Nano Convergence,
Journal Year:
2023,
Volume and Issue:
10(1)
Published: June 9, 2023
The
understanding
of
the
endocytosis
process
internalized
nanomedicines
through
membrane
biomarker
is
essential
for
development
molecular-specific
nanomedicines.
In
various
recent
reports,
metalloproteases
have
been
identified
as
important
markers
during
metastasis
cancer
cells.
particular,
MT1-MMP
has
provoked
concern
due
to
its
protease
activity
in
degradation
extracellular
matrix
adjacent
tumors.
Thus,
current
work,
we
applied
fluorescent
Au
nanoclusters
which
present
strong
resistance
chemical
quenching
investigation
MT1-MMP-mediated
endocytosis.
We
synthesized
protein-based
nanocluster
(PAuNC)
and
MT1-MMP-specific
peptide
was
conjugated
with
PAuNC
(pPAuNC)
monitoring
protease-mediated
fluorescence
capacity
pPAuNC
investigated
intracellular
uptake
subsequently
confirmed
by
a
co-localization
analysis
using
confocal
microscopy
molecular
competition
test.
Furthermore,
change
lipophilic
network
after
an
event
pPAuNC.
identical
did
not
occur
bare
PAuNC.
By
classification
branched
between
organelles
at
nanoscale,
image-based
cell
organelle
networking
allowed
evaluation
nanoparticle
internalization
impaired
cellular
components
accumulation
single-cell
level.
Our
analyses
suggest
methodology
achieve
better
mechanism
nanoparticles
enter
ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
7(3), P. 1810 - 1819
Published: Feb. 26, 2024
Polymer-drug
conjugates
(PDCs)
provide
possibilities
for
the
development
of
multiresponsive
drug
delivery
and
release
platforms
utilized
in
cancer
therapy.
The
Temozolomide
(TMZ,
a
DNA
methylation
agent)
by
PDCs
has
been
developed
to
improve
TMZ
stability
under
physiological
conditions
treatment
glioblastoma
multiforme
(GBM);
however,
with
inefficient
chemotherapeutic
efficacy.
In
this
work,
we
synthesized
an
amphiphilic
triblock
copolymer
(P1-SNO)
four
pendant
functionalities,
including
(1)
intermediate
(named
MTIC)
as
prodrug
moiety,
(2)
disulfide
bond
redox-responsive
trigger
cage
MTIC,
(3)
S-nitrosothiol
light/heat-responsive
donor
nitric
oxide
(NO),
(4)
poly(ethylene
glycol)
chain
enable
self-assembly
aqueous
media.
P1-SNO
was
demonstrated
liberate
MTIC
presence
reduced
glutathione
gaseous
NO
upon
exposure
light
or
heat.
vitro
results
revealed
synergistic
effect
released
on
both
TMZ-sensitive
TMZ-resistant
GBM
cells.
environment-responsive
PDC
system
codelivery
is
promising
overcome
efficacy
issue
TMZ-based
Macromolecular Chemistry and Physics,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 12, 2025
Abstract
The
therapeutic
efficacy
of
Bortezomib
(BTZ)
is
severely
limited
by
its
low
solubility,
poor
stability
in
vivo
and
nonspecific
toxicity.
PEGylated
nanocarriers
can
improve
drug
delivery
efficiency,
but
their
applications
often
suffer
from
loading,
premature
leakage
accelerated
blood
clearance
phenomenon.
Herein
a
kind
catechol‐functionalized
sulfobetaine‐based
zwitterionic
block
copolymer
(PGMAD‐PSBMA)
prepared
RAFT
copolymerization
an
epoxy‐amino
click
reaction.
And
then
PGMAD‐PSBMA
readily
used
to
conjugate
with
BTZ
the
formation
dynamic
boronate
bonds
obtain
prodrug
(PGMAD@BTZ‐PSBMA)
PGMAD@BTZ‐PSBMA
micelles.
structure
morphology,
physicochemical
characteristics,
pH‐triggered
release
as
well
vitro
cytotoxicity
micelles
are
investigated
detail.
results
demonstrate
that
not
only
possess
high
loading
(12.9%)
stable
dispersion
physiological
pH
condition
(pH
7.4),
also
respond
tumor
acid
microenvironment
achieve
pH‐responsive
release.
designed
here
combine
desirable
functions
polycatechols
for
conjugation
acid‐triggered
polysulfobetaines
long
circulation
blood,
which
have
great
potential
enhance
reduce
toxic
side
effects
other
boronic
acid‐containing
drugs,
such
Ixazomib
Steboronine.
Journal of Translational Medicine,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: April 15, 2025
Cancer
immunotherapy
aims
to
harness
the
body's
own
immune
system
for
effective
and
long-lasting
elimination
of
malignant
neoplastic
tissues.
Owing
advance
in
understanding
cancer
pathology
immunology,
many
novel
strategies
enhancing
immunological
responses
against
various
cancers
have
been
successfully
developed,
some
translated
into
excellent
clinical
outcomes.
As
one
promising
strategy
next
generation
immunotherapies,
activating
multi-cellular
network
(MCN)
within
tumor
microenvironment
(TME)
deploy
multiple
mechanisms
action
(MOAs)
has
attracted
significant
attention.
To
achieve
this
effectively
safely,
delivering
or
pleiotropic
therapeutic
cargoes
targeted
sites
cancerous
tissues,
cells,
intracellular
organelles
is
critical,
which
numerous
nanocarriers
developed
leveraged.
In
review,
we
first
introduce
payloads
categorized
according
their
predicted
functions
physicochemical
structures
forms.
Then,
nanocarriers,
along
with
unique
characteristics,
properties,
advantages,
limitations,
are
introduced
notable
recent
applications
immunotherapy.
Following
discussions
on
targeting
strategies,
a
summary
each
nanocarrier
matching
suitable
provided
comprehensive
background
information
designing
regimens.
Journal of Polymer Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 5, 2025
ABSTRACT
Cancer‐targeted
nanomedicines
demonstrate
considerable
potential
in
anticancer
treatment
due
to
their
unique
properties
that
improve
therapeutic
efficiency
while
minimizing
off‐target
effects.
In
this
research,
curcumin
(Cur)
and
paclitaxel
(PTX)
were
co‐loaded
into
dual‐targeting
folate
receptor/P‐selectin
nanocarriers,
which
based
on
folate‐conjugated
fucoidan‐poloxamer
407
copolymers
(FA‐FP407),
aiming
inhibit
breast
cancer
through
intravenous
administration.
The
successful
synthesis
of
the
self‐assembled
nanogels
was
confirmed
by
analyzing
chemical
composition.
resulting
exhibited
optimal
physicochemical
properties,
including
a
negative
surface
charge,
spherical
morphology,
hydrodynamic
diameter
158.27
±
3.15
nm,
along
with
high
drug‐loading
efficiency.
vitro
drug
release
from
significantly
accelerated
within
tumor
microenvironment
at
pH
5.5,
it
slowed
down
under
physiological
conditions.
kinetics
adhered
Fickian
diffusion
model.
Additionally,
blank
nanocarriers
both
hemocompatible
cytocompatible,
although
they
slight
growth
inhibition
MCF‐7
cells.
FA‐FP407@Cur@PTX
demonstrated
lower
IC
50
compared
free
formulations
single
drug‐loaded
cells,
indicating
could
enhance
activity
co‐administering
different
drugs
precisely
accumulating
cancerous
site.
This
effect
is
attributed
strong
synergistic
actions
receptor‐mediated
cellular
uptake.
study
provides
solid
foundation
for
advancing
targeted
nanomedicine,
facilitating
co‐delivery
multiple
agents
achieve
superior
effects
chemotherapy.
