Nanoscale, Journal Year: 2023, Volume and Issue: 15(48), P. 19407 - 19422
Published: Jan. 1, 2023
Sonocatalytic cancer therapy has emerged as a promising strategy through the combination of ultrasound waves and catalytic materials to selectively target destroy cells.
Language: Английский
ACS Nano, Journal Year: 2024, Volume and Issue: 18(19), P. 12049 - 12095
Published: May 2, 2024
Cancer, as one of the leading causes death worldwide, drives advancement cutting-edge technologies for cancer treatment. Transition-metal-based nanozymes emerge promising therapeutic nanodrugs that provide a reference therapy. In this review, we present recent breakthrough First, comprehensively outline preparation strategies involved in creating transition-metal-based nanozymes, including hydrothermal method, solvothermal chemical reduction biomimetic mineralization and sol–gel method. Subsequently, elucidate catalytic mechanisms (catalase (CAT)-like activities), peroxidase (POD)-like oxidase (OXD)-like activities) superoxide dismutase (SOD)-like along with their activity regulation such morphology control, size manipulation, modulation, composition adjustment surface modification under environmental stimulation. Furthermore, elaborate on diverse applications anticancer therapies encompassing radiotherapy (RT), chemodynamic therapy (CDT), photodynamic (PDT), photothermal (PTT), sonodynamic (SDT), immunotherapy, synergistic Finally, challenges faced by are discussed alongside future research directions. The purpose review is to offer scientific guidance will enhance clinical based transition metals.
Language: Английский
Citations
52
Inorganics, Journal Year: 2024, Volume and Issue: 12(12), P. 331 - 331
Published: Dec. 18, 2024
A type of nanoparticle has been developed to simultaneously alleviate tumor hypoxia and enhance the effectiveness sonodynamic therapy aimed at improving cancer treatment outcomes. Small-sized iron–platinum nanoparticles were prepared using a thermal reduction method, their particle size crystal structure characterized. The ability these decompose hydrogen peroxide produce oxygen generate singlet under ultrasound irradiation was further tested. effect on inhibition proliferation MCF-7 cells hypoxic conditions also evaluated. effectively decomposed oxygen, reversing environment tumors. Additionally, they generated irradiation, which killed inhibited proliferation. This study successfully small-sized that can by decomposing excess in oxygen. Under inhibiting growth. demonstrated good safety are potentially valuable enhancing oxygen-enhanced therapy.
Language: Английский
Citations
40
Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(13), P. 8307 - 8472
Published: June 26, 2024
Due to the intrinsic non-invasive nature, cost-effectiveness, high safety, and real-time capabilities, besides diagnostic imaging, ultrasound as a typical mechanical wave has been extensively developed physical tool for versatile biomedical applications. Especially, prosperity of nanotechnology nanomedicine invigorates landscape ultrasound-based medicine. The unprecedented surge in research enthusiasm dedicated efforts have led mass multifunctional micro-/nanosystems being applied biomedicine, facilitating precise diagnosis, effective treatment, personalized theranostics. deployment applications is rooted profound understanding relationship among composition, structure, property, bioactivity, application, performance. In this comprehensive review, we elaborate on general principles regarding design, synthesis, functionalization, optimization abundant particular, recent advancements imaging are meticulously summarized. Furthermore, systematically elucidate state-of-the-art studies concerning progress therapeutic targeting various pathological abnormalities including cancer, bacterial infection, brain diseases, cardiovascular metabolic diseases. Finally, conclude provide an outlook field with in-depth discussion challenges faced future developments further extensive clinical translation application.
Language: Английский
Citations
32
ACS Nano, Journal Year: 2024, Volume and Issue: 18(5), P. 3916 - 3968
Published: Jan. 23, 2024
Dynamic variations in the concentration and abnormal distribution of endogenous biomarkers are strongly associated with multiple physiological pathological states. Therefore, it is crucial to design imaging systems capable real-time detection dynamic changes for accurate diagnosis effective treatment diseases. Recently, ratiometric has emerged as a widely used technique sensing due its advantage circumventing limitations inherent conventional intensity-dependent signal readout methods while also providing built-in self-calibration correction. Here, recent progress probes their applications outlined. Ratiometric classified according mechanisms, photoacoustic imaging, optical including photoluminescence self-luminescence magnetic resonance dual-modal discussed. The such pH, reactive oxygen species (ROS), nitrogen (RNS), glutathione (GSH), gas molecules, enzymes, metal ions, hypoxia discussed detail. Additionally, this Review presents an overview challenges faced field along future research directions.
Language: Английский
Citations
29
Small, Journal Year: 2024, Volume and Issue: 20(25)
Published: Jan. 15, 2024
Abstract Sonodynamic therapy (SDT) as a promising non‐invasive anti‐tumor means features the preferable penetration depth, which nevertheless, usually can't work without sonosensitizers. Sonosensitizers produce reactive oxygen species (ROS) in presence of ultrasound to directly kill tumor cells, and concurrently activate immunity especially after integration with microenvironment (TME)‐engineered nanobiotechnologies combined therapy. Current sonosensitizers are classified into organic inorganic ones, current most reviews only cover highlighted their applications. However, there have few specific that focus on including design principles, regulation, etc. In this review, first according rationales rather than composition, action underlying chemistry highlighted. Afterward, what how TME is regulated based sonosensitizers‐based SDT nanoplatform an emphasis targets‐engineered elucidated. Additionally, applications non‐cancer diseases also outlined. Finally, setbacks challenges, proposed potential solutions future directions pointed out. This review provides comprehensive detailed horizon sonosensitizers, will arouse more attentions SDT.
Language: Английский
Citations
28
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(26)
Published: Feb. 27, 2024
Abstract Reactive oxygen species (ROS)‐induced endoplasmic reticulum (ER) stress in sonodynamic therapy (SDT) can elicit immunogenic cell death (ICD)‐initiated antitumor immunity for augmented sono‐immunotherapy. However, unsatisfactory activity and mediocre ER induction ability of sonosensitizers essentially restrict SDT efficacy ICD stimulation. Herein, a versatile ER‐targeting Iridium(III) nanosonosensitizer is developed as superior inducer boosted tumor An ingenious cholic acid (CA)‐functionalized sonosensitizer Ir‐CA well‐designed skillfully crosslinked with human serum albumin (HSA) to form HSA@Ir‐CA. With high stability, favorable tumor‐targeting ability, reduction‐responsiveness, HSA@Ir‐CA preferentially accumulates sites enhanced cellular uptake, followed by rapid disassembly responding intracellular reductive environment. The uncaged selectively accumulate precisely disrupt situ produced type I II ROS upon US irradiation high‐efficiency SDT. Moreover, the maximized eminently amplifies evoke robust systemic immunity, inhibiting growths primary/distant tumor, lung metastasis, recurrence. This combined immune checkpoint inhibitor (αPD‐L1) further achieves reinforced therapeutic outcome against immunologically “cold” tumor. study presents an effective paradigm optimize amplify ICD‐initiated responses
Language: Английский
Citations
19
Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123134 - 123134
Published: Jan. 1, 2025
Language: Английский
Citations
4
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125285 - 125285
Published: Jan. 1, 2025
Language: Английский
Citations
2
Redox Biology, Journal Year: 2025, Volume and Issue: unknown, P. 103515 - 103515
Published: Jan. 1, 2025
Language: Английский
Citations
2
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 261, P. 129901 - 129901
Published: Feb. 3, 2024
Language: Английский
Citations
14