A tumor-targeting porphyrin-micelle with enhanced STING agonist delivery and synergistic photo-/immuno- therapy for cancer treatment DOI
Yuqing Pan,

Haijing Qu,

Han Chen

et al.

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Macrophage membrane-camouflaged pure-drug nanomedicine for synergistic chemo- and interstitial photodynamic therapy against glioblastoma DOI
Wei Cheng,

Zhiran Duan,

Han Chen

et al.

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

2
Manganese-coordinated nanoparticle with high drug-loading capacity and synergistic photo-/immuno-therapy for cancer treatments DOI
Han Chen,

Haijing Qu,

Yuqing Pan

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 312, P. 122745 - 122745

Published: Aug. 3, 2024

Language: Английский

Citations

9
Smart self-transforming nano-systems for overcoming biological barrier and enhancing tumor treatment efficacy DOI
Jun Tao,

Weiqing Ning,

Wei Lü

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 85 - 107

Published: Feb. 5, 2025

Language: Английский

Citations

1
Nanotechnology‐Empowered Combination Cancer Immunotherapies: Mechanisms, Synergies, and Perspectives DOI Creative Commons
Yuqing Pan, Xiangdong Xue, Xing‐Jie Liang

et al.

Advanced NanoBiomed Research, Journal Year: 2024, Volume and Issue: 4(4)

Published: Jan. 26, 2024

This review is aiming to systematically elucidate the unique role of nanotechnology in optimizing therapeutic modalities for combinatorial cancer immunotherapy, which enables synergistic integration multiple treatment strategies. In particular, has enabled combination immunotherapy with physical therapies, chemotherapy, metal therapy, and nucleic acid therapy. each regimen, nanocarriers play multifaceted roles by achieving targeted codelivery different therapeutics individual modality. offers new paradigms guide precision medicine treatment. Immunotherapy alone unlikely achieve personalized cancer, are needed future. To overcome technical bottlenecks realize precise regulation tumor microenvironment treatment, it crucial develop novel nanosystems integrated sensing, targeting, functionalities.

Language: Английский

Citations

6
pH-responsive oxygen self-sufficient smart nanoplatform for enhanced tumor chemotherapy and photodynamic therapy DOI
Xinhe Liu, Xin Wang,

Dan Zang

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 675, P. 1080 - 1090

Published: July 14, 2024

Language: Английский

Citations

6
Study on the regulatory mechanisms of mitochondrial biosynthesis by polyoxometalates DOI Creative Commons
Lei Shan,

Bingnian Chen,

Li Wang

et al.

Polyoxometalates, Journal Year: 2025, Volume and Issue: 4(1), P. 9140074 - 9140074

Published: March 1, 2025

In recent years, polyoxometalates have been systematically studied in the treatment of diabetes, tumor, cancer, inflammation and other diseases vitro vivo, their main therapeutic mechanisms are related to generation reactive oxygen species causing oxidative stress. The site production is mitochondria, therefore, mechanism may be mitochondrial biosynthesis. This paper describes one diabetes mellitus, which involves increase species, resulting stress; at same time, preliminarily as antioxidants antitumor mellitus tumors, antioxidant properties provide an additional possibility for future a drug disease treatment; on basis study stress biomolecule due it, associating therapy actually closely through biosynthesis regulation relationship between mitochondria its impact three aspects order in-depth role drugs aspects.

Language: Английский

Citations

0
Smart Upconversion Nanocapsules: Harnessing Photodegradation and Glutathione Responsiveness of Polymers for Controlled Release of Payloads DOI
Xiaotao Wang, Chuan Xu, Yonggui Liao

et al.

Polymer, Journal Year: 2025, Volume and Issue: unknown, P. 128314 - 128314

Published: March 1, 2025

Language: Английский

Citations

0
A metal-coordination stabilized small-molecule nanomedicine with high drug-loading capacity and synergistic photochemotherapy for cancer treatment DOI
Han Y. H. Chen,

Haijing Qu,

Beike Lu

et al.

Nanoscale, Journal Year: 2024, Volume and Issue: 16(31), P. 14734 - 14747

Published: Jan. 1, 2024

A small-molecule nanomedicine with high drug loading, robust stability, responsive release and a synergistic photochemotherapeutic effect has been developed for cancer therapy. Image created Biorender.

Language: Английский

Citations

3
Twin-Tail Tadpole-Shaped Ce6-Peptide Conjugate for Enhanced Photodynamic Cancer Therapy DOI
Mengmeng Jiang,

Shaowen Wu,

Hongxia Zhang

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Despite its therapeutic potential, photodynamic therapy faces several key limitations in clinical applications, including poor drug delivery and insufficient tumor selectivity. We engineered RFYFYR-Ce6-RFYFYR (R-Ce6-R), a twin-tail peptide–photosensitizer conjugate that self-assembles into nanostructures for improved cancer treatment. By incorporating arginine-rich peptide sequences, this design not only enhances cellular internalization but also promotes peroxynitrite (ONOO–) formation, amplifying the effect. Our studies revealed R-Ce6-R achieves 33-fold higher potency than unmodified Ce6, with an IC50 of 0.18 μM. The demonstrated selective accumulation tissue, robust ROS generation, complete regression animal models while maintaining favorable safety profile. These results establish as innovative approach advancing

Language: Английский

Citations

0
Remodeling Tumor Metabolism via Self‐Amplifying Energy‐Depleting Nanocomplexes for Effective Photodynamic‐Immunotherapy DOI Open Access
Yu Liu, Wen Li,

Jiahui Cao

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 16, 2025

Abstract The abnormal metabolism of tumor cells fulfills their high energy demands for rapid growth while simultaneously reshaping the microenvironment (TME), which suppresses immune cell function and facilitates evasion. Herein, a peptide‐based nanocomplex (DCK@siGLUT1) that synergizes with photodynamic therapy (PDT) to disrupt is developed. DCK@siGLUT1, utilizing mitochondria‐targeting peptide (dKLA) selectively accumulates in mitochondria, where it impairs mitochondrial membrane integrity, disrupts metabolism, induces apoptosis. Upon apoptosis, activated caspase‐3 (Casp3) cleaves releasing siGLUT1 silence glucose transporter 1 (GLUT1) expression, further inhibits uptake intensifies metabolic collapse, thereby amplifying apoptotic effects. Moreover, Ce6, conjugated dKLA, co‐delivered mitochondria and, upon light activation, exacerbates damage disruption. These combined mechanisms intensify oxidative stress activate Casp3, promote DCK@siGLUT1 cleavage, driving self‐amplifying tumoricidal cascade. Furthermore, effectively immunogenic death (ICD), triggers antitumor responses, both primary distant metastasis. This strategy offers novel approach targeting immunotherapy.

Language: Английский

Citations

0