Therapeutic Potential of Polyphenols and Other Micronutrients of Marine Origin

Marine Drugs, Journal Year: 2023, Volume and Issue: 21(6), P. 323 - 323

Published: May 26, 2023

Polyphenols are compounds found in various plants and foods, known for their antioxidant anti-inflammatory properties. Recently, researchers have been exploring the therapeutic potential of marine polyphenols other minor nutrients that algae, fish crustaceans. These unique chemical structures exhibit diverse biological properties, including anti-inflammatory, antioxidant, antimicrobial antitumor action. Due to these being investigated as possible agents treatment a wide variety conditions, such cardiovascular disease, diabetes, neurodegenerative diseases cancer. This review focuses on applications human health, also, phenolic classes, extraction methods, purification techniques future compounds.

Language: Английский

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Coordinating caffeic acid and salvianic acid A pathways for efficient production of rosmarinic acid in Escherichia coli

Metabolic Engineering, Journal Year: 2023, Volume and Issue: 76, P. 29 - 38

Published: Jan. 6, 2023

Language: Английский

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Advanced application of nanotechnology in active constituents of Traditional Chinese Medicines

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Nov. 29, 2023

Abstract Traditional Chinese Medicines (TCMs) have been used for centuries the treatment and management of various diseases. However, their effective delivery to targeted sites may be a major challenge due poor water solubility, low bioavailability, potential toxicity. Nanocarriers, such as liposomes, polymeric nanoparticles, inorganic nanoparticles organic/inorganic nanohybrids based on active constituents from TCMs extensively studied promising strategy improve achieve higher therapeutic effect with fewer side effects compared conventional formulations. This review summarizes recent advances in nanocarrier-based systems types TCMs, including terpenoids, polyphenols, alkaloids, flavonoids, quinones, different natural sources. covers design preparation nanocarriers, characterization, vitro/vivo evaluations. Additionally, this highlights challenges opportunities field suggests future directions research. Nanocarrier-based shown great improving efficacy serve comprehensive resource researchers field. Graphical abstract

Language: Английский

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How climate change-related abiotic factors affect the production of industrial valuable compounds in Lamiaceae plant species: a review

Frontiers in Plant Science, Journal Year: 2024, Volume and Issue: 15

Published: July 10, 2024

The interest in medicinal and aromatic plants (MAPs) has increased significantly recent years, driven by the growing demand for natural products. MAPs are a valuable source of secondary metabolites, which renders them useful to number industries, including cosmetics, pharmaceuticals, food. Lamiaceae family includes economically important that produce metabolites such as essential oils (EOs) phenolic compounds (PCs). quantity quality these affected abiotic stress factors. In climate change scenario, is one most families, especially due its wide distribution Mediterranean region. present study, common climate-related environmental factors, namely, drought, salinity, temperature, light, heavy metals, were reviewed discussed order assess their impact on chemical profiles EOs PCs, well biological properties (antioxidant, antibacterial, antimelanogenic, pest-repellent, UV-protective) species. It can be posited stresses typically act catalyst metabolism plants, resulting production EO (e.g., 1,8-cineole, linalool, camphor, borneol, limonene) PCs rosmarinic, caffeic, salvianolic acids) subsequent enhancement activities. view industrial applications bioactive compounds, it explore changes induced factors possible increase accumulation metabolites.

Language: Английский

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Investigation the biological activities and the metabolite profiles of endophytic fungi isolated from Gundelia tournefortii L.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 25, 2024

Abstract Endophytic fungi are microorganisms that considered as a potential source of natural compounds, and can be applied in various industries. The aims this research were molecular identification endophytic isolated from the Gundelia tournefortii stems, investigation their biological activities well phenolic fatty acid profile. Surface sterilized stems G. placed on potato dextrose agar (PDA) to isolate fungal endophytes. Genomic DNA was extracted by CTAB method, PCR amplification performed ITS 1 4 primers. enzyme production determined based formation clear zone appeared around colonies fungus. anti-oxidant activity evaluated measuring amount free radicals DPPH. Also, total phenol flavonoid contents measured obtained Folin-Ciocalteu aluminum chloride colorimetric methods, respectively. Moreover, separation acids done HPLC GC, Phylogenetic analysis Internal Transcribed Spacer (ITS) region, five isolates identified following: Aspergillus niger , Penicillium glabrum Alternaria alternata A. tenuissima Mucor circinelloides . Evaluation enzymatic properties showed P. gabrum (31 ± 1.9 mm), (23 1.7) had more ability for producing pectinase cellulase. extract (IC 50 = 471 29 µg/mL) highest properties, followed 512 19 µg/mL). greatest phenols flavonoids (8.2 0.4 mg GAL/g 2.3 0.3 QE/g, respectively). quantification rosmarinic acid, para-coumaric meta-coumaric (42.02 1.31, 7.53 0.19, 5.41 0.21 mg/g, respectively) main studied fungi. confirmed that, all fungi, stearic (27.9–35.2%), oleic (11.3–17.3%), palmitic (16.9–23.2%), linoleic (5.8–11.6%), caprylic (6.3–10.9%). Our finding bioactive which could used This is first report associated with provides knowledge future use biotechnological processes.

Language: Английский

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A bi‐functional nanofibrous composite membrane for wound healing applications

Archiv der Pharmazie, Journal Year: 2024, Volume and Issue: 357(8)

Published: May 15, 2024

Various wound dressings have been developed so far for healing, but most of them are ineffective in properly reestablishing the skin's structure, which increases infection risks and dehydration. Electrospun membranes particularly interesting dressing applications because they mimic extracellular matrix healthy skin. In this study, a potential healing platform capable inducing synergistic antibacterial antioxidation activities was by incorporating bio-active rosmarinic acid-hydroxyapatite hybrid (HAP-RA) with different contents (0.5, 1, 1.5 wt.%) into electrospun polyamide 6 (PA6) nanofibers. Then, polyethylene glycol (PEG) introduced to nanofibrous composite improve biocompatibility biodegradability dressing. The results indicated that hydrophilicity, water uptake, biodegradability, mechanical properties obtained PA6/PEG/HAP-RA enhanced at 1 wt.% HAP-RA. had excellent activity. samples assessed vitro. MTT assay performed on L929 cell line confirmed positive effects scaffold viability proliferation. According results, showed desirable physiochemical biological besides antioxidative capabilities, making it promising candidate further studies applications.

Language: Английский

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Rosmarinic acid-grafted gelatin nanogels for efficient diquafosol delivery in dry eye disease therapy

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 373, P. 306 - 318

Published: July 19, 2024

Language: Английский

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Evaluation of Antimicrobial Properties and Antioxidant Activity of Rosmarinic Acid-Loaded Resomer RG 502 H-Based Nanoparticles Against Tert-Butyl Hydroperoxide-Induced Oxidative Stress: A detailed formulation, characterization and efficacy determination study

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106721 - 106721

Published: Feb. 1, 2025

Language: Английский

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Rosmarinic acid-chondroitin sulfate nanoconjugate for targeted treatment of ulcerative colitis

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141008 - 141008

Published: Feb. 1, 2025

Language: Английский

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Anxiolytic, Antidepressant and Healthy Sleep-Promoting Potential of Rosmarinic Acid: Mechanisms and Molecular Targets

Neuropsychiatric Disease and Treatment, Journal Year: 2025, Volume and Issue: Volume 21, P. 641 - 661

Published: March 1, 2025

The etiology of psychiatric disorders is complex and results from intricate interactions among multiple neurobiological, psychological, environmental, genetic factors. Furthermore, the roles gut microbiome dyshomeostasis in their pathogeneses are just beginning to be uncovered, adding another level complexity. In recent years, significant efforts have been directed toward discovering multimodal yet safe therapeutics counteract psychological deficits. Rosmarinic acid (RA), a polyphenol found several medicinal herbs, has received considerable attention as potential multifaceted therapeutic agent, particularly for neuropsychiatric conditions. order critically evaluate this aspect, data was compiled consolidated after extensive searches on scholarly databases like PubMed, Google Scholar, Web Science. Peer-reviewed publications which focused RA agent were included regardless year publication country origin. Based pre-clinical clinical evidence, review delves into various mechanistic aspects antidepressant, anxiolytic, sleep-promoting functions RA. beneficial effects gut-microbiome-brain (GMB) axis implications regulation neuroprotective pathways also discussed, with particular focus exploiting them ameliorate Our assessment indicated that neuroprotectant against conditions beneficially influences plethora targets related redox, inflammatory, synaptic, cell death, neurotrophic, signaling pathways. As dietary may relevant favorably altering GMB axis, indicating its prospects adjuvant regulating pathogenic mechanisms underlying However, more studies required ascertain neuromodulatory actions neuronal pathophysiologies, including ailments.

Language: Английский

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