Zwitterionic
polymers
possess
equal
total
positive
and
negative
charges
in
the
repeating
units,
making
them
electrically
neutral
overall.
This
unique
property
results
superhydrophilicity,
which
makes
zwitterionic
highly
effective
resisting
protein
adsorption,
thus
endowing
drug
carriers
with
long
blood
circulation
time,
inhibiting
thrombus
formation
on
biomedical
devices
contact
blood,
ensuring
good
sensitivity
of
sensors
application.
Moreover,
have
excellent
tumor-targeting
ability
pH-responsiveness,
rendering
ideal
candidates
for
antitumor
delivery.
Additionally,
high
ionic
conductivity
an
important
raw
material
skin.
exhibit
remarkable
resistance
to
bacterial
adsorption
growth,
proving
their
suitability
a
wide
range
applications
such
as
ophthalmic
applications,
wound
dressings,
marine
anti-fouling.
In
this
paper,
we
provide
in-depth
analysis
different
structures
characteristics
highlight
qualities
applications.
Furthermore,
discuss
limitations
challenges
that
must
be
overcome
realize
full
potential
present
optimistic
perspective
fields.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 5, 2024
Abstract
Nanomedicine
has
shown
great
anticancer
potential
by
disrupting
redox
homeostasis
and
increasing
the
levels
of
oxidative
stress,
but
therapeutic
effect
is
limited
factors
including
intrinsic
self‐protection
mechanism
tumors.
Cancer
cell
death
can
be
induced
exploration
different
mechanisms,
such
as
apoptosis,
pyroptosis,
necroptosis,
cuproptosis,
ferroptosis.
The
merging
nanotechnology
with
biomedicine
provided
tremendous
opportunities
to
construct
death‐based
nanomedicine
for
innovative
cancer
therapy.
Nanocarriers
are
not
only
used
targeted
delivery
inducers,
also
components
induce
achieve
efficient
tumor
treatment.
This
review
focuses
on
seven
modalities
mediated
nanomaterials,
ferroptosis,
cuprotosis,
immunogenic
death,
autophagy.
mechanisms
these
described
in
detail,
well
preparation
nanomaterials
that
them
they
exert
their
effects.
Finally,
this
work
describes
future
development
based
current
knowledge
related
nanomaterials.
Engineering,
Journal Year:
2024,
Volume and Issue:
36, P. 178 - 192
Published: Jan. 20, 2024
Multiple
myeloma
(MM)
is
the
second
most
prevalent
hematological
malignancy.
Current
MM
treatment
strategies
are
hampered
by
systemic
toxicity
and
suboptimal
therapeutic
efficacy.
This
study
addressed
these
limitations
through
development
of
a
potent
MM-targeting
chemotherapy
strategy,
which
capitalized
on
high
binding
affinity
alendronate
for
hydroxyapatite
in
bone
matrix
homologous
targeting
cell
membranes,
termed
T-PB@M.
The
results
from
our
investigations
highlight
considerable
T-PB@M,
both
vitro
vivo.
Additionally,
this
material
demonstrated
capability
drug
release
triggered
low
pH
conditions.
Moreover,
T-PB@M
induced
generation
reactive
oxygen
species
apoptosis
poly(ADP-ribose)
polymerase
1
(PARP1)–Caspase-3–B-cell
lymphoma-2
(Bcl-2)
pathway
cells.
Notably,
preferentially
targeted
bone-involved
sites,
thereby
circumventing
toxic
side
effects
leading
to
prolonged
survival
orthotopic
mice.
Therefore,
designed
target-MM
nanocarrier
presents
promising
potentially
effective
platform
precise
MM.
Biomacromolecules,
Journal Year:
2024,
Volume and Issue:
26(1), P. 33 - 42
Published: Dec. 12, 2024
Bioresponsive
polymeric
nanoparticles
(NPs)
that
are
capable
of
delivering
and
releasing
therapeutics
biotherapeutics
to
target
sites
have
attracted
vivid
interest
in
cancer
therapy
immunotherapy.
In
contrast
enthusiastic
evolution
the
academic
world,
clinical
translation
these
smart
systems
is
scarce,
partly
due
concerns
about
safety,
stability,
complexity,
scalability.
The
moderate
targetability,
responsivity,
benefits
other
concerns.
past
17
years,
we
devoted
ourselves
exploring
elegant
strategies
address
above
basic
translational
problems
by
introducing
diverse
functional
groups
and/or
targeting
ligands
safe
biomedical
materials,
such
as
biodegradable
polymers
water-soluble
polymers.
This
minimal
modification
critical
for
further
translation.
We
tailor-made
various
bioresponsive
NPs
including
shell-sheddable
acid-sensitive
NPs,
disulfide-cross-linked
micelles
polymersomes,
blood–brain
barrier
(BBB)-permeable
different
tumors.
perspective
provides
an
overview
our
work
path
toward
targeted
nanomedicines
personalized
vaccines,
which
might
inspire
future
research
on
therapy.
Medical Review,
Journal Year:
2024,
Volume and Issue:
5(2), P. 117 - 138
Published: Sept. 11, 2024
The
therapeutic
efficacy
of
anticancer
drugs
heavily
relies
on
their
concentration
and
retention
at
the
corresponding
target
site.
Hence,
merely
increasing
cellular
is
insufficient
to
achieve
satisfactory
outcomes,
especially
for
that
specific
intracellular
sites.
This
necessitates
implementation
more
precise
targeting
strategies
overcome
limitations
posed
by
diffusion
distribution
nonspecific
interactions
within
cells.
Consequently,
subcellular
organelle-targeted
cancer
therapy,
characterized
its
exceptional
precision,
have
emerged
as
a
promising
approach
eradicate
cells
through
disruption
organelles.
Owing
several
advantages
including
minimized
dosage
side
effect,
optimized
efficacy,
reversal
multidrug
resistance,
therapies
garnered
significant
research
interest
in
recent
years.
In
this
review,
we
comprehensively
summarize
drug
targets,
targeted
delivery
various
levels,
sophisticated
Additionally,
highlight
significance
therapy
present
essential
considerations
clinical
translation.
New Journal of Chemistry,
Journal Year:
2023,
Volume and Issue:
48(2), P. 703 - 711
Published: Dec. 4, 2023
Excited
new
insights
for
future
functional
and
technological
applications
of
polymeric
gels
as
sustainable
carriers
health
agricultural
purposes
was
demonstrated.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(12), P. 2781 - 2781
Published: Dec. 15, 2023
Messenger
RNA
(mRNA)
therapies
have
emerged
as
potent
and
personalized
alternatives
to
conventional
DNA-based
therapies.
However,
their
therapeutic
potential
is
frequently
constrained
by
molecular
instability,
susceptibility
degradation,
inefficient
cellular
delivery.
This
study
presents
the
nanoparticle
"ChargeSome"
a
novel
solution.
ChargeSomes
are
designed
protect
mRNAs
from
degradation
ribonucleases
(RNases)
enable
cell
uptake,
allowing
reach
cytoplasm
for
protein
expression
via
endosome
escape.
We
evaluated
physicochemical
properties
of
using
1H
nuclear
magnetic
resonance,
Fourier-transform
infrared,
dynamic
light
scattering.
formulated
with
9:1
ratio
mPEG-b-PLL
mPEG-b-PLL-SA
demonstrated
superior
uptake
mRNA
delivery
efficiency.
These
minimal
cytotoxicity
in
various
vitro
structures,
suggesting
safety
applications.
Inherent
pH
sensitivity
enables
precise
release
acidic
environments
structurally
protects
encapsulated
external
threats.
Their
design
led
rupture
efficient
into
proton
sponge
effect
environments.
In
conclusion,
serve
effective
secure
systems.
combination
stability,
protection,
efficiency
makes
them
promising
tools
advancement
mRNA-based
therapeutics
vaccines.
