bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Дек. 23, 2023
Abstract
Gut
microbe-derived
short-chain
fatty
acids
(SCFAs)
are
known
to
have
a
profound
impact
on
various
brain
functions,
including
cognition,
mood,
and
overall
neurological
health.
However,
their
role,
if
any,
in
protecting
against
hypoxic
injury
ischemic
stroke
has
not
been
extensively
studied.
In
this
study,
we
investigated
the
effects
of
two
major
SCFAs
abundant
gut,
propionate
(P)
butyrate
(B),
hypoxia-reperfusion
using
neuronal
cell
line
zebrafish
model.
Neuro
2a
(N2a)
cells
treated
with
P
B
exhibited
reduced
levels
mitochondrial
cytosolic
reactive
oxygen
species
(ROS),
diminished
loss
membrane
potential,
suppressed
caspase
activation,
lower
rates
death
when
exposed
CoCl
2
-induced
hypoxia,
compared
control
group.
Furthermore,
adult
fed
SCFAs-supplemented
feeds
showed
less
susceptibility
conditions
group,
as
indicated
by
multiple
behavioral
measures.
Histological
analysis
TTC-stained
sections
revealed
lesser
damage
SCFAs-fed
We
also
found
that
FABP7
(also
BLBP),
neuroprotective
acid
binding
protein,
was
upregulated
brains
Additionally,
overexpressed
N2a
cells,
it
protected
from
injury.
Overall,
our
data
clearly
demonstrates
role
suggests
potential
dietary
supplementation
mitigate
stroke-induced
damage.
Highlights
Short-chain
(SCFA)
Propionate
Butyrate
(B)
protect
hypoxia-reperfusion.
Zebrafish,
an
SCFA-supplemented
diet,
more
resilient
diet
boost
expression
(fatty
protein).
overexpression
provides
protection
reduce
(ROS)
increase
FABP7,
contributing
neuroprotection.
Cells,
Год журнала:
2024,
Номер
13(9), С. 770 - 770
Опубликована: Апрель 30, 2024
Parkinson’s
disease
(PD)
is
recognized
as
the
second
most
prevalent
primary
chronic
neurodegenerative
disorder
of
central
nervous
system.
Clinically,
PD
characterized
a
movement
disorder,
exhibiting
an
incidence
and
mortality
rate
that
increasing
faster
than
any
other
neurological
condition.
In
recent
years,
there
has
been
growing
interest
concerning
role
gut
microbiota
in
etiology
pathophysiology
PD.
The
establishment
brain–gut
axis
now
real,
with
evidence
denoting
bidirectional
communication
between
brain
through
metabolic,
immune,
neuronal,
endocrine
mechanisms
pathways.
Among
these,
vagus
nerve
represents
direct
form
gut.
Given
potential
interactions
bacteria
drugs,
it
observed
therapies
for
can
have
impact
on
composition
microbiota.
Therefore,
scope
present
review,
we
will
discuss
current
understanding
whether
this
may
be
new
paradigm
treating
devastating
disease.
Biomolecules & Therapeutics,
Год журнала:
2024,
Номер
32(4), С. 403 - 423
Опубликована: Июнь 20, 2024
The
human
gastrointestinal
(GI)
tract
houses
a
diverse
microbial
community,
known
as
the
gut
microbiome
comprising
bacteria,
viruses,
fungi,
and
protozoa.The
plays
crucial
role
in
maintaining
body's
equilibrium
has
recently
been
discovered
to
influence
functioning
of
central
nervous
system
(CNS).The
communication
between
GI
occurs
through
two-way
network
called
gut-brain
axis.The
can
modulate
each
other
activated
neuronal
cells,
immune
system,
metabolites
produced
by
microbiome.Extensive
research
both
preclinical
clinical
realms,
highlighted
complex
relationship
diseases
associated
with
CNS,
such
Alzheimer's
disease,
Parkinson's
amyotrophic
lateral
sclerosis.This
review
aims
delineate
receptor
target
enzymes
linked
microbiota
explore
their
specific
roles
within
brain,
particularly
impact
on
CNS-related
diseases.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 29, 2024
Abstract
Epidemiological
studies
reveal
that
a
diagnosis
of
inflammatory
bowel
disease
(IBD)
is
associated
with
an
increased
risk
developing
Parkinson’s
(PD).
The
presence
gut
dysbiosis
has
been
documented
in
both
PD
and
IBD
patients,
however
it
currently
unknown
how
alterations
the
microbiome
may
contribute
to
epidemiological
link
between
diseases.
To
identify
shared
distinct
features
microbiome,
we
performed
first
joint
analysis
54
PD,
26
IBD,
16
healthy
control
metagenomes
recruited
from
clinics
at
University
Florida,
directly
compared
microbiomes
persons.
Larger,
publicly
available
metagenomic
datasets
were
also
analyzed
validate
extend
our
findings.
Depletions
short-chain
fatty
acid
(SCFA)
producing
bacteria,
including
Roseburia
intestinalis,
Faecalibacterium
prausnitzii,
Anaerostipes
hadrus,
Eubacterium
rectale
,
as
well
depletions
SCFA
synthesis
pathways,
demonstrated
across
datasets.
We
posit
direct
comparison
will
be
important
identifying
within
which
PD.
data
revealed
consistent
depletion
SCFA-producing
bacteria
suggesting
loss
these
microbes
influence
pathophysiology
states.
Metabolites,
Год журнала:
2024,
Номер
14(7), С. 352 - 352
Опубликована: Июнь 22, 2024
The
present
review
provides
a
comprehensive
examination
of
the
intricate
dynamics
between
α-synuclein,
protein
crucially
involved
in
pathogenesis
several
neurodegenerative
diseases,
including
Parkinson's
disease
and
multiple
system
atrophy,
endogenously-produced
bioactive
lipids,
which
play
pivotal
role
neuroinflammation
neurodegeneration.
interaction
α-synuclein
with
lipids
is
emerging
as
critical
factor
development
progression
neuroinflammatory
offering
new
insights
into
mechanisms
novel
perspectives
identification
potential
biomarkers
therapeutic
targets.
We
delve
molecular
pathways
through
interacts
biological
membranes
influencing
aggregation
triggering
responses,
highlighting
for
early
detection
monitoring.
Moreover,
we
explore
innovative
strategies
aimed
at
modulating
small
molecules
nutritional
interventions.
Finally,
addresses
significance
gut-to-brain
axis
mediating
effects
on
pathology
discusses
altered
gut
lipid
metabolism
microbiota
composition
aims
to
underscore
targeting
α-synuclein-lipid
interactions
multifaceted
approach
treatment
diseases.
Cells,
Год журнала:
2024,
Номер
13(15), С. 1265 - 1265
Опубликована: Июль 27, 2024
Parkinson's
disease
(PD)
is
a
common
multisystem
neurodegenerative
disorder
affecting
1%
of
the
population
over
age
60
years.
The
main
neuropathological
features
PD
are
loss
dopaminergic
neurons
in
substantia
nigra
pars
compacta
(SNpc)
and
presence
alpha
synuclein
(αSyn)-rich
Lewy
bodies
both
manifesting
with
classical
motor
signs.
αSyn
has
emerged
as
key
protein
pathology
it
can
spread
through
synaptic
networks
to
reach
several
anatomical
regions
body
contributing
appearance
non-motor
symptoms
(NMS)
considered
prevalent
among
individuals
prior
diagnosis
persisting
throughout
patient's
life.
NMS
mainly
includes
taste
smell,
constipation,
psychiatric
disorders,
dementia,
impaired
rapid
eye
movement
(REM)
sleep,
urogenital
dysfunction,
cardiovascular
impairment.
This
review
summarizes
more
recent
findings
on
impact
deposits
prodromal
emphasizes
importance
early
detection
toxic
species
biofluids
peripheral
biopsies
prospective
biomarkers
PD.
Frontiers in Nutrition,
Год журнала:
2024,
Номер
11
Опубликована: Ноя. 6, 2024
The
human
gut
microbiome
dysbiosis
plays
an
important
role
in
the
pathogenesis
of
Parkinson’s
disease
(PD).
bidirectional
relationship
between
enteric
nervous
system
(ENS)
and
central
(CNS)
under
mediation
gut-brain
axis
control
gastrointestinal
functioning.
This
review
article
discusses
key
mechanisms
by
which
modifications
composition
function
microbiota
(GM)
influence
PD
progression
motor
loss.
Increased
intestinal
permeability,
chronic
inflammation,
oxidative
stress,
α-synuclein
aggregation,
neurotransmitter
imbalances
are
some
factors
that
govern
pathology
progression.
bacterial
taxa
associated
with
development
discussed
emphasis
on
(ENS),
as
well
impact
bacteria
dopamine
production
levodopa
metabolism.
pathophysiology
course
several
inflammatory
markers,
including
TNF-α,
IL-1β,
IL-6.
Emerging
therapeutic
strategies
targeting
include
probiotics,
prebiotics,
synbiotics,
postbiotics,
fecal
transplantation
(FMT).
explored
how
dietary
changes
may
affect
ways
can
(PD),
a
focus
nutrition-based,
Mediterranean,
ketogenic
diets.
comprehensive
synthesizes
current
evidence
explores
its
potential
target.
Understanding
these
complex
interactions
assist
novel
diagnostic
tools
treatment
options
for
this
neurodegenerative
disorder.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2024,
Номер
unknown, С. 1 - 13
Опубликована: Дек. 13, 2024
Acrylamide
(AA),
a
compound
formed
during
the
thermal
processing
of
high-carbohydrate
foods,
has
been
implicated
in
onset
and
progression
neurodegenerative
diseases.
An
increasing
number
reports
support
that
gut
microbiota
plays
significant
role
brain
function
diseases,
suggesting
it
may
act
as
mediator
between
AA
exposure
development
Available
studies
have
shown
intake
affects
composition
integrity
intestinal
barrier,
both
which
are
often
thought
to
be
associated
with
pathogenesis
given
numerous
evidences
linking
brain.
Based
on
current
understanding,
this
paper
discusses
induces
diseases
by
disrupting
structure
barrier.
Furthermore,
explores
interaction
probiotics
exposure,
well
potential
for
polysaccharides
polyphenols
improve
microenvironment,
provides
novel
perspectives
modulating
caused
through
diet.
