Iron chelators loaded on myocardiocyte mitochondria-targeted nanozyme system for treating myocardial ischemia-reperfusion injury in mouse models DOI Creative Commons
Ke Zhu, Kun Wang,

Rongting Zhang

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 15, 2025

Ferroptosis plays a critical role in myocardial ischemia-reperfusion injury (MIRI), posing significant clinical challenge. Nanoenzymes like cerium oxide (CeO2) hold promise for mitigating oxidative damage and inhibiting ferroptosis, but their delivery efficiency biological activity require optimization. This study aims to develop targeted nanozyme system MIRI treatment by integrating CeO2 with mesoporous polydopamine (mPDA) dexrazoxane (DXZ) achieve synergistic therapeutic effects. A biomineralization technique was used synthesize nanoparticles (2–3 nm) within mPDA, forming ~ 130 nm composite (Ce@mPDA). Surface modifications cardiac homing peptide (CHP) triphenylphosphine (TPP) enabled hierarchical targeting injured myocardium mitochondria. DXZ-loaded Ce@mPDA-C/P (D/Ce@mPDA-C/P) were evaluated vitro mouse model effects on stress, apoptosis, inflammation, function. D/Ce@mPDA-C/P exhibited robust ROS scavenging, sustained DXZ release, efficient mitochondrial targeting. The significantly reduced upregulated GPX4 expression, inhibited modulated the inflammatory microenvironment. Long-term studies demonstrated reductions fibrosis improvements function, including enhanced fractional shortening ejection fraction. effectively combines antioxidant properties of iron-chelating DXZ, providing promising strategy MIRI. approach may expand use advance nanomedicine-based interventions repair.

Language: Английский

The enhanced oxidase-like activity of modified nanoceria/ZIF-67 for fluorescence and smartphone-assisted visual detection of tannic acid DOI

Xixi Ye,

Xiaowan Zhang, Chenchen Wang

et al.

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 418, P. 136130 - 136130

Published: July 3, 2024

Language: Английский

Citations

9
Ascorbate-loaded Mg Fe layered double hydroxide for osteomyelitis treatment DOI
Wei Li, Yuliang Huang,

Dongqiang Gu

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 378, P. 1045 - 1060

Published: Jan. 5, 2025

Language: Английский

Citations

1
Nanozymes: An innovative approach to regulating heavy metal accumulation in plants and alleviating toxicity-A comprehensive review DOI
Yaoyao Wang, Xueyuan Gu, Lijuan Zhao

et al.

Critical Reviews in Environmental Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 25

Published: Jan. 3, 2025

Managing farmlands' heavy metal (HM) pollution is crucial for improving plant growth and ensuring agricultural product safety. While low to medium doses of HM exposure may not directly result in crop reduction, they can lead accumulation plants potential food-chain risks, as well trigger the reactive oxygen species (ROS). Excessive ROS cause oxidative stress irreversible damage cells. Nanozymes, cost-effective stable artificial nanoparticles with enzyme-like activity, have been widely used multiple fields. Over past decade, research has confirmed certain nanozymes' effectiveness systemic immunity during remediation. The activities nanozymes hinge on their physicochemical properties, while biological effects also depend application methods, size, charge, coating, varieties, stages. Therefore, it understand nanozyme-plant interactions resistance mechanisms HMs. This paper comprehensively reviews nanozyme-mediated scavenging across enzymology, metabolomics, proteomics, transcriptomics. It introduces pathways effects, influencing factors, possible prospects. review provide a theoretical framework mitigation along other abiotic stresses agriculture sustainable "precision fertilization" nanozymes.

Language: Английский

Citations

1
CeO2@Mn Nanozymes for Colorimetric and Fluorescence Detection of Iodide Ions in Urine and Blood DOI

Xiaoxin Xu,

Tingting Xu, Tong Wu

et al.

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

The abnormal levels of small molecules, such as iodide ions (I–), in biological systems can be key indicators certain diseases and may pose risks to human health, playing a significant role various physiological processes. Herein, we developed solvothermal method for the synthesis CeO2-based nanozymes (CeO2 NPs, CeO2@Mn CeO2@Se NPs), which serve recognition probes quantitative detection I– urine blood using both colorimetric fluorescence dual methods. NPs showed excellent catalytic activity with aid O-phenylenediamine (OPD) chromogenic substrate; oxidation OPD presence H2O2 produce yellow OPDOX was catalyzed by acting peroxidase enzyme, neutral environment (pH = 6) I–. displayed distinct absorption peaks at 275 nm 450 nm, along maximum emission peak 575 under 380 excitation. Based on these observations, recognition, utilizing detection, developed. limits were found 20 μg/L (3σ/S) mode 0.085 mode. Furthermore, achieved precise blood, offering advantages use resource-limited settings on-site testing. This enhances its potential broader application public health surveillance early disease screening.

Language: Английский

Citations

1
Iron chelators loaded on myocardiocyte mitochondria-targeted nanozyme system for treating myocardial ischemia-reperfusion injury in mouse models DOI Creative Commons
Ke Zhu, Kun Wang,

Rongting Zhang

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 15, 2025

Ferroptosis plays a critical role in myocardial ischemia-reperfusion injury (MIRI), posing significant clinical challenge. Nanoenzymes like cerium oxide (CeO2) hold promise for mitigating oxidative damage and inhibiting ferroptosis, but their delivery efficiency biological activity require optimization. This study aims to develop targeted nanozyme system MIRI treatment by integrating CeO2 with mesoporous polydopamine (mPDA) dexrazoxane (DXZ) achieve synergistic therapeutic effects. A biomineralization technique was used synthesize nanoparticles (2–3 nm) within mPDA, forming ~ 130 nm composite (Ce@mPDA). Surface modifications cardiac homing peptide (CHP) triphenylphosphine (TPP) enabled hierarchical targeting injured myocardium mitochondria. DXZ-loaded Ce@mPDA-C/P (D/Ce@mPDA-C/P) were evaluated vitro mouse model effects on stress, apoptosis, inflammation, function. D/Ce@mPDA-C/P exhibited robust ROS scavenging, sustained DXZ release, efficient mitochondrial targeting. The significantly reduced upregulated GPX4 expression, inhibited modulated the inflammatory microenvironment. Long-term studies demonstrated reductions fibrosis improvements function, including enhanced fractional shortening ejection fraction. effectively combines antioxidant properties of iron-chelating DXZ, providing promising strategy MIRI. approach may expand use advance nanomedicine-based interventions repair.

Language: Английский

Citations

1