Understanding the Mechanical Properties of Ultra-Deformable Liposomes Using Molecular Dynamics Simulations DOI Creative Commons
Jiaming Xu, Vyshnavi Karra, Danielle E. Large

et al.

Published: Sept. 21, 2023

Improving drug delivery efficiency to solid tumor sites is a central challenge in anti-cancer therapeutic research. Our previous experimental study (Guo et al., Nat. Commun. 2018, 9, 130) showed that soft, elastic liposomes had increased uptake and accumulation cancer cells tumors vitro vivo respectively, relative rigid particles. As first step towards understanding how liposomes’ molecular structure composition modulates their elasticity, we performed all-atom coarse-grained classical dynamics (MD) simulations of lipid bilayers formed by mixing long-tailed, unsaturated phospholipid with short-tailed saturated the same head group. The former type phospholipids considered were 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) 1,2-dipalmitoleoyl-sn-glycero-3-phosphocholine (termed here DPMPC). shorter lipids examined 1,2-diheptanoyl-sn-glycero-3-phosphocholine (DHPC), 1,2-didecanoyl-sn-glycero-3-phosphocholine (DDPC), 1,2-dilauroyl-sn-glycero-3-phosphocholine (DLPC), 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC). Several concentrations surface tensions considered. results show DOPC or DPMPC systems having 25-35 mol% shortest DHPC DDPC are least rigid, area compressibility moduli KA ~10% smaller than values observed pure bilayers. These agree measurements stretching modulus lysis tension compositions. also have lower areas per lipid, form more uneven x-y interfaces water, tails both primary secondary disordered, terminal methyl groups long wriggle vertical direction, compared mixtures longer DLPC DMPC. observations confirm our hypothesis adding increasing short bilayers, alters packing thus make resulting less rigid. No formation nanodomains was noted simulations, no clear trends lateral diffusivities as concentration, varied.

Language: Английский

Stimuli responsive nanosonosensitizers for sonodynamic therapy DOI

Zeyu Jiang,

Wen‐Jing Xiao, Qinrui Fu

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 361, P. 547 - 567

Published: Aug. 15, 2023

Language: Английский

Citations

73
pH‐responsive polymers for drug delivery: Trends and opportunities DOI Open Access
Jagtar Singh, Pallavi Nayak

Journal of Polymer Science, Journal Year: 2023, Volume and Issue: 61(22), P. 2828 - 2850

Published: Aug. 23, 2023

Abstract Polymer science has applications in biomedical engineering, prosthetics, surgical implants, and prospective pharmaceutical excipients for drug delivery. “Intelligent or Smart Polymers” are created targeting either by derivatization of natural polymers controlled radical polymerization electrolytes. Their mode action is governed the environmental stimuli viz. temperature, pH, ionic concentration, magnetism, so on. pH‐responsive polymers, because their self‐assembling behavior, alter solubility, conformation, surface activity, hydrophilicity when exposed to a specific pH. The physiological pH varies from acidic nuclei alkaline cytoplasm highly gastric juice slightly plasma; thus, various under study delivering small molecules, genes, peptides, enzymes, growth factors, antibodies. non‐invasive delivery routes like oral, ocular, nasal, pulmonary, transdermal, rectal can be explored recombinant proteins, monoclonal antibodies, molecules with particular emphasis on individual's pathological state. Further, these designed into architectures dendrimers, liposomes, micelles, metallic nanoparticles that serve as reservoirs sustaining release. challenges this field selection biocompatible ease synthesis scale‐up, ensuring effective drug‐loading, stability aspects, producing robust pharmacological data, timely regulatory approvals. This review exclusively explores physicochemical characteristics categorization, architectural entities, recent studies patents, emerging concerning diseases.

Language: Английский

Citations

59
Advances and applications of nanoparticles in cancer therapy DOI Creative Commons

Xianzhou Huang,

Tao He, Xiuqi Liang

et al.

MedComm – Oncology, Journal Year: 2024, Volume and Issue: 3(1)

Published: March 1, 2024

Abstract Rapid growth in nanoparticles (NPs) as delivery systems holds vast promise to promote therapeutic approaches for cancer treatment. Presently, a diverse array of NPs with unique properties have been developed overcome different challenges and achieve sophisticated routes enhancement series therapies. Inspiring advances achieved the field therapy using NPs. In this review, we aim summarize up‐to‐date progression addressing various challenges, expect elicit novel potential opportunities alternatively. We first introduce sorts NP technologies, illustrate their mechanisms, present applications. Then, achievements made by break obstacles delivering cargoes specific sites through particular are highlighted, including long‐circulation, tumor targeting, responsive release, subcellular localization. subsequently retrospect recent research treatments from single therapy, like chemotherapy, combination chemoradiotherapy, integrative therapy. Finally, perspectives impact on oncology discussed. believe review can offer deeper understanding

Language: Английский

Citations

26
Selective organ targeting nanoparticles: from design to clinical translation DOI
Jian Li, Hai Wang

Nanoscale Horizons, Journal Year: 2023, Volume and Issue: 8(9), P. 1155 - 1173

Published: Jan. 1, 2023

This review briefly describes the fate of nanoparticles in vivo and expounds mechanism organ targeting nanoparticles.

Language: Английский

Citations

14
Flash nanoprecipitation allows easy fabrication of pH-responsive acetalated dextran nanoparticles for intracellular release of payloads DOI Creative Commons
Krystal A. Hughes, Bishal Misra,

Maryam Maghareh

et al.

Discover Nano, Journal Year: 2024, Volume and Issue: 19(1)

Published: Jan. 4, 2024

Acetalated dextran (Ac-Dex) nanoparticles are currently of immense interest due to their sharp pH-responsive nature and high biodegradability. Ac-Dex often formulated through single- or double-emulsion methods utilizing polyvinyl alcohol as the stabilizer. The emulsion utilize toxic organic solvents such dichloromethane chloroform require multi-step processing form stable nanoparticles. Here, we introduce a simple flash nanoprecipitation (FNP) approach that utilizes confined impinging jet mixer non-toxic solvent, ethanol, rapidly. were stabilized using nonionic PEGylated surfactants, D-α-Tocopherol polyethylene glycol succinate (TPGS), Pluronic (F-127). formed FNP highly monodisperse stably encapsulated wide range payloads, including hydrophobic, hydrophilic, macromolecules. When lyophilized, TPGS remained for at least one year with greater than 80% payload retention. cells achieved intracellular release payloads into cytoplasm. In vivo studies demonstrated predominant biodistribution in liver, lungs, spleen after intravenous administration. Taken together, technique allows easy fabrication loading can precisely environments diverse therapeutic applications. Acetalateddextran be F-127, payloads. Highly created simple, scalable technique, which impingement mixer.

Language: Английский

Citations

5
Flash nanoprecipitation assisted self-assembly of ionizable lipid nanoparticles for nucleic acid delivery DOI
Bishal Misra, Krystal A. Hughes, William Pentz

et al.

Nanoscale, Journal Year: 2024, Volume and Issue: 16(14), P. 6939 - 6948

Published: Jan. 1, 2024

Ionizable lipid nanoparticles (LNPs) have emerged as a powerful tool for the intracellular delivery of nucleic acids. Following recent success LNP-based siRNA therapeutics and mRNA vaccines, use ionizable lipids acid has tremendously increased. Here, we introduce flash nanoprecipitation (FNP) approach using confined impingement (CIJ) mixer to stably self-assemble LNPs. To validate this approach, employed three clinically relevant LNP formulations containing SM102, ALC0315, DLin-MC3-DMA lipids. FNP-assembled LNPs showed >95% encapsulation efficiency payloads particle sizes below 150 nm. SM102 or ALC0315 demonstrated efficient into immune cells in vitro lymphoid organs vivo, whereas Dlin-MC3-DMA allowed effective with great functional ability. The FNP technique could economically produce smaller volumes that are highly suitable discovery phase.

Language: Английский

Citations

5
Advances in Targeted Therapy for Tumor with Nanocarriers: A Review DOI Creative Commons

Hongxia Cheng,

Juan Liao,

Yuhan Ma

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101583 - 101583

Published: Feb. 16, 2025

The application of Nanocarriers (NCs) provides a promising strategy to solve the problems faced by traditional chemotherapy drugs, like imprecise delivery, poor bioavailability, high dose requirement, and tendency develop multidrug resistance. With protection NCs, drugs can reach lesion site then release accurately completely. Although some reviews have summarized biological applications little attention has been given advantages disadvantages analyzing organic, inorganic, hybrid NCs separately for targeted therapy identifying means further improve targeting ability. First, in this review, we emphasize three factors that marked impact on therapy: tumor microenvironment (TME), different administration modalities (intravenous, oral, intracavitary administration), pathways (passive active). Second, systematic examination polymeric dendrimers, micelles, liposomes, mesoporous silica gold quantum dots, nano clay, core-shell MOFs are reviewed. Further, propose ways efficiency therapy, including regulating size, shape, surface properties NCs.

Language: Английский

Citations

0
An overview of nanotherapeutics and nanodiagnostics DOI
Shashi Ravi Suman Rudrangi,

H. Basavaraj,

Ashok Pawar

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 19 - 40

Published: Jan. 1, 2025

Language: Английский

Citations

0
Efficacy of Benznidazole Delivery During Chagas Disease Nanotherapy is Dependent on the Nanocarrier Morphology DOI
Débora B. Scariot, Austeja Staneviciute, Rayanne Regina Beltrame Machado

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123358 - 123358

Published: April 1, 2025

Language: Английский

Citations

0
Versatile Platforms of Microneedle Patches Loaded with Responsive Nanoparticles: Synthesis and Promising Biomedical Applications DOI Creative Commons

Rixin Xie,

Wenjing Li, Kexin Shi

et al.

Advanced NanoBiomed Research, Journal Year: 2024, Volume and Issue: 4(4)

Published: Feb. 15, 2024

Microneedle array systems loaded with responsive nanoparticles have received increasing attention due to the advantages of good drug stability, targeting ability, controlled release drugs, high bioavailability, painlessness, and patient compliance. Compared oral delivery, microneedle transdermal delivery eliminates need pass through gastrointestinal tract liver, reducing metabolic consumption drugs by first‐pass effect. While compared intravenous reduces discomfort does not require professional administration. However, there are few review articles on microneedles nanoparticles. Herein, current researches specific such as glucose‐responsive, pH‐responsive, enzyme‐responsive, light‐responsive, magnetic‐responsive, ultrasound‐responsive, multiresponsive, biomedical application these summarized. In addition, challenges prospects strategies briefly discussed, which will facilitate development versatile drug‐delivery strategy.

Language: Английский

Citations

3