesting loss these microbes influence pathophysiology states.

Language: Английский

Citations

2
The role of gut-derived short-chain fatty acids in Parkinson's disease DOI
Mohamed J. Saadh,

Anfal Nabeel Mustafa,

Mohammed Ahmed Mustafa

et al.

Neurogenetics, Journal Year: 2024, Volume and Issue: 25(4), P. 307 - 336

Published: Sept. 13, 2024

Language: Английский

Citations

2
Interaction between α-Synuclein and Bioactive Lipids: Neurodegeneration, Disease Biomarkers and Emerging Therapies DOI Creative Commons

Chiara Sanluca,

P. Spagnolo, Romina Mancinelli

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 14(7), P. 352 - 352

Published: June 22, 2024

The present review provides a comprehensive examination of the intricate dynamics between α-synuclein, protein crucially involved in pathogenesis several neurodegenerative diseases, including Parkinson's disease and multiple system atrophy, endogenously-produced bioactive lipids, which play pivotal role neuroinflammation neurodegeneration. interaction α-synuclein with lipids is emerging as critical factor development progression neuroinflammatory offering new insights into mechanisms novel perspectives identification potential biomarkers therapeutic targets. We delve molecular pathways through interacts biological membranes influencing aggregation triggering responses, highlighting for early detection monitoring. Moreover, we explore innovative strategies aimed at modulating small molecules nutritional interventions. Finally, addresses significance gut-to-brain axis mediating effects on pathology discusses altered gut lipid metabolism microbiota composition aims to underscore targeting α-synuclein-lipid interactions multifaceted approach treatment diseases.

Language: Английский

Citations

1
Alpha Synuclein Toxicity and Non-Motor Parkinson’s DOI Creative Commons
G. Mazzotta, Carmela Conte

Cells, Journal Year: 2024, Volume and Issue: 13(15), P. 1265 - 1265

Published: July 27, 2024

Parkinson's disease (PD) is a common multisystem neurodegenerative disorder affecting 1% of the population over age 60 years. The main neuropathological features PD are loss dopaminergic neurons in substantia nigra pars compacta (SNpc) and presence alpha synuclein (αSyn)-rich Lewy bodies both manifesting with classical motor signs. αSyn has emerged as key protein pathology it can spread through synaptic networks to reach several anatomical regions body contributing appearance non-motor symptoms (NMS) considered prevalent among individuals prior diagnosis persisting throughout patient's life. NMS mainly includes taste smell, constipation, psychiatric disorders, dementia, impaired rapid eye movement (REM) sleep, urogenital dysfunction, cardiovascular impairment. This review summarizes more recent findings on impact deposits prodromal emphasizes importance early detection toxic species biofluids peripheral biopsies prospective biomarkers PD.

Language: Английский

Citations

1
The neuroprotective effect of short-chain fatty acids against hypoxia-reperfusion injury DOI

Anjit K. Harijan,

Retnamony Kalaiarasan,

Amit Ghosh

et al.

Molecular and Cellular Neuroscience, Journal Year: 2024, Volume and Issue: unknown, P. 103972 - 103972

Published: Sept. 1, 2024

Language: Английский

Citations

1
Microbiome-based therapies for Parkinson’s disease DOI Creative Commons
Mudassir Alam,

Kashif Abbas,

Mohd Rais Mustafa

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 6, 2024

The human gut microbiome dysbiosis plays an important role in the pathogenesis of Parkinson’s disease (PD). bidirectional relationship between enteric nervous system (ENS) and central (CNS) under mediation gut-brain axis control gastrointestinal functioning. This review article discusses key mechanisms by which modifications composition function microbiota (GM) influence PD progression motor loss. Increased intestinal permeability, chronic inflammation, oxidative stress, α-synuclein aggregation, neurotransmitter imbalances are some factors that govern pathology progression. bacterial taxa associated with development discussed emphasis on (ENS), as well impact bacteria dopamine production levodopa metabolism. pathophysiology course several inflammatory markers, including TNF-α, IL-1β, IL-6. Emerging therapeutic strategies targeting include probiotics, prebiotics, synbiotics, postbiotics, fecal transplantation (FMT). explored how dietary changes may affect ways can (PD), a focus nutrition-based, Mediterranean, ketogenic diets. comprehensive synthesizes current evidence explores its potential target. Understanding these complex interactions assist novel diagnostic tools treatment options for this neurodegenerative disorder.

Language: Английский

Citations

1
The relationship between acrylamide and neurodegenerative diseases: gut microbiota as a new intermediate cue DOI
Xinrui Xu, Siyu Wei,

Mengyi Lin

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 13

Published: Dec. 13, 2024

Acrylamide (AA), a compound formed during the thermal processing of high-carbohydrate foods, has been implicated in onset and progression neurodegenerative diseases. An increasing number reports support that gut microbiota plays significant role brain function diseases, suggesting it may act as mediator between AA exposure development Available studies have shown intake affects composition integrity intestinal barrier, both which are often thought to be associated with pathogenesis given numerous evidences linking brain. Based on current understanding, this paper discusses induces diseases by disrupting structure barrier. Furthermore, explores interaction probiotics exposure, well potential for polysaccharides polyphenols improve microenvironment, provides novel perspectives modulating caused through diet.

Language: Английский

Citations

1
Natural Products: Harnessing the Power of Gut Microbiota for Neurological Health DOI
Hao Cheng, Juan Liu, Dandan Zhang

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: unknown, P. 156019 - 156019

Published: Sept. 1, 2024

Language: Английский

Citations

0